CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	RNASLOpt		NanoFolder
MCC	0.460	>	0.179
Average MCC ± 95% Confidence Intervals	0.458 ± 0.032	>	0.177 ± 0.024
Sensitivity	0.428	>	0.210
Positive Predictive Value	0.496	>	0.155
Total TP	3856	>	1889
Total TN	5269190	>	5264754
Total FP	4270	<	10618
Total FP CONTRA	469	<	1800
Total FP INCONS	3444	<	8516
Total FP COMP	357	>	302
Total FN	5150	<	7117
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of RNASLOpt and NanoFolder. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNASLOpt and NanoFolder).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNASLOpt and NanoFolder).
Comparison of average Matthews Correlation Coefficients (MCCs) for RNASLOpt and NanoFolder. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNASLOpt and NanoFolder).

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Performance of RNASLOpt - scored higher in this pairwise comparison

1. Total counts & total scores for RNASLOpt

Total Base Pair Counts
Total TP	3856
Total TN	5269190
Total FP	4270
Total FP CONTRA	469
Total FP INCONS	3444
Total FP COMP	357
Total FN	5150

Total Scores
MCC	0.460
Average MCC ± 95% Confidence Intervals	0.458 ± 0.032
Sensitivity	0.428
Positive Predictive Value	0.496
Nr of predictions	89

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2. Individual counts for RNASLOpt [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00017	RNaseP_nuc links to Rfam database...	0.24	0.25	0.24	16	50973	67	12	39	16	48
ASE_00083	RNaseP_bact_a links to Rfam database...	0.52	0.47	0.58	52	62392	43	5	32	6	58
ASE_00122	RNaseP_bact_a links to Rfam database...	0.58	0.53	0.63	47	43290	28	1	27	0	41
ASE_00185	RNaseP_bact_a links to Rfam database...	0.65	0.59	0.71	76	73429	31	0	31	0	52
ASE_00190	RNaseP_bact_b links to Rfam database...	0.52	0.48	0.57	43	45375	39	1	32	6	47
ASE_00196	RNaseP_arch links to Rfam database...	0.41	0.37	0.46	28	31565	36	2	31	3	47
ASE_00221	RNaseP_bact_a links to Rfam database...	0.31	0.26	0.36	31	64535	54	1	53	0	86
ASE_00227	RNaseP_bact_a links to Rfam database...	0.33	0.29	0.38	38	78903	62	6	56	0	95
ASE_00228	RNaseP_bact_a links to Rfam database...	0.42	0.40	0.45	34	46895	44	8	34	2	52
ASE_00229	RNaseP_bact_a links to Rfam database...	0.67	0.62	0.73	54	42412	22	2	18	2	33
ASE_00231	RNaseP_bact_a links to Rfam database...	0.71	0.66	0.76	63	47812	21	1	19	1	33
ASE_00234	RNaseP_bact_a links to Rfam database...	0.43	0.37	0.49	48	75368	52	1	49	2	81
ASE_00238	RNaseP_bact_a links to Rfam database...	0.39	0.38	0.41	43	64155	65	4	59	2	71
ASE_00248	RNaseP_bact_a links to Rfam database...	0.31	0.28	0.34	32	62388	62	1	60	1	82
ASE_00250	RNaseP_bact_a links to Rfam database...	0.64	0.59	0.70	77	78893	36	5	28	3	54
ASE_00254	RNaseP_bact_a links to Rfam database...	0.26	0.24	0.29	20	36787	54	3	46	5	62
ASE_00255	RNaseP_bact_a links to Rfam database...	0.51	0.47	0.56	61	74583	47	5	42	0	69
ASE_00257	RNaseP_bact_a links to Rfam database...	0.52	0.45	0.59	44	50965	31	3	28	0	53
ASE_00267	RNaseP_bact_a links to Rfam database...	0.24	0.22	0.27	19	45080	57	5	46	6	69
ASE_00270	RNaseP_bact_a links to Rfam database...	0.43	0.40	0.46	51	72280	59	7	52	0	77
ASE_00274	RNaseP_bact_a links to Rfam database...	0.25	0.22	0.28	23	55528	60	4	56	0	80
ASE_00277	RNaseP_bact_a links to Rfam database...	0.28	0.25	0.32	23	48132	50	8	42	0	68
ASE_00279	RNaseP_bact_a links to Rfam database...	0.18	0.16	0.21	16	53226	60	3	56	1	85
ASE_00285	RNaseP_bact_a links to Rfam database...	0.62	0.54	0.71	66	68913	33	0	27	6	56
ASE_00287	RNaseP_bact_a links to Rfam database...	0.28	0.23	0.33	24	54873	49	3	46	0	79
ASE_00295	RNaseP_bact_a links to Rfam database...	0.52	0.46	0.58	60	73817	45	9	34	2	71
ASE_00298	RNaseP_bact_a links to Rfam database...	0.39	0.35	0.42	40	67433	56	5	50	1	73
ASE_00335	RNaseP_bact_b links to Rfam database...	0.55	0.51	0.59	59	75366	48	3	38	7	57
ASE_00340	RNaseP_bact_a links to Rfam database...	0.39	0.35	0.44	30	45988	38	7	31	0	55
ASE_00367	RNaseP_bact_a links to Rfam database...	0.46	0.42	0.50	36	42999	41	4	32	5	50
ASE_00370	RNaseP_bact_a links to Rfam database...	0.57	0.51	0.63	43	41837	26	1	24	1	41
ASE_00372	RNaseP_bact_a links to Rfam database...	0.46	0.44	0.47	44	51910	53	5	44	4	56
ASE_00375	RNaseP_bact_a links to Rfam database...	0.65	0.58	0.72	64	60289	26	2	23	1	46
ASE_00376	RNaseP_bact_a links to Rfam database...	0.54	0.49	0.59	51	56867	38	4	31	3	54
ASE_00377	RNaseP_bact_a links to Rfam database...	0.55	0.50	0.59	54	57539	42	1	36	5	53
ASE_00386	RNaseP_bact_a links to Rfam database...	0.51	0.48	0.55	46	50319	43	6	32	5	50
ASE_00393	RNaseP_bact_a links to Rfam database...	0.48	0.43	0.54	40	47821	41	3	31	7	53
ASE_00412	RNaseP_bact_a links to Rfam database...	0.36	0.33	0.38	35	58220	56	10	46	0	70
ASE_00413	RNaseP_bact_a links to Rfam database...	0.51	0.48	0.55	39	44480	36	2	30	4	42
ASE_00416	RNaseP_bact_a links to Rfam database...	0.49	0.45	0.54	57	77315	53	4	45	4	70
ASE_00417	RNaseP_arch links to Rfam database...	0.43	0.41	0.45	41	54523	53	4	47	2	59
ASE_00422	RNaseP_bact_a links to Rfam database...	0.79	0.72	0.86	68	46892	16	0	11	5	26
ASE_00428	RNaseP_bact_a links to Rfam database...	0.51	0.47	0.55	59	76529	51	3	45	3	66
ASE_00429	-	0.54	0.52	0.58	34	28144	26	3	22	1	32
ASE_00430	RNaseP_bact_a links to Rfam database...	0.78	0.70	0.87	68	46893	15	0	10	5	29
ASE_00434	RNaseP_bact_b links to Rfam database...	0.64	0.61	0.68	67	68167	39	9	22	8	43
ASE_00437	RNaseP_bact_a links to Rfam database...	0.40	0.36	0.45	48	79294	60	3	56	1	87
ASE_00451	RNaseP_bact_a links to Rfam database...	0.44	0.40	0.48	50	70772	55	3	51	1	75
CRW_00654	-	0.84	0.79	0.90	98	78101	14	1	10	3	26
CRW_00658	-	0.39	0.37	0.40	38	74597	58	9	47	2	64
CRW_00663	-	0.16	0.16	0.17	10	26046	55	4	46	5	51
CRW_00664	-	0.17	0.17	0.17	13	53551	71	8	56	7	65
CRW_00671	Intron_gpI links to Rfam database...	0.60	0.53	0.68	62	62744	32	2	27	3	55
CRW_00672	Intron_gpI links to Rfam database...	0.43	0.41	0.45	45	72291	57	6	48	3	66
CRW_00688	-	0.74	0.70	0.78	40	21894	12	1	10	1	17
CRW_00721	-	0.65	0.66	0.64	45	58583	51	7	18	26	23
PDB_00078	-	0.35	0.32	0.38	37	49673	60	6	54	0	78
PDB_00278	-	0.38	0.36	0.41	26	24912	38	3	35	0	46
PDB_00701	-	0.32	0.30	0.33	33	45352	67	6	60	1	76
PDB_00917	-	0.44	0.42	0.47	40	35160	48	7	38	3	55
TMR_00123	tmRNA links to Rfam database...	0.43	0.39	0.47	39	66347	49	5	39	5	62
TMR_00180	tmRNA links to Rfam database...	0.52	0.51	0.54	50	67069	50	9	33	8	49
TMR_00240	tmRNA links to Rfam database...	0.47	0.47	0.48	40	63106	50	7	37	6	45
TMR_00384	tmRNA links to Rfam database...	0.32	0.30	0.34	32	65609	67	2	60	5	76
TMR_00395	tmRNA links to Rfam database...	0.60	0.54	0.67	59	64532	34	4	25	5	50
TMR_00398	tmRNA links to Rfam database...	0.68	0.62	0.73	66	65251	29	2	22	5	40
TMR_00399	tmRNA links to Rfam database...	0.31	0.30	0.32	28	64892	65	13	47	5	66
TMR_00431	tmRNA links to Rfam database...	0.68	0.62	0.76	34	51958	47	5	6	36	21
TMR_00443	tmRNA links to Rfam database...	0.32	0.28	0.36	29	67080	58	5	47	6	75
TMR_00457	tmRNA links to Rfam database...	0.29	0.28	0.30	29	78508	73	14	55	4	73
TMR_00469	tmRNA links to Rfam database...	0.34	0.33	0.35	33	64525	62	10	52	0	67
TMR_00502	tmRNA links to Rfam database...	0.30	0.30	0.31	28	75375	71	12	51	8	65
TMR_00503	tmRNA links to Rfam database...	0.47	0.45	0.50	50	67795	58	0	51	7	61
TMR_00519	tmRNA links to Rfam database...	0.24	0.24	0.24	23	63095	82	13	59	10	72
TMR_00528	tmRNA links to Rfam database...	0.13	0.12	0.14	12	63102	86	8	68	10	85
TMR_00541	tmRNA links to Rfam database...	0.49	0.47	0.51	49	61680	49	3	44	2	56
TMR_00547	tmRNA links to Rfam database...	0.46	0.43	0.49	43	65253	45	1	44	0	57
TMR_00562	tmRNA links to Rfam database...	0.39	0.36	0.42	37	72683	58	9	42	7	65
TMR_00566	tmRNA links to Rfam database...	0.46	0.46	0.46	46	60626	54	7	47	0	54
TMR_00571	tmRNA links to Rfam database...	0.35	0.33	0.38	33	60639	62	8	46	8	66
TMR_00584	tmRNA links to Rfam database...	0.46	0.43	0.48	42	60988	52	5	40	7	55
TMR_00594	tmRNA links to Rfam database...	0.48	0.48	0.49	50	79299	57	10	42	5	54
TMR_00605	tmRNA links to Rfam database...	0.50	0.48	0.52	52	74205	51	12	36	3	56
TMR_00609	tmRNA links to Rfam database...	0.71	0.68	0.75	77	63443	26	6	20	0	36
TMR_00624	tmRNA links to Rfam database...	0.69	0.67	0.71	72	62379	32	10	20	2	36
TMR_00698	tmRNA links to Rfam database...	0.49	0.49	0.50	51	63088	51	16	35	0	53
TMR_00703	tmRNA links to Rfam database...	0.26	0.24	0.29	24	67444	64	5	55	4	75
TMR_00706	tmRNA links to Rfam database...	0.37	0.34	0.40	35	66342	54	11	42	1	68
TMR_00711	tmRNA links to Rfam database...	0.47	0.45	0.49	44	67807	52	15	30	7	54

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Performance of NanoFolder - scored lower in this pairwise comparison

1. Total counts & total scores for NanoFolder

Total Base Pair Counts
Total TP	1889
Total TN	5264754
Total FP	10618
Total FP CONTRA	1800
Total FP INCONS	8516
Total FP COMP	302
Total FN	7117

Total Scores
MCC	0.179
Average MCC ± 95% Confidence Intervals	0.177 ± 0.024
Sensitivity	0.210
Positive Predictive Value	0.155
Nr of predictions	89

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2. Individual counts for NanoFolder [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00017	RNaseP_nuc links to Rfam database...	0.02	0.03	0.02	2	50914	131	38	86	7	62
ASE_00083	RNaseP_bact_a links to Rfam database...	0.22	0.25	0.20	27	62347	108	12	95	1	83
ASE_00122	RNaseP_bact_a links to Rfam database...	0.27	0.30	0.24	26	43258	84	13	68	3	62
ASE_00185	RNaseP_bact_a links to Rfam database...	0.17	0.19	0.16	24	73382	134	14	116	4	104
ASE_00190	RNaseP_bact_b links to Rfam database...	0.24	0.28	0.21	25	45334	93	14	78	1	65
ASE_00196	RNaseP_arch links to Rfam database...	0.49	0.57	0.42	43	31524	62	16	43	3	32
ASE_00221	RNaseP_bact_a links to Rfam database...	0.20	0.21	0.18	25	64484	112	10	101	1	92
ASE_00227	RNaseP_bact_a links to Rfam database...	0.28	0.31	0.25	41	78840	122	20	102	0	92
ASE_00228	RNaseP_bact_a links to Rfam database...	0.05	0.06	0.04	5	46858	109	17	91	1	81
ASE_00229	RNaseP_bact_a links to Rfam database...	0.12	0.14	0.11	12	42380	97	12	82	3	75
ASE_00231	RNaseP_bact_a links to Rfam database...	0.37	0.42	0.33	40	47773	84	17	65	2	56
ASE_00234	RNaseP_bact_a links to Rfam database...	0.25	0.27	0.23	35	75315	117	10	106	1	94
ASE_00238	RNaseP_bact_a links to Rfam database...	0.26	0.30	0.23	34	64111	119	18	98	3	80
ASE_00248	RNaseP_bact_a links to Rfam database...	0.13	0.15	0.12	17	62340	124	9	115	0	97
ASE_00250	RNaseP_bact_a links to Rfam database...	0.25	0.29	0.23	38	78835	135	17	113	5	93
ASE_00254	RNaseP_bact_a links to Rfam database...	0.15	0.16	0.14	13	36761	88	3	79	6	69
ASE_00255	RNaseP_bact_a links to Rfam database...	0.11	0.12	0.10	16	74530	146	16	129	1	114
ASE_00257	RNaseP_bact_a links to Rfam database...	0.37	0.42	0.33	41	50917	85	15	67	3	56
ASE_00267	RNaseP_bact_a links to Rfam database...	0.00	0.00	0.00	0	45036	115	9	105	1	88
ASE_00270	RNaseP_bact_a links to Rfam database...	0.19	0.21	0.17	27	72232	132	14	117	1	101
ASE_00274	RNaseP_bact_a links to Rfam database...	0.00	0.00	0.00	0	55487	126	12	112	2	103
ASE_00277	RNaseP_bact_a links to Rfam database...	0.10	0.12	0.08	11	48071	123	23	100	0	80
ASE_00279	RNaseP_bact_a links to Rfam database...	0.14	0.16	0.13	16	53177	109	16	92	1	85
ASE_00285	RNaseP_bact_a links to Rfam database...	0.34	0.36	0.31	44	68866	98	14	82	2	78
ASE_00287	RNaseP_bact_a links to Rfam database...	0.15	0.17	0.14	17	54824	107	14	91	2	86
ASE_00295	RNaseP_bact_a links to Rfam database...	0.14	0.16	0.13	21	73761	140	19	119	2	110
ASE_00298	RNaseP_bact_a links to Rfam database...	0.09	0.10	0.08	11	67389	129	8	120	1	102
ASE_00335	RNaseP_bact_b links to Rfam database...	0.10	0.12	0.09	14	75304	151	22	126	3	102
ASE_00340	RNaseP_bact_a links to Rfam database...	0.06	0.07	0.05	6	45943	110	13	94	3	79
ASE_00367	RNaseP_bact_a links to Rfam database...	0.08	0.09	0.07	8	42960	110	10	93	7	78
ASE_00370	RNaseP_bact_a links to Rfam database...	0.03	0.04	0.03	3	41796	109	18	88	3	81
ASE_00372	RNaseP_bact_a links to Rfam database...	0.17	0.20	0.15	20	51871	113	19	93	1	80
ASE_00375	RNaseP_bact_a links to Rfam database...	0.12	0.14	0.11	15	60246	120	10	107	3	95
ASE_00376	RNaseP_bact_a links to Rfam database...	0.00	0.00	0.00	0	56822	136	9	122	5	105
ASE_00377	RNaseP_bact_a links to Rfam database...	0.25	0.27	0.23	29	57505	98	10	86	2	78
ASE_00386	RNaseP_bact_a links to Rfam database...	0.14	0.16	0.13	15	50284	106	9	95	2	81
ASE_00393	RNaseP_bact_a links to Rfam database...	0.31	0.35	0.27	33	47773	90	18	71	1	60
ASE_00412	RNaseP_bact_a links to Rfam database...	0.15	0.17	0.14	18	58183	111	14	96	1	87
ASE_00413	RNaseP_bact_a links to Rfam database...	0.08	0.10	0.07	8	44438	108	19	86	3	73
ASE_00416	RNaseP_bact_a links to Rfam database...	0.39	0.43	0.35	54	77267	103	18	82	3	73
ASE_00417	RNaseP_arch links to Rfam database...	0.32	0.36	0.28	36	54486	98	18	75	5	64
ASE_00422	RNaseP_bact_a links to Rfam database...	0.28	0.31	0.25	29	46856	87	9	77	1	65
ASE_00428	RNaseP_bact_a links to Rfam database...	0.24	0.26	0.22	33	76483	121	13	107	1	92
ASE_00429	-	0.08	0.09	0.07	6	28114	84	14	69	1	60
ASE_00430	RNaseP_bact_a links to Rfam database...	0.16	0.18	0.14	17	46852	102	10	92	0	80
ASE_00434	RNaseP_bact_b links to Rfam database...	0.29	0.34	0.25	37	68116	122	20	92	10	73
ASE_00437	RNaseP_bact_a links to Rfam database...	0.00	0.00	0.00	0	79238	164	12	151	1	135
ASE_00451	RNaseP_bact_a links to Rfam database...	0.20	0.22	0.19	27	70731	118	8	110	0	98
CRW_00654	-	0.41	0.47	0.36	58	78049	105	18	85	2	66
CRW_00658	-	0.21	0.26	0.16	27	74527	137	28	109	0	75
CRW_00663	-	0.08	0.10	0.07	6	26014	90	17	69	4	55
CRW_00664	-	0.14	0.19	0.11	15	53486	134	42	85	7	63
CRW_00671	Intron_gpI links to Rfam database...	0.18	0.21	0.16	24	62682	130	23	106	1	93
CRW_00672	Intron_gpI links to Rfam database...	0.36	0.43	0.31	48	72233	114	35	74	5	63
CRW_00688	-	0.33	0.40	0.27	23	21859	64	21	42	1	34
CRW_00721	-	0.22	0.31	0.15	21	58515	133	46	71	16	47
PDB_00078	-	0.00	0.00	0.00	0	49644	126	10	116	0	115
PDB_00278	-	0.04	0.06	0.04	4	24875	98	13	84	1	68
PDB_00701	-	0.04	0.05	0.04	5	45319	127	14	113	0	104
PDB_00917	-	0.31	0.34	0.29	32	35136	81	10	67	4	63
TMR_00123	tmRNA links to Rfam database...	0.19	0.23	0.16	23	66283	126	20	104	2	78
TMR_00180	tmRNA links to Rfam database...	0.12	0.16	0.10	16	66999	149	35	111	3	83
TMR_00240	tmRNA links to Rfam database...	0.23	0.31	0.17	26	63041	128	39	84	5	59
TMR_00384	tmRNA links to Rfam database...	0.17	0.20	0.14	22	65550	133	26	105	2	86
TMR_00395	tmRNA links to Rfam database...	0.27	0.31	0.24	34	64478	115	10	98	7	75
TMR_00398	tmRNA links to Rfam database...	0.05	0.07	0.05	7	65197	139	24	113	2	99
TMR_00399	tmRNA links to Rfam database...	0.20	0.26	0.16	24	64833	130	38	85	7	70
TMR_00431	tmRNA links to Rfam database...	0.24	0.33	0.17	18	51899	127	26	60	41	37
TMR_00443	tmRNA links to Rfam database...	0.17	0.20	0.15	21	67018	126	24	98	4	83
TMR_00457	tmRNA links to Rfam database...	0.19	0.25	0.15	25	78443	141	39	99	3	77
TMR_00469	tmRNA links to Rfam database...	0.10	0.12	0.08	12	64469	145	27	112	6	88
TMR_00502	tmRNA links to Rfam database...	0.14	0.19	0.11	18	75303	150	45	100	5	75
TMR_00503	tmRNA links to Rfam database...	0.11	0.14	0.10	15	67741	141	20	120	1	96
TMR_00519	tmRNA links to Rfam database...	0.04	0.05	0.03	5	63046	141	33	106	2	90
TMR_00528	tmRNA links to Rfam database...	0.13	0.15	0.11	15	63051	131	20	104	7	82
TMR_00541	tmRNA links to Rfam database...	0.12	0.14	0.10	15	61630	139	22	109	8	90
TMR_00547	tmRNA links to Rfam database...	0.28	0.35	0.23	35	65188	122	37	81	4	65
TMR_00562	tmRNA links to Rfam database...	0.09	0.12	0.08	12	72617	147	27	115	5	90
TMR_00566	tmRNA links to Rfam database...	0.13	0.16	0.11	16	60582	132	22	106	4	84
TMR_00571	tmRNA links to Rfam database...	0.05	0.06	0.04	6	60577	149	19	124	6	93
TMR_00584	tmRNA links to Rfam database...	0.01	0.01	0.01	1	60922	159	33	119	7	96
TMR_00594	tmRNA links to Rfam database...	0.08	0.10	0.06	10	79238	156	30	123	3	94
TMR_00605	tmRNA links to Rfam database...	0.28	0.35	0.23	38	74141	129	36	90	3	70
TMR_00609	tmRNA links to Rfam database...	0.53	0.62	0.45	70	63391	89	28	57	4	43
TMR_00624	tmRNA links to Rfam database...	0.36	0.44	0.30	47	62325	111	27	82	2	61
TMR_00698	tmRNA links to Rfam database...	0.20	0.24	0.17	25	63042	124	27	96	1	79
TMR_00703	tmRNA links to Rfam database...	0.10	0.12	0.08	12	67376	140	26	114	0	87
TMR_00706	tmRNA links to Rfam database...	0.14	0.17	0.11	17	66281	133	29	103	1	86
TMR_00711	tmRNA links to Rfam database...	0.18	0.22	0.14	22	67740	137	41	93	3	76

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of RNASLOpt - scored higher in this pairwise comparison

1. Total counts & total scores for RNASLOpt

2. Individual counts for RNASLOpt [ download as .csv ]

Performance of NanoFolder - scored lower in this pairwise comparison

1. Total counts & total scores for NanoFolder

2. Individual counts for NanoFolder [ download as .csv ]