CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of RNASampler(20) - scored higher in this pairwise comparison

  4. Performance of RSpredict(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for RNASampler(20) & RSpredict(seed) [.zip] - may take several seconds...


Overview

Metric RNASampler(20) RSpredict(seed)
MCC 0.480 > 0.006
Average MCC ± 95% Confidence Intervals 0.474 ± 0.098 > 0.005 ± 0.012
Sensitivity 0.343 > 0.001
Positive Predictive Value 0.673 > 0.030
Total TP 282 > 1
Total TN 482477 < 482863
Total FP 163 > 36
Total FP CONTRA 16 > 1
Total FP INCONS 121 > 31
Total FP COMP 26 > 4
Total FN 540 < 821
P-value 0.0

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Performance plots


  1. Comparison of performance of RNASampler(20) and RSpredict(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNASampler(20) and RSpredict(seed)).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNASampler(20) and RSpredict(seed)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for RNASampler(20) and RSpredict(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNASampler(20) and RSpredict(seed)).

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Performance of RNASampler(20) - scored higher in this pairwise comparison

1. Total counts & total scores for RNASampler(20)

Total Base Pair Counts
Total TP 282
Total TN 482477
Total FP 163
Total FP CONTRA 16
Total FP INCONS 121
Total FP COMP 26
Total FN 540
Total Scores
MCC 0.480
Average MCC ± 95% Confidence Intervals 0.474 ± 0.098
Sensitivity 0.343
Positive Predictive Value 0.673
Nr of predictions 8

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2. Individual counts for RNASampler(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
ASE_00064 0.44 0.34 0.58 30 45399 23 1 21 1 59
ASE_00090 0.54 0.40 0.74 40 55557 14 0 14 0 61
ASE_00135 0.54 0.36 0.83 39 63143 16 0 8 8 70
ASE_00153 0.38 0.33 0.44 24 57576 38 7 23 8 49
ASE_00215 0.38 0.23 0.62 23 48479 16 0 14 2 76
ASE_00328 0.70 0.57 0.85 64 72696 14 5 6 3 48
ASE_00361 0.34 0.21 0.55 27 75417 26 3 19 4 100
ASE_00441 0.46 0.31 0.69 35 64210 16 0 16 0 77

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Performance of RSpredict(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for RSpredict(seed)

Total Base Pair Counts
Total TP 1
Total TN 482863
Total FP 36
Total FP CONTRA 1
Total FP INCONS 31
Total FP COMP 4
Total FN 821
Total Scores
MCC 0.006
Average MCC ± 95% Confidence Intervals 0.005 ± 0.012
Sensitivity 0.001
Positive Predictive Value 0.030
Nr of predictions 8

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2. Individual counts for RSpredict(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
ASE_00064 0.00 0.00 0.00 0 45448 3 0 3 0 89
ASE_00090 0.04 0.01 0.17 1 55605 5 0 5 0 100
ASE_00135 0.00 0.00 0.00 0 63187 3 0 3 0 109
ASE_00153 0.00 0.00 0.00 0 57629 1 1 0 0 73
ASE_00215 0.00 0.00 0.00 0 48513 3 0 3 0 99
ASE_00328 0.00 0.00 0.00 0 72760 15 0 11 4 112
ASE_00361 0.00 0.00 0.00 0 75463 3 0 3 0 127
ASE_00441 0.00 0.00 0.00 0 64258 3 0 3 0 112

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.