CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	RNAalifold(seed)		Carnac(seed)
MCC	0.619	>	0.000
Average MCC ± 95% Confidence Intervals	0.603 ± 0.051	>	0.000 ± 0.000
Sensitivity	0.427	>	0.000
Positive Predictive Value	0.899	>	0.000
Total TP	1950	>	0
Total TN	3423707	<	3425877
Total FP	293	>	0
Total FP CONTRA	18	>	0
Total FP INCONS	202	>	0
Total FP COMP	73	>	0
Total FN	2621	<	4571
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of RNAalifold(seed) and Carnac(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNAalifold(seed) and Carnac(seed)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNAalifold(seed) and Carnac(seed)).
Comparison of average Matthews Correlation Coefficients (MCCs) for RNAalifold(seed) and Carnac(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNAalifold(seed) and Carnac(seed)).

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Performance of RNAalifold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for RNAalifold(seed)

Total Base Pair Counts
Total TP	1950
Total TN	3423707
Total FP	293
Total FP CONTRA	18
Total FP INCONS	202
Total FP COMP	73
Total FN	2621

Total Scores
MCC	0.619
Average MCC ± 95% Confidence Intervals	0.603 ± 0.051
Sensitivity	0.427
Positive Predictive Value	0.899
Nr of predictions	48

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2. Individual counts for RNAalifold(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00001	RNaseP_arch links to Rfam database...	0.77	0.59	1.00	44	34147	0	0	0	0	31
ASE_00002	RNaseP_arch links to Rfam database...	0.78	0.60	1.00	44	35467	0	0	0	0	29
ASE_00009	RNaseP_arch links to Rfam database...	0.74	0.60	0.93	40	26063	3	0	3	0	27
ASE_00014	RNaseP_arch links to Rfam database...	0.70	0.52	0.95	55	54227	3	0	3	0	51
ASE_00116	RNaseP_arch links to Rfam database...	0.82	0.68	0.98	45	31580	1	0	1	0	21
ASE_00120	RNaseP_arch links to Rfam database...	0.76	0.59	0.98	55	46915	2	0	1	1	39
ASE_00121	RNaseP_arch links to Rfam database...	0.77	0.61	0.98	56	45093	1	0	1	0	36
ASE_00145	RNaseP_arch links to Rfam database...	0.73	0.54	1.00	60	70065	0	0	0	0	51
ASE_00148	RNaseP_arch links to Rfam database...	0.59	0.37	0.95	57	112515	3	0	3	0	97
ASE_00154	RNaseP_arch links to Rfam database...	0.71	0.53	0.95	57	65281	3	0	3	0	50
ASE_00155	RNaseP_arch links to Rfam database...	0.65	0.42	1.00	60	93468	0	0	0	0	82
ASE_00187	RNaseP_arch links to Rfam database...	0.65	0.46	0.91	53	68577	5	1	4	0	62
ASE_00196	RNaseP_arch links to Rfam database...	0.77	0.63	0.96	47	31577	2	0	2	0	28
ASE_00205	RNaseP_arch links to Rfam database...	0.77	0.60	1.00	54	46002	1	0	0	1	36
ASE_00209	RNaseP_arch links to Rfam database...	0.79	0.64	0.98	56	43014	1	0	1	0	32
ASE_00210	RNaseP_arch links to Rfam database...	0.68	0.55	0.84	36	27218	9	0	7	2	29
ASE_00213	RNaseP_arch links to Rfam database...	0.78	0.62	0.98	41	27219	3	0	1	2	25
ASE_00222	RNaseP_arch links to Rfam database...	0.62	0.38	1.00	60	112041	0	0	0	0	97
ASE_00346	RNaseP_arch links to Rfam database...	0.57	0.44	0.74	43	48147	15	0	15	0	54
ASE_00359	RNaseP_arch links to Rfam database...	0.73	0.55	0.98	44	42733	2	0	1	1	36
ASE_00360	RNaseP_arch links to Rfam database...	0.82	0.69	0.98	45	29357	1	0	1	0	20
ASE_00417	RNaseP_arch links to Rfam database...	0.76	0.59	0.98	59	54555	1	0	1	0	41
ASE_00418	RNaseP_arch links to Rfam database...	0.77	0.60	0.98	45	38735	1	0	1	0	30
CRW_00013	Intron_gpI links to Rfam database...	0.46	0.23	0.90	27	103710	3	0	3	0	88
CRW_00016	Intron_gpI links to Rfam database...	0.45	0.23	0.90	27	77391	3	0	3	0	93
CRW_00610	Intron_gpI links to Rfam database...	0.54	0.31	0.96	25	36289	3	0	1	2	56
CRW_00613	Intron_gpI links to Rfam database...	0.42	0.22	0.81	17	34959	6	0	4	2	61
CRW_00614	Intron_gpI links to Rfam database...	0.45	0.32	0.64	18	121743	11	2	8	1	39
CRW_00618	Intron_gpI links to Rfam database...	0.39	0.26	0.59	16	56253	11	2	9	0	45
CRW_00619	Intron_gpI links to Rfam database...	0.41	0.23	0.74	17	165002	7	0	6	1	56
CRW_00620	Intron_gpI links to Rfam database...	0.35	0.21	0.59	13	150953	16	0	9	7	50
CRW_00621	Intron_gpI links to Rfam database...	0.36	0.21	0.60	15	153156	11	2	8	1	56
CRW_00623	Intron_gpI links to Rfam database...	0.35	0.18	0.68	15	129773	9	1	6	2	68
CRW_00633	Intron_gpI links to Rfam database...	0.40	0.21	0.76	22	63517	7	2	5	0	84
CRW_00634	Intron_gpI links to Rfam database...	0.37	0.18	0.74	17	64597	12	0	6	6	77
CRW_00670	Intron_gpI links to Rfam database...	0.48	0.24	0.97	29	70095	1	0	1	0	91
CRW_00671	Intron_gpI links to Rfam database...	0.49	0.25	0.97	29	62805	1	0	1	0	88
CRW_00672	Intron_gpI links to Rfam database...	0.50	0.26	0.97	29	72360	1	0	1	0	82
CRW_00674	Intron_gpI links to Rfam database...	0.29	0.14	0.63	17	83409	10	6	4	0	107
CRW_00676	Intron_gpI links to Rfam database...	0.32	0.15	0.68	17	93503	13	0	8	5	98
CRW_00692	Intron_gpI links to Rfam database...	0.34	0.17	0.68	15	68613	13	0	7	6	75
PDB_00827	Intron_gpI links to Rfam database...	0.35	0.21	0.59	17	26999	12	2	10	0	64
RFA_00597	Telomerase-vert links to Rfam database...	0.71	0.61	0.84	66	97824	18	0	13	5	43
RFA_00598	Telomerase-vert links to Rfam database...	0.68	0.58	0.79	59	84591	25	0	16	9	42
RFA_00599	Telomerase-vert links to Rfam database...	0.79	0.66	0.95	73	101398	7	0	4	3	38
RFA_00600	Telomerase-vert links to Rfam database...	0.76	0.63	0.91	63	120226	15	0	6	9	37
RFA_00601	Telomerase-vert links to Rfam database...	0.79	0.67	0.93	76	99153	10	0	6	4	38
RFA_00602	Telomerase-vert links to Rfam database...	0.76	0.65	0.90	75	101392	11	0	8	3	41

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Performance of Carnac(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Carnac(seed)

Total Base Pair Counts
Total TP	0
Total TN	3425877
Total FP	0
Total FP CONTRA	0
Total FP INCONS	0
Total FP COMP	0
Total FN	4571

Total Scores
MCC	0.000
Average MCC ± 95% Confidence Intervals	0.000 ± 0.000
Sensitivity	0.000
Positive Predictive Value	0.000
Nr of predictions	48

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2. Individual counts for Carnac(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00001	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	34191	0	0	0	0	75
ASE_00002	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	35511	0	0	0	0	73
ASE_00009	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	26106	0	0	0	0	67
ASE_00014	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	54285	0	0	0	0	106
ASE_00116	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	31626	0	0	0	0	66
ASE_00120	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	46971	0	0	0	0	94
ASE_00121	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	45150	0	0	0	0	92
ASE_00145	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	70125	0	0	0	0	111
ASE_00148	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	112575	0	0	0	0	154
ASE_00154	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	65341	0	0	0	0	107
ASE_00155	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	93528	0	0	0	0	142
ASE_00187	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	68635	0	0	0	0	115
ASE_00196	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	31626	0	0	0	0	75
ASE_00205	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	46056	0	0	0	0	90
ASE_00209	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	43071	0	0	0	0	88
ASE_00210	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	27261	0	0	0	0	65
ASE_00213	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	27261	0	0	0	0	66
ASE_00222	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	112101	0	0	0	0	157
ASE_00346	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	48205	0	0	0	0	97
ASE_00359	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	42778	0	0	0	0	80
ASE_00360	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	29403	0	0	0	0	65
ASE_00417	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	54615	0	0	0	0	100
ASE_00418	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	38781	0	0	0	0	75
CRW_00013	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	103740	0	0	0	0	115
CRW_00016	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	77421	0	0	0	0	120
CRW_00610	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	36315	0	0	0	0	81
CRW_00613	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	34980	0	0	0	0	78
CRW_00614	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	121771	0	0	0	0	57
CRW_00618	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	56280	0	0	0	0	61
CRW_00619	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	165025	0	0	0	0	73
CRW_00620	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	150975	0	0	0	0	63
CRW_00621	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	153181	0	0	0	0	71
CRW_00623	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	129795	0	0	0	0	83
CRW_00633	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	63546	0	0	0	0	106
CRW_00634	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	64620	0	0	0	0	94
CRW_00670	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	70125	0	0	0	0	120
CRW_00671	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	62835	0	0	0	0	117
CRW_00672	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	72390	0	0	0	0	111
CRW_00674	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	83436	0	0	0	0	124
CRW_00676	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	93528	0	0	0	0	115
CRW_00692	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	68635	0	0	0	0	90
PDB_00827	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	27028	0	0	0	0	81
RFA_00597	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	97903	0	0	0	0	109
RFA_00598	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	84666	0	0	0	0	101
RFA_00599	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	101475	0	0	0	0	111
RFA_00600	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	120295	0	0	0	0	100
RFA_00601	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	99235	0	0	0	0	114
RFA_00602	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	101475	0	0	0	0	116

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of RNAalifold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for RNAalifold(seed)

2. Individual counts for RNAalifold(seed) [ download as .csv ]

Performance of Carnac(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Carnac(seed)

2. Individual counts for Carnac(seed) [ download as .csv ]