CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	RNAfold		Carnac(seed)
MCC	0.475	>	0.000
Average MCC ± 95% Confidence Intervals	0.463 ± 0.053	>	0.000 ± 0.000
Sensitivity	0.479	>	0.000
Positive Predictive Value	0.472	>	0.000
Total TP	2191	>	0
Total TN	3421239	<	3425877
Total FP	3147	>	0
Total FP CONTRA	486	>	0
Total FP INCONS	1961	>	0
Total FP COMP	700	>	0
Total FN	2380	<	4571
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of RNAfold and Carnac(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNAfold and Carnac(seed)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNAfold and Carnac(seed)).
Comparison of average Matthews Correlation Coefficients (MCCs) for RNAfold and Carnac(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNAfold and Carnac(seed)).

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Performance of RNAfold - scored higher in this pairwise comparison

1. Total counts & total scores for RNAfold

Total Base Pair Counts
Total TP	2191
Total TN	3421239
Total FP	3147
Total FP CONTRA	486
Total FP INCONS	1961
Total FP COMP	700
Total FN	2380

Total Scores
MCC	0.475
Average MCC ± 95% Confidence Intervals	0.463 ± 0.053
Sensitivity	0.479
Positive Predictive Value	0.472
Nr of predictions	48

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2. Individual counts for RNAfold [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00001	RNaseP_arch links to Rfam database...	0.62	0.61	0.63	46	34118	34	3	24	7	29
ASE_00002	RNaseP_arch links to Rfam database...	0.64	0.62	0.67	45	35444	27	2	20	5	28
ASE_00009	RNaseP_arch links to Rfam database...	0.78	0.75	0.82	50	26045	14	0	11	3	17
ASE_00014	RNaseP_arch links to Rfam database...	0.24	0.25	0.24	26	54178	82	8	73	1	80
ASE_00116	RNaseP_arch links to Rfam database...	0.20	0.20	0.20	13	31560	56	2	51	3	53
ASE_00120	RNaseP_arch links to Rfam database...	0.39	0.37	0.40	35	46884	52	10	42	0	59
ASE_00121	RNaseP_arch links to Rfam database...	0.25	0.25	0.26	23	45060	67	5	62	0	69
ASE_00145	RNaseP_arch links to Rfam database...	0.46	0.46	0.46	51	70013	69	6	55	8	60
ASE_00148	RNaseP_arch links to Rfam database...	0.70	0.67	0.73	103	112434	42	4	34	4	51
ASE_00154	RNaseP_arch links to Rfam database...	0.63	0.63	0.64	67	65236	42	4	34	4	40
ASE_00155	RNaseP_arch links to Rfam database...	0.51	0.50	0.52	71	93391	71	10	56	5	71
ASE_00187	RNaseP_arch links to Rfam database...	0.51	0.50	0.52	57	68526	57	7	45	5	58
ASE_00196	RNaseP_arch links to Rfam database...	0.75	0.73	0.76	55	31554	21	2	15	4	20
ASE_00205	RNaseP_arch links to Rfam database...	0.44	0.43	0.44	39	45968	56	4	45	7	51
ASE_00209	RNaseP_arch links to Rfam database...	0.39	0.38	0.41	33	42990	48	5	43	0	55
ASE_00210	RNaseP_arch links to Rfam database...	0.59	0.60	0.59	39	27195	28	6	21	1	26
ASE_00213	RNaseP_arch links to Rfam database...	0.70	0.70	0.70	46	27195	21	6	14	1	20
ASE_00222	RNaseP_arch links to Rfam database...	0.64	0.62	0.66	97	111953	53	9	42	2	60
ASE_00346	RNaseP_arch links to Rfam database...	0.30	0.29	0.31	28	48116	63	7	54	2	69
ASE_00359	RNaseP_arch links to Rfam database...	0.48	0.49	0.48	39	42696	50	3	40	7	41
ASE_00360	RNaseP_arch links to Rfam database...	0.31	0.31	0.31	20	29338	51	11	34	6	45
ASE_00417	RNaseP_arch links to Rfam database...	0.36	0.37	0.35	37	54508	73	10	60	3	63
ASE_00418	RNaseP_arch links to Rfam database...	0.20	0.21	0.20	16	38700	67	12	53	2	59
CRW_00013	Intron_gpI links to Rfam database...	0.21	0.22	0.21	25	103623	116	12	80	24	90
CRW_00016	Intron_gpI links to Rfam database...	0.64	0.62	0.67	74	77311	47	5	31	11	46
CRW_00610	Intron_gpI links to Rfam database...	0.21	0.21	0.22	17	36239	59	7	52	0	64
CRW_00613	Intron_gpI links to Rfam database...	0.65	0.60	0.70	47	34913	28	1	19	8	31
CRW_00614	Intron_gpI links to Rfam database...	0.16	0.19	0.14	11	121692	131	25	43	63	46
CRW_00618	Intron_gpI links to Rfam database...	0.12	0.13	0.12	8	56212	82	13	47	22	53
CRW_00619	Intron_gpI links to Rfam database...	0.39	0.45	0.34	33	164929	139	28	35	76	40
CRW_00620	Intron_gpI links to Rfam database...	0.17	0.22	0.13	14	150871	157	32	58	67	49
CRW_00621	Intron_gpI links to Rfam database...	0.10	0.10	0.10	7	153109	156	13	52	91	64
CRW_00623	Intron_gpI links to Rfam database...	0.39	0.37	0.40	31	129718	114	8	38	68	52
CRW_00633	Intron_gpI links to Rfam database...	0.44	0.43	0.45	46	63444	58	13	43	2	60
CRW_00634	Intron_gpI links to Rfam database...	0.50	0.52	0.49	49	64519	57	10	42	5	45
CRW_00670	Intron_gpI links to Rfam database...	0.69	0.68	0.71	82	70009	36	9	25	2	38
CRW_00671	Intron_gpI links to Rfam database...	0.60	0.59	0.61	69	62722	49	6	38	5	48
CRW_00672	Intron_gpI links to Rfam database...	0.48	0.50	0.47	55	72273	65	19	43	3	56
CRW_00674	Intron_gpI links to Rfam database...	0.53	0.53	0.52	66	83310	62	12	48	2	58
CRW_00676	Intron_gpI links to Rfam database...	0.54	0.56	0.52	64	93406	74	17	41	16	51
CRW_00692	Intron_gpI links to Rfam database...	0.40	0.42	0.38	38	68536	66	24	37	5	52
PDB_00827	Intron_gpI links to Rfam database...	0.50	0.46	0.55	37	26961	31	1	29	1	44
RFA_00597	Telomerase-vert links to Rfam database...	0.49	0.50	0.49	54	97793	83	5	51	27	55
RFA_00598	Telomerase-vert links to Rfam database...	0.61	0.59	0.63	60	84570	63	6	30	27	41
RFA_00599	Telomerase-vert links to Rfam database...	0.66	0.70	0.63	78	101351	65	17	29	19	33
RFA_00600	Telomerase-vert links to Rfam database...	0.63	0.70	0.56	70	120170	90	29	26	35	30
RFA_00601	Telomerase-vert links to Rfam database...	0.47	0.49	0.44	56	99109	88	22	48	18	58
RFA_00602	Telomerase-vert links to Rfam database...	0.52	0.55	0.50	64	101347	87	16	48	23	52

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Performance of Carnac(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Carnac(seed)

Total Base Pair Counts
Total TP	0
Total TN	3425877
Total FP	0
Total FP CONTRA	0
Total FP INCONS	0
Total FP COMP	0
Total FN	4571

Total Scores
MCC	0.000
Average MCC ± 95% Confidence Intervals	0.000 ± 0.000
Sensitivity	0.000
Positive Predictive Value	0.000
Nr of predictions	48

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2. Individual counts for Carnac(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00001	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	34191	0	0	0	0	75
ASE_00002	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	35511	0	0	0	0	73
ASE_00009	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	26106	0	0	0	0	67
ASE_00014	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	54285	0	0	0	0	106
ASE_00116	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	31626	0	0	0	0	66
ASE_00120	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	46971	0	0	0	0	94
ASE_00121	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	45150	0	0	0	0	92
ASE_00145	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	70125	0	0	0	0	111
ASE_00148	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	112575	0	0	0	0	154
ASE_00154	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	65341	0	0	0	0	107
ASE_00155	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	93528	0	0	0	0	142
ASE_00187	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	68635	0	0	0	0	115
ASE_00196	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	31626	0	0	0	0	75
ASE_00205	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	46056	0	0	0	0	90
ASE_00209	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	43071	0	0	0	0	88
ASE_00210	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	27261	0	0	0	0	65
ASE_00213	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	27261	0	0	0	0	66
ASE_00222	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	112101	0	0	0	0	157
ASE_00346	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	48205	0	0	0	0	97
ASE_00359	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	42778	0	0	0	0	80
ASE_00360	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	29403	0	0	0	0	65
ASE_00417	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	54615	0	0	0	0	100
ASE_00418	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	38781	0	0	0	0	75
CRW_00013	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	103740	0	0	0	0	115
CRW_00016	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	77421	0	0	0	0	120
CRW_00610	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	36315	0	0	0	0	81
CRW_00613	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	34980	0	0	0	0	78
CRW_00614	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	121771	0	0	0	0	57
CRW_00618	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	56280	0	0	0	0	61
CRW_00619	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	165025	0	0	0	0	73
CRW_00620	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	150975	0	0	0	0	63
CRW_00621	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	153181	0	0	0	0	71
CRW_00623	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	129795	0	0	0	0	83
CRW_00633	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	63546	0	0	0	0	106
CRW_00634	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	64620	0	0	0	0	94
CRW_00670	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	70125	0	0	0	0	120
CRW_00671	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	62835	0	0	0	0	117
CRW_00672	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	72390	0	0	0	0	111
CRW_00674	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	83436	0	0	0	0	124
CRW_00676	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	93528	0	0	0	0	115
CRW_00692	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	68635	0	0	0	0	90
PDB_00827	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	27028	0	0	0	0	81
RFA_00597	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	97903	0	0	0	0	109
RFA_00598	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	84666	0	0	0	0	101
RFA_00599	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	101475	0	0	0	0	111
RFA_00600	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	120295	0	0	0	0	100
RFA_00601	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	99235	0	0	0	0	114
RFA_00602	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	101475	0	0	0	0	116

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of RNAfold - scored higher in this pairwise comparison

1. Total counts & total scores for RNAfold

2. Individual counts for RNAfold [ download as .csv ]

Performance of Carnac(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Carnac(seed)

2. Individual counts for Carnac(seed) [ download as .csv ]