CompaRNA - on-line benchmarks of RNA structure prediction methods

FAQ

Metric	RNAshapes		CMfinder(seed)
MCC	0.559	>	0.343
Average MCC ± 95% Confidence Intervals	0.546 ± 0.095	>	0.348 ± 0.069
Sensitivity	0.552	>	0.157
Positive Predictive Value	0.568	<	0.750
Total TP	717	>	204
Total TN	809876	<	810867
Total FP	643	>	68
Total FP CONTRA	86	>	3
Total FP INCONS	460	>	65
Total FP COMP	97	>	0
Total FN	581	<	1094
P-value	2.39162260866e-08

Comparison of performance of RNAshapes and CMfinder(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNAshapes and CMfinder(seed)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNAshapes and CMfinder(seed)).
Comparison of average Matthews Correlation Coefficients (MCCs) for RNAshapes and CMfinder(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNAshapes and CMfinder(seed)).

Total Scores
MCC	0.559
Average MCC ± 95% Confidence Intervals	0.546 ± 0.095
Sensitivity	0.552
Positive Predictive Value	0.568
Nr of predictions	13

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00016	Intron_gpI links to Rfam database...	0.49	0.48	0.51	57	77309	66	7	48	11	63
CRW_00610	Intron_gpI links to Rfam database...	0.55	0.53	0.57	43	36240	37	3	29	5	38
CRW_00613	Intron_gpI links to Rfam database...	0.64	0.58	0.70	45	34916	28	1	18	9	33
CRW_00618	Intron_gpI links to Rfam database...	0.17	0.18	0.16	11	56213	77	9	47	21	50
CRW_00633	Intron_gpI links to Rfam database...	0.55	0.54	0.56	57	63445	45	8	36	1	49
CRW_00634	Intron_gpI links to Rfam database...	0.33	0.34	0.33	32	64522	75	8	58	9	62
CRW_00670	Intron_gpI links to Rfam database...	0.74	0.72	0.76	86	70012	32	0	27	5	34
CRW_00671	Intron_gpI links to Rfam database...	0.65	0.62	0.67	73	62726	43	1	35	7	44
CRW_00672	Intron_gpI links to Rfam database...	0.66	0.66	0.66	73	72279	45	8	30	7	38
CRW_00674	Intron_gpI links to Rfam database...	0.68	0.67	0.69	83	83316	41	6	31	4	41
CRW_00676	Intron_gpI links to Rfam database...	0.58	0.62	0.55	71	93398	67	17	42	8	44
CRW_00692	Intron_gpI links to Rfam database...	0.43	0.46	0.40	41	68533	70	18	43	9	49
PDB_00827	Intron_gpI links to Rfam database...	0.64	0.56	0.74	45	26967	17	0	16	1	36

Total Scores
MCC	0.343
Average MCC ± 95% Confidence Intervals	0.348 ± 0.069
Sensitivity	0.157
Positive Predictive Value	0.750
Nr of predictions	13

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00016	Intron_gpI links to Rfam database...	0.36	0.14	0.89	17	77402	2	0	2	0	103
CRW_00610	Intron_gpI links to Rfam database...	0.49	0.31	0.78	25	36283	7	1	6	0	56
CRW_00613	Intron_gpI links to Rfam database...	0.54	0.33	0.87	26	34950	4	0	4	0	52
CRW_00618	Intron_gpI links to Rfam database...	0.36	0.13	1.00	8	56272	0	0	0	0	53
CRW_00633	Intron_gpI links to Rfam database...	0.32	0.12	0.81	13	63530	3	1	2	0	93
CRW_00634	Intron_gpI links to Rfam database...	0.40	0.17	0.94	16	64603	1	0	1	0	78
CRW_00670	Intron_gpI links to Rfam database...	0.32	0.18	0.55	22	70085	18	0	18	0	98
CRW_00671	Intron_gpI links to Rfam database...	0.20	0.09	0.41	11	62808	16	0	16	0	106
CRW_00672	Intron_gpI links to Rfam database...	0.38	0.15	0.94	17	72372	1	0	1	0	94
CRW_00674	Intron_gpI links to Rfam database...	0.40	0.17	0.95	21	83414	1	0	1	0	103
CRW_00676	Intron_gpI links to Rfam database...	0.12	0.04	0.33	5	93513	10	1	9	0	110
CRW_00692	Intron_gpI links to Rfam database...	0.41	0.17	1.00	15	68620	0	0	0	0	75
PDB_00827	Intron_gpI links to Rfam database...	0.25	0.10	0.62	8	27015	5	0	5	0	73

Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.