CompaRNA - on-line benchmarks of RNA structure prediction methods

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Metric	RNAsubopt		CMfinder(seed)
MCC	0.496	>	0.350
Average MCC ± 95% Confidence Intervals	0.480 ± 0.111	>	0.358 ± 0.060
Sensitivity	0.505	>	0.159
Positive Predictive Value	0.488	<	0.770
Total TP	743	>	234
Total TN	1035127	<	1036346
Total FP	958	>	77
Total FP CONTRA	157	>	3
Total FP INCONS	623	>	67
Total FP COMP	178	>	7
Total FN	727	<	1236
P-value	3.42071836373e-08

Comparison of performance of RNAsubopt and CMfinder(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNAsubopt and CMfinder(seed)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNAsubopt and CMfinder(seed)).
Comparison of average Matthews Correlation Coefficients (MCCs) for RNAsubopt and CMfinder(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNAsubopt and CMfinder(seed)).

Total Scores
MCC	0.496
Average MCC ± 95% Confidence Intervals	0.480 ± 0.111
Sensitivity	0.505
Positive Predictive Value	0.488
Nr of predictions	15

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00013	Intron_gpI links to Rfam database...	0.21	0.22	0.21	25	103620	117	13	82	22	90
CRW_00016	Intron_gpI links to Rfam database...	0.60	0.58	0.63	70	77309	55	5	37	13	50
CRW_00610	Intron_gpI links to Rfam database...	0.49	0.51	0.48	41	36230	44	9	35	0	40
CRW_00613	Intron_gpI links to Rfam database...	0.66	0.62	0.71	48	34912	28	1	19	8	30
CRW_00614	Intron_gpI links to Rfam database...	0.16	0.19	0.13	11	121684	137	27	49	61	46
CRW_00618	Intron_gpI links to Rfam database...	0.07	0.08	0.07	5	56205	92	15	55	22	56
CRW_00633	Intron_gpI links to Rfam database...	0.40	0.42	0.39	44	63434	70	10	58	2	62
CRW_00634	Intron_gpI links to Rfam database...	0.50	0.53	0.48	50	64516	59	11	43	5	44
CRW_00670	Intron_gpI links to Rfam database...	0.62	0.61	0.63	73	70009	45	9	34	2	47
CRW_00671	Intron_gpI links to Rfam database...	0.65	0.63	0.67	74	62725	43	1	35	7	43
CRW_00672	Intron_gpI links to Rfam database...	0.74	0.75	0.74	83	72278	38	6	23	9	28
CRW_00674	Intron_gpI links to Rfam database...	0.60	0.61	0.59	76	83308	55	10	42	3	48
CRW_00676	Intron_gpI links to Rfam database...	0.56	0.58	0.54	67	93403	71	15	43	13	48
CRW_00692	Intron_gpI links to Rfam database...	0.34	0.37	0.32	33	68532	80	22	48	10	57
PDB_00827	Intron_gpI links to Rfam database...	0.59	0.53	0.65	43	26962	24	3	20	1	38

Total Scores
MCC	0.350
Average MCC ± 95% Confidence Intervals	0.358 ± 0.060
Sensitivity	0.159
Positive Predictive Value	0.770
Nr of predictions	15

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00013	Intron_gpI links to Rfam database...	0.37	0.14	1.00	16	103724	0	0	0	0	99
CRW_00016	Intron_gpI links to Rfam database...	0.36	0.14	0.89	17	77402	2	0	2	0	103
CRW_00610	Intron_gpI links to Rfam database...	0.49	0.31	0.78	25	36283	7	1	6	0	56
CRW_00613	Intron_gpI links to Rfam database...	0.54	0.33	0.87	26	34950	4	0	4	0	52
CRW_00614	Intron_gpI links to Rfam database...	0.46	0.25	0.88	14	121755	9	0	2	7	43
CRW_00618	Intron_gpI links to Rfam database...	0.36	0.13	1.00	8	56272	0	0	0	0	53
CRW_00633	Intron_gpI links to Rfam database...	0.32	0.12	0.81	13	63530	3	1	2	0	93
CRW_00634	Intron_gpI links to Rfam database...	0.40	0.17	0.94	16	64603	1	0	1	0	78
CRW_00670	Intron_gpI links to Rfam database...	0.32	0.18	0.55	22	70085	18	0	18	0	98
CRW_00671	Intron_gpI links to Rfam database...	0.20	0.09	0.41	11	62808	16	0	16	0	106
CRW_00672	Intron_gpI links to Rfam database...	0.38	0.15	0.94	17	72372	1	0	1	0	94
CRW_00674	Intron_gpI links to Rfam database...	0.40	0.17	0.95	21	83414	1	0	1	0	103
CRW_00676	Intron_gpI links to Rfam database...	0.12	0.04	0.33	5	93513	10	1	9	0	110
CRW_00692	Intron_gpI links to Rfam database...	0.41	0.17	1.00	15	68620	0	0	0	0	75
PDB_00827	Intron_gpI links to Rfam database...	0.25	0.10	0.62	8	27015	5	0	5	0	73

Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.