CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	Sfold		Carnac(seed)
MCC	0.544	>	0.000
Average MCC ± 95% Confidence Intervals	0.529 ± 0.053	>	0.000 ± 0.000
Sensitivity	0.487	>	0.000
Positive Predictive Value	0.609	>	0.000
Total TP	2228	>	0
Total TN	3422216	<	3425877
Total FP	2026	>	0
Total FP CONTRA	254	>	0
Total FP INCONS	1179	>	0
Total FP COMP	593	>	0
Total FN	2343	<	4571
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of Sfold and Carnac(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Sfold and Carnac(seed)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Sfold and Carnac(seed)).
Comparison of average Matthews Correlation Coefficients (MCCs) for Sfold and Carnac(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Sfold and Carnac(seed)).

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Performance of Sfold - scored higher in this pairwise comparison

1. Total counts & total scores for Sfold

Total Base Pair Counts
Total TP	2228
Total TN	3422216
Total FP	2026
Total FP CONTRA	254
Total FP INCONS	1179
Total FP COMP	593
Total FN	2343

Total Scores
MCC	0.544
Average MCC ± 95% Confidence Intervals	0.529 ± 0.053
Sensitivity	0.487
Positive Predictive Value	0.609
Nr of predictions	48

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2. Individual counts for Sfold [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00001	RNaseP_arch links to Rfam database...	0.64	0.61	0.67	46	34122	27	3	20	4	29
ASE_00002	RNaseP_arch links to Rfam database...	0.69	0.60	0.80	44	35456	16	2	9	5	29
ASE_00009	RNaseP_arch links to Rfam database...	0.78	0.75	0.82	50	26045	12	0	11	1	17
ASE_00014	RNaseP_arch links to Rfam database...	0.25	0.25	0.26	26	54184	76	8	67	1	80
ASE_00116	RNaseP_arch links to Rfam database...	0.22	0.17	0.31	11	31590	28	0	25	3	55
ASE_00120	RNaseP_arch links to Rfam database...	0.61	0.53	0.69	50	46899	22	4	18	0	44
ASE_00121	RNaseP_arch links to Rfam database...	0.37	0.25	0.55	23	45108	19	2	17	0	69
ASE_00145	RNaseP_arch links to Rfam database...	0.47	0.42	0.53	47	70036	48	4	38	6	64
ASE_00148	RNaseP_arch links to Rfam database...	0.72	0.66	0.78	102	112445	30	1	27	2	52
ASE_00154	RNaseP_arch links to Rfam database...	0.67	0.63	0.72	67	65248	29	2	24	3	40
ASE_00155	RNaseP_arch links to Rfam database...	0.64	0.51	0.80	73	93437	21	3	15	3	69
ASE_00187	RNaseP_arch links to Rfam database...	0.47	0.43	0.53	49	68542	48	5	39	4	66
ASE_00196	RNaseP_arch links to Rfam database...	0.79	0.77	0.81	58	31554	17	2	12	3	17
ASE_00205	RNaseP_arch links to Rfam database...	0.51	0.43	0.59	39	45990	30	2	25	3	51
ASE_00209	RNaseP_arch links to Rfam database...	0.41	0.38	0.46	33	42999	39	5	34	0	55
ASE_00210	RNaseP_arch links to Rfam database...	0.59	0.60	0.59	39	27195	27	6	21	0	26
ASE_00213	RNaseP_arch links to Rfam database...	0.69	0.62	0.76	41	27207	13	1	12	0	25
ASE_00222	RNaseP_arch links to Rfam database...	0.69	0.59	0.79	93	111984	24	3	21	0	64
ASE_00346	RNaseP_arch links to Rfam database...	0.36	0.33	0.40	32	48125	51	4	44	3	65
ASE_00359	RNaseP_arch links to Rfam database...	0.50	0.49	0.52	39	42703	43	3	33	7	41
ASE_00360	RNaseP_arch links to Rfam database...	0.35	0.29	0.41	19	29357	30	3	24	3	46
ASE_00417	RNaseP_arch links to Rfam database...	0.41	0.41	0.41	41	54516	61	7	51	3	59
ASE_00418	RNaseP_arch links to Rfam database...	0.34	0.27	0.44	20	38736	27	2	23	2	55
CRW_00013	Intron_gpI links to Rfam database...	0.36	0.27	0.48	31	103675	57	8	26	23	84
CRW_00016	Intron_gpI links to Rfam database...	0.80	0.65	0.98	78	77341	14	0	2	12	42
CRW_00610	Intron_gpI links to Rfam database...	0.51	0.49	0.52	40	36238	37	9	28	0	41
CRW_00613	Intron_gpI links to Rfam database...	0.74	0.67	0.83	52	34917	19	0	11	8	26
CRW_00614	Intron_gpI links to Rfam database...	0.19	0.19	0.19	11	121713	102	12	35	55	46
CRW_00618	Intron_gpI links to Rfam database...	0.13	0.13	0.14	8	56223	68	13	36	19	53
CRW_00619	Intron_gpI links to Rfam database...	0.41	0.30	0.56	22	164986	76	2	15	59	51
CRW_00620	Intron_gpI links to Rfam database...	0.18	0.22	0.14	14	150874	138	30	57	51	49
CRW_00621	Intron_gpI links to Rfam database...	0.31	0.30	0.33	21	153118	131	6	36	89	50
CRW_00623	Intron_gpI links to Rfam database...	0.41	0.30	0.57	25	129751	78	2	17	59	58
CRW_00633	Intron_gpI links to Rfam database...	0.65	0.49	0.85	52	63485	11	2	7	2	54
CRW_00634	Intron_gpI links to Rfam database...	0.54	0.51	0.58	48	64537	40	6	29	5	46
CRW_00670	Intron_gpI links to Rfam database...	0.80	0.74	0.87	89	70023	15	6	7	2	31
CRW_00671	Intron_gpI links to Rfam database...	0.75	0.70	0.81	82	62734	23	5	14	4	35
CRW_00672	Intron_gpI links to Rfam database...	0.78	0.71	0.85	79	72297	20	6	8	6	32
CRW_00674	Intron_gpI links to Rfam database...	0.60	0.54	0.66	67	83335	36	6	28	2	57
CRW_00676	Intron_gpI links to Rfam database...	0.61	0.57	0.66	65	93430	48	9	24	15	50
CRW_00692	Intron_gpI links to Rfam database...	0.54	0.42	0.69	38	68580	27	6	11	10	52
PDB_00827	Intron_gpI links to Rfam database...	0.64	0.47	0.86	38	26984	8	0	6	2	43
RFA_00597	Telomerase-vert links to Rfam database...	0.57	0.49	0.67	53	97824	46	4	22	20	56
RFA_00598	Telomerase-vert links to Rfam database...	0.62	0.54	0.71	55	84589	43	2	20	21	46
RFA_00599	Telomerase-vert links to Rfam database...	0.69	0.68	0.70	75	101368	52	8	24	20	36
RFA_00600	Telomerase-vert links to Rfam database...	0.55	0.57	0.52	57	120186	79	15	37	27	43
RFA_00601	Telomerase-vert links to Rfam database...	0.27	0.21	0.35	24	99167	52	9	35	8	90
RFA_00602	Telomerase-vert links to Rfam database...	0.54	0.53	0.55	62	101363	68	16	34	18	54

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Performance of Carnac(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Carnac(seed)

Total Base Pair Counts
Total TP	0
Total TN	3425877
Total FP	0
Total FP CONTRA	0
Total FP INCONS	0
Total FP COMP	0
Total FN	4571

Total Scores
MCC	0.000
Average MCC ± 95% Confidence Intervals	0.000 ± 0.000
Sensitivity	0.000
Positive Predictive Value	0.000
Nr of predictions	48

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2. Individual counts for Carnac(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00001	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	34191	0	0	0	0	75
ASE_00002	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	35511	0	0	0	0	73
ASE_00009	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	26106	0	0	0	0	67
ASE_00014	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	54285	0	0	0	0	106
ASE_00116	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	31626	0	0	0	0	66
ASE_00120	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	46971	0	0	0	0	94
ASE_00121	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	45150	0	0	0	0	92
ASE_00145	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	70125	0	0	0	0	111
ASE_00148	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	112575	0	0	0	0	154
ASE_00154	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	65341	0	0	0	0	107
ASE_00155	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	93528	0	0	0	0	142
ASE_00187	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	68635	0	0	0	0	115
ASE_00196	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	31626	0	0	0	0	75
ASE_00205	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	46056	0	0	0	0	90
ASE_00209	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	43071	0	0	0	0	88
ASE_00210	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	27261	0	0	0	0	65
ASE_00213	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	27261	0	0	0	0	66
ASE_00222	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	112101	0	0	0	0	157
ASE_00346	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	48205	0	0	0	0	97
ASE_00359	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	42778	0	0	0	0	80
ASE_00360	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	29403	0	0	0	0	65
ASE_00417	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	54615	0	0	0	0	100
ASE_00418	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	38781	0	0	0	0	75
CRW_00013	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	103740	0	0	0	0	115
CRW_00016	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	77421	0	0	0	0	120
CRW_00610	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	36315	0	0	0	0	81
CRW_00613	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	34980	0	0	0	0	78
CRW_00614	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	121771	0	0	0	0	57
CRW_00618	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	56280	0	0	0	0	61
CRW_00619	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	165025	0	0	0	0	73
CRW_00620	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	150975	0	0	0	0	63
CRW_00621	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	153181	0	0	0	0	71
CRW_00623	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	129795	0	0	0	0	83
CRW_00633	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	63546	0	0	0	0	106
CRW_00634	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	64620	0	0	0	0	94
CRW_00670	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	70125	0	0	0	0	120
CRW_00671	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	62835	0	0	0	0	117
CRW_00672	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	72390	0	0	0	0	111
CRW_00674	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	83436	0	0	0	0	124
CRW_00676	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	93528	0	0	0	0	115
CRW_00692	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	68635	0	0	0	0	90
PDB_00827	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	27028	0	0	0	0	81
RFA_00597	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	97903	0	0	0	0	109
RFA_00598	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	84666	0	0	0	0	101
RFA_00599	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	101475	0	0	0	0	111
RFA_00600	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	120295	0	0	0	0	100
RFA_00601	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	99235	0	0	0	0	114
RFA_00602	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	101475	0	0	0	0	116

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of Sfold - scored higher in this pairwise comparison

1. Total counts & total scores for Sfold

2. Individual counts for Sfold [ download as .csv ]

Performance of Carnac(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Carnac(seed)

2. Individual counts for Carnac(seed) [ download as .csv ]