CompaRNA - on-line benchmarks of RNA structure prediction methods

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Metric	UNAFold		CMfinder(seed)
MCC	0.487	>	0.350
Average MCC ± 95% Confidence Intervals	0.470 ± 0.117	>	0.358 ± 0.060
Sensitivity	0.480	>	0.159
Positive Predictive Value	0.495	<	0.770
Total TP	706	>	234
Total TN	1035223	<	1036346
Total FP	896	>	77
Total FP CONTRA	161	>	3
Total FP INCONS	560	>	67
Total FP COMP	175	>	7
Total FN	764	<	1236
P-value	2.41358941668e-08

Comparison of performance of UNAFold and CMfinder(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for UNAFold and CMfinder(seed)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for UNAFold and CMfinder(seed)).
Comparison of average Matthews Correlation Coefficients (MCCs) for UNAFold and CMfinder(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for UNAFold and CMfinder(seed)).

Total Scores
MCC	0.487
Average MCC ± 95% Confidence Intervals	0.470 ± 0.117
Sensitivity	0.480
Positive Predictive Value	0.495
Nr of predictions	15

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00013	Intron_gpI links to Rfam database...	0.24	0.24	0.24	28	103624	107	18	70	19	87
CRW_00016	Intron_gpI links to Rfam database...	0.62	0.57	0.67	68	77320	45	5	28	12	52
CRW_00610	Intron_gpI links to Rfam database...	0.45	0.44	0.46	36	36236	43	6	37	0	45
CRW_00613	Intron_gpI links to Rfam database...	0.63	0.58	0.68	45	34914	29	1	20	8	33
CRW_00614	Intron_gpI links to Rfam database...	0.09	0.11	0.08	6	121694	140	20	51	69	51
CRW_00618	Intron_gpI links to Rfam database...	0.18	0.20	0.17	12	56210	83	10	48	25	49
CRW_00633	Intron_gpI links to Rfam database...	0.69	0.67	0.71	71	63446	33	8	21	4	35
CRW_00634	Intron_gpI links to Rfam database...	0.33	0.34	0.33	32	64522	70	14	52	4	62
CRW_00670	Intron_gpI links to Rfam database...	0.79	0.74	0.83	89	70018	21	6	12	3	31
CRW_00671	Intron_gpI links to Rfam database...	0.65	0.62	0.68	72	62729	39	7	27	5	45
CRW_00672	Intron_gpI links to Rfam database...	0.48	0.49	0.47	54	72275	65	19	42	4	57
CRW_00674	Intron_gpI links to Rfam database...	0.58	0.56	0.62	69	83324	45	7	36	2	55
CRW_00676	Intron_gpI links to Rfam database...	0.54	0.55	0.53	63	93410	69	15	40	14	52
CRW_00692	Intron_gpI links to Rfam database...	0.20	0.21	0.19	19	68537	84	24	55	5	71
PDB_00827	Intron_gpI links to Rfam database...	0.58	0.52	0.66	42	26964	23	1	21	1	39

Total Scores
MCC	0.350
Average MCC ± 95% Confidence Intervals	0.358 ± 0.060
Sensitivity	0.159
Positive Predictive Value	0.770
Nr of predictions	15

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00013	Intron_gpI links to Rfam database...	0.37	0.14	1.00	16	103724	0	0	0	0	99
CRW_00016	Intron_gpI links to Rfam database...	0.36	0.14	0.89	17	77402	2	0	2	0	103
CRW_00610	Intron_gpI links to Rfam database...	0.49	0.31	0.78	25	36283	7	1	6	0	56
CRW_00613	Intron_gpI links to Rfam database...	0.54	0.33	0.87	26	34950	4	0	4	0	52
CRW_00614	Intron_gpI links to Rfam database...	0.46	0.25	0.88	14	121755	9	0	2	7	43
CRW_00618	Intron_gpI links to Rfam database...	0.36	0.13	1.00	8	56272	0	0	0	0	53
CRW_00633	Intron_gpI links to Rfam database...	0.32	0.12	0.81	13	63530	3	1	2	0	93
CRW_00634	Intron_gpI links to Rfam database...	0.40	0.17	0.94	16	64603	1	0	1	0	78
CRW_00670	Intron_gpI links to Rfam database...	0.32	0.18	0.55	22	70085	18	0	18	0	98
CRW_00671	Intron_gpI links to Rfam database...	0.20	0.09	0.41	11	62808	16	0	16	0	106
CRW_00672	Intron_gpI links to Rfam database...	0.38	0.15	0.94	17	72372	1	0	1	0	94
CRW_00674	Intron_gpI links to Rfam database...	0.40	0.17	0.95	21	83414	1	0	1	0	103
CRW_00676	Intron_gpI links to Rfam database...	0.12	0.04	0.33	5	93513	10	1	9	0	110
CRW_00692	Intron_gpI links to Rfam database...	0.41	0.17	1.00	15	68620	0	0	0	0	75
PDB_00827	Intron_gpI links to Rfam database...	0.25	0.10	0.62	8	27015	5	0	5	0	73

Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.