CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	Carnac(20)		Afold
MCC	0.559	>	0.410
Average MCC ± 95% Confidence Intervals	0.553 ± 0.024	>	0.413 ± 0.031
Sensitivity	0.349	<	0.410
Positive Predictive Value	0.895	>	0.411
Total TP	12241	<	14374
Total TN	99047256	>	99025973
Total FP	2462	<	23038
Total FP CONTRA	162	<	3302
Total FP INCONS	1273	<	17283
Total FP COMP	1027	<	2453
Total FN	22822	>	20689
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of Carnac(20) and Afold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Carnac(20) and Afold).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Carnac(20) and Afold).
Comparison of average Matthews Correlation Coefficients (MCCs) for Carnac(20) and Afold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Carnac(20) and Afold).

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Performance of Carnac(20) - scored higher in this pairwise comparison

1. Total counts & total scores for Carnac(20)

Total Base Pair Counts
Total TP	12241
Total TN	99047256
Total FP	2462
Total FP CONTRA	162
Total FP INCONS	1273
Total FP COMP	1027
Total FN	22822

Total Scores
MCC	0.559
Average MCC ± 95% Confidence Intervals	0.553 ± 0.024
Sensitivity	0.349
Positive Predictive Value	0.895
Nr of predictions	73

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2. Individual counts for Carnac(20) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00024	SSU_rRNA_archaea links to Rfam database...	0.74	0.59	0.94	270	1085313	35	5	13	17	188
CRW_00048	SSU_rRNA_bacteria links to Rfam database...	0.62	0.43	0.91	202	1170992	29	3	18	8	268
CRW_00054	SSU_rRNA_bacteria links to Rfam database...	0.62	0.42	0.91	191	1107607	23	4	14	5	265
CRW_00059	SSU_rRNA_bacteria links to Rfam database...	0.64	0.43	0.95	204	1172532	17	3	7	7	269
CRW_00061	SSU_rRNA_bacteria links to Rfam database...	0.63	0.42	0.94	199	1181742	19	2	10	7	277
CRW_00068	SSU_rRNA_bacteria links to Rfam database...	0.69	0.51	0.94	234	1109056	28	2	13	13	223
CRW_00096	SSU_rRNA_bacteria links to Rfam database...	0.62	0.43	0.92	198	1178664	29	0	18	11	267
CRW_00140	SSU_rRNA_bacteria links to Rfam database...	0.71	0.53	0.95	246	1136018	21	2	12	7	217
CRW_00141	SSU_rRNA_bacteria links to Rfam database...	0.64	0.43	0.93	207	1201802	26	4	12	10	269
CRW_00150	SSU_rRNA_bacteria links to Rfam database...	0.66	0.46	0.95	216	1152694	16	3	8	5	250
CRW_00152	SSU_rRNA_bacteria links to Rfam database...	0.69	0.52	0.92	244	1180151	26	4	17	5	227
CRW_00166	SSU_rRNA_bacteria links to Rfam database...	0.64	0.44	0.93	207	1190974	24	0	15	9	261
CRW_00173	SSU_rRNA_bacteria links to Rfam database...	0.56	0.36	0.89	158	1082478	26	2	18	6	287
CRW_00177	SSU_rRNA_bacteria links to Rfam database...	0.52	0.32	0.87	149	1178708	29	3	20	6	324
CRW_00196	SSU_rRNA_bacteria links to Rfam database...	0.64	0.43	0.96	204	1208022	12	2	7	3	271
CRW_00230	SSU_rRNA_bacteria links to Rfam database...	0.66	0.47	0.93	227	1198681	28	3	15	10	251
CRW_00245	SSU_rRNA_bacteria links to Rfam database...	0.65	0.45	0.93	205	1106108	20	3	12	5	248
CRW_00248	SSU_rRNA_bacteria links to Rfam database...	0.56	0.35	0.91	168	1218956	27	4	13	10	316
CRW_00250	SSU_rRNA_bacteria links to Rfam database...	0.68	0.50	0.91	241	1198660	33	4	21	8	237
CRW_00256	SSU_rRNA_bacteria links to Rfam database...	0.64	0.43	0.97	200	1192533	11	3	4	4	268
CRW_00270	SSU_rRNA_bacteria links to Rfam database...	0.66	0.47	0.93	212	1112057	22	4	13	5	243
CRW_00271	SSU_rRNA_bacteria links to Rfam database...	0.62	0.41	0.94	191	1122548	17	3	9	5	271
CRW_00273	SSU_rRNA_bacteria links to Rfam database...	0.57	0.35	0.92	156	1085431	16	4	10	2	290
CRW_00275	SSU_rRNA_bacteria links to Rfam database...	0.60	0.37	0.95	171	1115091	13	2	7	4	286
CRW_00277	SSU_rRNA_bacteria links to Rfam database...	0.64	0.44	0.93	201	1110578	20	3	13	4	252
CRW_00278	SSU_rRNA_bacteria links to Rfam database...	0.52	0.29	0.92	130	1130115	15	4	7	4	320
CRW_00279	SSU_rRNA_bacteria links to Rfam database...	0.68	0.51	0.92	237	1180158	31	3	18	10	227
CRW_00280	SSU_rRNA_bacteria links to Rfam database...	0.66	0.46	0.96	209	1118042	12	1	8	3	244
CRW_00281	SSU_rRNA_bacteria links to Rfam database...	0.65	0.45	0.95	209	1145120	17	2	10	5	255
CRW_00284	SSU_rRNA_bacteria links to Rfam database...	0.53	0.33	0.87	150	1131587	27	3	20	4	306
CRW_00285	SSU_rRNA_bacteria links to Rfam database...	0.62	0.41	0.93	188	1118058	18	2	12	4	270
CRW_00289	SSU_rRNA_bacteria links to Rfam database...	0.58	0.41	0.84	194	1189422	41	5	32	4	282
CRW_00298	SSU_rRNA_eukarya links to Rfam database...	0.41	0.19	0.86	95	1620790	37	0	15	22	399
CRW_00301	SSU_rRNA_eukarya links to Rfam database...	0.46	0.25	0.83	131	1762345	56	0	27	29	388
CRW_00310	SSU_rRNA_eukarya links to Rfam database...	0.42	0.22	0.81	116	1805806	46	5	23	18	405
CRW_00326	SSU_rRNA_eukarya links to Rfam database...	0.45	0.23	0.92	113	1627987	32	1	9	22	389
CRW_00330	SSU_rRNA_eukarya links to Rfam database...	0.34	0.17	0.67	89	1988883	69	3	40	26	428
CRW_00332	SSU_rRNA_eukarya links to Rfam database...	0.39	0.20	0.76	97	1769893	46	1	30	15	380
CRW_00333	SSU_rRNA_eukarya links to Rfam database...	0.35	0.17	0.70	88	1892359	50	4	34	12	426
CRW_00345	SSU_rRNA_eukarya links to Rfam database...	0.48	0.29	0.81	145	1586691	63	2	33	28	353
CRW_00348	SSU_rRNA_eukarya links to Rfam database...	0.40	0.23	0.72	114	1615344	78	4	41	33	389
CRW_00358	SSU_rRNA_eukarya links to Rfam database...	0.49	0.25	0.96	129	1675231	29	0	5	24	378
CRW_00366	SSU_rRNA_eukarya links to Rfam database...	0.47	0.25	0.87	122	1579613	37	1	17	19	360
CRW_00370	SSU_rRNA_eukarya links to Rfam database...	0.47	0.27	0.84	135	1640605	54	1	25	28	371
CRW_00371	SSU_rRNA_eukarya links to Rfam database...	0.48	0.29	0.81	143	1611733	59	1	33	25	353
CRW_00372	SSU_rRNA_eukarya links to Rfam database...	0.44	0.23	0.84	117	1626166	46	2	21	23	381
CRW_00379	SSU_rRNA_eukarya links to Rfam database...	0.49	0.26	0.93	140	2126802	50	1	10	39	394
CRW_00386	SSU_rRNA_eukarya links to Rfam database...	0.30	0.13	0.71	67	1751161	53	2	26	25	448
CRW_00403	SSU_rRNA_eukarya links to Rfam database...	0.48	0.27	0.83	127	1606375	60	0	26	34	337
CRW_00411	SSU_rRNA_eukarya links to Rfam database...	0.39	0.19	0.81	94	1615387	42	0	22	20	402
CRW_00414	SSU_rRNA_eukarya links to Rfam database...	0.38	0.19	0.74	96	1666095	60	1	33	26	399
CRW_00466	SSU_rRNA_bacteria links to Rfam database...	0.62	0.42	0.91	192	1116554	28	4	15	9	266
CRW_00589	SSU_rRNA_bacteria links to Rfam database...	0.58	0.35	0.97	156	1094299	10	0	5	5	289
CRW_00590	SSU_rRNA_bacteria links to Rfam database...	0.55	0.33	0.93	148	1119597	15	1	10	4	304
CRW_00591	SSU_rRNA_bacteria links to Rfam database...	0.66	0.46	0.93	206	1098682	26	1	14	11	240
CRW_00598	SSU_rRNA_eukarya links to Rfam database...	0.42	0.20	0.85	100	1666107	41	0	18	23	391
CRW_00758	SSU_rRNA_eukarya links to Rfam database...	0.46	0.26	0.79	127	1640605	57	4	30	23	356
CRW_00759	SSU_rRNA_eukarya links to Rfam database...	0.39	0.19	0.79	93	1637028	51	3	21	27	388
CRW_00760	SSU_rRNA_eukarya links to Rfam database...	0.45	0.24	0.84	117	1638815	55	0	23	32	369
CRW_00772	SSU_rRNA_bacteria links to Rfam database...	0.48	0.30	0.77	122	945842	42	3	33	6	282
CRW_00789	SSU_rRNA_bacteria links to Rfam database...	0.61	0.43	0.88	191	1137570	34	1	24	9	256
CRW_00795	SSU_rRNA_bacteria links to Rfam database...	0.59	0.38	0.90	150	1152755	40	0	16	24	244
CRW_00849	SSU_rRNA_bacteria links to Rfam database...	0.62	0.42	0.92	196	1118046	27	3	15	9	274
CRW_01153	SSU_rRNA_eukarya links to Rfam database...	0.44	0.25	0.76	126	1606363	56	1	38	17	377
CRW_01171	SSU_rRNA_eukarya links to Rfam database...	0.47	0.25	0.90	125	1593866	44	0	14	30	381
CRW_01300	SSU_rRNA_eukarya links to Rfam database...	0.47	0.25	0.88	128	1693575	38	0	17	21	387
PDB_00703	SSU_rRNA_bacteria links to Rfam database...	0.60	0.40	0.92	196	1073633	28	3	13	12	299
PDB_00854	SSU_rRNA_bacteria links to Rfam database...	0.62	0.41	0.95	218	1500548	29	3	9	17	317
PDB_01088	SSU_rRNA_bacteria links to Rfam database...	0.59	0.38	0.92	206	1471246	35	2	16	17	341
PDB_01103	SSU_rRNA_bacteria links to Rfam database...	0.62	0.40	0.96	226	1606292	20	3	7	10	336
PDB_01105	SSU_rRNA_bacteria links to Rfam database...	0.58	0.36	0.94	192	1433767	24	1	11	12	348
PDB_01120	SSU_rRNA_bacteria links to Rfam database...	0.62	0.41	0.93	216	1204895	30	4	13	13	311
PDB_01273	SSU_rRNA_bacteria links to Rfam database...	0.66	0.48	0.92	234	1118007	37	4	15	18	257

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Performance of Afold - scored lower in this pairwise comparison

1. Total counts & total scores for Afold

Total Base Pair Counts
Total TP	14374
Total TN	99025973
Total FP	23038
Total FP CONTRA	3302
Total FP INCONS	17283
Total FP COMP	2453
Total FN	20689

Total Scores
MCC	0.410
Average MCC ± 95% Confidence Intervals	0.413 ± 0.031
Sensitivity	0.410
Positive Predictive Value	0.411
Nr of predictions	73

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2. Individual counts for Afold [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00024	SSU_rRNA_archaea links to Rfam database...	0.78	0.77	0.79	351	1085158	132	17	75	40	107
CRW_00048	SSU_rRNA_bacteria links to Rfam database...	0.49	0.49	0.50	228	1170758	252	20	209	23	242
CRW_00054	SSU_rRNA_bacteria links to Rfam database...	0.46	0.46	0.46	208	1107368	260	31	209	20	248
CRW_00059	SSU_rRNA_bacteria links to Rfam database...	0.52	0.51	0.53	240	1172289	233	26	191	16	233
CRW_00061	SSU_rRNA_bacteria links to Rfam database...	0.55	0.54	0.55	259	1181483	231	27	184	20	217
CRW_00068	SSU_rRNA_bacteria links to Rfam database...	0.49	0.49	0.50	226	1108849	247	24	206	17	231
CRW_00096	SSU_rRNA_bacteria links to Rfam database...	0.46	0.46	0.47	214	1178420	264	32	214	18	251
CRW_00140	SSU_rRNA_bacteria links to Rfam database...	0.64	0.63	0.64	291	1135826	182	20	141	21	172
CRW_00141	SSU_rRNA_bacteria links to Rfam database...	0.59	0.58	0.60	274	1201566	212	26	159	27	202
CRW_00150	SSU_rRNA_bacteria links to Rfam database...	0.42	0.41	0.42	193	1152465	282	35	228	19	273
CRW_00152	SSU_rRNA_bacteria links to Rfam database...	0.64	0.62	0.65	293	1179965	180	30	128	22	178
CRW_00166	SSU_rRNA_bacteria links to Rfam database...	0.54	0.53	0.55	248	1190745	226	28	175	23	220
CRW_00173	SSU_rRNA_bacteria links to Rfam database...	0.29	0.29	0.29	127	1082216	323	37	276	10	318
CRW_00177	SSU_rRNA_bacteria links to Rfam database...	0.44	0.43	0.45	203	1178433	259	22	222	15	270
CRW_00196	SSU_rRNA_bacteria links to Rfam database...	0.47	0.46	0.48	220	1207772	267	24	219	24	255
CRW_00230	SSU_rRNA_bacteria links to Rfam database...	0.57	0.56	0.58	266	1198467	216	21	172	23	212
CRW_00245	SSU_rRNA_bacteria links to Rfam database...	0.38	0.38	0.38	172	1105880	289	44	232	13	281
CRW_00248	SSU_rRNA_bacteria links to Rfam database...	0.57	0.57	0.58	274	1218666	234	21	180	33	210
CRW_00250	SSU_rRNA_bacteria links to Rfam database...	0.44	0.44	0.45	210	1198459	274	34	223	17	268
CRW_00256	SSU_rRNA_bacteria links to Rfam database...	0.41	0.40	0.42	188	1192291	278	39	222	17	280
CRW_00270	SSU_rRNA_bacteria links to Rfam database...	0.44	0.43	0.45	196	1111850	260	40	200	20	259
CRW_00271	SSU_rRNA_bacteria links to Rfam database...	0.51	0.50	0.51	231	1122302	237	43	175	19	231
CRW_00273	SSU_rRNA_bacteria links to Rfam database...	0.59	0.58	0.60	258	1085174	195	26	143	26	188
CRW_00275	SSU_rRNA_bacteria links to Rfam database...	0.47	0.47	0.48	213	1114826	258	28	204	26	244
CRW_00277	SSU_rRNA_bacteria links to Rfam database...	0.38	0.38	0.38	172	1110338	300	45	240	15	281
CRW_00278	SSU_rRNA_bacteria links to Rfam database...	0.41	0.40	0.42	180	1129825	274	33	218	23	270
CRW_00279	SSU_rRNA_bacteria links to Rfam database...	0.51	0.49	0.53	229	1179985	227	29	173	25	235
CRW_00280	SSU_rRNA_bacteria links to Rfam database...	0.51	0.50	0.51	227	1117817	231	28	188	15	226
CRW_00281	SSU_rRNA_bacteria links to Rfam database...	0.30	0.30	0.29	138	1144872	347	41	290	16	326
CRW_00284	SSU_rRNA_bacteria links to Rfam database...	0.28	0.27	0.28	124	1131316	337	30	290	17	332
CRW_00285	SSU_rRNA_bacteria links to Rfam database...	0.72	0.71	0.74	325	1117819	142	23	93	26	133
CRW_00289	SSU_rRNA_bacteria links to Rfam database...	0.46	0.45	0.48	214	1189204	258	34	201	23	262
CRW_00298	SSU_rRNA_eukarya links to Rfam database...	0.19	0.20	0.18	99	1620353	490	81	367	42	395
CRW_00301	SSU_rRNA_eukarya links to Rfam database...	0.30	0.31	0.30	162	1761957	428	86	298	44	357
CRW_00310	SSU_rRNA_eukarya links to Rfam database...	0.29	0.30	0.28	157	1805386	453	81	326	46	364
CRW_00326	SSU_rRNA_eukarya links to Rfam database...	0.41	0.41	0.42	204	1627621	339	47	238	54	298
CRW_00330	SSU_rRNA_eukarya links to Rfam database...	0.32	0.32	0.31	167	1988474	452	69	305	78	350
CRW_00332	SSU_rRNA_eukarya links to Rfam database...	0.18	0.20	0.17	94	1769479	492	105	343	44	383
CRW_00333	SSU_rRNA_eukarya links to Rfam database...	0.29	0.30	0.28	153	1891946	449	74	312	63	361
CRW_00345	SSU_rRNA_eukarya links to Rfam database...	0.34	0.35	0.33	175	1586340	403	71	285	47	323
CRW_00348	SSU_rRNA_eukarya links to Rfam database...	0.25	0.25	0.24	127	1614982	437	68	326	43	376
CRW_00358	SSU_rRNA_eukarya links to Rfam database...	0.36	0.36	0.35	183	1674845	391	61	276	54	324
CRW_00366	SSU_rRNA_eukarya links to Rfam database...	0.35	0.36	0.33	174	1579230	395	88	261	46	308
CRW_00370	SSU_rRNA_eukarya links to Rfam database...	0.28	0.28	0.28	143	1640248	420	77	298	45	363
CRW_00371	SSU_rRNA_eukarya links to Rfam database...	0.29	0.29	0.28	145	1611389	409	77	299	33	351
CRW_00372	SSU_rRNA_eukarya links to Rfam database...	0.36	0.36	0.35	181	1625787	378	59	279	40	317
CRW_00379	SSU_rRNA_eukarya links to Rfam database...	0.42	0.43	0.41	227	2126401	423	55	270	98	307
CRW_00386	SSU_rRNA_eukarya links to Rfam database...	0.24	0.25	0.23	129	1750683	478	83	361	34	386
CRW_00403	SSU_rRNA_eukarya links to Rfam database...	0.31	0.31	0.30	146	1606035	431	65	282	84	318
CRW_00411	SSU_rRNA_eukarya links to Rfam database...	0.34	0.34	0.34	169	1615006	381	62	266	53	327
CRW_00414	SSU_rRNA_eukarya links to Rfam database...	0.27	0.28	0.26	140	1665694	436	77	314	45	355
CRW_00466	SSU_rRNA_bacteria links to Rfam database...	0.60	0.59	0.62	268	1116330	196	21	146	29	190
CRW_00589	SSU_rRNA_bacteria links to Rfam database...	0.18	0.18	0.18	78	1094024	374	34	324	16	367
CRW_00590	SSU_rRNA_bacteria links to Rfam database...	0.36	0.36	0.37	161	1119326	290	30	239	21	291
CRW_00591	SSU_rRNA_bacteria links to Rfam database...	0.57	0.56	0.59	251	1098476	205	23	153	29	195
CRW_00598	SSU_rRNA_eukarya links to Rfam database...	0.31	0.33	0.29	162	1665675	440	88	300	52	329
CRW_00758	SSU_rRNA_eukarya links to Rfam database...	0.29	0.30	0.29	144	1640268	416	66	288	62	339
CRW_00759	SSU_rRNA_eukarya links to Rfam database...	0.22	0.22	0.21	107	1636633	462	78	327	57	374
CRW_00760	SSU_rRNA_eukarya links to Rfam database...	0.28	0.29	0.28	140	1638458	411	74	283	54	346
CRW_00772	SSU_rRNA_bacteria links to Rfam database...	0.26	0.25	0.26	103	945610	313	37	250	26	301
CRW_00789	SSU_rRNA_bacteria links to Rfam database...	0.36	0.36	0.36	160	1137342	302	44	240	18	287
CRW_00795	SSU_rRNA_bacteria links to Rfam database...	0.21	0.22	0.21	85	1152511	379	51	274	54	309
CRW_00849	SSU_rRNA_bacteria links to Rfam database...	0.49	0.48	0.49	227	1117798	259	23	212	24	243
CRW_01153	SSU_rRNA_eukarya links to Rfam database...	0.32	0.32	0.32	160	1606024	390	54	290	46	343
CRW_01171	SSU_rRNA_eukarya links to Rfam database...	0.32	0.33	0.31	167	1593473	402	81	284	37	339
CRW_01300	SSU_rRNA_eukarya links to Rfam database...	0.36	0.37	0.35	189	1693186	392	71	274	47	326
PDB_00703	SSU_rRNA_bacteria links to Rfam database...	0.53	0.50	0.56	246	1073408	220	17	174	29	249
PDB_00854	SSU_rRNA_bacteria links to Rfam database...	0.55	0.53	0.56	284	1500271	276	22	201	53	251
PDB_01088	SSU_rRNA_bacteria links to Rfam database...	0.36	0.35	0.37	191	1470959	352	45	275	32	356
PDB_01103	SSU_rRNA_bacteria links to Rfam database...	0.56	0.54	0.58	306	1605999	254	32	191	31	256
PDB_01105	SSU_rRNA_bacteria links to Rfam database...	0.60	0.58	0.63	313	1433471	221	15	172	34	227
PDB_01120	SSU_rRNA_bacteria links to Rfam database...	0.46	0.43	0.49	228	1204659	250	31	210	9	299
PDB_01273	SSU_rRNA_bacteria links to Rfam database...	0.51	0.48	0.53	237	1117812	242	21	190	31	254

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of Carnac(20) - scored higher in this pairwise comparison

1. Total counts & total scores for Carnac(20)

2. Individual counts for Carnac(20) [ download as .csv ]

Performance of Afold - scored lower in this pairwise comparison

1. Total counts & total scores for Afold

2. Individual counts for Afold [ download as .csv ]