CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	Carnac(20)		PknotsRG
MCC	0.622	>	0.450
Average MCC ± 95% Confidence Intervals	0.620 ± 0.016	>	0.448 ± 0.036
Sensitivity	0.420	<	0.444
Positive Predictive Value	0.922	>	0.456
Total TP	8964	<	9486
Total TN	52701760	>	52690681
Total FP	1116	<	12203
Total FP CONTRA	124	<	1478
Total FP INCONS	635	<	9838
Total FP COMP	357	<	887
Total FN	12390	>	11868
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of Carnac(20) and PknotsRG. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Carnac(20) and PknotsRG).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Carnac(20) and PknotsRG).
Comparison of average Matthews Correlation Coefficients (MCCs) for Carnac(20) and PknotsRG. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Carnac(20) and PknotsRG).

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Performance of Carnac(20) - scored higher in this pairwise comparison

1. Total counts & total scores for Carnac(20)

Total Base Pair Counts
Total TP	8964
Total TN	52701760
Total FP	1116
Total FP CONTRA	124
Total FP INCONS	635
Total FP COMP	357
Total FN	12390

Total Scores
MCC	0.622
Average MCC ± 95% Confidence Intervals	0.620 ± 0.016
Sensitivity	0.420
Positive Predictive Value	0.922
Nr of predictions	46

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2. Individual counts for Carnac(20) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00024	SSU_rRNA_archaea links to Rfam database...	0.74	0.59	0.94	270	1085313	35	5	13	17	188
CRW_00034	SSU_rRNA_bacteria links to Rfam database...	0.56	0.35	0.90	166	1142131	28	4	15	9	308
CRW_00048	SSU_rRNA_bacteria links to Rfam database...	0.62	0.43	0.91	202	1170992	29	3	18	8	268
CRW_00054	SSU_rRNA_bacteria links to Rfam database...	0.62	0.42	0.91	191	1107607	23	4	14	5	265
CRW_00059	SSU_rRNA_bacteria links to Rfam database...	0.64	0.43	0.95	204	1172532	17	3	7	7	269
CRW_00061	SSU_rRNA_bacteria links to Rfam database...	0.63	0.42	0.94	199	1181742	19	2	10	7	277
CRW_00068	SSU_rRNA_bacteria links to Rfam database...	0.69	0.51	0.94	234	1109056	28	2	13	13	223
CRW_00096	SSU_rRNA_bacteria links to Rfam database...	0.62	0.43	0.92	198	1178664	29	0	18	11	267
CRW_00140	SSU_rRNA_bacteria links to Rfam database...	0.71	0.53	0.95	246	1136018	21	2	12	7	217
CRW_00141	SSU_rRNA_bacteria links to Rfam database...	0.64	0.43	0.93	207	1201802	26	4	12	10	269
CRW_00150	SSU_rRNA_bacteria links to Rfam database...	0.66	0.46	0.95	216	1152694	16	3	8	5	250
CRW_00152	SSU_rRNA_bacteria links to Rfam database...	0.69	0.52	0.92	244	1180151	26	4	17	5	227
CRW_00166	SSU_rRNA_bacteria links to Rfam database...	0.64	0.44	0.93	207	1190974	24	0	15	9	261
CRW_00173	SSU_rRNA_bacteria links to Rfam database...	0.56	0.36	0.89	158	1082478	26	2	18	6	287
CRW_00177	SSU_rRNA_bacteria links to Rfam database...	0.52	0.32	0.87	149	1178708	29	3	20	6	324
CRW_00196	SSU_rRNA_bacteria links to Rfam database...	0.64	0.43	0.96	204	1208022	12	2	7	3	271
CRW_00230	SSU_rRNA_bacteria links to Rfam database...	0.66	0.47	0.93	227	1198681	28	3	15	10	251
CRW_00245	SSU_rRNA_bacteria links to Rfam database...	0.65	0.45	0.93	205	1106108	20	3	12	5	248
CRW_00248	SSU_rRNA_bacteria links to Rfam database...	0.56	0.35	0.91	168	1218956	27	4	13	10	316
CRW_00250	SSU_rRNA_bacteria links to Rfam database...	0.68	0.50	0.91	241	1198660	33	4	21	8	237
CRW_00256	SSU_rRNA_bacteria links to Rfam database...	0.64	0.43	0.97	200	1192533	11	3	4	4	268
CRW_00270	SSU_rRNA_bacteria links to Rfam database...	0.66	0.47	0.93	212	1112057	22	4	13	5	243
CRW_00271	SSU_rRNA_bacteria links to Rfam database...	0.62	0.41	0.94	191	1122548	17	3	9	5	271
CRW_00273	SSU_rRNA_bacteria links to Rfam database...	0.57	0.35	0.92	156	1085431	16	4	10	2	290
CRW_00275	SSU_rRNA_bacteria links to Rfam database...	0.60	0.37	0.95	171	1115091	13	2	7	4	286
CRW_00277	SSU_rRNA_bacteria links to Rfam database...	0.64	0.44	0.93	201	1110578	20	3	13	4	252
CRW_00278	SSU_rRNA_bacteria links to Rfam database...	0.52	0.29	0.92	130	1130115	15	4	7	4	320
CRW_00279	SSU_rRNA_bacteria links to Rfam database...	0.68	0.51	0.92	237	1180158	31	3	18	10	227
CRW_00280	SSU_rRNA_bacteria links to Rfam database...	0.66	0.46	0.96	209	1118042	12	1	8	3	244
CRW_00281	SSU_rRNA_bacteria links to Rfam database...	0.65	0.45	0.95	209	1145120	17	2	10	5	255
CRW_00284	SSU_rRNA_bacteria links to Rfam database...	0.53	0.33	0.87	150	1131587	27	3	20	4	306
CRW_00285	SSU_rRNA_bacteria links to Rfam database...	0.62	0.41	0.93	188	1118058	18	2	12	4	270
CRW_00289	SSU_rRNA_bacteria links to Rfam database...	0.58	0.41	0.84	194	1189422	41	5	32	4	282
CRW_00466	SSU_rRNA_bacteria links to Rfam database...	0.62	0.42	0.91	192	1116554	28	4	15	9	266
CRW_00589	SSU_rRNA_bacteria links to Rfam database...	0.58	0.35	0.97	156	1094299	10	0	5	5	289
CRW_00590	SSU_rRNA_bacteria links to Rfam database...	0.55	0.33	0.93	148	1119597	15	1	10	4	304
CRW_00591	SSU_rRNA_bacteria links to Rfam database...	0.66	0.46	0.93	206	1098682	26	1	14	11	240
CRW_00772	SSU_rRNA_bacteria links to Rfam database...	0.48	0.30	0.77	122	945842	42	3	33	6	282
CRW_00789	SSU_rRNA_bacteria links to Rfam database...	0.61	0.43	0.88	191	1137570	34	1	24	9	256
CRW_00795	SSU_rRNA_bacteria links to Rfam database...	0.59	0.38	0.90	150	1152755	40	0	16	24	244
CRW_00849	SSU_rRNA_bacteria links to Rfam database...	0.62	0.42	0.92	196	1118046	27	3	15	9	274
CRW_00997	SSU_rRNA_bacteria links to Rfam database...	0.60	0.39	0.93	181	1136084	19	3	10	6	283
PDB_00703	SSU_rRNA_bacteria links to Rfam database...	0.60	0.40	0.92	196	1073633	28	3	13	12	299
PDB_01105	SSU_rRNA_bacteria links to Rfam database...	0.58	0.36	0.94	192	1433767	24	1	11	12	348
PDB_01120	SSU_rRNA_bacteria links to Rfam database...	0.62	0.41	0.93	216	1204895	30	4	13	13	311
PDB_01273	SSU_rRNA_bacteria links to Rfam database...	0.66	0.48	0.92	234	1118007	37	4	15	18	257

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Performance of PknotsRG - scored lower in this pairwise comparison

1. Total counts & total scores for PknotsRG

Total Base Pair Counts
Total TP	9486
Total TN	52690681
Total FP	12203
Total FP CONTRA	1478
Total FP INCONS	9838
Total FP COMP	887
Total FN	11868

Total Scores
MCC	0.450
Average MCC ± 95% Confidence Intervals	0.448 ± 0.036
Sensitivity	0.444
Positive Predictive Value	0.456
Nr of predictions	46

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2. Individual counts for PknotsRG [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00024	SSU_rRNA_archaea links to Rfam database...	0.77	0.76	0.79	348	1085160	130	18	75	37	110
CRW_00034	SSU_rRNA_bacteria links to Rfam database...	0.63	0.63	0.63	300	1141843	196	31	142	23	174
CRW_00048	SSU_rRNA_bacteria links to Rfam database...	0.45	0.45	0.45	210	1170748	276	27	230	19	260
CRW_00054	SSU_rRNA_bacteria links to Rfam database...	0.53	0.52	0.54	236	1107378	216	34	168	14	220
CRW_00059	SSU_rRNA_bacteria links to Rfam database...	0.50	0.49	0.51	233	1172293	234	28	192	14	240
CRW_00061	SSU_rRNA_bacteria links to Rfam database...	0.43	0.44	0.43	208	1181469	284	32	244	8	268
CRW_00068	SSU_rRNA_bacteria links to Rfam database...	0.33	0.33	0.34	152	1108852	312	37	264	11	305
CRW_00096	SSU_rRNA_bacteria links to Rfam database...	0.55	0.55	0.55	255	1178420	227	21	184	22	210
CRW_00140	SSU_rRNA_bacteria links to Rfam database...	0.64	0.64	0.65	296	1135820	182	22	140	20	167
CRW_00141	SSU_rRNA_bacteria links to Rfam database...	0.51	0.50	0.52	238	1201566	240	29	192	19	238
CRW_00150	SSU_rRNA_bacteria links to Rfam database...	0.41	0.41	0.42	190	1152467	282	34	230	18	276
CRW_00152	SSU_rRNA_bacteria links to Rfam database...	0.51	0.50	0.52	236	1179961	240	37	182	21	235
CRW_00166	SSU_rRNA_bacteria links to Rfam database...	0.53	0.52	0.54	242	1190746	234	25	183	26	226
CRW_00173	SSU_rRNA_bacteria links to Rfam database...	0.29	0.29	0.29	128	1082212	325	37	279	9	317
CRW_00177	SSU_rRNA_bacteria links to Rfam database...	0.42	0.41	0.42	196	1178413	284	31	240	13	277
CRW_00196	SSU_rRNA_bacteria links to Rfam database...	0.47	0.46	0.47	220	1207767	270	26	222	22	255
CRW_00230	SSU_rRNA_bacteria links to Rfam database...	0.55	0.54	0.57	260	1198467	221	30	169	22	218
CRW_00245	SSU_rRNA_bacteria links to Rfam database...	0.35	0.35	0.34	157	1105872	312	45	254	13	296
CRW_00248	SSU_rRNA_bacteria links to Rfam database...	0.57	0.57	0.58	275	1218668	230	24	174	32	209
CRW_00250	SSU_rRNA_bacteria links to Rfam database...	0.43	0.43	0.43	205	1198449	287	30	242	15	273
CRW_00256	SSU_rRNA_bacteria links to Rfam database...	0.45	0.44	0.46	206	1192291	257	41	202	14	262
CRW_00270	SSU_rRNA_bacteria links to Rfam database...	0.38	0.37	0.39	168	1111857	279	39	222	18	287
CRW_00271	SSU_rRNA_bacteria links to Rfam database...	0.49	0.48	0.50	220	1122307	239	36	188	15	242
CRW_00273	SSU_rRNA_bacteria links to Rfam database...	0.51	0.50	0.51	222	1085169	227	31	179	17	224
CRW_00275	SSU_rRNA_bacteria links to Rfam database...	0.42	0.42	0.43	193	1114817	278	26	235	17	264
CRW_00277	SSU_rRNA_bacteria links to Rfam database...	0.25	0.25	0.24	113	1110332	354	55	295	4	340
CRW_00278	SSU_rRNA_bacteria links to Rfam database...	0.41	0.40	0.42	180	1129825	270	35	216	19	270
CRW_00279	SSU_rRNA_bacteria links to Rfam database...	0.29	0.29	0.30	134	1179968	334	40	274	20	330
CRW_00280	SSU_rRNA_bacteria links to Rfam database...	0.50	0.50	0.51	226	1117813	234	28	193	13	227
CRW_00281	SSU_rRNA_bacteria links to Rfam database...	0.30	0.30	0.30	138	1144878	340	40	285	15	326
CRW_00284	SSU_rRNA_bacteria links to Rfam database...	0.26	0.25	0.26	115	1131320	336	35	290	11	341
CRW_00285	SSU_rRNA_bacteria links to Rfam database...	0.47	0.47	0.47	214	1117807	257	31	208	18	244
CRW_00289	SSU_rRNA_bacteria links to Rfam database...	0.45	0.44	0.46	209	1189197	272	34	213	25	267
CRW_00466	SSU_rRNA_bacteria links to Rfam database...	0.61	0.60	0.62	273	1116325	194	25	142	27	185
CRW_00589	SSU_rRNA_bacteria links to Rfam database...	0.22	0.21	0.22	95	1094029	351	37	299	15	350
CRW_00590	SSU_rRNA_bacteria links to Rfam database...	0.32	0.31	0.33	141	1119330	303	41	244	18	311
CRW_00591	SSU_rRNA_bacteria links to Rfam database...	0.61	0.60	0.62	267	1098475	190	19	142	29	179
CRW_00772	SSU_rRNA_bacteria links to Rfam database...	0.24	0.24	0.25	97	945607	320	41	255	24	307
CRW_00789	SSU_rRNA_bacteria links to Rfam database...	0.35	0.35	0.35	156	1137342	304	48	240	16	291
CRW_00795	SSU_rRNA_bacteria links to Rfam database...	0.24	0.25	0.23	98	1152503	357	51	269	37	296
CRW_00849	SSU_rRNA_bacteria links to Rfam database...	0.48	0.48	0.49	225	1117798	260	25	212	23	245
CRW_00997	SSU_rRNA_bacteria links to Rfam database...	0.52	0.52	0.52	239	1135819	238	24	196	18	225
PDB_00703	SSU_rRNA_bacteria links to Rfam database...	0.50	0.48	0.53	239	1073392	239	21	193	25	256
PDB_01105	SSU_rRNA_bacteria links to Rfam database...	0.51	0.50	0.52	269	1433453	278	27	222	29	271
PDB_01120	SSU_rRNA_bacteria links to Rfam database...	0.48	0.45	0.51	239	1204657	247	27	205	15	288
PDB_01273	SSU_rRNA_bacteria links to Rfam database...	0.47	0.46	0.49	225	1117799	263	23	213	27	266

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of Carnac(20) - scored higher in this pairwise comparison

1. Total counts & total scores for Carnac(20)

2. Individual counts for Carnac(20) [ download as .csv ]

Performance of PknotsRG - scored lower in this pairwise comparison

1. Total counts & total scores for PknotsRG

2. Individual counts for PknotsRG [ download as .csv ]