CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

Home

Methods

Datasets

Rankings

RNA 2D Atlas

Help

FAQ

Contact us

RSS feeds

Twitter

Overview

Metric	CentroidAlifold(seed)		CRWrnafold
MCC	0.844	>	0.515
Average MCC ± 95% Confidence Intervals	0.844 ± 0.012	>	0.512 ± 0.050
Sensitivity	0.786	>	0.508
Positive Predictive Value	0.908	>	0.523
Total TP	10303	>	6664
Total TN	32002127	>	32000733
Total FP	1480	<	6747
Total FP CONTRA	225	<	823
Total FP INCONS	823	<	5258
Total FP COMP	432	<	666
Total FN	2808	<	6447
P-value	5.23657817852e-08

^top

Performance plots

Comparison of performance of CentroidAlifold(seed) and CRWrnafold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for CentroidAlifold(seed) and CRWrnafold).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for CentroidAlifold(seed) and CRWrnafold).
Comparison of average Matthews Correlation Coefficients (MCCs) for CentroidAlifold(seed) and CRWrnafold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for CentroidAlifold(seed) and CRWrnafold).

^top

Performance of CentroidAlifold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for CentroidAlifold(seed)

Total Base Pair Counts
Total TP	10303
Total TN	32002127
Total FP	1480
Total FP CONTRA	225
Total FP INCONS	823
Total FP COMP	432
Total FN	2808

Total Scores
MCC	0.844
Average MCC ± 95% Confidence Intervals	0.844 ± 0.012
Sensitivity	0.786
Positive Predictive Value	0.908
Nr of predictions	29

^top

2. Individual counts for CentroidAlifold(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00054	SSU_rRNA_bacteria links to Rfam database...	0.87	0.82	0.93	374	1107413	39	9	20	10	82
CRW_00068	SSU_rRNA_bacteria links to Rfam database...	0.87	0.82	0.93	375	1108900	39	9	21	9	82
CRW_00140	SSU_rRNA_bacteria links to Rfam database...	0.87	0.82	0.92	379	1135867	41	9	23	9	84
CRW_00173	SSU_rRNA_bacteria links to Rfam database...	0.82	0.76	0.88	340	1082268	59	9	39	11	105
CRW_00245	SSU_rRNA_bacteria links to Rfam database...	0.87	0.82	0.93	372	1105927	39	9	20	10	81
CRW_00270	SSU_rRNA_bacteria links to Rfam database...	0.87	0.82	0.93	373	1111883	39	9	21	9	82
CRW_00271	SSU_rRNA_bacteria links to Rfam database...	0.84	0.77	0.90	358	1122354	48	8	31	9	104
CRW_00273	SSU_rRNA_bacteria links to Rfam database...	0.86	0.81	0.92	361	1085207	41	8	25	8	85
CRW_00275	SSU_rRNA_bacteria links to Rfam database...	0.87	0.81	0.92	371	1114869	40	9	22	9	86
CRW_00277	SSU_rRNA_bacteria links to Rfam database...	0.85	0.80	0.90	363	1110392	50	13	27	10	90
CRW_00278	SSU_rRNA_bacteria links to Rfam database...	0.83	0.77	0.90	347	1129872	48	8	29	11	103
CRW_00280	SSU_rRNA_bacteria links to Rfam database...	0.84	0.79	0.90	357	1117863	52	9	31	12	96
CRW_00281	SSU_rRNA_bacteria links to Rfam database...	0.86	0.79	0.92	368	1144943	39	9	21	9	96
CRW_00283	SSU_rRNA_bacteria links to Rfam database...	0.79	0.73	0.84	316	1015651	66	12	46	8	116
CRW_00284	SSU_rRNA_bacteria links to Rfam database...	0.84	0.79	0.90	360	1131361	50	9	30	11	96
CRW_00285	SSU_rRNA_bacteria links to Rfam database...	0.85	0.79	0.91	361	1117862	46	11	26	9	97
CRW_00292	SSU_rRNA_bacteria links to Rfam database...	0.76	0.70	0.82	322	1123856	83	13	59	11	139
CRW_00466	SSU_rRNA_bacteria links to Rfam database...	0.87	0.82	0.93	374	1116361	39	8	22	9	84
CRW_00589	SSU_rRNA_bacteria links to Rfam database...	0.87	0.81	0.93	360	1094074	43	2	24	17	85
CRW_00590	SSU_rRNA_bacteria links to Rfam database...	0.87	0.81	0.93	364	1119366	44	2	24	18	88
CRW_00591	SSU_rRNA_bacteria links to Rfam database...	0.88	0.82	0.94	365	1098513	44	3	22	19	81
CRW_00772	SSU_rRNA_bacteria links to Rfam database...	0.80	0.74	0.87	297	945660	69	2	41	26	107
CRW_00778	SSU_rRNA_bacteria links to Rfam database...	0.84	0.79	0.90	303	1201687	92	4	31	57	81
CRW_00789	SSU_rRNA_bacteria links to Rfam database...	0.85	0.79	0.92	353	1137401	53	5	27	21	94
CRW_00849	SSU_rRNA_bacteria links to Rfam database...	0.82	0.76	0.89	358	1117856	57	12	34	11	112
CRW_00997	SSU_rRNA_bacteria links to Rfam database...	0.87	0.81	0.93	377	1135871	39	9	21	9	87
CRW_01343	SSU_rRNA_archaea links to Rfam database...	0.86	0.81	0.92	351	977520	61	3	27	31	83
PDB_00703	SSU_rRNA_bacteria links to Rfam database...	0.81	0.72	0.92	356	1073456	57	6	27	24	139
PDB_01273	SSU_rRNA_bacteria links to Rfam database...	0.80	0.71	0.90	348	1117874	63	6	32	25	143

^top

Performance of CRWrnafold - scored lower in this pairwise comparison

1. Total counts & total scores for CRWrnafold

Total Base Pair Counts
Total TP	6664
Total TN	32000733
Total FP	6747
Total FP CONTRA	823
Total FP INCONS	5258
Total FP COMP	666
Total FN	6447

Total Scores
MCC	0.515
Average MCC ± 95% Confidence Intervals	0.512 ± 0.050
Sensitivity	0.508
Positive Predictive Value	0.523
Nr of predictions	29

^top

2. Individual counts for CRWrnafold [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00054	SSU_rRNA_bacteria links to Rfam database...	0.57	0.56	0.57	257	1107367	210	22	170	18	199
CRW_00068	SSU_rRNA_bacteria links to Rfam database...	0.57	0.57	0.58	259	1108856	209	20	170	19	198
CRW_00140	SSU_rRNA_bacteria links to Rfam database...	0.49	0.49	0.48	226	1135811	256	30	211	15	237
CRW_00173	SSU_rRNA_bacteria links to Rfam database...	0.38	0.38	0.39	168	1082220	282	31	237	14	277
CRW_00245	SSU_rRNA_bacteria links to Rfam database...	0.53	0.53	0.54	240	1105883	225	26	179	20	213
CRW_00270	SSU_rRNA_bacteria links to Rfam database...	0.49	0.49	0.50	225	1111832	246	27	202	17	230
CRW_00271	SSU_rRNA_bacteria links to Rfam database...	0.69	0.67	0.71	311	1122312	152	21	107	24	151
CRW_00273	SSU_rRNA_bacteria links to Rfam database...	0.41	0.41	0.41	181	1085155	279	39	226	14	265
CRW_00275	SSU_rRNA_bacteria links to Rfam database...	0.65	0.65	0.66	296	1114820	177	28	127	22	161
CRW_00277	SSU_rRNA_bacteria links to Rfam database...	0.44	0.43	0.44	196	1110351	263	35	213	15	257
CRW_00278	SSU_rRNA_bacteria links to Rfam database...	0.41	0.40	0.42	182	1129824	270	20	230	20	268
CRW_00280	SSU_rRNA_bacteria links to Rfam database...	0.67	0.66	0.68	299	1117818	160	18	125	17	154
CRW_00281	SSU_rRNA_bacteria links to Rfam database...	0.60	0.59	0.61	274	1144893	197	27	147	23	190
CRW_00283	SSU_rRNA_bacteria links to Rfam database...	0.38	0.38	0.37	164	1015587	296	41	233	22	268
CRW_00284	SSU_rRNA_bacteria links to Rfam database...	0.51	0.50	0.51	228	1131314	245	27	191	27	228
CRW_00285	SSU_rRNA_bacteria links to Rfam database...	0.68	0.67	0.69	305	1117819	160	25	111	24	153
CRW_00292	SSU_rRNA_bacteria links to Rfam database...	0.33	0.33	0.34	151	1123806	312	48	245	19	310
CRW_00466	SSU_rRNA_bacteria links to Rfam database...	0.71	0.70	0.71	320	1116316	158	22	107	29	138
CRW_00589	SSU_rRNA_bacteria links to Rfam database...	0.35	0.34	0.36	153	1094035	290	40	232	18	292
CRW_00590	SSU_rRNA_bacteria links to Rfam database...	0.61	0.59	0.64	268	1119334	184	21	133	30	184
CRW_00591	SSU_rRNA_bacteria links to Rfam database...	0.56	0.56	0.56	249	1098461	218	30	163	25	197
CRW_00772	SSU_rRNA_bacteria links to Rfam database...	0.19	0.18	0.19	74	945610	325	42	274	9	330
CRW_00778	SSU_rRNA_bacteria links to Rfam database...	0.42	0.41	0.42	159	1201646	291	25	195	71	225
CRW_00789	SSU_rRNA_bacteria links to Rfam database...	0.51	0.50	0.52	224	1137356	236	32	174	30	223
CRW_00849	SSU_rRNA_bacteria links to Rfam database...	0.47	0.47	0.47	222	1117790	269	18	230	21	248
CRW_00997	SSU_rRNA_bacteria links to Rfam database...	0.69	0.69	0.69	318	1135820	167	27	113	27	146
CRW_01343	SSU_rRNA_archaea links to Rfam database...	0.37	0.36	0.38	158	977489	271	43	211	17	276
PDB_00703	SSU_rRNA_bacteria links to Rfam database...	0.65	0.61	0.69	304	1073402	166	18	121	27	191
PDB_01273	SSU_rRNA_bacteria links to Rfam database...	0.54	0.52	0.56	253	1117806	233	20	181	32	238

^top

Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of CentroidAlifold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for CentroidAlifold(seed)

2. Individual counts for CentroidAlifold(seed) [ download as .csv ]

Performance of CRWrnafold - scored lower in this pairwise comparison

1. Total counts & total scores for CRWrnafold

2. Individual counts for CRWrnafold [ download as .csv ]