CompaRNA - on-line benchmarks of RNA structure prediction methods

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Overview

Metric	CentroidAlifold(seed)		IPknot
MCC	0.796	>	0.581
Average MCC ± 95% Confidence Intervals	0.790 ± 0.032	>	0.577 ± 0.033
Sensitivity	0.706	>	0.505
Positive Predictive Value	0.897	>	0.670
Total TP	21223	>	15195
Total TN	79088671	<	79089635
Total FP	3503	<	8884
Total FP CONTRA	450	<	1175
Total FP INCONS	1983	<	6322
Total FP COMP	1070	<	1387
Total FN	8857	<	14885
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of CentroidAlifold(seed) and IPknot. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for CentroidAlifold(seed) and IPknot).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for CentroidAlifold(seed) and IPknot).
Comparison of average Matthews Correlation Coefficients (MCCs) for CentroidAlifold(seed) and IPknot. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for CentroidAlifold(seed) and IPknot).

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Performance of CentroidAlifold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for CentroidAlifold(seed)

Total Base Pair Counts
Total TP	21223
Total TN	79088671
Total FP	3503
Total FP CONTRA	450
Total FP INCONS	1983
Total FP COMP	1070
Total FN	8857

Total Scores
MCC	0.796
Average MCC ± 95% Confidence Intervals	0.790 ± 0.032
Sensitivity	0.706
Positive Predictive Value	0.897
Nr of predictions	64

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2. Individual counts for CentroidAlifold(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00024	SSU_rRNA_archaea links to Rfam database...	0.90	0.86	0.95	393	1085187	55	6	15	34	65
CRW_00034	SSU_rRNA_bacteria links to Rfam database...	0.83	0.78	0.90	368	1141906	52	10	32	10	106
CRW_00048	SSU_rRNA_bacteria links to Rfam database...	0.87	0.82	0.93	385	1170801	38	9	20	9	85
CRW_00054	SSU_rRNA_bacteria links to Rfam database...	0.87	0.82	0.93	374	1107413	39	9	20	10	82
CRW_00059	SSU_rRNA_bacteria links to Rfam database...	0.85	0.79	0.92	372	1172342	41	9	23	9	101
CRW_00061	SSU_rRNA_bacteria links to Rfam database...	0.86	0.80	0.92	381	1181541	41	9	22	10	95
CRW_00068	SSU_rRNA_bacteria links to Rfam database...	0.87	0.82	0.93	375	1108900	39	9	21	9	82
CRW_00096	SSU_rRNA_bacteria links to Rfam database...	0.87	0.80	0.93	373	1178481	41	4	22	15	92
CRW_00140	SSU_rRNA_bacteria links to Rfam database...	0.87	0.82	0.92	379	1135867	41	9	23	9	84
CRW_00141	SSU_rRNA_bacteria links to Rfam database...	0.86	0.80	0.93	381	1201614	41	9	21	11	95
CRW_00150	SSU_rRNA_bacteria links to Rfam database...	0.86	0.80	0.93	372	1152519	39	9	21	9	94
CRW_00152	SSU_rRNA_bacteria links to Rfam database...	0.86	0.80	0.93	376	1180010	40	9	21	10	95
CRW_00166	SSU_rRNA_bacteria links to Rfam database...	0.86	0.80	0.94	374	1190796	41	4	22	15	94
CRW_00173	SSU_rRNA_bacteria links to Rfam database...	0.82	0.76	0.88	340	1082268	59	9	39	11	105
CRW_00177	SSU_rRNA_bacteria links to Rfam database...	0.84	0.78	0.91	368	1178477	47	9	26	12	105
CRW_00196	SSU_rRNA_bacteria links to Rfam database...	0.87	0.81	0.93	383	1207823	39	9	20	10	92
CRW_00230	SSU_rRNA_bacteria links to Rfam database...	0.86	0.80	0.93	381	1198515	40	9	21	10	97
CRW_00245	SSU_rRNA_bacteria links to Rfam database...	0.87	0.82	0.93	372	1105927	39	9	20	10	81
CRW_00248	SSU_rRNA_bacteria links to Rfam database...	0.85	0.78	0.92	379	1218731	41	9	22	10	105
CRW_00250	SSU_rRNA_bacteria links to Rfam database...	0.86	0.80	0.92	382	1198513	40	9	22	9	96
CRW_00256	SSU_rRNA_bacteria links to Rfam database...	0.86	0.80	0.93	374	1192336	40	9	21	10	94
CRW_00270	SSU_rRNA_bacteria links to Rfam database...	0.87	0.82	0.93	373	1111883	39	9	21	9	82
CRW_00271	SSU_rRNA_bacteria links to Rfam database...	0.84	0.77	0.90	358	1122354	48	8	31	9	104
CRW_00273	SSU_rRNA_bacteria links to Rfam database...	0.86	0.81	0.92	361	1085207	41	8	25	8	85
CRW_00275	SSU_rRNA_bacteria links to Rfam database...	0.87	0.81	0.92	371	1114869	40	9	22	9	86
CRW_00277	SSU_rRNA_bacteria links to Rfam database...	0.85	0.80	0.90	363	1110392	50	13	27	10	90
CRW_00278	SSU_rRNA_bacteria links to Rfam database...	0.83	0.77	0.90	347	1129872	48	8	29	11	103
CRW_00279	SSU_rRNA_bacteria links to Rfam database...	0.86	0.80	0.92	371	1180013	46	9	23	14	93
CRW_00280	SSU_rRNA_bacteria links to Rfam database...	0.84	0.79	0.90	357	1117863	52	9	31	12	96
CRW_00281	SSU_rRNA_bacteria links to Rfam database...	0.86	0.79	0.92	368	1144943	39	9	21	9	96
CRW_00283	SSU_rRNA_bacteria links to Rfam database...	0.79	0.73	0.84	316	1015651	66	12	46	8	116
CRW_00284	SSU_rRNA_bacteria links to Rfam database...	0.84	0.79	0.90	360	1131361	50	9	30	11	96
CRW_00285	SSU_rRNA_bacteria links to Rfam database...	0.85	0.79	0.91	361	1117862	46	11	26	9	97
CRW_00289	SSU_rRNA_bacteria links to Rfam database...	0.83	0.77	0.90	367	1189245	50	10	31	9	109
CRW_00292	SSU_rRNA_bacteria links to Rfam database...	0.76	0.70	0.82	322	1123856	83	13	59	11	139
CRW_00306	SSU_rRNA_eukarya links to Rfam database...	0.53	0.37	0.77	170	1445629	73	4	47	22	292
CRW_00366	SSU_rRNA_eukarya links to Rfam database...	0.53	0.37	0.77	177	1579523	74	4	49	21	305
CRW_00371	SSU_rRNA_eukarya links to Rfam database...	0.54	0.37	0.78	185	1611673	73	4	48	21	311
CRW_00379	SSU_rRNA_eukarya links to Rfam database...	0.45	0.30	0.69	158	2126723	93	6	66	21	376
CRW_00411	SSU_rRNA_eukarya links to Rfam database...	0.53	0.37	0.76	182	1615264	78	4	53	21	314
CRW_00414	SSU_rRNA_eukarya links to Rfam database...	0.52	0.36	0.74	177	1665987	83	5	56	22	318
CRW_00466	SSU_rRNA_bacteria links to Rfam database...	0.87	0.82	0.93	374	1116361	39	8	22	9	84
CRW_00589	SSU_rRNA_bacteria links to Rfam database...	0.87	0.81	0.93	360	1094074	43	2	24	17	85
CRW_00590	SSU_rRNA_bacteria links to Rfam database...	0.87	0.81	0.93	364	1119366	44	2	24	18	88
CRW_00591	SSU_rRNA_bacteria links to Rfam database...	0.88	0.82	0.94	365	1098513	44	3	22	19	81
CRW_00759	SSU_rRNA_eukarya links to Rfam database...	0.50	0.35	0.72	168	1636913	92	3	61	28	313
CRW_00763	SSU_rRNA_bacteria links to Rfam database...	0.85	0.77	0.93	344	1215650	51	2	24	25	102
CRW_00772	SSU_rRNA_bacteria links to Rfam database...	0.80	0.74	0.87	297	945660	69	2	41	26	107
CRW_00778	SSU_rRNA_bacteria links to Rfam database...	0.84	0.79	0.90	303	1201687	92	4	31	57	81
CRW_00789	SSU_rRNA_bacteria links to Rfam database...	0.85	0.79	0.92	353	1137401	53	5	27	21	94
CRW_00795	SSU_rRNA_bacteria links to Rfam database...	0.81	0.74	0.88	291	1152590	94	3	37	54	103
CRW_00800	SSU_rRNA_eukarya links to Rfam database...	0.45	0.30	0.67	141	1401765	92	7	62	23	329
CRW_00849	SSU_rRNA_bacteria links to Rfam database...	0.82	0.76	0.89	358	1117856	57	12	34	11	112
CRW_00997	SSU_rRNA_bacteria links to Rfam database...	0.87	0.81	0.93	377	1135871	39	9	21	9	87
CRW_01153	SSU_rRNA_eukarya links to Rfam database...	0.48	0.33	0.70	167	1606289	89	4	68	17	336
CRW_01171	SSU_rRNA_eukarya links to Rfam database...	0.52	0.35	0.77	179	1593773	71	4	49	18	327
CRW_01343	SSU_rRNA_archaea links to Rfam database...	0.86	0.81	0.92	351	977520	61	3	27	31	83
PDB_00703	SSU_rRNA_bacteria links to Rfam database...	0.81	0.72	0.92	356	1073456	57	6	27	24	139
PDB_00854	SSU_rRNA_bacteria links to Rfam database...	0.78	0.66	0.92	354	1500393	66	5	26	35	181
PDB_01088	SSU_rRNA_bacteria links to Rfam database...	0.75	0.63	0.90	344	1471089	68	3	34	31	203
PDB_01103	SSU_rRNA_bacteria links to Rfam database...	0.78	0.65	0.92	368	1606129	52	6	25	21	194
PDB_01105	SSU_rRNA_bacteria links to Rfam database...	0.79	0.68	0.93	367	1433576	53	2	26	25	173
PDB_01120	SSU_rRNA_bacteria links to Rfam database...	0.80	0.70	0.92	368	1204728	49	8	24	17	159
PDB_01273	SSU_rRNA_bacteria links to Rfam database...	0.80	0.71	0.90	348	1117874	63	6	32	25	143

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Performance of IPknot - scored lower in this pairwise comparison

1. Total counts & total scores for IPknot

Total Base Pair Counts
Total TP	15195
Total TN	79089635
Total FP	8884
Total FP CONTRA	1175
Total FP INCONS	6322
Total FP COMP	1387
Total FN	14885

Total Scores
MCC	0.581
Average MCC ± 95% Confidence Intervals	0.577 ± 0.033
Sensitivity	0.505
Positive Predictive Value	0.670
Nr of predictions	64

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2. Individual counts for IPknot [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00024	SSU_rRNA_archaea links to Rfam database...	0.83	0.77	0.89	352	1085204	78	4	41	33	106
CRW_00034	SSU_rRNA_bacteria links to Rfam database...	0.78	0.76	0.79	360	1141862	121	19	75	27	114
CRW_00048	SSU_rRNA_bacteria links to Rfam database...	0.72	0.63	0.83	297	1170856	75	6	56	13	173
CRW_00054	SSU_rRNA_bacteria links to Rfam database...	0.58	0.50	0.66	229	1107469	137	16	102	19	227
CRW_00059	SSU_rRNA_bacteria links to Rfam database...	0.71	0.61	0.83	287	1172399	74	4	56	14	186
CRW_00061	SSU_rRNA_bacteria links to Rfam database...	0.66	0.60	0.72	287	1181556	121	23	87	11	189
CRW_00068	SSU_rRNA_bacteria links to Rfam database...	0.59	0.52	0.66	236	1108950	134	23	96	15	221
CRW_00096	SSU_rRNA_bacteria links to Rfam database...	0.55	0.50	0.60	231	1178495	170	17	137	16	234
CRW_00140	SSU_rRNA_bacteria links to Rfam database...	0.76	0.68	0.83	317	1135898	79	6	57	16	146
CRW_00141	SSU_rRNA_bacteria links to Rfam database...	0.70	0.64	0.77	307	1201626	111	11	81	19	169
CRW_00150	SSU_rRNA_bacteria links to Rfam database...	0.58	0.50	0.68	231	1152582	123	17	91	15	235
CRW_00152	SSU_rRNA_bacteria links to Rfam database...	0.54	0.48	0.62	225	1180051	148	20	120	8	246
CRW_00166	SSU_rRNA_bacteria links to Rfam database...	0.61	0.53	0.70	249	1190838	118	6	103	9	219
CRW_00173	SSU_rRNA_bacteria links to Rfam database...	0.37	0.34	0.40	150	1082284	231	30	192	9	295
CRW_00177	SSU_rRNA_bacteria links to Rfam database...	0.59	0.53	0.65	252	1178495	145	17	116	12	221
CRW_00196	SSU_rRNA_bacteria links to Rfam database...	0.61	0.55	0.67	261	1207844	146	17	113	16	214
CRW_00230	SSU_rRNA_bacteria links to Rfam database...	0.73	0.63	0.85	302	1198569	73	7	48	18	176
CRW_00245	SSU_rRNA_bacteria links to Rfam database...	0.62	0.53	0.74	239	1106005	96	13	71	12	214
CRW_00248	SSU_rRNA_bacteria links to Rfam database...	0.76	0.72	0.81	347	1218713	108	15	66	27	137
CRW_00250	SSU_rRNA_bacteria links to Rfam database...	0.57	0.52	0.63	250	1198526	164	23	127	14	228
CRW_00256	SSU_rRNA_bacteria links to Rfam database...	0.56	0.44	0.71	207	1192448	104	18	67	19	261
CRW_00270	SSU_rRNA_bacteria links to Rfam database...	0.66	0.55	0.79	250	1111971	79	11	54	14	205
CRW_00271	SSU_rRNA_bacteria links to Rfam database...	0.56	0.47	0.66	216	1122424	126	25	86	15	246
CRW_00273	SSU_rRNA_bacteria links to Rfam database...	0.52	0.47	0.58	208	1085244	163	20	129	14	238
CRW_00275	SSU_rRNA_bacteria links to Rfam database...	0.76	0.69	0.83	314	1114894	79	11	52	16	143
CRW_00277	SSU_rRNA_bacteria links to Rfam database...	0.53	0.43	0.66	194	1110503	106	22	76	8	259
CRW_00278	SSU_rRNA_bacteria links to Rfam database...	0.60	0.48	0.74	218	1129962	95	5	71	19	232
CRW_00279	SSU_rRNA_bacteria links to Rfam database...	0.66	0.58	0.76	270	1180060	100	16	70	14	194
CRW_00280	SSU_rRNA_bacteria links to Rfam database...	0.67	0.58	0.77	265	1117916	90	11	68	11	188
CRW_00281	SSU_rRNA_bacteria links to Rfam database...	0.65	0.59	0.72	276	1144958	123	17	90	16	188
CRW_00283	SSU_rRNA_bacteria links to Rfam database...	0.42	0.31	0.56	136	1015781	124	17	91	16	296
CRW_00284	SSU_rRNA_bacteria links to Rfam database...	0.55	0.42	0.71	193	1131487	92	13	67	12	263
CRW_00285	SSU_rRNA_bacteria links to Rfam database...	0.79	0.71	0.88	327	1117890	60	13	30	17	131
CRW_00289	SSU_rRNA_bacteria links to Rfam database...	0.64	0.56	0.73	268	1189284	121	17	84	20	208
CRW_00292	SSU_rRNA_bacteria links to Rfam database...	0.41	0.35	0.48	160	1123920	187	28	142	17	301
CRW_00306	SSU_rRNA_eukarya links to Rfam database...	0.28	0.24	0.34	109	1445531	252	37	173	42	353
CRW_00366	SSU_rRNA_eukarya links to Rfam database...	0.37	0.32	0.42	153	1579390	248	42	168	38	329
CRW_00371	SSU_rRNA_eukarya links to Rfam database...	0.49	0.41	0.59	203	1611565	179	27	115	37	293
CRW_00379	SSU_rRNA_eukarya links to Rfam database...	0.49	0.40	0.59	214	2126590	218	30	119	69	320
CRW_00411	SSU_rRNA_eukarya links to Rfam database...	0.40	0.34	0.46	170	1615137	238	31	165	42	326
CRW_00414	SSU_rRNA_eukarya links to Rfam database...	0.41	0.33	0.51	163	1665906	188	30	126	32	332
CRW_00466	SSU_rRNA_bacteria links to Rfam database...	0.81	0.75	0.88	344	1116375	69	10	36	23	114
CRW_00589	SSU_rRNA_bacteria links to Rfam database...	0.44	0.37	0.53	164	1094152	163	21	123	19	281
CRW_00590	SSU_rRNA_bacteria links to Rfam database...	0.53	0.48	0.59	217	1119386	165	27	126	12	235
CRW_00591	SSU_rRNA_bacteria links to Rfam database...	0.70	0.63	0.77	282	1098536	110	15	70	25	164
CRW_00759	SSU_rRNA_eukarya links to Rfam database...	0.28	0.24	0.33	116	1636796	279	54	179	46	365
CRW_00763	SSU_rRNA_bacteria links to Rfam database...	0.48	0.34	0.67	153	1215790	109	10	67	32	293
CRW_00772	SSU_rRNA_bacteria links to Rfam database...	0.44	0.34	0.57	136	945760	126	16	88	22	268
CRW_00778	SSU_rRNA_bacteria links to Rfam database...	0.42	0.29	0.60	111	1201840	104	12	62	30	273
CRW_00789	SSU_rRNA_bacteria links to Rfam database...	0.55	0.46	0.66	206	1137473	121	11	96	14	241
CRW_00795	SSU_rRNA_bacteria links to Rfam database...	0.36	0.26	0.50	102	1152715	143	20	84	39	292
CRW_00800	SSU_rRNA_eukarya links to Rfam database...	0.62	0.51	0.75	240	1401657	117	12	66	39	230
CRW_00849	SSU_rRNA_bacteria links to Rfam database...	0.68	0.63	0.73	295	1117857	132	9	99	24	175
CRW_00997	SSU_rRNA_bacteria links to Rfam database...	0.68	0.62	0.75	289	1135893	113	17	79	17	175
CRW_01153	SSU_rRNA_eukarya links to Rfam database...	0.37	0.35	0.40	174	1606096	291	43	215	33	329
CRW_01171	SSU_rRNA_eukarya links to Rfam database...	0.45	0.41	0.50	207	1593595	240	34	169	37	299
CRW_01343	SSU_rRNA_archaea links to Rfam database...	0.50	0.42	0.59	182	977595	134	16	108	10	252
PDB_00703	SSU_rRNA_bacteria links to Rfam database...	0.64	0.57	0.72	282	1073454	132	13	96	23	213
PDB_00854	SSU_rRNA_bacteria links to Rfam database...	0.67	0.62	0.73	331	1500326	158	17	104	37	204
PDB_01088	SSU_rRNA_bacteria links to Rfam database...	0.55	0.46	0.66	252	1471087	150	21	110	19	295
PDB_01103	SSU_rRNA_bacteria links to Rfam database...	0.62	0.57	0.67	319	1606055	171	20	134	17	243
PDB_01105	SSU_rRNA_bacteria links to Rfam database...	0.69	0.63	0.76	342	1433519	132	10	100	22	198
PDB_01120	SSU_rRNA_bacteria links to Rfam database...	0.56	0.48	0.66	252	1204748	138	22	106	10	275
PDB_01273	SSU_rRNA_bacteria links to Rfam database...	0.61	0.56	0.67	276	1117847	163	10	127	26	215

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of CentroidAlifold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for CentroidAlifold(seed)

2. Individual counts for CentroidAlifold(seed) [ download as .csv ]

Performance of IPknot - scored lower in this pairwise comparison

1. Total counts & total scores for IPknot

2. Individual counts for IPknot [ download as .csv ]