CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	CentroidAlifold(seed)		RSpredict(seed)
MCC	0.796	>	0.532
Average MCC ± 95% Confidence Intervals	0.791 ± 0.034	>	0.529 ± 0.062
Sensitivity	0.705	>	0.447
Positive Predictive Value	0.899	>	0.632
Total TP	18978	>	12037
Total TN	71040232	<	71042306
Total FP	3100	<	8416
Total FP CONTRA	394	<	1137
Total FP INCONS	1740	<	5864
Total FP COMP	966	<	1415
Total FN	7926	<	14867
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of CentroidAlifold(seed) and RSpredict(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for CentroidAlifold(seed) and RSpredict(seed)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for CentroidAlifold(seed) and RSpredict(seed)).
Comparison of average Matthews Correlation Coefficients (MCCs) for CentroidAlifold(seed) and RSpredict(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for CentroidAlifold(seed) and RSpredict(seed)).

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Performance of CentroidAlifold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for CentroidAlifold(seed)

Total Base Pair Counts
Total TP	18978
Total TN	71040232
Total FP	3100
Total FP CONTRA	394
Total FP INCONS	1740
Total FP COMP	966
Total FN	7926

Total Scores
MCC	0.796
Average MCC ± 95% Confidence Intervals	0.791 ± 0.034
Sensitivity	0.705
Positive Predictive Value	0.899
Nr of predictions	57

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2. Individual counts for CentroidAlifold(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00024	SSU_rRNA_archaea links to Rfam database...	0.90	0.86	0.95	393	1085187	55	6	15	34	65
CRW_00048	SSU_rRNA_bacteria links to Rfam database...	0.87	0.82	0.93	385	1170801	38	9	20	9	85
CRW_00054	SSU_rRNA_bacteria links to Rfam database...	0.87	0.82	0.93	374	1107413	39	9	20	10	82
CRW_00059	SSU_rRNA_bacteria links to Rfam database...	0.85	0.79	0.92	372	1172342	41	9	23	9	101
CRW_00061	SSU_rRNA_bacteria links to Rfam database...	0.86	0.80	0.92	381	1181541	41	9	22	10	95
CRW_00068	SSU_rRNA_bacteria links to Rfam database...	0.87	0.82	0.93	375	1108900	39	9	21	9	82
CRW_00096	SSU_rRNA_bacteria links to Rfam database...	0.87	0.80	0.93	373	1178481	41	4	22	15	92
CRW_00140	SSU_rRNA_bacteria links to Rfam database...	0.87	0.82	0.92	379	1135867	41	9	23	9	84
CRW_00141	SSU_rRNA_bacteria links to Rfam database...	0.86	0.80	0.93	381	1201614	41	9	21	11	95
CRW_00150	SSU_rRNA_bacteria links to Rfam database...	0.86	0.80	0.93	372	1152519	39	9	21	9	94
CRW_00152	SSU_rRNA_bacteria links to Rfam database...	0.86	0.80	0.93	376	1180010	40	9	21	10	95
CRW_00166	SSU_rRNA_bacteria links to Rfam database...	0.86	0.80	0.94	374	1190796	41	4	22	15	94
CRW_00173	SSU_rRNA_bacteria links to Rfam database...	0.82	0.76	0.88	340	1082268	59	9	39	11	105
CRW_00177	SSU_rRNA_bacteria links to Rfam database...	0.84	0.78	0.91	368	1178477	47	9	26	12	105
CRW_00196	SSU_rRNA_bacteria links to Rfam database...	0.87	0.81	0.93	383	1207823	39	9	20	10	92
CRW_00230	SSU_rRNA_bacteria links to Rfam database...	0.86	0.80	0.93	381	1198515	40	9	21	10	97
CRW_00245	SSU_rRNA_bacteria links to Rfam database...	0.87	0.82	0.93	372	1105927	39	9	20	10	81
CRW_00248	SSU_rRNA_bacteria links to Rfam database...	0.85	0.78	0.92	379	1218731	41	9	22	10	105
CRW_00250	SSU_rRNA_bacteria links to Rfam database...	0.86	0.80	0.92	382	1198513	40	9	22	9	96
CRW_00256	SSU_rRNA_bacteria links to Rfam database...	0.86	0.80	0.93	374	1192336	40	9	21	10	94
CRW_00270	SSU_rRNA_bacteria links to Rfam database...	0.87	0.82	0.93	373	1111883	39	9	21	9	82
CRW_00271	SSU_rRNA_bacteria links to Rfam database...	0.84	0.77	0.90	358	1122354	48	8	31	9	104
CRW_00273	SSU_rRNA_bacteria links to Rfam database...	0.86	0.81	0.92	361	1085207	41	8	25	8	85
CRW_00275	SSU_rRNA_bacteria links to Rfam database...	0.87	0.81	0.92	371	1114869	40	9	22	9	86
CRW_00277	SSU_rRNA_bacteria links to Rfam database...	0.85	0.80	0.90	363	1110392	50	13	27	10	90
CRW_00280	SSU_rRNA_bacteria links to Rfam database...	0.84	0.79	0.90	357	1117863	52	9	31	12	96
CRW_00281	SSU_rRNA_bacteria links to Rfam database...	0.86	0.79	0.92	368	1144943	39	9	21	9	96
CRW_00283	SSU_rRNA_bacteria links to Rfam database...	0.79	0.73	0.84	316	1015651	66	12	46	8	116
CRW_00289	SSU_rRNA_bacteria links to Rfam database...	0.83	0.77	0.90	367	1189245	50	10	31	9	109
CRW_00292	SSU_rRNA_bacteria links to Rfam database...	0.76	0.70	0.82	322	1123856	83	13	59	11	139
CRW_00306	SSU_rRNA_eukarya links to Rfam database...	0.53	0.37	0.77	170	1445629	73	4	47	22	292
CRW_00366	SSU_rRNA_eukarya links to Rfam database...	0.53	0.37	0.77	177	1579523	74	4	49	21	305
CRW_00371	SSU_rRNA_eukarya links to Rfam database...	0.54	0.37	0.78	185	1611673	73	4	48	21	311
CRW_00379	SSU_rRNA_eukarya links to Rfam database...	0.45	0.30	0.69	158	2126723	93	6	66	21	376
CRW_00411	SSU_rRNA_eukarya links to Rfam database...	0.53	0.37	0.76	182	1615264	78	4	53	21	314
CRW_00414	SSU_rRNA_eukarya links to Rfam database...	0.52	0.36	0.74	177	1665987	83	5	56	22	318
CRW_00466	SSU_rRNA_bacteria links to Rfam database...	0.87	0.82	0.93	374	1116361	39	8	22	9	84
CRW_00589	SSU_rRNA_bacteria links to Rfam database...	0.87	0.81	0.93	360	1094074	43	2	24	17	85
CRW_00590	SSU_rRNA_bacteria links to Rfam database...	0.87	0.81	0.93	364	1119366	44	2	24	18	88
CRW_00591	SSU_rRNA_bacteria links to Rfam database...	0.88	0.82	0.94	365	1098513	44	3	22	19	81
CRW_00759	SSU_rRNA_eukarya links to Rfam database...	0.50	0.35	0.72	168	1636913	92	3	61	28	313
CRW_00763	SSU_rRNA_bacteria links to Rfam database...	0.85	0.77	0.93	344	1215650	51	2	24	25	102
CRW_00778	SSU_rRNA_bacteria links to Rfam database...	0.84	0.79	0.90	303	1201687	92	4	31	57	81
CRW_00789	SSU_rRNA_bacteria links to Rfam database...	0.85	0.79	0.92	353	1137401	53	5	27	21	94
CRW_00795	SSU_rRNA_bacteria links to Rfam database...	0.81	0.74	0.88	291	1152590	94	3	37	54	103
CRW_00849	SSU_rRNA_bacteria links to Rfam database...	0.82	0.76	0.89	358	1117856	57	12	34	11	112
CRW_00997	SSU_rRNA_bacteria links to Rfam database...	0.87	0.81	0.93	377	1135871	39	9	21	9	87
CRW_01153	SSU_rRNA_eukarya links to Rfam database...	0.48	0.33	0.70	167	1606289	89	4	68	17	336
CRW_01171	SSU_rRNA_eukarya links to Rfam database...	0.52	0.35	0.77	179	1593773	71	4	49	18	327
CRW_01343	SSU_rRNA_archaea links to Rfam database...	0.86	0.81	0.92	351	977520	61	3	27	31	83
PDB_00703	SSU_rRNA_bacteria links to Rfam database...	0.81	0.72	0.92	356	1073456	57	6	27	24	139
PDB_00854	SSU_rRNA_bacteria links to Rfam database...	0.78	0.66	0.92	354	1500393	66	5	26	35	181
PDB_01088	SSU_rRNA_bacteria links to Rfam database...	0.75	0.63	0.90	344	1471089	68	3	34	31	203
PDB_01103	SSU_rRNA_bacteria links to Rfam database...	0.78	0.65	0.92	368	1606129	52	6	25	21	194
PDB_01105	SSU_rRNA_bacteria links to Rfam database...	0.79	0.68	0.93	367	1433576	53	2	26	25	173
PDB_01120	SSU_rRNA_bacteria links to Rfam database...	0.80	0.70	0.92	368	1204728	49	8	24	17	159
PDB_01273	SSU_rRNA_bacteria links to Rfam database...	0.80	0.71	0.90	348	1117874	63	6	32	25	143

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Performance of RSpredict(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for RSpredict(seed)

Total Base Pair Counts
Total TP	12037
Total TN	71042306
Total FP	8416
Total FP CONTRA	1137
Total FP INCONS	5864
Total FP COMP	1415
Total FN	14867

Total Scores
MCC	0.532
Average MCC ± 95% Confidence Intervals	0.529 ± 0.062
Sensitivity	0.447
Positive Predictive Value	0.632
Nr of predictions	57

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2. Individual counts for RSpredict(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00024	SSU_rRNA_archaea links to Rfam database...	0.78	0.76	0.80	346	1085169	116	15	71	30	112
CRW_00048	SSU_rRNA_bacteria links to Rfam database...	0.65	0.57	0.74	268	1170853	120	15	79	26	202
CRW_00054	SSU_rRNA_bacteria links to Rfam database...	0.66	0.59	0.75	269	1107457	114	15	75	24	187
CRW_00059	SSU_rRNA_bacteria links to Rfam database...	0.63	0.54	0.73	257	1172394	120	18	77	25	216
CRW_00061	SSU_rRNA_bacteria links to Rfam database...	0.62	0.54	0.72	258	1181594	124	19	82	23	218
CRW_00068	SSU_rRNA_bacteria links to Rfam database...	0.65	0.57	0.75	261	1108955	113	16	73	24	196
CRW_00096	SSU_rRNA_bacteria links to Rfam database...	0.66	0.57	0.75	267	1178524	119	14	75	30	198
CRW_00140	SSU_rRNA_bacteria links to Rfam database...	0.67	0.59	0.76	273	1135921	112	13	71	28	190
CRW_00141	SSU_rRNA_bacteria links to Rfam database...	0.63	0.55	0.72	260	1201662	126	16	87	23	216
CRW_00150	SSU_rRNA_bacteria links to Rfam database...	0.66	0.58	0.74	270	1152558	117	19	74	24	196
CRW_00152	SSU_rRNA_bacteria links to Rfam database...	0.63	0.54	0.74	252	1180075	110	15	74	21	219
CRW_00166	SSU_rRNA_bacteria links to Rfam database...	0.64	0.55	0.74	258	1190849	118	11	78	29	210
CRW_00173	SSU_rRNA_bacteria links to Rfam database...	0.62	0.55	0.71	243	1082316	119	17	80	22	202
CRW_00177	SSU_rRNA_bacteria links to Rfam database...	0.67	0.58	0.77	274	1178524	103	15	67	21	199
CRW_00196	SSU_rRNA_bacteria links to Rfam database...	0.63	0.54	0.73	257	1207883	117	16	79	22	218
CRW_00230	SSU_rRNA_bacteria links to Rfam database...	0.62	0.54	0.71	257	1198565	127	16	88	23	221
CRW_00245	SSU_rRNA_bacteria links to Rfam database...	0.63	0.55	0.72	248	1105984	121	17	79	25	205
CRW_00248	SSU_rRNA_bacteria links to Rfam database...	0.65	0.57	0.75	278	1218768	123	17	78	28	206
CRW_00250	SSU_rRNA_bacteria links to Rfam database...	0.67	0.60	0.74	285	1198543	124	18	80	26	193
CRW_00256	SSU_rRNA_bacteria links to Rfam database...	0.62	0.54	0.72	251	1192392	119	17	80	22	217
CRW_00270	SSU_rRNA_bacteria links to Rfam database...	0.64	0.56	0.74	255	1111941	113	15	75	23	200
CRW_00271	SSU_rRNA_bacteria links to Rfam database...	0.62	0.53	0.73	243	1122417	115	15	76	24	219
CRW_00273	SSU_rRNA_bacteria links to Rfam database...	0.64	0.56	0.73	250	1085260	113	15	76	22	196
CRW_00275	SSU_rRNA_bacteria links to Rfam database...	0.63	0.54	0.72	249	1114926	120	15	81	24	208
CRW_00277	SSU_rRNA_bacteria links to Rfam database...	0.61	0.52	0.72	235	1110468	113	17	75	21	218
CRW_00280	SSU_rRNA_bacteria links to Rfam database...	0.61	0.53	0.70	240	1117918	122	15	87	20	213
CRW_00281	SSU_rRNA_bacteria links to Rfam database...	0.65	0.56	0.74	260	1144991	117	12	78	27	204
CRW_00283	SSU_rRNA_bacteria links to Rfam database...	0.53	0.42	0.68	180	1015761	96	14	70	12	252
CRW_00289	SSU_rRNA_bacteria links to Rfam database...	0.60	0.50	0.70	240	1189312	122	16	85	21	236
CRW_00292	SSU_rRNA_bacteria links to Rfam database...	0.55	0.43	0.72	196	1123976	99	12	66	21	265
CRW_00306	SSU_rRNA_eukarya links to Rfam database...	0.00	0.00	0.00	0	1445558	306	53	239	14	462
CRW_00366	SSU_rRNA_eukarya links to Rfam database...	0.00	0.00	0.00	0	1579464	301	50	239	12	482
CRW_00371	SSU_rRNA_eukarya links to Rfam database...	0.00	0.00	0.00	0	1611598	319	50	262	7	496
CRW_00379	SSU_rRNA_eukarya links to Rfam database...	0.00	0.00	0.00	0	2126581	414	77	295	42	534
CRW_00411	SSU_rRNA_eukarya links to Rfam database...	0.00	0.00	0.00	0	1615206	309	45	252	12	496
CRW_00414	SSU_rRNA_eukarya links to Rfam database...	0.00	0.00	0.00	0	1665933	312	53	239	20	495
CRW_00466	SSU_rRNA_bacteria links to Rfam database...	0.64	0.55	0.74	252	1116423	114	13	77	24	206
CRW_00589	SSU_rRNA_bacteria links to Rfam database...	0.63	0.53	0.74	236	1094141	110	9	74	27	209
CRW_00590	SSU_rRNA_bacteria links to Rfam database...	0.64	0.54	0.76	245	1119432	103	8	71	24	207
CRW_00591	SSU_rRNA_bacteria links to Rfam database...	0.66	0.58	0.76	258	1098562	118	11	72	35	188
CRW_00759	SSU_rRNA_eukarya links to Rfam database...	0.00	0.00	0.00	1	1636859	310	50	235	25	480
CRW_00763	SSU_rRNA_bacteria links to Rfam database...	0.62	0.49	0.79	217	1215744	86	5	54	27	229
CRW_00778	SSU_rRNA_bacteria links to Rfam database...	0.59	0.48	0.73	185	1201773	99	7	60	32	199
CRW_00789	SSU_rRNA_bacteria links to Rfam database...	0.64	0.56	0.74	249	1137451	114	13	73	28	198
CRW_00795	SSU_rRNA_bacteria links to Rfam database...	0.58	0.47	0.72	184	1152666	117	7	64	46	210
CRW_00849	SSU_rRNA_bacteria links to Rfam database...	0.60	0.49	0.73	232	1117943	100	11	74	15	238
CRW_00997	SSU_rRNA_bacteria links to Rfam database...	0.63	0.55	0.72	256	1135921	123	14	87	22	208
CRW_01153	SSU_rRNA_eukarya links to Rfam database...	0.00	0.00	0.00	0	1606225	319	65	238	16	503
CRW_01171	SSU_rRNA_eukarya links to Rfam database...	0.00	0.00	0.00	0	1593701	318	50	254	14	506
CRW_01343	SSU_rRNA_archaea links to Rfam database...	0.52	0.41	0.68	177	977639	95	12	73	10	257
PDB_00703	SSU_rRNA_bacteria links to Rfam database...	0.63	0.53	0.76	261	1073500	115	11	73	31	234
PDB_00854	SSU_rRNA_bacteria links to Rfam database...	0.60	0.48	0.76	259	1500435	126	9	75	42	276
PDB_01088	SSU_rRNA_bacteria links to Rfam database...	0.60	0.47	0.76	259	1471129	122	8	74	40	288
PDB_01103	SSU_rRNA_bacteria links to Rfam database...	0.60	0.47	0.76	266	1606178	119	12	72	35	296
PDB_01105	SSU_rRNA_bacteria links to Rfam database...	0.61	0.50	0.76	268	1433617	119	7	79	33	272
PDB_01120	SSU_rRNA_bacteria links to Rfam database...	0.64	0.53	0.78	280	1204768	120	9	71	40	247
PDB_01273	SSU_rRNA_bacteria links to Rfam database...	0.65	0.55	0.76	272	1117903	116	13	72	31	219

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of CentroidAlifold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for CentroidAlifold(seed)

2. Individual counts for CentroidAlifold(seed) [ download as .csv ]

Performance of RSpredict(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for RSpredict(seed)

2. Individual counts for RSpredict(seed) [ download as .csv ]