CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of ContextFold - scored higher in this pairwise comparison

  4. Performance of Mastr(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for ContextFold & Mastr(seed) [.zip] - may take several seconds...


Overview

Metric ContextFold Mastr(seed)
MCC 0.602 > 0.000
Average MCC ± 95% Confidence Intervals 0.605 ± 0.570 > 0.000 ± 0.000
Sensitivity 0.575 > 0.000
Positive Predictive Value 0.630 > 0.000
Total TP 843 > 0
Total TN 4973440 < 4974778
Total FP 652 > 0
Total FP CONTRA 104 > 0
Total FP INCONS 391 > 0
Total FP COMP 157 > 0
Total FN 623 < 1466
P-value 0.0

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Performance plots


  1. Comparison of performance of ContextFold and Mastr(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for ContextFold and Mastr(seed)).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for ContextFold and Mastr(seed)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for ContextFold and Mastr(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for ContextFold and Mastr(seed)).

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Performance of ContextFold - scored higher in this pairwise comparison

1. Total counts & total scores for ContextFold

Total Base Pair Counts
Total TP 843
Total TN 4973440
Total FP 652
Total FP CONTRA 104
Total FP INCONS 391
Total FP COMP 157
Total FN 623
Total Scores
MCC 0.602
Average MCC ± 95% Confidence Intervals 0.605 ± 0.570
Sensitivity 0.575
Positive Predictive Value 0.630
Nr of predictions 3

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2. Individual counts for ContextFold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
CRW_00306 0.37 0.36 0.37 168 1445399 304 63 220 21 294
CRW_00379 0.62 0.59 0.65 314 2126472 237 36 131 70 220
CRW_00800 0.83 0.77 0.89 361 1401569 111 5 40 66 109

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Performance of Mastr(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Mastr(seed)

Total Base Pair Counts
Total TP 0
Total TN 4974778
Total FP 0
Total FP CONTRA 0
Total FP INCONS 0
Total FP COMP 0
Total FN 1466
Total Scores
MCC 0.000
Average MCC ± 95% Confidence Intervals 0.000 ± 0.000
Sensitivity 0.000
Positive Predictive Value 0.000
Nr of predictions 3

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2. Individual counts for Mastr(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
CRW_00306 0.00 0.00 0.00 0 1445850 0 0 0 0 462
CRW_00379 0.00 0.00 0.00 0 2126953 0 0 0 0 534
CRW_00800 0.00 0.00 0.00 0 1401975 0 0 0 0 470

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.