CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	MXScarna(20)		Afold
MCC	0.599	>	0.410
Average MCC ± 95% Confidence Intervals	0.604 ± 0.030	>	0.413 ± 0.031
Sensitivity	0.549	>	0.410
Positive Predictive Value	0.654	>	0.411
Total TP	19234	>	14374
Total TN	99031526	>	99025973
Total FP	13689	<	23038
Total FP CONTRA	1684	<	3302
Total FP INCONS	8488	<	17283
Total FP COMP	3517	>	2453
Total FN	15829	<	20689
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of MXScarna(20) and Afold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for MXScarna(20) and Afold).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for MXScarna(20) and Afold).
Comparison of average Matthews Correlation Coefficients (MCCs) for MXScarna(20) and Afold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for MXScarna(20) and Afold).

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Performance of MXScarna(20) - scored higher in this pairwise comparison

1. Total counts & total scores for MXScarna(20)

Total Base Pair Counts
Total TP	19234
Total TN	99031526
Total FP	13689
Total FP CONTRA	1684
Total FP INCONS	8488
Total FP COMP	3517
Total FN	15829

Total Scores
MCC	0.599
Average MCC ± 95% Confidence Intervals	0.604 ± 0.030
Sensitivity	0.549
Positive Predictive Value	0.654
Nr of predictions	73

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2. Individual counts for MXScarna(20) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00024	SSU_rRNA_archaea links to Rfam database...	0.84	0.81	0.87	369	1085176	107	10	46	51	89
CRW_00048	SSU_rRNA_bacteria links to Rfam database...	0.72	0.67	0.78	317	1170807	127	11	80	36	153
CRW_00054	SSU_rRNA_bacteria links to Rfam database...	0.68	0.63	0.74	288	1107425	137	16	87	34	168
CRW_00059	SSU_rRNA_bacteria links to Rfam database...	0.72	0.66	0.78	312	1172344	127	16	74	37	161
CRW_00061	SSU_rRNA_bacteria links to Rfam database...	0.73	0.66	0.81	316	1181563	109	13	61	35	160
CRW_00068	SSU_rRNA_bacteria links to Rfam database...	0.69	0.64	0.74	293	1108909	137	18	85	34	164
CRW_00096	SSU_rRNA_bacteria links to Rfam database...	0.75	0.68	0.81	318	1178489	108	6	67	35	147
CRW_00140	SSU_rRNA_bacteria links to Rfam database...	0.76	0.71	0.81	328	1135874	114	12	64	38	135
CRW_00141	SSU_rRNA_bacteria links to Rfam database...	0.69	0.64	0.75	305	1201619	132	14	87	31	171
CRW_00150	SSU_rRNA_bacteria links to Rfam database...	0.72	0.65	0.80	303	1152540	113	14	64	35	163
CRW_00152	SSU_rRNA_bacteria links to Rfam database...	0.76	0.70	0.82	332	1180009	110	11	64	35	139
CRW_00166	SSU_rRNA_bacteria links to Rfam database...	0.65	0.60	0.71	281	1190800	160	10	105	45	187
CRW_00173	SSU_rRNA_bacteria links to Rfam database...	0.57	0.52	0.63	232	1082285	168	19	120	29	213
CRW_00177	SSU_rRNA_bacteria links to Rfam database...	0.62	0.56	0.68	264	1178492	152	16	108	28	209
CRW_00196	SSU_rRNA_bacteria links to Rfam database...	0.73	0.67	0.80	319	1207837	117	10	69	38	156
CRW_00230	SSU_rRNA_bacteria links to Rfam database...	0.73	0.67	0.80	319	1198526	122	12	69	41	159
CRW_00245	SSU_rRNA_bacteria links to Rfam database...	0.73	0.67	0.81	302	1105955	106	13	58	35	151
CRW_00248	SSU_rRNA_bacteria links to Rfam database...	0.71	0.65	0.77	317	1218729	129	13	82	34	167
CRW_00250	SSU_rRNA_bacteria links to Rfam database...	0.73	0.67	0.79	321	1198521	119	12	72	35	157
CRW_00256	SSU_rRNA_bacteria links to Rfam database...	0.70	0.64	0.77	299	1192353	124	11	77	36	169
CRW_00270	SSU_rRNA_bacteria links to Rfam database...	0.72	0.67	0.77	306	1111891	121	14	75	32	149
CRW_00271	SSU_rRNA_bacteria links to Rfam database...	0.70	0.65	0.77	298	1122364	122	17	72	33	164
CRW_00273	SSU_rRNA_bacteria links to Rfam database...	0.68	0.62	0.74	277	1085225	135	13	86	36	169
CRW_00275	SSU_rRNA_bacteria links to Rfam database...	0.71	0.63	0.80	289	1114908	114	13	61	40	168
CRW_00277	SSU_rRNA_bacteria links to Rfam database...	0.68	0.63	0.73	286	1110405	132	17	87	28	167
CRW_00278	SSU_rRNA_bacteria links to Rfam database...	0.71	0.62	0.80	280	1129906	107	12	58	37	170
CRW_00279	SSU_rRNA_bacteria links to Rfam database...	0.70	0.64	0.77	299	1180027	133	10	80	43	165
CRW_00280	SSU_rRNA_bacteria links to Rfam database...	0.72	0.66	0.78	301	1117875	125	10	74	41	152
CRW_00281	SSU_rRNA_bacteria links to Rfam database...	0.71	0.65	0.78	303	1144954	117	13	71	33	161
CRW_00284	SSU_rRNA_bacteria links to Rfam database...	0.69	0.62	0.77	281	1131397	117	9	73	35	175
CRW_00285	SSU_rRNA_bacteria links to Rfam database...	0.70	0.64	0.77	292	1117883	123	15	70	38	166
CRW_00289	SSU_rRNA_bacteria links to Rfam database...	0.62	0.58	0.66	274	1189239	172	18	122	32	202
CRW_00298	SSU_rRNA_eukarya links to Rfam database...	0.48	0.46	0.51	226	1620454	284	45	175	64	268
CRW_00301	SSU_rRNA_eukarya links to Rfam database...	0.42	0.39	0.45	204	1762046	308	49	204	55	315
CRW_00310	SSU_rRNA_eukarya links to Rfam database...	0.45	0.41	0.49	212	1805516	285	39	183	63	309
CRW_00326	SSU_rRNA_eukarya links to Rfam database...	0.49	0.45	0.53	227	1627679	267	35	169	63	275
CRW_00330	SSU_rRNA_eukarya links to Rfam database...	0.41	0.37	0.45	190	1988597	294	32	196	66	327
CRW_00332	SSU_rRNA_eukarya links to Rfam database...	0.37	0.34	0.40	163	1769615	307	47	196	64	314
CRW_00333	SSU_rRNA_eukarya links to Rfam database...	0.31	0.26	0.35	136	1892099	328	47	203	78	378
CRW_00345	SSU_rRNA_eukarya links to Rfam database...	0.46	0.44	0.49	219	1586422	293	53	177	63	279
CRW_00348	SSU_rRNA_eukarya links to Rfam database...	0.49	0.47	0.52	235	1615052	277	51	165	61	268
CRW_00358	SSU_rRNA_eukarya links to Rfam database...	0.48	0.44	0.53	224	1674941	262	38	162	62	283
CRW_00366	SSU_rRNA_eukarya links to Rfam database...	0.42	0.40	0.43	195	1579299	332	47	212	73	287
CRW_00370	SSU_rRNA_eukarya links to Rfam database...	0.50	0.48	0.52	242	1640302	281	47	175	59	264
CRW_00371	SSU_rRNA_eukarya links to Rfam database...	0.49	0.46	0.53	229	1611474	266	39	168	59	267
CRW_00372	SSU_rRNA_eukarya links to Rfam database...	0.51	0.47	0.54	236	1625872	273	37	161	75	262
CRW_00379	SSU_rRNA_eukarya links to Rfam database...	0.37	0.33	0.42	175	2126532	323	40	206	77	359
CRW_00386	SSU_rRNA_eukarya links to Rfam database...	0.47	0.43	0.50	223	1750812	281	44	177	60	292
CRW_00403	SSU_rRNA_eukarya links to Rfam database...	0.45	0.41	0.48	192	1606131	304	37	168	99	272
CRW_00411	SSU_rRNA_eukarya links to Rfam database...	0.49	0.46	0.52	227	1615066	271	42	168	61	269
CRW_00414	SSU_rRNA_eukarya links to Rfam database...	0.39	0.37	0.41	181	1665782	316	50	212	54	314
CRW_00466	SSU_rRNA_bacteria links to Rfam database...	0.63	0.58	0.69	266	1116382	147	16	101	30	192
CRW_00589	SSU_rRNA_bacteria links to Rfam database...	0.69	0.62	0.76	277	1094097	130	6	80	44	168
CRW_00590	SSU_rRNA_bacteria links to Rfam database...	0.72	0.67	0.78	303	1119366	134	11	76	47	149
CRW_00591	SSU_rRNA_bacteria links to Rfam database...	0.74	0.68	0.81	303	1098531	115	7	62	46	143
CRW_00598	SSU_rRNA_eukarya links to Rfam database...	0.49	0.46	0.52	226	1665793	276	41	165	70	265
CRW_00758	SSU_rRNA_eukarya links to Rfam database...	0.46	0.43	0.48	207	1640338	292	44	177	71	276
CRW_00759	SSU_rRNA_eukarya links to Rfam database...	0.42	0.40	0.44	191	1636712	314	43	199	72	290
CRW_00760	SSU_rRNA_eukarya links to Rfam database...	0.46	0.43	0.49	208	1638533	291	37	177	77	278
CRW_00772	SSU_rRNA_bacteria links to Rfam database...	0.60	0.54	0.67	217	945677	148	10	96	42	187
CRW_00789	SSU_rRNA_bacteria links to Rfam database...	0.67	0.60	0.75	268	1137427	134	8	83	43	179
CRW_00795	SSU_rRNA_bacteria links to Rfam database...	0.63	0.57	0.71	224	1152605	176	10	82	84	170
CRW_00849	SSU_rRNA_bacteria links to Rfam database...	0.61	0.55	0.68	260	1117878	154	17	105	32	210
CRW_01153	SSU_rRNA_eukarya links to Rfam database...	0.44	0.42	0.46	211	1606072	295	46	199	50	292
CRW_01171	SSU_rRNA_eukarya links to Rfam database...	0.48	0.45	0.51	229	1593556	274	47	173	54	277
CRW_01300	SSU_rRNA_eukarya links to Rfam database...	0.47	0.45	0.50	230	1693258	286	45	187	54	285
PDB_00703	SSU_rRNA_bacteria links to Rfam database...	0.69	0.60	0.79	295	1073472	114	10	68	36	200
PDB_00854	SSU_rRNA_bacteria links to Rfam database...	0.62	0.51	0.75	274	1500415	142	2	87	53	261
PDB_01088	SSU_rRNA_bacteria links to Rfam database...	0.66	0.56	0.78	308	1471077	135	7	78	50	239
PDB_01103	SSU_rRNA_bacteria links to Rfam database...	0.61	0.52	0.71	293	1606118	156	16	101	39	269
PDB_01105	SSU_rRNA_bacteria links to Rfam database...	0.64	0.54	0.75	291	1433583	134	3	94	37	249
PDB_01120	SSU_rRNA_bacteria links to Rfam database...	0.66	0.57	0.76	302	1204732	134	11	83	40	225
PDB_01273	SSU_rRNA_bacteria links to Rfam database...	0.69	0.60	0.79	294	1117886	120	10	70	40	197

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Performance of Afold - scored lower in this pairwise comparison

1. Total counts & total scores for Afold

Total Base Pair Counts
Total TP	14374
Total TN	99025973
Total FP	23038
Total FP CONTRA	3302
Total FP INCONS	17283
Total FP COMP	2453
Total FN	20689

Total Scores
MCC	0.410
Average MCC ± 95% Confidence Intervals	0.413 ± 0.031
Sensitivity	0.410
Positive Predictive Value	0.411
Nr of predictions	73

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2. Individual counts for Afold [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00024	SSU_rRNA_archaea links to Rfam database...	0.78	0.77	0.79	351	1085158	132	17	75	40	107
CRW_00048	SSU_rRNA_bacteria links to Rfam database...	0.49	0.49	0.50	228	1170758	252	20	209	23	242
CRW_00054	SSU_rRNA_bacteria links to Rfam database...	0.46	0.46	0.46	208	1107368	260	31	209	20	248
CRW_00059	SSU_rRNA_bacteria links to Rfam database...	0.52	0.51	0.53	240	1172289	233	26	191	16	233
CRW_00061	SSU_rRNA_bacteria links to Rfam database...	0.55	0.54	0.55	259	1181483	231	27	184	20	217
CRW_00068	SSU_rRNA_bacteria links to Rfam database...	0.49	0.49	0.50	226	1108849	247	24	206	17	231
CRW_00096	SSU_rRNA_bacteria links to Rfam database...	0.46	0.46	0.47	214	1178420	264	32	214	18	251
CRW_00140	SSU_rRNA_bacteria links to Rfam database...	0.64	0.63	0.64	291	1135826	182	20	141	21	172
CRW_00141	SSU_rRNA_bacteria links to Rfam database...	0.59	0.58	0.60	274	1201566	212	26	159	27	202
CRW_00150	SSU_rRNA_bacteria links to Rfam database...	0.42	0.41	0.42	193	1152465	282	35	228	19	273
CRW_00152	SSU_rRNA_bacteria links to Rfam database...	0.64	0.62	0.65	293	1179965	180	30	128	22	178
CRW_00166	SSU_rRNA_bacteria links to Rfam database...	0.54	0.53	0.55	248	1190745	226	28	175	23	220
CRW_00173	SSU_rRNA_bacteria links to Rfam database...	0.29	0.29	0.29	127	1082216	323	37	276	10	318
CRW_00177	SSU_rRNA_bacteria links to Rfam database...	0.44	0.43	0.45	203	1178433	259	22	222	15	270
CRW_00196	SSU_rRNA_bacteria links to Rfam database...	0.47	0.46	0.48	220	1207772	267	24	219	24	255
CRW_00230	SSU_rRNA_bacteria links to Rfam database...	0.57	0.56	0.58	266	1198467	216	21	172	23	212
CRW_00245	SSU_rRNA_bacteria links to Rfam database...	0.38	0.38	0.38	172	1105880	289	44	232	13	281
CRW_00248	SSU_rRNA_bacteria links to Rfam database...	0.57	0.57	0.58	274	1218666	234	21	180	33	210
CRW_00250	SSU_rRNA_bacteria links to Rfam database...	0.44	0.44	0.45	210	1198459	274	34	223	17	268
CRW_00256	SSU_rRNA_bacteria links to Rfam database...	0.41	0.40	0.42	188	1192291	278	39	222	17	280
CRW_00270	SSU_rRNA_bacteria links to Rfam database...	0.44	0.43	0.45	196	1111850	260	40	200	20	259
CRW_00271	SSU_rRNA_bacteria links to Rfam database...	0.51	0.50	0.51	231	1122302	237	43	175	19	231
CRW_00273	SSU_rRNA_bacteria links to Rfam database...	0.59	0.58	0.60	258	1085174	195	26	143	26	188
CRW_00275	SSU_rRNA_bacteria links to Rfam database...	0.47	0.47	0.48	213	1114826	258	28	204	26	244
CRW_00277	SSU_rRNA_bacteria links to Rfam database...	0.38	0.38	0.38	172	1110338	300	45	240	15	281
CRW_00278	SSU_rRNA_bacteria links to Rfam database...	0.41	0.40	0.42	180	1129825	274	33	218	23	270
CRW_00279	SSU_rRNA_bacteria links to Rfam database...	0.51	0.49	0.53	229	1179985	227	29	173	25	235
CRW_00280	SSU_rRNA_bacteria links to Rfam database...	0.51	0.50	0.51	227	1117817	231	28	188	15	226
CRW_00281	SSU_rRNA_bacteria links to Rfam database...	0.30	0.30	0.29	138	1144872	347	41	290	16	326
CRW_00284	SSU_rRNA_bacteria links to Rfam database...	0.28	0.27	0.28	124	1131316	337	30	290	17	332
CRW_00285	SSU_rRNA_bacteria links to Rfam database...	0.72	0.71	0.74	325	1117819	142	23	93	26	133
CRW_00289	SSU_rRNA_bacteria links to Rfam database...	0.46	0.45	0.48	214	1189204	258	34	201	23	262
CRW_00298	SSU_rRNA_eukarya links to Rfam database...	0.19	0.20	0.18	99	1620353	490	81	367	42	395
CRW_00301	SSU_rRNA_eukarya links to Rfam database...	0.30	0.31	0.30	162	1761957	428	86	298	44	357
CRW_00310	SSU_rRNA_eukarya links to Rfam database...	0.29	0.30	0.28	157	1805386	453	81	326	46	364
CRW_00326	SSU_rRNA_eukarya links to Rfam database...	0.41	0.41	0.42	204	1627621	339	47	238	54	298
CRW_00330	SSU_rRNA_eukarya links to Rfam database...	0.32	0.32	0.31	167	1988474	452	69	305	78	350
CRW_00332	SSU_rRNA_eukarya links to Rfam database...	0.18	0.20	0.17	94	1769479	492	105	343	44	383
CRW_00333	SSU_rRNA_eukarya links to Rfam database...	0.29	0.30	0.28	153	1891946	449	74	312	63	361
CRW_00345	SSU_rRNA_eukarya links to Rfam database...	0.34	0.35	0.33	175	1586340	403	71	285	47	323
CRW_00348	SSU_rRNA_eukarya links to Rfam database...	0.25	0.25	0.24	127	1614982	437	68	326	43	376
CRW_00358	SSU_rRNA_eukarya links to Rfam database...	0.36	0.36	0.35	183	1674845	391	61	276	54	324
CRW_00366	SSU_rRNA_eukarya links to Rfam database...	0.35	0.36	0.33	174	1579230	395	88	261	46	308
CRW_00370	SSU_rRNA_eukarya links to Rfam database...	0.28	0.28	0.28	143	1640248	420	77	298	45	363
CRW_00371	SSU_rRNA_eukarya links to Rfam database...	0.29	0.29	0.28	145	1611389	409	77	299	33	351
CRW_00372	SSU_rRNA_eukarya links to Rfam database...	0.36	0.36	0.35	181	1625787	378	59	279	40	317
CRW_00379	SSU_rRNA_eukarya links to Rfam database...	0.42	0.43	0.41	227	2126401	423	55	270	98	307
CRW_00386	SSU_rRNA_eukarya links to Rfam database...	0.24	0.25	0.23	129	1750683	478	83	361	34	386
CRW_00403	SSU_rRNA_eukarya links to Rfam database...	0.31	0.31	0.30	146	1606035	431	65	282	84	318
CRW_00411	SSU_rRNA_eukarya links to Rfam database...	0.34	0.34	0.34	169	1615006	381	62	266	53	327
CRW_00414	SSU_rRNA_eukarya links to Rfam database...	0.27	0.28	0.26	140	1665694	436	77	314	45	355
CRW_00466	SSU_rRNA_bacteria links to Rfam database...	0.60	0.59	0.62	268	1116330	196	21	146	29	190
CRW_00589	SSU_rRNA_bacteria links to Rfam database...	0.18	0.18	0.18	78	1094024	374	34	324	16	367
CRW_00590	SSU_rRNA_bacteria links to Rfam database...	0.36	0.36	0.37	161	1119326	290	30	239	21	291
CRW_00591	SSU_rRNA_bacteria links to Rfam database...	0.57	0.56	0.59	251	1098476	205	23	153	29	195
CRW_00598	SSU_rRNA_eukarya links to Rfam database...	0.31	0.33	0.29	162	1665675	440	88	300	52	329
CRW_00758	SSU_rRNA_eukarya links to Rfam database...	0.29	0.30	0.29	144	1640268	416	66	288	62	339
CRW_00759	SSU_rRNA_eukarya links to Rfam database...	0.22	0.22	0.21	107	1636633	462	78	327	57	374
CRW_00760	SSU_rRNA_eukarya links to Rfam database...	0.28	0.29	0.28	140	1638458	411	74	283	54	346
CRW_00772	SSU_rRNA_bacteria links to Rfam database...	0.26	0.25	0.26	103	945610	313	37	250	26	301
CRW_00789	SSU_rRNA_bacteria links to Rfam database...	0.36	0.36	0.36	160	1137342	302	44	240	18	287
CRW_00795	SSU_rRNA_bacteria links to Rfam database...	0.21	0.22	0.21	85	1152511	379	51	274	54	309
CRW_00849	SSU_rRNA_bacteria links to Rfam database...	0.49	0.48	0.49	227	1117798	259	23	212	24	243
CRW_01153	SSU_rRNA_eukarya links to Rfam database...	0.32	0.32	0.32	160	1606024	390	54	290	46	343
CRW_01171	SSU_rRNA_eukarya links to Rfam database...	0.32	0.33	0.31	167	1593473	402	81	284	37	339
CRW_01300	SSU_rRNA_eukarya links to Rfam database...	0.36	0.37	0.35	189	1693186	392	71	274	47	326
PDB_00703	SSU_rRNA_bacteria links to Rfam database...	0.53	0.50	0.56	246	1073408	220	17	174	29	249
PDB_00854	SSU_rRNA_bacteria links to Rfam database...	0.55	0.53	0.56	284	1500271	276	22	201	53	251
PDB_01088	SSU_rRNA_bacteria links to Rfam database...	0.36	0.35	0.37	191	1470959	352	45	275	32	356
PDB_01103	SSU_rRNA_bacteria links to Rfam database...	0.56	0.54	0.58	306	1605999	254	32	191	31	256
PDB_01105	SSU_rRNA_bacteria links to Rfam database...	0.60	0.58	0.63	313	1433471	221	15	172	34	227
PDB_01120	SSU_rRNA_bacteria links to Rfam database...	0.46	0.43	0.49	228	1204659	250	31	210	9	299
PDB_01273	SSU_rRNA_bacteria links to Rfam database...	0.51	0.48	0.53	237	1117812	242	21	190	31	254

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of MXScarna(20) - scored higher in this pairwise comparison

1. Total counts & total scores for MXScarna(20)

2. Individual counts for MXScarna(20) [ download as .csv ]

Performance of Afold - scored lower in this pairwise comparison

1. Total counts & total scores for Afold

2. Individual counts for Afold [ download as .csv ]