CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	MXScarna(20)		CentroidFold
MCC	0.601	>	0.492
Average MCC ± 95% Confidence Intervals	0.606 ± 0.029	>	0.493 ± 0.028
Sensitivity	0.551	>	0.430
Positive Predictive Value	0.656	>	0.563
Total TP	20076	>	15655
Total TN	102212915	<	102215715
Total FP	14154	<	14303
Total FP CONTRA	1758	<	1836
Total FP INCONS	8764	<	10307
Total FP COMP	3632	>	2160
Total FN	16354	<	20775
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of MXScarna(20) and CentroidFold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for MXScarna(20) and CentroidFold).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for MXScarna(20) and CentroidFold).
Comparison of average Matthews Correlation Coefficients (MCCs) for MXScarna(20) and CentroidFold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for MXScarna(20) and CentroidFold).

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Performance of MXScarna(20) - scored higher in this pairwise comparison

1. Total counts & total scores for MXScarna(20)

Total Base Pair Counts
Total TP	20076
Total TN	102212915
Total FP	14154
Total FP CONTRA	1758
Total FP INCONS	8764
Total FP COMP	3632
Total FN	16354

Total Scores
MCC	0.601
Average MCC ± 95% Confidence Intervals	0.606 ± 0.029
Sensitivity	0.551
Positive Predictive Value	0.656
Nr of predictions	76

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2. Individual counts for MXScarna(20) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00024	SSU_rRNA_archaea links to Rfam database...	0.84	0.81	0.87	369	1085176	107	10	46	51	89
CRW_00034	SSU_rRNA_bacteria links to Rfam database...	0.68	0.60	0.77	283	1141947	122	12	74	36	191
CRW_00048	SSU_rRNA_bacteria links to Rfam database...	0.72	0.67	0.78	317	1170807	127	11	80	36	153
CRW_00054	SSU_rRNA_bacteria links to Rfam database...	0.68	0.63	0.74	288	1107425	137	16	87	34	168
CRW_00059	SSU_rRNA_bacteria links to Rfam database...	0.72	0.66	0.78	312	1172344	127	16	74	37	161
CRW_00061	SSU_rRNA_bacteria links to Rfam database...	0.73	0.66	0.81	316	1181563	109	13	61	35	160
CRW_00068	SSU_rRNA_bacteria links to Rfam database...	0.69	0.64	0.74	293	1108909	137	18	85	34	164
CRW_00096	SSU_rRNA_bacteria links to Rfam database...	0.75	0.68	0.81	318	1178489	108	6	67	35	147
CRW_00140	SSU_rRNA_bacteria links to Rfam database...	0.76	0.71	0.81	328	1135874	114	12	64	38	135
CRW_00141	SSU_rRNA_bacteria links to Rfam database...	0.69	0.64	0.75	305	1201619	132	14	87	31	171
CRW_00150	SSU_rRNA_bacteria links to Rfam database...	0.72	0.65	0.80	303	1152540	113	14	64	35	163
CRW_00152	SSU_rRNA_bacteria links to Rfam database...	0.76	0.70	0.82	332	1180009	110	11	64	35	139
CRW_00166	SSU_rRNA_bacteria links to Rfam database...	0.65	0.60	0.71	281	1190800	160	10	105	45	187
CRW_00173	SSU_rRNA_bacteria links to Rfam database...	0.57	0.52	0.63	232	1082285	168	19	120	29	213
CRW_00177	SSU_rRNA_bacteria links to Rfam database...	0.62	0.56	0.68	264	1178492	152	16	108	28	209
CRW_00196	SSU_rRNA_bacteria links to Rfam database...	0.73	0.67	0.80	319	1207837	117	10	69	38	156
CRW_00230	SSU_rRNA_bacteria links to Rfam database...	0.73	0.67	0.80	319	1198526	122	12	69	41	159
CRW_00245	SSU_rRNA_bacteria links to Rfam database...	0.73	0.67	0.81	302	1105955	106	13	58	35	151
CRW_00248	SSU_rRNA_bacteria links to Rfam database...	0.71	0.65	0.77	317	1218729	129	13	82	34	167
CRW_00250	SSU_rRNA_bacteria links to Rfam database...	0.73	0.67	0.79	321	1198521	119	12	72	35	157
CRW_00256	SSU_rRNA_bacteria links to Rfam database...	0.70	0.64	0.77	299	1192353	124	11	77	36	169
CRW_00270	SSU_rRNA_bacteria links to Rfam database...	0.72	0.67	0.77	306	1111891	121	14	75	32	149
CRW_00271	SSU_rRNA_bacteria links to Rfam database...	0.70	0.65	0.77	298	1122364	122	17	72	33	164
CRW_00273	SSU_rRNA_bacteria links to Rfam database...	0.68	0.62	0.74	277	1085225	135	13	86	36	169
CRW_00275	SSU_rRNA_bacteria links to Rfam database...	0.71	0.63	0.80	289	1114908	114	13	61	40	168
CRW_00277	SSU_rRNA_bacteria links to Rfam database...	0.68	0.63	0.73	286	1110405	132	17	87	28	167
CRW_00278	SSU_rRNA_bacteria links to Rfam database...	0.71	0.62	0.80	280	1129906	107	12	58	37	170
CRW_00279	SSU_rRNA_bacteria links to Rfam database...	0.70	0.64	0.77	299	1180027	133	10	80	43	165
CRW_00280	SSU_rRNA_bacteria links to Rfam database...	0.72	0.66	0.78	301	1117875	125	10	74	41	152
CRW_00281	SSU_rRNA_bacteria links to Rfam database...	0.71	0.65	0.78	303	1144954	117	13	71	33	161
CRW_00284	SSU_rRNA_bacteria links to Rfam database...	0.69	0.62	0.77	281	1131397	117	9	73	35	175
CRW_00285	SSU_rRNA_bacteria links to Rfam database...	0.70	0.64	0.77	292	1117883	123	15	70	38	166
CRW_00289	SSU_rRNA_bacteria links to Rfam database...	0.62	0.58	0.66	274	1189239	172	18	122	32	202
CRW_00298	SSU_rRNA_eukarya links to Rfam database...	0.48	0.46	0.51	226	1620454	284	45	175	64	268
CRW_00301	SSU_rRNA_eukarya links to Rfam database...	0.42	0.39	0.45	204	1762046	308	49	204	55	315
CRW_00306	SSU_rRNA_eukarya links to Rfam database...	0.43	0.40	0.46	183	1445453	276	47	167	62	279
CRW_00310	SSU_rRNA_eukarya links to Rfam database...	0.45	0.41	0.49	212	1805516	285	39	183	63	309
CRW_00326	SSU_rRNA_eukarya links to Rfam database...	0.49	0.45	0.53	227	1627679	267	35	169	63	275
CRW_00330	SSU_rRNA_eukarya links to Rfam database...	0.41	0.37	0.45	190	1988597	294	32	196	66	327
CRW_00332	SSU_rRNA_eukarya links to Rfam database...	0.37	0.34	0.40	163	1769615	307	47	196	64	314
CRW_00333	SSU_rRNA_eukarya links to Rfam database...	0.31	0.26	0.35	136	1892099	328	47	203	78	378
CRW_00345	SSU_rRNA_eukarya links to Rfam database...	0.46	0.44	0.49	219	1586422	293	53	177	63	279
CRW_00346	SSU_rRNA_eukarya links to Rfam database...	0.49	0.46	0.52	229	1584649	269	43	169	57	272
CRW_00348	SSU_rRNA_eukarya links to Rfam database...	0.49	0.47	0.52	235	1615052	277	51	165	61	268
CRW_00358	SSU_rRNA_eukarya links to Rfam database...	0.48	0.44	0.53	224	1674941	262	38	162	62	283
CRW_00366	SSU_rRNA_eukarya links to Rfam database...	0.42	0.40	0.43	195	1579299	332	47	212	73	287
CRW_00370	SSU_rRNA_eukarya links to Rfam database...	0.50	0.48	0.52	242	1640302	281	47	175	59	264
CRW_00371	SSU_rRNA_eukarya links to Rfam database...	0.49	0.46	0.53	229	1611474	266	39	168	59	267
CRW_00372	SSU_rRNA_eukarya links to Rfam database...	0.51	0.47	0.54	236	1625872	273	37	161	75	262
CRW_00386	SSU_rRNA_eukarya links to Rfam database...	0.47	0.43	0.50	223	1750812	281	44	177	60	292
CRW_00403	SSU_rRNA_eukarya links to Rfam database...	0.45	0.41	0.48	192	1606131	304	37	168	99	272
CRW_00411	SSU_rRNA_eukarya links to Rfam database...	0.49	0.46	0.52	227	1615066	271	42	168	61	269
CRW_00414	SSU_rRNA_eukarya links to Rfam database...	0.39	0.37	0.41	181	1665782	316	50	212	54	314
CRW_00466	SSU_rRNA_bacteria links to Rfam database...	0.63	0.58	0.69	266	1116382	147	16	101	30	192
CRW_00589	SSU_rRNA_bacteria links to Rfam database...	0.69	0.62	0.76	277	1094097	130	6	80	44	168
CRW_00590	SSU_rRNA_bacteria links to Rfam database...	0.72	0.67	0.78	303	1119366	134	11	76	47	149
CRW_00591	SSU_rRNA_bacteria links to Rfam database...	0.74	0.68	0.81	303	1098531	115	7	62	46	143
CRW_00598	SSU_rRNA_eukarya links to Rfam database...	0.49	0.46	0.52	226	1665793	276	41	165	70	265
CRW_00758	SSU_rRNA_eukarya links to Rfam database...	0.46	0.43	0.48	207	1640338	292	44	177	71	276
CRW_00759	SSU_rRNA_eukarya links to Rfam database...	0.42	0.40	0.44	191	1636712	314	43	199	72	290
CRW_00760	SSU_rRNA_eukarya links to Rfam database...	0.46	0.43	0.49	208	1638533	291	37	177	77	278
CRW_00772	SSU_rRNA_bacteria links to Rfam database...	0.60	0.54	0.67	217	945677	148	10	96	42	187
CRW_00789	SSU_rRNA_bacteria links to Rfam database...	0.67	0.60	0.75	268	1137427	134	8	83	43	179
CRW_00795	SSU_rRNA_bacteria links to Rfam database...	0.63	0.57	0.71	224	1152605	176	10	82	84	170
CRW_00849	SSU_rRNA_bacteria links to Rfam database...	0.61	0.55	0.68	260	1117878	154	17	105	32	210
CRW_00997	SSU_rRNA_bacteria links to Rfam database...	0.74	0.69	0.79	322	1135872	121	12	72	37	142
CRW_01153	SSU_rRNA_eukarya links to Rfam database...	0.44	0.42	0.46	211	1606072	295	46	199	50	292
CRW_01171	SSU_rRNA_eukarya links to Rfam database...	0.48	0.45	0.51	229	1593556	274	47	173	54	277
CRW_01300	SSU_rRNA_eukarya links to Rfam database...	0.47	0.45	0.50	230	1693258	286	45	187	54	285
PDB_00703	SSU_rRNA_bacteria links to Rfam database...	0.69	0.60	0.79	295	1073472	114	10	68	36	200
PDB_00854	SSU_rRNA_bacteria links to Rfam database...	0.62	0.51	0.75	274	1500415	142	2	87	53	261
PDB_01088	SSU_rRNA_bacteria links to Rfam database...	0.66	0.56	0.78	308	1471077	135	7	78	50	239
PDB_01103	SSU_rRNA_bacteria links to Rfam database...	0.61	0.52	0.71	293	1606118	156	16	101	39	269
PDB_01105	SSU_rRNA_bacteria links to Rfam database...	0.64	0.54	0.75	291	1433583	134	3	94	37	249
PDB_01120	SSU_rRNA_bacteria links to Rfam database...	0.66	0.57	0.76	302	1204732	134	11	83	40	225
PDB_01273	SSU_rRNA_bacteria links to Rfam database...	0.69	0.60	0.79	294	1117886	120	10	70	40	197

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Performance of CentroidFold - scored lower in this pairwise comparison

1. Total counts & total scores for CentroidFold

Total Base Pair Counts
Total TP	15655
Total TN	102215715
Total FP	14303
Total FP CONTRA	1836
Total FP INCONS	10307
Total FP COMP	2160
Total FN	20775

Total Scores
MCC	0.492
Average MCC ± 95% Confidence Intervals	0.493 ± 0.028
Sensitivity	0.430
Positive Predictive Value	0.563
Nr of predictions	76

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2. Individual counts for CentroidFold [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00024	SSU_rRNA_archaea links to Rfam database...	0.79	0.76	0.83	347	1085183	108	8	63	37	111
CRW_00034	SSU_rRNA_bacteria links to Rfam database...	0.68	0.66	0.71	312	1141875	159	19	110	30	162
CRW_00048	SSU_rRNA_bacteria links to Rfam database...	0.60	0.49	0.75	230	1170907	91	8	70	13	240
CRW_00054	SSU_rRNA_bacteria links to Rfam database...	0.56	0.49	0.64	223	1107466	140	16	111	13	233
CRW_00059	SSU_rRNA_bacteria links to Rfam database...	0.60	0.51	0.71	241	1172408	111	9	88	14	232
CRW_00061	SSU_rRNA_bacteria links to Rfam database...	0.64	0.57	0.72	269	1181581	110	23	80	7	207
CRW_00068	SSU_rRNA_bacteria links to Rfam database...	0.55	0.49	0.63	225	1108945	147	19	116	12	232
CRW_00096	SSU_rRNA_bacteria links to Rfam database...	0.56	0.49	0.63	228	1178519	155	15	118	22	237
CRW_00140	SSU_rRNA_bacteria links to Rfam database...	0.59	0.49	0.70	226	1135957	106	11	84	11	237
CRW_00141	SSU_rRNA_bacteria links to Rfam database...	0.63	0.56	0.70	268	1201642	136	16	99	21	208
CRW_00150	SSU_rRNA_bacteria links to Rfam database...	0.55	0.47	0.66	217	1152591	126	17	96	13	249
CRW_00152	SSU_rRNA_bacteria links to Rfam database...	0.51	0.42	0.62	200	1180095	129	14	107	8	271
CRW_00166	SSU_rRNA_bacteria links to Rfam database...	0.61	0.53	0.70	247	1190845	120	6	98	16	221
CRW_00173	SSU_rRNA_bacteria links to Rfam database...	0.35	0.31	0.39	139	1082299	226	23	195	8	306
CRW_00177	SSU_rRNA_bacteria links to Rfam database...	0.52	0.45	0.59	213	1178522	162	17	128	17	260
CRW_00196	SSU_rRNA_bacteria links to Rfam database...	0.59	0.52	0.67	247	1207869	131	18	101	12	228
CRW_00230	SSU_rRNA_bacteria links to Rfam database...	0.59	0.52	0.67	250	1198552	140	19	105	16	228
CRW_00245	SSU_rRNA_bacteria links to Rfam database...	0.56	0.49	0.65	221	1105989	128	13	105	10	232
CRW_00248	SSU_rRNA_bacteria links to Rfam database...	0.66	0.61	0.71	296	1218724	154	20	101	33	188
CRW_00250	SSU_rRNA_bacteria links to Rfam database...	0.57	0.50	0.66	237	1198568	130	20	101	9	241
CRW_00256	SSU_rRNA_bacteria links to Rfam database...	0.45	0.35	0.57	165	1192449	145	20	106	19	303
CRW_00270	SSU_rRNA_bacteria links to Rfam database...	0.67	0.57	0.79	260	1111955	83	11	60	12	195
CRW_00271	SSU_rRNA_bacteria links to Rfam database...	0.48	0.41	0.55	190	1122405	171	26	130	15	272
CRW_00273	SSU_rRNA_bacteria links to Rfam database...	0.51	0.43	0.60	194	1085280	142	14	113	15	252
CRW_00275	SSU_rRNA_bacteria links to Rfam database...	0.62	0.54	0.70	249	1114913	130	13	96	21	208
CRW_00277	SSU_rRNA_bacteria links to Rfam database...	0.48	0.36	0.64	165	1110536	105	15	79	11	288
CRW_00278	SSU_rRNA_bacteria links to Rfam database...	0.49	0.41	0.57	186	1129931	157	13	126	18	264
CRW_00279	SSU_rRNA_bacteria links to Rfam database...	0.54	0.45	0.64	209	1180088	132	19	100	13	255
CRW_00280	SSU_rRNA_bacteria links to Rfam database...	0.53	0.42	0.67	192	1117973	105	9	86	10	261
CRW_00281	SSU_rRNA_bacteria links to Rfam database...	0.62	0.57	0.68	265	1144950	146	18	108	20	199
CRW_00284	SSU_rRNA_bacteria links to Rfam database...	0.48	0.36	0.65	162	1131511	101	11	76	14	294
CRW_00285	SSU_rRNA_bacteria links to Rfam database...	0.67	0.59	0.76	268	1117909	98	16	67	15	190
CRW_00289	SSU_rRNA_bacteria links to Rfam database...	0.61	0.55	0.68	260	1189270	143	18	105	20	216
CRW_00298	SSU_rRNA_eukarya links to Rfam database...	0.25	0.22	0.28	109	1620517	295	50	224	21	385
CRW_00301	SSU_rRNA_eukarya links to Rfam database...	0.48	0.39	0.58	203	1762152	211	28	120	63	316
CRW_00306	SSU_rRNA_eukarya links to Rfam database...	0.29	0.26	0.32	120	1445480	309	50	200	59	342
CRW_00310	SSU_rRNA_eukarya links to Rfam database...	0.38	0.34	0.42	178	1805524	303	44	204	55	343
CRW_00326	SSU_rRNA_eukarya links to Rfam database...	0.57	0.48	0.67	240	1627752	163	19	99	45	262
CRW_00330	SSU_rRNA_eukarya links to Rfam database...	0.30	0.25	0.36	131	1988654	302	33	197	72	386
CRW_00332	SSU_rRNA_eukarya links to Rfam database...	0.25	0.22	0.28	104	1769656	299	47	214	38	373
CRW_00333	SSU_rRNA_eukarya links to Rfam database...	0.30	0.24	0.36	125	1892139	288	29	192	67	389
CRW_00345	SSU_rRNA_eukarya links to Rfam database...	0.41	0.37	0.45	186	1586456	267	40	189	38	312
CRW_00346	SSU_rRNA_eukarya links to Rfam database...	0.40	0.38	0.42	189	1584645	289	48	208	33	312
CRW_00348	SSU_rRNA_eukarya links to Rfam database...	0.37	0.31	0.44	157	1615148	235	27	171	37	346
CRW_00358	SSU_rRNA_eukarya links to Rfam database...	0.42	0.39	0.45	200	1674917	285	39	209	37	307
CRW_00366	SSU_rRNA_eukarya links to Rfam database...	0.34	0.31	0.38	150	1579355	289	44	204	41	332
CRW_00370	SSU_rRNA_eukarya links to Rfam database...	0.38	0.33	0.43	167	1640375	256	43	181	32	339
CRW_00371	SSU_rRNA_eukarya links to Rfam database...	0.47	0.39	0.56	194	1611562	196	29	125	42	302
CRW_00372	SSU_rRNA_eukarya links to Rfam database...	0.48	0.41	0.58	202	1625955	204	26	123	55	296
CRW_00386	SSU_rRNA_eukarya links to Rfam database...	0.32	0.30	0.34	156	1750800	337	47	253	37	359
CRW_00403	SSU_rRNA_eukarya links to Rfam database...	0.31	0.29	0.34	135	1606132	324	52	209	63	329
CRW_00411	SSU_rRNA_eukarya links to Rfam database...	0.42	0.35	0.49	173	1615153	226	27	150	49	323
CRW_00414	SSU_rRNA_eukarya links to Rfam database...	0.42	0.36	0.48	180	1665851	239	34	160	45	315
CRW_00466	SSU_rRNA_bacteria links to Rfam database...	0.71	0.64	0.79	292	1116394	100	14	65	21	166
CRW_00589	SSU_rRNA_bacteria links to Rfam database...	0.34	0.28	0.42	125	1094162	188	16	157	15	320
CRW_00590	SSU_rRNA_bacteria links to Rfam database...	0.37	0.32	0.43	143	1119420	207	36	157	14	309
CRW_00591	SSU_rRNA_bacteria links to Rfam database...	0.65	0.59	0.72	261	1098541	124	19	82	23	185
CRW_00598	SSU_rRNA_eukarya links to Rfam database...	0.40	0.37	0.45	180	1665823	270	42	180	48	311
CRW_00758	SSU_rRNA_eukarya links to Rfam database...	0.37	0.34	0.40	164	1640353	298	41	208	49	319
CRW_00759	SSU_rRNA_eukarya links to Rfam database...	0.34	0.28	0.42	134	1636828	232	34	149	49	347
CRW_00760	SSU_rRNA_eukarya links to Rfam database...	0.38	0.34	0.42	167	1638559	278	50	179	49	319
CRW_00772	SSU_rRNA_bacteria links to Rfam database...	0.38	0.30	0.50	120	945758	137	16	106	15	284
CRW_00789	SSU_rRNA_bacteria links to Rfam database...	0.51	0.40	0.65	179	1137510	120	5	92	23	268
CRW_00795	SSU_rRNA_bacteria links to Rfam database...	0.35	0.28	0.44	110	1152672	173	15	124	34	284
CRW_00849	SSU_rRNA_bacteria links to Rfam database...	0.59	0.56	0.62	265	1117830	190	14	151	25	205
CRW_00997	SSU_rRNA_bacteria links to Rfam database...	0.63	0.55	0.72	256	1135921	119	15	86	18	208
CRW_01153	SSU_rRNA_eukarya links to Rfam database...	0.41	0.37	0.45	185	1606114	268	39	190	39	318
CRW_01171	SSU_rRNA_eukarya links to Rfam database...	0.46	0.41	0.52	206	1593608	228	40	151	37	300
CRW_01300	SSU_rRNA_eukarya links to Rfam database...	0.41	0.37	0.45	192	1693289	291	56	183	52	323
PDB_00703	SSU_rRNA_bacteria links to Rfam database...	0.55	0.49	0.61	244	1073448	180	13	140	27	251
PDB_00854	SSU_rRNA_bacteria links to Rfam database...	0.53	0.49	0.57	264	1500316	234	15	183	36	271
PDB_01088	SSU_rRNA_bacteria links to Rfam database...	0.46	0.39	0.55	215	1471076	203	25	154	24	332
PDB_01103	SSU_rRNA_bacteria links to Rfam database...	0.57	0.53	0.61	297	1606045	214	20	166	28	265
PDB_01105	SSU_rRNA_bacteria links to Rfam database...	0.62	0.57	0.68	307	1433517	177	8	139	30	233
PDB_01120	SSU_rRNA_bacteria links to Rfam database...	0.49	0.42	0.59	220	1204752	177	19	137	21	307
PDB_01273	SSU_rRNA_bacteria links to Rfam database...	0.51	0.47	0.56	229	1117849	211	14	168	29	262

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of MXScarna(20) - scored higher in this pairwise comparison

1. Total counts & total scores for MXScarna(20)

2. Individual counts for MXScarna(20) [ download as .csv ]

Performance of CentroidFold - scored lower in this pairwise comparison

1. Total counts & total scores for CentroidFold

2. Individual counts for CentroidFold [ download as .csv ]