CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	MXScarna(seed)		UNAFold
MCC	0.659	>	0.451
Average MCC ± 95% Confidence Intervals	0.662 ± 0.026	>	0.450 ± 0.036
Sensitivity	0.589	>	0.445
Positive Predictive Value	0.738	>	0.458
Total TP	17728	>	13373
Total TN	79088306	>	79083104
Total FP	8922	<	17535
Total FP CONTRA	930	<	2301
Total FP INCONS	5363	<	13549
Total FP COMP	2629	>	1685
Total FN	12352	<	16707
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of MXScarna(seed) and UNAFold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for MXScarna(seed) and UNAFold).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for MXScarna(seed) and UNAFold).
Comparison of average Matthews Correlation Coefficients (MCCs) for MXScarna(seed) and UNAFold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for MXScarna(seed) and UNAFold).

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Performance of MXScarna(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for MXScarna(seed)

Total Base Pair Counts
Total TP	17728
Total TN	79088306
Total FP	8922
Total FP CONTRA	930
Total FP INCONS	5363
Total FP COMP	2629
Total FN	12352

Total Scores
MCC	0.659
Average MCC ± 95% Confidence Intervals	0.662 ± 0.026
Sensitivity	0.589
Positive Predictive Value	0.738
Nr of predictions	64

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2. Individual counts for MXScarna(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00024	SSU_rRNA_archaea links to Rfam database...	0.83	0.81	0.86	369	1085172	112	11	49	52	89
CRW_00034	SSU_rRNA_bacteria links to Rfam database...	0.68	0.60	0.78	285	1141950	117	9	72	36	189
CRW_00048	SSU_rRNA_bacteria links to Rfam database...	0.74	0.68	0.82	318	1170827	101	10	60	31	152
CRW_00054	SSU_rRNA_bacteria links to Rfam database...	0.73	0.66	0.81	302	1107443	101	13	58	30	154
CRW_00059	SSU_rRNA_bacteria links to Rfam database...	0.72	0.64	0.81	305	1172369	105	12	60	33	168
CRW_00061	SSU_rRNA_bacteria links to Rfam database...	0.73	0.66	0.81	312	1181569	104	11	61	32	164
CRW_00068	SSU_rRNA_bacteria links to Rfam database...	0.74	0.67	0.82	305	1108933	99	12	55	32	152
CRW_00096	SSU_rRNA_bacteria links to Rfam database...	0.72	0.65	0.81	301	1178507	110	5	67	38	164
CRW_00140	SSU_rRNA_bacteria links to Rfam database...	0.73	0.66	0.81	304	1135902	106	11	61	34	159
CRW_00141	SSU_rRNA_bacteria links to Rfam database...	0.73	0.66	0.82	312	1201645	103	12	56	35	164
CRW_00150	SSU_rRNA_bacteria links to Rfam database...	0.72	0.64	0.81	300	1152549	106	11	61	34	166
CRW_00152	SSU_rRNA_bacteria links to Rfam database...	0.74	0.68	0.82	319	1180025	107	12	60	35	152
CRW_00166	SSU_rRNA_bacteria links to Rfam database...	0.73	0.65	0.82	305	1190824	106	6	61	39	163
CRW_00173	SSU_rRNA_bacteria links to Rfam database...	0.65	0.59	0.72	264	1082289	130	14	89	27	181
CRW_00177	SSU_rRNA_bacteria links to Rfam database...	0.68	0.61	0.77	287	1178505	117	12	76	29	186
CRW_00196	SSU_rRNA_bacteria links to Rfam database...	0.76	0.69	0.83	327	1207841	102	11	56	35	148
CRW_00230	SSU_rRNA_bacteria links to Rfam database...	0.75	0.67	0.83	321	1198539	99	12	54	33	157
CRW_00245	SSU_rRNA_bacteria links to Rfam database...	0.73	0.66	0.81	299	1105958	104	12	59	33	154
CRW_00248	SSU_rRNA_bacteria links to Rfam database...	0.72	0.64	0.81	311	1218757	105	11	62	32	173
CRW_00250	SSU_rRNA_bacteria links to Rfam database...	0.71	0.64	0.78	307	1198533	120	11	75	34	171
CRW_00256	SSU_rRNA_bacteria links to Rfam database...	0.74	0.66	0.82	311	1192362	98	11	56	31	157
CRW_00270	SSU_rRNA_bacteria links to Rfam database...	0.74	0.67	0.82	304	1111915	100	11	56	33	151
CRW_00271	SSU_rRNA_bacteria links to Rfam database...	0.71	0.64	0.80	295	1122381	105	12	63	30	167
CRW_00273	SSU_rRNA_bacteria links to Rfam database...	0.72	0.65	0.80	290	1085237	110	10	64	36	156
CRW_00275	SSU_rRNA_bacteria links to Rfam database...	0.74	0.67	0.82	306	1114897	103	10	58	35	151
CRW_00277	SSU_rRNA_bacteria links to Rfam database...	0.73	0.66	0.80	300	1110421	108	12	62	34	153
CRW_00278	SSU_rRNA_bacteria links to Rfam database...	0.68	0.60	0.78	271	1129907	113	9	69	35	179
CRW_00279	SSU_rRNA_bacteria links to Rfam database...	0.72	0.64	0.81	299	1180047	107	10	60	37	165
CRW_00280	SSU_rRNA_bacteria links to Rfam database...	0.70	0.63	0.79	284	1117899	114	10	67	37	169
CRW_00281	SSU_rRNA_bacteria links to Rfam database...	0.73	0.66	0.82	305	1144968	102	10	58	34	159
CRW_00283	SSU_rRNA_bacteria links to Rfam database...	0.63	0.56	0.71	242	1015684	127	13	86	28	190
CRW_00284	SSU_rRNA_bacteria links to Rfam database...	0.73	0.65	0.81	297	1131394	104	10	59	35	159
CRW_00285	SSU_rRNA_bacteria links to Rfam database...	0.71	0.64	0.79	294	1117886	113	13	67	33	164
CRW_00289	SSU_rRNA_bacteria links to Rfam database...	0.68	0.60	0.77	287	1189280	118	12	74	32	189
CRW_00292	SSU_rRNA_bacteria links to Rfam database...	0.62	0.53	0.71	245	1123906	126	12	87	27	216
CRW_00306	SSU_rRNA_eukarya links to Rfam database...	0.42	0.39	0.46	181	1445456	267	46	167	54	281
CRW_00366	SSU_rRNA_eukarya links to Rfam database...	0.48	0.45	0.51	215	1579331	275	41	166	68	267
CRW_00371	SSU_rRNA_eukarya links to Rfam database...	0.50	0.47	0.53	232	1611469	276	42	167	67	264
CRW_00379	SSU_rRNA_eukarya links to Rfam database...	0.36	0.32	0.41	170	2126540	318	50	193	75	364
CRW_00411	SSU_rRNA_eukarya links to Rfam database...	0.49	0.47	0.52	231	1615062	273	41	169	63	265
CRW_00414	SSU_rRNA_eukarya links to Rfam database...	0.46	0.43	0.49	213	1665792	286	43	177	66	282
CRW_00466	SSU_rRNA_bacteria links to Rfam database...	0.74	0.66	0.82	304	1116392	101	11	58	32	154
CRW_00589	SSU_rRNA_bacteria links to Rfam database...	0.70	0.63	0.79	279	1094105	117	6	70	41	166
CRW_00590	SSU_rRNA_bacteria links to Rfam database...	0.73	0.65	0.82	294	1119399	104	6	57	41	158
CRW_00591	SSU_rRNA_bacteria links to Rfam database...	0.74	0.66	0.82	294	1098545	110	6	58	46	152
CRW_00759	SSU_rRNA_eukarya links to Rfam database...	0.45	0.42	0.48	201	1636722	295	39	183	73	280
CRW_00763	SSU_rRNA_bacteria links to Rfam database...	0.68	0.59	0.78	262	1215683	119	6	69	44	184
CRW_00772	SSU_rRNA_bacteria links to Rfam database...	0.63	0.55	0.72	223	945690	133	6	81	46	181
CRW_00778	SSU_rRNA_bacteria links to Rfam database...	0.63	0.55	0.73	212	1201733	150	4	76	70	172
CRW_00789	SSU_rRNA_bacteria links to Rfam database...	0.71	0.63	0.80	280	1137437	111	7	62	42	167
CRW_00795	SSU_rRNA_bacteria links to Rfam database...	0.63	0.55	0.72	216	1152623	164	8	74	82	178
CRW_00800	SSU_rRNA_eukarya links to Rfam database...	0.34	0.29	0.39	137	1401627	256	36	175	45	333
CRW_00849	SSU_rRNA_bacteria links to Rfam database...	0.67	0.59	0.76	279	1117895	114	13	73	28	191
CRW_00997	SSU_rRNA_bacteria links to Rfam database...	0.72	0.65	0.80	301	1135902	107	11	64	32	163
CRW_01153	SSU_rRNA_eukarya links to Rfam database...	0.47	0.44	0.50	221	1606085	276	37	185	54	282
CRW_01171	SSU_rRNA_eukarya links to Rfam database...	0.49	0.46	0.53	231	1593565	264	35	174	55	275
CRW_01343	SSU_rRNA_archaea links to Rfam database...	0.73	0.68	0.78	294	977526	128	10	71	47	140
PDB_00703	SSU_rRNA_bacteria links to Rfam database...	0.66	0.56	0.77	278	1073486	114	9	72	33	217
PDB_00854	SSU_rRNA_bacteria links to Rfam database...	0.63	0.52	0.77	280	1500414	135	2	82	51	255
PDB_01088	SSU_rRNA_bacteria links to Rfam database...	0.61	0.49	0.76	269	1471116	131	6	79	46	278
PDB_01103	SSU_rRNA_bacteria links to Rfam database...	0.57	0.47	0.69	263	1606145	154	8	112	34	299
PDB_01105	SSU_rRNA_bacteria links to Rfam database...	0.66	0.55	0.80	299	1433595	117	1	76	40	241
PDB_01120	SSU_rRNA_bacteria links to Rfam database...	0.66	0.56	0.79	296	1204752	112	8	72	32	231
PDB_01273	SSU_rRNA_bacteria links to Rfam database...	0.69	0.59	0.80	290	1117898	113	9	63	41	201

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Performance of UNAFold - scored lower in this pairwise comparison

1. Total counts & total scores for UNAFold

Total Base Pair Counts
Total TP	13373
Total TN	79083104
Total FP	17535
Total FP CONTRA	2301
Total FP INCONS	13549
Total FP COMP	1685
Total FN	16707

Total Scores
MCC	0.451
Average MCC ± 95% Confidence Intervals	0.450 ± 0.036
Sensitivity	0.445
Positive Predictive Value	0.458
Nr of predictions	64

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2. Individual counts for UNAFold [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00024	SSU_rRNA_archaea links to Rfam database...	0.77	0.76	0.78	347	1085158	132	19	77	36	111
CRW_00034	SSU_rRNA_bacteria links to Rfam database...	0.64	0.64	0.64	303	1141840	196	31	142	23	171
CRW_00048	SSU_rRNA_bacteria links to Rfam database...	0.52	0.51	0.53	241	1170762	229	24	188	17	229
CRW_00054	SSU_rRNA_bacteria links to Rfam database...	0.44	0.43	0.44	195	1107376	258	28	217	13	261
CRW_00059	SSU_rRNA_bacteria links to Rfam database...	0.49	0.48	0.50	227	1172295	238	32	192	14	246
CRW_00061	SSU_rRNA_bacteria links to Rfam database...	0.51	0.51	0.52	241	1181493	233	41	178	14	235
CRW_00068	SSU_rRNA_bacteria links to Rfam database...	0.46	0.46	0.47	209	1108862	250	23	211	16	248
CRW_00096	SSU_rRNA_bacteria links to Rfam database...	0.55	0.54	0.55	250	1178428	227	29	173	25	215
CRW_00140	SSU_rRNA_bacteria links to Rfam database...	0.66	0.65	0.67	303	1135826	172	19	130	23	160
CRW_00141	SSU_rRNA_bacteria links to Rfam database...	0.58	0.58	0.59	275	1201557	219	25	168	26	201
CRW_00150	SSU_rRNA_bacteria links to Rfam database...	0.41	0.41	0.42	190	1152471	280	32	228	20	276
CRW_00152	SSU_rRNA_bacteria links to Rfam database...	0.65	0.63	0.66	299	1179965	174	29	123	22	172
CRW_00166	SSU_rRNA_bacteria links to Rfam database...	0.45	0.44	0.45	207	1190736	269	34	219	16	261
CRW_00173	SSU_rRNA_bacteria links to Rfam database...	0.28	0.28	0.29	126	1082215	327	39	276	12	319
CRW_00177	SSU_rRNA_bacteria links to Rfam database...	0.51	0.49	0.53	234	1178440	221	29	177	15	239
CRW_00196	SSU_rRNA_bacteria links to Rfam database...	0.45	0.44	0.45	211	1207765	281	32	227	22	264
CRW_00230	SSU_rRNA_bacteria links to Rfam database...	0.55	0.54	0.57	256	1198474	218	27	169	22	222
CRW_00245	SSU_rRNA_bacteria links to Rfam database...	0.36	0.36	0.37	163	1105885	293	45	235	13	290
CRW_00248	SSU_rRNA_bacteria links to Rfam database...	0.58	0.57	0.58	276	1218667	230	24	174	32	208
CRW_00250	SSU_rRNA_bacteria links to Rfam database...	0.39	0.39	0.39	186	1198451	301	43	246	12	292
CRW_00256	SSU_rRNA_bacteria links to Rfam database...	0.50	0.49	0.52	228	1192304	228	35	173	20	240
CRW_00270	SSU_rRNA_bacteria links to Rfam database...	0.47	0.45	0.48	207	1111853	250	29	197	24	248
CRW_00271	SSU_rRNA_bacteria links to Rfam database...	0.48	0.47	0.50	217	1122314	236	33	187	16	245
CRW_00273	SSU_rRNA_bacteria links to Rfam database...	0.51	0.50	0.52	222	1085175	222	28	176	18	224
CRW_00275	SSU_rRNA_bacteria links to Rfam database...	0.68	0.68	0.69	310	1114822	160	19	120	21	147
CRW_00277	SSU_rRNA_bacteria links to Rfam database...	0.35	0.34	0.35	154	1110361	293	42	238	13	299
CRW_00278	SSU_rRNA_bacteria links to Rfam database...	0.43	0.41	0.44	186	1129832	259	29	209	21	264
CRW_00279	SSU_rRNA_bacteria links to Rfam database...	0.44	0.42	0.45	197	1179977	258	31	211	16	267
CRW_00280	SSU_rRNA_bacteria links to Rfam database...	0.68	0.67	0.68	302	1117819	159	19	120	20	151
CRW_00281	SSU_rRNA_bacteria links to Rfam database...	0.65	0.63	0.67	291	1144909	165	18	123	24	173
CRW_00283	SSU_rRNA_bacteria links to Rfam database...	0.25	0.24	0.25	103	1015621	323	37	264	22	329
CRW_00284	SSU_rRNA_bacteria links to Rfam database...	0.29	0.28	0.29	129	1131319	325	39	273	13	327
CRW_00285	SSU_rRNA_bacteria links to Rfam database...	0.75	0.74	0.76	338	1117818	130	22	82	26	120
CRW_00289	SSU_rRNA_bacteria links to Rfam database...	0.44	0.43	0.45	203	1189200	274	30	220	24	273
CRW_00292	SSU_rRNA_bacteria links to Rfam database...	0.41	0.40	0.43	184	1123823	255	41	202	12	277
CRW_00306	SSU_rRNA_eukarya links to Rfam database...	0.16	0.16	0.16	76	1445368	444	67	339	38	386
CRW_00366	SSU_rRNA_eukarya links to Rfam database...	0.33	0.35	0.32	167	1579237	391	83	266	42	315
CRW_00371	SSU_rRNA_eukarya links to Rfam database...	0.31	0.32	0.30	159	1611384	399	75	292	32	337
CRW_00379	SSU_rRNA_eukarya links to Rfam database...	0.40	0.40	0.39	215	2126404	429	56	278	95	319
CRW_00411	SSU_rRNA_eukarya links to Rfam database...	0.27	0.28	0.27	138	1614990	413	60	315	38	358
CRW_00414	SSU_rRNA_eukarya links to Rfam database...	0.30	0.31	0.29	154	1665688	426	77	306	43	341
CRW_00466	SSU_rRNA_bacteria links to Rfam database...	0.59	0.58	0.61	265	1116332	195	23	145	27	193
CRW_00589	SSU_rRNA_bacteria links to Rfam database...	0.28	0.27	0.29	121	1094037	315	38	264	13	324
CRW_00590	SSU_rRNA_bacteria links to Rfam database...	0.35	0.34	0.37	153	1119337	287	30	236	21	299
CRW_00591	SSU_rRNA_bacteria links to Rfam database...	0.56	0.54	0.58	243	1098483	208	22	155	31	203
CRW_00759	SSU_rRNA_eukarya links to Rfam database...	0.23	0.24	0.22	117	1636617	466	66	345	55	364
CRW_00763	SSU_rRNA_bacteria links to Rfam database...	0.29	0.27	0.30	122	1215612	330	26	260	44	324
CRW_00772	SSU_rRNA_bacteria links to Rfam database...	0.25	0.25	0.26	101	945612	317	39	248	30	303
CRW_00778	SSU_rRNA_bacteria links to Rfam database...	0.32	0.32	0.33	123	1201647	309	46	209	54	261
CRW_00789	SSU_rRNA_bacteria links to Rfam database...	0.34	0.33	0.34	147	1137356	300	35	248	17	300
CRW_00795	SSU_rRNA_bacteria links to Rfam database...	0.19	0.20	0.19	78	1152508	377	53	282	42	316
CRW_00800	SSU_rRNA_eukarya links to Rfam database...	0.51	0.51	0.52	238	1401519	271	33	185	53	232
CRW_00849	SSU_rRNA_bacteria links to Rfam database...	0.48	0.48	0.49	225	1117800	258	25	210	23	245
CRW_00997	SSU_rRNA_bacteria links to Rfam database...	0.59	0.58	0.61	268	1135838	197	24	148	25	196
CRW_01153	SSU_rRNA_eukarya links to Rfam database...	0.25	0.25	0.25	128	1606016	421	65	319	37	375
CRW_01171	SSU_rRNA_eukarya links to Rfam database...	0.24	0.24	0.24	123	1593484	433	84	314	35	383
CRW_01343	SSU_rRNA_archaea links to Rfam database...	0.35	0.35	0.35	151	977475	287	44	231	12	283
PDB_00703	SSU_rRNA_bacteria links to Rfam database...	0.54	0.52	0.57	258	1073389	221	20	178	23	237
PDB_00854	SSU_rRNA_bacteria links to Rfam database...	0.54	0.53	0.54	285	1500255	284	22	216	46	250
PDB_01088	SSU_rRNA_bacteria links to Rfam database...	0.39	0.37	0.41	202	1470973	322	44	251	27	345
PDB_01103	SSU_rRNA_bacteria links to Rfam database...	0.59	0.58	0.60	324	1605991	243	32	181	30	238
PDB_01105	SSU_rRNA_bacteria links to Rfam database...	0.60	0.58	0.61	315	1433457	227	14	185	28	225
PDB_01120	SSU_rRNA_bacteria links to Rfam database...	0.47	0.44	0.50	232	1204667	242	27	202	13	295
PDB_01273	SSU_rRNA_bacteria links to Rfam database...	0.50	0.48	0.53	235	1117815	238	14	196	28	256

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of MXScarna(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for MXScarna(seed)

2. Individual counts for MXScarna(seed) [ download as .csv ]

Performance of UNAFold - scored lower in this pairwise comparison

1. Total counts & total scores for UNAFold

2. Individual counts for UNAFold [ download as .csv ]