CompaRNA - on-line benchmarks of RNA structure prediction methods

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Metric	Murlet(20)		Sfold
MCC	0.621	>	0.458
Average MCC ± 95% Confidence Intervals	0.620 ± 0.161	>	0.457 ± 0.078
Sensitivity	0.544	>	0.395
Positive Predictive Value	0.708	>	0.530
Total TP	2368	>	1720
Total TN	12465477	<	12465576
Total FP	1159	<	1785
Total FP CONTRA	149	<	244
Total FP INCONS	828	<	1282
Total FP COMP	182	<	259
Total FN	1981	<	2629
P-value	0.0

Comparison of performance of Murlet(20) and Sfold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Murlet(20) and Sfold).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Murlet(20) and Sfold).
Comparison of average Matthews Correlation Coefficients (MCCs) for Murlet(20) and Sfold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Murlet(20) and Sfold).

Total Scores
MCC	0.621
Average MCC ± 95% Confidence Intervals	0.620 ± 0.161
Sensitivity	0.544
Positive Predictive Value	0.708
Nr of predictions	9

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00177	SSU_rRNA_bacteria links to Rfam database...	0.75	0.70	0.81	330	1178473	93	14	63	16	143
CRW_00250	SSU_rRNA_bacteria links to Rfam database...	0.75	0.68	0.84	325	1198537	73	14	50	9	153
CRW_00278	SSU_rRNA_bacteria links to Rfam database...	0.75	0.67	0.83	302	1129893	75	12	49	14	148
CRW_00280	SSU_rRNA_bacteria links to Rfam database...	0.78	0.72	0.85	328	1117874	75	11	47	17	125
CRW_00330	SSU_rRNA_eukarya links to Rfam database...	0.39	0.31	0.49	160	1988690	189	26	139	24	357
CRW_00411	SSU_rRNA_eukarya links to Rfam database...	0.31	0.25	0.40	122	1615195	206	23	163	20	374
CRW_00414	SSU_rRNA_eukarya links to Rfam database...	0.33	0.29	0.36	146	1665818	288	38	223	27	349
CRW_00789	SSU_rRNA_bacteria links to Rfam database...	0.78	0.71	0.86	318	1137416	79	8	44	27	129
PDB_01105	SSU_rRNA_bacteria links to Rfam database...	0.73	0.62	0.86	337	1433581	81	3	50	28	203

Total Scores
MCC	0.458
Average MCC ± 95% Confidence Intervals	0.457 ± 0.078
Sensitivity	0.395
Positive Predictive Value	0.530
Nr of predictions	9

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00177	SSU_rRNA_bacteria links to Rfam database...	0.45	0.41	0.50	195	1178491	206	27	167	12	278
CRW_00250	SSU_rRNA_bacteria links to Rfam database...	0.50	0.46	0.54	221	1198516	206	28	161	17	257
CRW_00278	SSU_rRNA_bacteria links to Rfam database...	0.51	0.37	0.70	166	1130018	88	6	66	16	284
CRW_00280	SSU_rRNA_bacteria links to Rfam database...	0.60	0.55	0.66	250	1117881	149	21	108	20	203
CRW_00330	SSU_rRNA_eukarya links to Rfam database...	0.34	0.28	0.41	145	1988661	279	50	159	70	372
CRW_00411	SSU_rRNA_eukarya links to Rfam database...	0.39	0.32	0.47	157	1615171	217	28	147	42	339
CRW_00414	SSU_rRNA_eukarya links to Rfam database...	0.33	0.29	0.38	146	1665840	278	40	199	39	349
CRW_00789	SSU_rRNA_bacteria links to Rfam database...	0.40	0.34	0.46	152	1137458	193	30	146	17	295
PDB_01105	SSU_rRNA_bacteria links to Rfam database...	0.60	0.53	0.67	288	1433540	169	14	129	26	252

Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.