CompaRNA - on-line benchmarks of RNA structure prediction methods

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Metric	PETfold_pre2.0(seed)		Murlet(20)
MCC	0.765	>	0.621
Average MCC ± 95% Confidence Intervals	0.768 ± 0.070	>	0.620 ± 0.161
Sensitivity	0.733	>	0.544
Positive Predictive Value	0.799	>	0.708
Total TP	3189	>	2368
Total TN	12464831	<	12465477
Total FP	1270	>	1159
Total FP CONTRA	126	<	149
Total FP INCONS	676	<	828
Total FP COMP	468	>	182
Total FN	1160	<	1981
P-value	0.0

Comparison of performance of PETfold_pre2.0(seed) and Murlet(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and Murlet(20)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and Murlet(20)).
Comparison of average Matthews Correlation Coefficients (MCCs) for PETfold_pre2.0(seed) and Murlet(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and Murlet(20)).

Total Scores
MCC	0.765
Average MCC ± 95% Confidence Intervals	0.768 ± 0.070
Sensitivity	0.733
Positive Predictive Value	0.799
Nr of predictions	9

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00177	SSU_rRNA_bacteria links to Rfam database...	0.84	0.82	0.86	386	1178430	105	17	47	41	87
CRW_00250	SSU_rRNA_bacteria links to Rfam database...	0.84	0.82	0.87	391	1198474	97	16	45	36	87
CRW_00278	SSU_rRNA_bacteria links to Rfam database...	0.84	0.82	0.85	369	1129823	106	15	49	42	81
CRW_00280	SSU_rRNA_bacteria links to Rfam database...	0.84	0.83	0.85	377	1117815	109	16	52	41	76
CRW_00330	SSU_rRNA_eukarya links to Rfam database...	0.64	0.59	0.69	307	1988567	210	13	128	69	210
CRW_00411	SSU_rRNA_eukarya links to Rfam database...	0.67	0.64	0.71	318	1615053	200	15	117	68	178
CRW_00414	SSU_rRNA_eukarya links to Rfam database...	0.64	0.61	0.67	303	1665770	223	20	132	71	192
CRW_00789	SSU_rRNA_bacteria links to Rfam database...	0.83	0.81	0.86	362	1137365	112	11	48	53	85
PDB_01105	SSU_rRNA_bacteria links to Rfam database...	0.77	0.70	0.86	376	1433534	108	3	58	47	164

Total Scores
MCC	0.621
Average MCC ± 95% Confidence Intervals	0.620 ± 0.161
Sensitivity	0.544
Positive Predictive Value	0.708
Nr of predictions	9

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00177	SSU_rRNA_bacteria links to Rfam database...	0.75	0.70	0.81	330	1178473	93	14	63	16	143
CRW_00250	SSU_rRNA_bacteria links to Rfam database...	0.75	0.68	0.84	325	1198537	73	14	50	9	153
CRW_00278	SSU_rRNA_bacteria links to Rfam database...	0.75	0.67	0.83	302	1129893	75	12	49	14	148
CRW_00280	SSU_rRNA_bacteria links to Rfam database...	0.78	0.72	0.85	328	1117874	75	11	47	17	125
CRW_00330	SSU_rRNA_eukarya links to Rfam database...	0.39	0.31	0.49	160	1988690	189	26	139	24	357
CRW_00411	SSU_rRNA_eukarya links to Rfam database...	0.31	0.25	0.40	122	1615195	206	23	163	20	374
CRW_00414	SSU_rRNA_eukarya links to Rfam database...	0.33	0.29	0.36	146	1665818	288	38	223	27	349
CRW_00789	SSU_rRNA_bacteria links to Rfam database...	0.78	0.71	0.86	318	1137416	79	8	44	27	129
PDB_01105	SSU_rRNA_bacteria links to Rfam database...	0.73	0.62	0.86	337	1433581	81	3	50	28	203

Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.