CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	PETfold_pre2.0(seed)		PknotsRG
MCC	0.832	>	0.435
Average MCC ± 95% Confidence Intervals	0.831 ± 0.012	>	0.432 ± 0.035
Sensitivity	0.809	>	0.430
Positive Predictive Value	0.855	>	0.441
Total TP	19402	>	10306
Total TN	59626980	>	59626314
Total FP	5500	<	14139
Total FP CONTRA	711	<	1732
Total FP INCONS	2586	<	11327
Total FP COMP	2203	>	1080
Total FN	4579	<	13675
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of PETfold_pre2.0(seed) and PknotsRG. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and PknotsRG).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and PknotsRG).
Comparison of average Matthews Correlation Coefficients (MCCs) for PETfold_pre2.0(seed) and PknotsRG. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and PknotsRG).

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Performance of PETfold_pre2.0(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for PETfold_pre2.0(seed)

Total Base Pair Counts
Total TP	19402
Total TN	59626980
Total FP	5500
Total FP CONTRA	711
Total FP INCONS	2586
Total FP COMP	2203
Total FN	4579

Total Scores
MCC	0.832
Average MCC ± 95% Confidence Intervals	0.831 ± 0.012
Sensitivity	0.809
Positive Predictive Value	0.855
Nr of predictions	52

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2. Individual counts for PETfold_pre2.0(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00024	SSU_rRNA_archaea links to Rfam database...	0.89	0.88	0.90	405	1085153	80	10	33	37	53
CRW_00034	SSU_rRNA_bacteria links to Rfam database...	0.80	0.78	0.83	369	1141870	113	17	60	36	105
CRW_00048	SSU_rRNA_bacteria links to Rfam database...	0.85	0.84	0.87	395	1170759	96	18	43	35	75
CRW_00054	SSU_rRNA_bacteria links to Rfam database...	0.86	0.86	0.87	390	1107367	95	16	43	36	66
CRW_00059	SSU_rRNA_bacteria links to Rfam database...	0.85	0.83	0.87	392	1172293	95	17	44	34	81
CRW_00061	SSU_rRNA_bacteria links to Rfam database...	0.84	0.82	0.86	388	1181504	96	16	45	35	88
CRW_00068	SSU_rRNA_bacteria links to Rfam database...	0.86	0.86	0.87	394	1108851	94	17	43	34	63
CRW_00096	SSU_rRNA_bacteria links to Rfam database...	0.86	0.84	0.88	392	1178434	98	11	43	44	73
CRW_00140	SSU_rRNA_bacteria links to Rfam database...	0.85	0.84	0.86	387	1135829	97	15	47	35	76
CRW_00141	SSU_rRNA_bacteria links to Rfam database...	0.85	0.82	0.87	392	1201573	98	16	44	38	84
CRW_00150	SSU_rRNA_bacteria links to Rfam database...	0.85	0.83	0.87	385	1152477	92	16	43	33	81
CRW_00152	SSU_rRNA_bacteria links to Rfam database...	0.84	0.82	0.86	386	1179969	96	16	45	35	85
CRW_00166	SSU_rRNA_bacteria links to Rfam database...	0.86	0.84	0.88	393	1190749	97	11	43	43	75
CRW_00173	SSU_rRNA_bacteria links to Rfam database...	0.80	0.79	0.81	353	1082222	118	17	64	37	92
CRW_00177	SSU_rRNA_bacteria links to Rfam database...	0.84	0.82	0.86	386	1178430	105	17	47	41	87
CRW_00196	SSU_rRNA_bacteria links to Rfam database...	0.83	0.81	0.86	384	1207786	102	15	50	37	91
CRW_00230	SSU_rRNA_bacteria links to Rfam database...	0.84	0.82	0.87	392	1198473	97	16	45	36	86
CRW_00245	SSU_rRNA_bacteria links to Rfam database...	0.86	0.86	0.87	388	1105880	95	18	42	35	65
CRW_00248	SSU_rRNA_bacteria links to Rfam database...	0.83	0.80	0.86	388	1218691	98	16	46	36	96
CRW_00250	SSU_rRNA_bacteria links to Rfam database...	0.84	0.82	0.87	391	1198474	97	16	45	36	87
CRW_00256	SSU_rRNA_bacteria links to Rfam database...	0.85	0.82	0.87	386	1192295	93	16	43	34	82
CRW_00270	SSU_rRNA_bacteria links to Rfam database...	0.87	0.86	0.87	391	1111838	94	15	42	37	64
CRW_00271	SSU_rRNA_bacteria links to Rfam database...	0.83	0.82	0.85	378	1122307	105	14	52	39	84
CRW_00273	SSU_rRNA_bacteria links to Rfam database...	0.86	0.85	0.86	380	1085161	98	14	46	38	66
CRW_00275	SSU_rRNA_bacteria links to Rfam database...	0.86	0.85	0.87	390	1114823	98	15	43	40	67
CRW_00277	SSU_rRNA_bacteria links to Rfam database...	0.84	0.83	0.85	377	1110354	101	16	48	37	76
CRW_00278	SSU_rRNA_bacteria links to Rfam database...	0.84	0.82	0.85	369	1129823	106	15	49	42	81
CRW_00279	SSU_rRNA_bacteria links to Rfam database...	0.85	0.83	0.86	385	1179970	103	16	45	42	79
CRW_00280	SSU_rRNA_bacteria links to Rfam database...	0.84	0.83	0.85	377	1117815	109	16	52	41	76
CRW_00281	SSU_rRNA_bacteria links to Rfam database...	0.85	0.84	0.87	388	1144894	97	16	43	38	76
CRW_00283	SSU_rRNA_bacteria links to Rfam database...	0.78	0.77	0.80	331	1015610	118	18	66	34	101
CRW_00284	SSU_rRNA_bacteria links to Rfam database...	0.83	0.82	0.84	372	1131319	111	16	53	42	84
CRW_00285	SSU_rRNA_bacteria links to Rfam database...	0.84	0.82	0.85	377	1117816	104	17	50	37	81
CRW_00289	SSU_rRNA_bacteria links to Rfam database...	0.82	0.80	0.84	382	1189200	109	16	55	38	94
CRW_00292	SSU_rRNA_bacteria links to Rfam database...	0.74	0.72	0.77	332	1123817	133	22	79	32	129
CRW_00466	SSU_rRNA_bacteria links to Rfam database...	0.86	0.85	0.87	391	1116315	99	14	45	40	67
CRW_00589	SSU_rRNA_bacteria links to Rfam database...	0.87	0.84	0.89	376	1094037	99	6	41	52	69
CRW_00590	SSU_rRNA_bacteria links to Rfam database...	0.87	0.84	0.89	381	1119327	104	6	42	56	71
CRW_00591	SSU_rRNA_bacteria links to Rfam database...	0.87	0.86	0.89	382	1098473	103	6	42	55	64
CRW_00763	SSU_rRNA_bacteria links to Rfam database...	0.83	0.80	0.87	357	1215610	110	5	48	57	89
CRW_00772	SSU_rRNA_bacteria links to Rfam database...	0.79	0.76	0.81	309	945618	130	6	67	57	95
CRW_00778	SSU_rRNA_bacteria links to Rfam database...	0.84	0.83	0.85	317	1201654	139	6	48	85	67
CRW_00789	SSU_rRNA_bacteria links to Rfam database...	0.83	0.81	0.86	362	1137365	112	11	48	53	85
CRW_00795	SSU_rRNA_bacteria links to Rfam database...	0.79	0.76	0.82	299	1152557	159	6	59	94	95
CRW_00800	SSU_rRNA_eukarya links to Rfam database...	0.59	0.53	0.66	250	1401598	188	21	106	61	220
CRW_00849	SSU_rRNA_bacteria links to Rfam database...	0.79	0.76	0.81	359	1117819	116	16	66	34	111
CRW_00997	SSU_rRNA_bacteria links to Rfam database...	0.86	0.85	0.87	395	1135823	93	17	43	33	69
CRW_01343	SSU_rRNA_archaea links to Rfam database...	0.87	0.85	0.89	367	977489	81	8	37	36	67
PDB_00703	SSU_rRNA_bacteria links to Rfam database...	0.79	0.73	0.86	361	1073423	107	9	52	46	134
PDB_01105	SSU_rRNA_bacteria links to Rfam database...	0.77	0.70	0.86	376	1433534	108	3	58	47	164
PDB_01120	SSU_rRNA_bacteria links to Rfam database...	0.80	0.73	0.86	387	1204680	102	10	51	41	140
PDB_01273	SSU_rRNA_bacteria links to Rfam database...	0.80	0.75	0.86	368	1117832	112	8	52	52	123

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Performance of PknotsRG - scored lower in this pairwise comparison

1. Total counts & total scores for PknotsRG

Total Base Pair Counts
Total TP	10306
Total TN	59626314
Total FP	14139
Total FP CONTRA	1732
Total FP INCONS	11327
Total FP COMP	1080
Total FN	13675

Total Scores
MCC	0.435
Average MCC ± 95% Confidence Intervals	0.432 ± 0.035
Sensitivity	0.430
Positive Predictive Value	0.441
Nr of predictions	52

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2. Individual counts for PknotsRG [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00024	SSU_rRNA_archaea links to Rfam database...	0.77	0.76	0.79	348	1085160	130	18	75	37	110
CRW_00034	SSU_rRNA_bacteria links to Rfam database...	0.63	0.63	0.63	300	1141843	196	31	142	23	174
CRW_00048	SSU_rRNA_bacteria links to Rfam database...	0.45	0.45	0.45	210	1170748	276	27	230	19	260
CRW_00054	SSU_rRNA_bacteria links to Rfam database...	0.53	0.52	0.54	236	1107378	216	34	168	14	220
CRW_00059	SSU_rRNA_bacteria links to Rfam database...	0.50	0.49	0.51	233	1172293	234	28	192	14	240
CRW_00061	SSU_rRNA_bacteria links to Rfam database...	0.43	0.44	0.43	208	1181469	284	32	244	8	268
CRW_00068	SSU_rRNA_bacteria links to Rfam database...	0.33	0.33	0.34	152	1108852	312	37	264	11	305
CRW_00096	SSU_rRNA_bacteria links to Rfam database...	0.55	0.55	0.55	255	1178420	227	21	184	22	210
CRW_00140	SSU_rRNA_bacteria links to Rfam database...	0.64	0.64	0.65	296	1135820	182	22	140	20	167
CRW_00141	SSU_rRNA_bacteria links to Rfam database...	0.51	0.50	0.52	238	1201566	240	29	192	19	238
CRW_00150	SSU_rRNA_bacteria links to Rfam database...	0.41	0.41	0.42	190	1152467	282	34	230	18	276
CRW_00152	SSU_rRNA_bacteria links to Rfam database...	0.51	0.50	0.52	236	1179961	240	37	182	21	235
CRW_00166	SSU_rRNA_bacteria links to Rfam database...	0.53	0.52	0.54	242	1190746	234	25	183	26	226
CRW_00173	SSU_rRNA_bacteria links to Rfam database...	0.29	0.29	0.29	128	1082212	325	37	279	9	317
CRW_00177	SSU_rRNA_bacteria links to Rfam database...	0.42	0.41	0.42	196	1178413	284	31	240	13	277
CRW_00196	SSU_rRNA_bacteria links to Rfam database...	0.47	0.46	0.47	220	1207767	270	26	222	22	255
CRW_00230	SSU_rRNA_bacteria links to Rfam database...	0.55	0.54	0.57	260	1198467	221	30	169	22	218
CRW_00245	SSU_rRNA_bacteria links to Rfam database...	0.35	0.35	0.34	157	1105872	312	45	254	13	296
CRW_00248	SSU_rRNA_bacteria links to Rfam database...	0.57	0.57	0.58	275	1218668	230	24	174	32	209
CRW_00250	SSU_rRNA_bacteria links to Rfam database...	0.43	0.43	0.43	205	1198449	287	30	242	15	273
CRW_00256	SSU_rRNA_bacteria links to Rfam database...	0.45	0.44	0.46	206	1192291	257	41	202	14	262
CRW_00270	SSU_rRNA_bacteria links to Rfam database...	0.38	0.37	0.39	168	1111857	279	39	222	18	287
CRW_00271	SSU_rRNA_bacteria links to Rfam database...	0.49	0.48	0.50	220	1122307	239	36	188	15	242
CRW_00273	SSU_rRNA_bacteria links to Rfam database...	0.51	0.50	0.51	222	1085169	227	31	179	17	224
CRW_00275	SSU_rRNA_bacteria links to Rfam database...	0.42	0.42	0.43	193	1114817	278	26	235	17	264
CRW_00277	SSU_rRNA_bacteria links to Rfam database...	0.25	0.25	0.24	113	1110332	354	55	295	4	340
CRW_00278	SSU_rRNA_bacteria links to Rfam database...	0.41	0.40	0.42	180	1129825	270	35	216	19	270
CRW_00279	SSU_rRNA_bacteria links to Rfam database...	0.29	0.29	0.30	134	1179968	334	40	274	20	330
CRW_00280	SSU_rRNA_bacteria links to Rfam database...	0.50	0.50	0.51	226	1117813	234	28	193	13	227
CRW_00281	SSU_rRNA_bacteria links to Rfam database...	0.30	0.30	0.30	138	1144878	340	40	285	15	326
CRW_00283	SSU_rRNA_bacteria links to Rfam database...	0.28	0.28	0.29	120	1015605	317	42	258	17	312
CRW_00284	SSU_rRNA_bacteria links to Rfam database...	0.26	0.25	0.26	115	1131320	336	35	290	11	341
CRW_00285	SSU_rRNA_bacteria links to Rfam database...	0.47	0.47	0.47	214	1117807	257	31	208	18	244
CRW_00289	SSU_rRNA_bacteria links to Rfam database...	0.45	0.44	0.46	209	1189197	272	34	213	25	267
CRW_00292	SSU_rRNA_bacteria links to Rfam database...	0.31	0.30	0.32	138	1123818	305	44	250	11	323
CRW_00466	SSU_rRNA_bacteria links to Rfam database...	0.61	0.60	0.62	273	1116325	194	25	142	27	185
CRW_00589	SSU_rRNA_bacteria links to Rfam database...	0.22	0.21	0.22	95	1094029	351	37	299	15	350
CRW_00590	SSU_rRNA_bacteria links to Rfam database...	0.32	0.31	0.33	141	1119330	303	41	244	18	311
CRW_00591	SSU_rRNA_bacteria links to Rfam database...	0.61	0.60	0.62	267	1098475	190	19	142	29	179
CRW_00763	SSU_rRNA_bacteria links to Rfam database...	0.20	0.20	0.21	90	1215581	387	50	299	38	356
CRW_00772	SSU_rRNA_bacteria links to Rfam database...	0.24	0.24	0.25	97	945607	320	41	255	24	307
CRW_00778	SSU_rRNA_bacteria links to Rfam database...	0.22	0.22	0.22	84	1201649	346	41	251	54	300
CRW_00789	SSU_rRNA_bacteria links to Rfam database...	0.35	0.35	0.35	156	1137342	304	48	240	16	291
CRW_00795	SSU_rRNA_bacteria links to Rfam database...	0.24	0.25	0.23	98	1152503	357	51	269	37	296
CRW_00800	SSU_rRNA_eukarya links to Rfam database...	0.52	0.52	0.52	243	1401506	288	31	195	62	227
CRW_00849	SSU_rRNA_bacteria links to Rfam database...	0.48	0.48	0.49	225	1117798	260	25	212	23	245
CRW_00997	SSU_rRNA_bacteria links to Rfam database...	0.52	0.52	0.52	239	1135819	238	24	196	18	225
CRW_01343	SSU_rRNA_archaea links to Rfam database...	0.34	0.33	0.34	145	977474	293	46	236	11	289
PDB_00703	SSU_rRNA_bacteria links to Rfam database...	0.50	0.48	0.53	239	1073392	239	21	193	25	256
PDB_01105	SSU_rRNA_bacteria links to Rfam database...	0.51	0.50	0.52	269	1433453	278	27	222	29	271
PDB_01120	SSU_rRNA_bacteria links to Rfam database...	0.48	0.45	0.51	239	1204657	247	27	205	15	288
PDB_01273	SSU_rRNA_bacteria links to Rfam database...	0.47	0.46	0.49	225	1117799	263	23	213	27	266

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of PETfold_pre2.0(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for PETfold_pre2.0(seed)

2. Individual counts for PETfold_pre2.0(seed) [ download as .csv ]

Performance of PknotsRG - scored lower in this pairwise comparison

1. Total counts & total scores for PknotsRG

2. Individual counts for PknotsRG [ download as .csv ]