CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	PETfold_pre2.0(seed)		RSpredict(seed)
MCC	0.801	>	0.532
Average MCC ± 95% Confidence Intervals	0.803 ± 0.020	>	0.529 ± 0.062
Sensitivity	0.773	>	0.447
Positive Predictive Value	0.831	>	0.632
Total TP	20805	>	12037
Total TN	71036304	<	71042306
Total FP	6889	<	8416
Total FP CONTRA	769	<	1137
Total FP INCONS	3466	<	5864
Total FP COMP	2654	>	1415
Total FN	6099	<	14867
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of PETfold_pre2.0(seed) and RSpredict(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and RSpredict(seed)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and RSpredict(seed)).
Comparison of average Matthews Correlation Coefficients (MCCs) for PETfold_pre2.0(seed) and RSpredict(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and RSpredict(seed)).

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Performance of PETfold_pre2.0(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for PETfold_pre2.0(seed)

Total Base Pair Counts
Total TP	20805
Total TN	71036304
Total FP	6889
Total FP CONTRA	769
Total FP INCONS	3466
Total FP COMP	2654
Total FN	6099

Total Scores
MCC	0.801
Average MCC ± 95% Confidence Intervals	0.803 ± 0.020
Sensitivity	0.773
Positive Predictive Value	0.831
Nr of predictions	57

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2. Individual counts for PETfold_pre2.0(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00024	SSU_rRNA_archaea links to Rfam database...	0.89	0.88	0.90	405	1085153	80	10	33	37	53
CRW_00048	SSU_rRNA_bacteria links to Rfam database...	0.85	0.84	0.87	395	1170759	96	18	43	35	75
CRW_00054	SSU_rRNA_bacteria links to Rfam database...	0.86	0.86	0.87	390	1107367	95	16	43	36	66
CRW_00059	SSU_rRNA_bacteria links to Rfam database...	0.85	0.83	0.87	392	1172293	95	17	44	34	81
CRW_00061	SSU_rRNA_bacteria links to Rfam database...	0.84	0.82	0.86	388	1181504	96	16	45	35	88
CRW_00068	SSU_rRNA_bacteria links to Rfam database...	0.86	0.86	0.87	394	1108851	94	17	43	34	63
CRW_00096	SSU_rRNA_bacteria links to Rfam database...	0.86	0.84	0.88	392	1178434	98	11	43	44	73
CRW_00140	SSU_rRNA_bacteria links to Rfam database...	0.85	0.84	0.86	387	1135829	97	15	47	35	76
CRW_00141	SSU_rRNA_bacteria links to Rfam database...	0.85	0.82	0.87	392	1201573	98	16	44	38	84
CRW_00150	SSU_rRNA_bacteria links to Rfam database...	0.85	0.83	0.87	385	1152477	92	16	43	33	81
CRW_00152	SSU_rRNA_bacteria links to Rfam database...	0.84	0.82	0.86	386	1179969	96	16	45	35	85
CRW_00166	SSU_rRNA_bacteria links to Rfam database...	0.86	0.84	0.88	393	1190749	97	11	43	43	75
CRW_00173	SSU_rRNA_bacteria links to Rfam database...	0.80	0.79	0.81	353	1082222	118	17	64	37	92
CRW_00177	SSU_rRNA_bacteria links to Rfam database...	0.84	0.82	0.86	386	1178430	105	17	47	41	87
CRW_00196	SSU_rRNA_bacteria links to Rfam database...	0.83	0.81	0.86	384	1207786	102	15	50	37	91
CRW_00230	SSU_rRNA_bacteria links to Rfam database...	0.84	0.82	0.87	392	1198473	97	16	45	36	86
CRW_00245	SSU_rRNA_bacteria links to Rfam database...	0.86	0.86	0.87	388	1105880	95	18	42	35	65
CRW_00248	SSU_rRNA_bacteria links to Rfam database...	0.83	0.80	0.86	388	1218691	98	16	46	36	96
CRW_00250	SSU_rRNA_bacteria links to Rfam database...	0.84	0.82	0.87	391	1198474	97	16	45	36	87
CRW_00256	SSU_rRNA_bacteria links to Rfam database...	0.85	0.82	0.87	386	1192295	93	16	43	34	82
CRW_00270	SSU_rRNA_bacteria links to Rfam database...	0.87	0.86	0.87	391	1111838	94	15	42	37	64
CRW_00271	SSU_rRNA_bacteria links to Rfam database...	0.83	0.82	0.85	378	1122307	105	14	52	39	84
CRW_00273	SSU_rRNA_bacteria links to Rfam database...	0.86	0.85	0.86	380	1085161	98	14	46	38	66
CRW_00275	SSU_rRNA_bacteria links to Rfam database...	0.86	0.85	0.87	390	1114823	98	15	43	40	67
CRW_00277	SSU_rRNA_bacteria links to Rfam database...	0.84	0.83	0.85	377	1110354	101	16	48	37	76
CRW_00280	SSU_rRNA_bacteria links to Rfam database...	0.84	0.83	0.85	377	1117815	109	16	52	41	76
CRW_00281	SSU_rRNA_bacteria links to Rfam database...	0.85	0.84	0.87	388	1144894	97	16	43	38	76
CRW_00283	SSU_rRNA_bacteria links to Rfam database...	0.78	0.77	0.80	331	1015610	118	18	66	34	101
CRW_00289	SSU_rRNA_bacteria links to Rfam database...	0.82	0.80	0.84	382	1189200	109	16	55	38	94
CRW_00292	SSU_rRNA_bacteria links to Rfam database...	0.74	0.72	0.77	332	1123817	133	22	79	32	129
CRW_00306	SSU_rRNA_eukarya links to Rfam database...	0.68	0.66	0.70	305	1445417	186	15	113	58	157
CRW_00366	SSU_rRNA_eukarya links to Rfam database...	0.65	0.62	0.68	300	1579311	211	15	127	69	182
CRW_00371	SSU_rRNA_eukarya links to Rfam database...	0.68	0.65	0.71	322	1611455	199	13	120	66	174
CRW_00379	SSU_rRNA_eukarya links to Rfam database...	0.60	0.54	0.66	286	2126521	223	18	128	77	248
CRW_00411	SSU_rRNA_eukarya links to Rfam database...	0.67	0.64	0.71	318	1615053	200	15	117	68	178
CRW_00414	SSU_rRNA_eukarya links to Rfam database...	0.64	0.61	0.67	303	1665770	223	20	132	71	192
CRW_00466	SSU_rRNA_bacteria links to Rfam database...	0.86	0.85	0.87	391	1116315	99	14	45	40	67
CRW_00589	SSU_rRNA_bacteria links to Rfam database...	0.87	0.84	0.89	376	1094037	99	6	41	52	69
CRW_00590	SSU_rRNA_bacteria links to Rfam database...	0.87	0.84	0.89	381	1119327	104	6	42	56	71
CRW_00591	SSU_rRNA_bacteria links to Rfam database...	0.87	0.86	0.89	382	1098473	103	6	42	55	64
CRW_00759	SSU_rRNA_eukarya links to Rfam database...	0.65	0.62	0.68	297	1636709	218	15	124	79	184
CRW_00763	SSU_rRNA_bacteria links to Rfam database...	0.83	0.80	0.87	357	1215610	110	5	48	57	89
CRW_00778	SSU_rRNA_bacteria links to Rfam database...	0.84	0.83	0.85	317	1201654	139	6	48	85	67
CRW_00789	SSU_rRNA_bacteria links to Rfam database...	0.83	0.81	0.86	362	1137365	112	11	48	53	85
CRW_00795	SSU_rRNA_bacteria links to Rfam database...	0.79	0.76	0.82	299	1152557	159	6	59	94	95
CRW_00849	SSU_rRNA_bacteria links to Rfam database...	0.79	0.76	0.81	359	1117819	116	16	66	34	111
CRW_00997	SSU_rRNA_bacteria links to Rfam database...	0.86	0.85	0.87	395	1135823	93	17	43	33	69
CRW_01153	SSU_rRNA_eukarya links to Rfam database...	0.61	0.58	0.64	294	1606070	223	18	146	59	209
CRW_01171	SSU_rRNA_eukarya links to Rfam database...	0.63	0.60	0.67	304	1593548	214	15	138	61	202
CRW_01343	SSU_rRNA_archaea links to Rfam database...	0.87	0.85	0.89	367	977489	81	8	37	36	67
PDB_00703	SSU_rRNA_bacteria links to Rfam database...	0.79	0.73	0.86	361	1073423	107	9	52	46	134
PDB_00854	SSU_rRNA_bacteria links to Rfam database...	0.76	0.68	0.86	364	1500354	120	9	51	60	171
PDB_01088	SSU_rRNA_bacteria links to Rfam database...	0.75	0.67	0.85	365	1471040	119	5	60	54	182
PDB_01103	SSU_rRNA_bacteria links to Rfam database...	0.76	0.67	0.86	376	1606090	108	8	54	46	186
PDB_01105	SSU_rRNA_bacteria links to Rfam database...	0.77	0.70	0.86	376	1433534	108	3	58	47	164
PDB_01120	SSU_rRNA_bacteria links to Rfam database...	0.80	0.73	0.86	387	1204680	102	10	51	41	140
PDB_01273	SSU_rRNA_bacteria links to Rfam database...	0.80	0.75	0.86	368	1117832	112	8	52	52	123

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Performance of RSpredict(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for RSpredict(seed)

Total Base Pair Counts
Total TP	12037
Total TN	71042306
Total FP	8416
Total FP CONTRA	1137
Total FP INCONS	5864
Total FP COMP	1415
Total FN	14867

Total Scores
MCC	0.532
Average MCC ± 95% Confidence Intervals	0.529 ± 0.062
Sensitivity	0.447
Positive Predictive Value	0.632
Nr of predictions	57

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2. Individual counts for RSpredict(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00024	SSU_rRNA_archaea links to Rfam database...	0.78	0.76	0.80	346	1085169	116	15	71	30	112
CRW_00048	SSU_rRNA_bacteria links to Rfam database...	0.65	0.57	0.74	268	1170853	120	15	79	26	202
CRW_00054	SSU_rRNA_bacteria links to Rfam database...	0.66	0.59	0.75	269	1107457	114	15	75	24	187
CRW_00059	SSU_rRNA_bacteria links to Rfam database...	0.63	0.54	0.73	257	1172394	120	18	77	25	216
CRW_00061	SSU_rRNA_bacteria links to Rfam database...	0.62	0.54	0.72	258	1181594	124	19	82	23	218
CRW_00068	SSU_rRNA_bacteria links to Rfam database...	0.65	0.57	0.75	261	1108955	113	16	73	24	196
CRW_00096	SSU_rRNA_bacteria links to Rfam database...	0.66	0.57	0.75	267	1178524	119	14	75	30	198
CRW_00140	SSU_rRNA_bacteria links to Rfam database...	0.67	0.59	0.76	273	1135921	112	13	71	28	190
CRW_00141	SSU_rRNA_bacteria links to Rfam database...	0.63	0.55	0.72	260	1201662	126	16	87	23	216
CRW_00150	SSU_rRNA_bacteria links to Rfam database...	0.66	0.58	0.74	270	1152558	117	19	74	24	196
CRW_00152	SSU_rRNA_bacteria links to Rfam database...	0.63	0.54	0.74	252	1180075	110	15	74	21	219
CRW_00166	SSU_rRNA_bacteria links to Rfam database...	0.64	0.55	0.74	258	1190849	118	11	78	29	210
CRW_00173	SSU_rRNA_bacteria links to Rfam database...	0.62	0.55	0.71	243	1082316	119	17	80	22	202
CRW_00177	SSU_rRNA_bacteria links to Rfam database...	0.67	0.58	0.77	274	1178524	103	15	67	21	199
CRW_00196	SSU_rRNA_bacteria links to Rfam database...	0.63	0.54	0.73	257	1207883	117	16	79	22	218
CRW_00230	SSU_rRNA_bacteria links to Rfam database...	0.62	0.54	0.71	257	1198565	127	16	88	23	221
CRW_00245	SSU_rRNA_bacteria links to Rfam database...	0.63	0.55	0.72	248	1105984	121	17	79	25	205
CRW_00248	SSU_rRNA_bacteria links to Rfam database...	0.65	0.57	0.75	278	1218768	123	17	78	28	206
CRW_00250	SSU_rRNA_bacteria links to Rfam database...	0.67	0.60	0.74	285	1198543	124	18	80	26	193
CRW_00256	SSU_rRNA_bacteria links to Rfam database...	0.62	0.54	0.72	251	1192392	119	17	80	22	217
CRW_00270	SSU_rRNA_bacteria links to Rfam database...	0.64	0.56	0.74	255	1111941	113	15	75	23	200
CRW_00271	SSU_rRNA_bacteria links to Rfam database...	0.62	0.53	0.73	243	1122417	115	15	76	24	219
CRW_00273	SSU_rRNA_bacteria links to Rfam database...	0.64	0.56	0.73	250	1085260	113	15	76	22	196
CRW_00275	SSU_rRNA_bacteria links to Rfam database...	0.63	0.54	0.72	249	1114926	120	15	81	24	208
CRW_00277	SSU_rRNA_bacteria links to Rfam database...	0.61	0.52	0.72	235	1110468	113	17	75	21	218
CRW_00280	SSU_rRNA_bacteria links to Rfam database...	0.61	0.53	0.70	240	1117918	122	15	87	20	213
CRW_00281	SSU_rRNA_bacteria links to Rfam database...	0.65	0.56	0.74	260	1144991	117	12	78	27	204
CRW_00283	SSU_rRNA_bacteria links to Rfam database...	0.53	0.42	0.68	180	1015761	96	14	70	12	252
CRW_00289	SSU_rRNA_bacteria links to Rfam database...	0.60	0.50	0.70	240	1189312	122	16	85	21	236
CRW_00292	SSU_rRNA_bacteria links to Rfam database...	0.55	0.43	0.72	196	1123976	99	12	66	21	265
CRW_00306	SSU_rRNA_eukarya links to Rfam database...	0.00	0.00	0.00	0	1445558	306	53	239	14	462
CRW_00366	SSU_rRNA_eukarya links to Rfam database...	0.00	0.00	0.00	0	1579464	301	50	239	12	482
CRW_00371	SSU_rRNA_eukarya links to Rfam database...	0.00	0.00	0.00	0	1611598	319	50	262	7	496
CRW_00379	SSU_rRNA_eukarya links to Rfam database...	0.00	0.00	0.00	0	2126581	414	77	295	42	534
CRW_00411	SSU_rRNA_eukarya links to Rfam database...	0.00	0.00	0.00	0	1615206	309	45	252	12	496
CRW_00414	SSU_rRNA_eukarya links to Rfam database...	0.00	0.00	0.00	0	1665933	312	53	239	20	495
CRW_00466	SSU_rRNA_bacteria links to Rfam database...	0.64	0.55	0.74	252	1116423	114	13	77	24	206
CRW_00589	SSU_rRNA_bacteria links to Rfam database...	0.63	0.53	0.74	236	1094141	110	9	74	27	209
CRW_00590	SSU_rRNA_bacteria links to Rfam database...	0.64	0.54	0.76	245	1119432	103	8	71	24	207
CRW_00591	SSU_rRNA_bacteria links to Rfam database...	0.66	0.58	0.76	258	1098562	118	11	72	35	188
CRW_00759	SSU_rRNA_eukarya links to Rfam database...	0.00	0.00	0.00	1	1636859	310	50	235	25	480
CRW_00763	SSU_rRNA_bacteria links to Rfam database...	0.62	0.49	0.79	217	1215744	86	5	54	27	229
CRW_00778	SSU_rRNA_bacteria links to Rfam database...	0.59	0.48	0.73	185	1201773	99	7	60	32	199
CRW_00789	SSU_rRNA_bacteria links to Rfam database...	0.64	0.56	0.74	249	1137451	114	13	73	28	198
CRW_00795	SSU_rRNA_bacteria links to Rfam database...	0.58	0.47	0.72	184	1152666	117	7	64	46	210
CRW_00849	SSU_rRNA_bacteria links to Rfam database...	0.60	0.49	0.73	232	1117943	100	11	74	15	238
CRW_00997	SSU_rRNA_bacteria links to Rfam database...	0.63	0.55	0.72	256	1135921	123	14	87	22	208
CRW_01153	SSU_rRNA_eukarya links to Rfam database...	0.00	0.00	0.00	0	1606225	319	65	238	16	503
CRW_01171	SSU_rRNA_eukarya links to Rfam database...	0.00	0.00	0.00	0	1593701	318	50	254	14	506
CRW_01343	SSU_rRNA_archaea links to Rfam database...	0.52	0.41	0.68	177	977639	95	12	73	10	257
PDB_00703	SSU_rRNA_bacteria links to Rfam database...	0.63	0.53	0.76	261	1073500	115	11	73	31	234
PDB_00854	SSU_rRNA_bacteria links to Rfam database...	0.60	0.48	0.76	259	1500435	126	9	75	42	276
PDB_01088	SSU_rRNA_bacteria links to Rfam database...	0.60	0.47	0.76	259	1471129	122	8	74	40	288
PDB_01103	SSU_rRNA_bacteria links to Rfam database...	0.60	0.47	0.76	266	1606178	119	12	72	35	296
PDB_01105	SSU_rRNA_bacteria links to Rfam database...	0.61	0.50	0.76	268	1433617	119	7	79	33	272
PDB_01120	SSU_rRNA_bacteria links to Rfam database...	0.64	0.53	0.78	280	1204768	120	9	71	40	247
PDB_01273	SSU_rRNA_bacteria links to Rfam database...	0.65	0.55	0.76	272	1117903	116	13	72	31	219

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of PETfold_pre2.0(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for PETfold_pre2.0(seed)

2. Individual counts for PETfold_pre2.0(seed) [ download as .csv ]

Performance of RSpredict(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for RSpredict(seed)

2. Individual counts for RSpredict(seed) [ download as .csv ]