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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of PPfold(20) - scored higher in this pairwise comparison

  4. Performance of CRWrnafold - scored lower in this pairwise comparison

  5. Compile and download dataset for PPfold(20) & CRWrnafold [.zip] - may take several seconds...


Overview

Metric PPfold(20) CRWrnafold
MCC 0.844 > 0.653
Average MCC ± 95% Confidence Intervals 0.844 ± 0.129 > 0.652 ± 0.484
Sensitivity 0.809 > 0.640
Positive Predictive Value 0.881 > 0.666
Total TP 741 > 586
Total TN 2255193 > 2255154
Total FP 144 < 351
Total FP CONTRA 19 < 48
Total FP INCONS 81 < 246
Total FP COMP 44 < 57
Total FN 175 < 330
P-value 0.0

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Performance plots


  1. Comparison of performance of PPfold(20) and CRWrnafold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PPfold(20) and CRWrnafold).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for PPfold(20) and CRWrnafold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PPfold(20) and CRWrnafold).

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Performance of PPfold(20) - scored higher in this pairwise comparison

1. Total counts & total scores for PPfold(20)

Total Base Pair Counts
Total TP 741
Total TN 2255193
Total FP 144
Total FP CONTRA 19
Total FP INCONS 81
Total FP COMP 44
Total FN 175
Total Scores
MCC 0.844
Average MCC ± 95% Confidence Intervals 0.844 ± 0.129
Sensitivity 0.809
Positive Predictive Value 0.881
Nr of predictions 2

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2. Individual counts for PPfold(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
CRW_00590 0.85 0.81 0.90 367 1119348 69 4 37 28 85
CRW_00997 0.83 0.81 0.86 374 1135845 75 15 44 16 90

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Performance of CRWrnafold - scored lower in this pairwise comparison

1. Total counts & total scores for CRWrnafold

Total Base Pair Counts
Total TP 586
Total TN 2255154
Total FP 351
Total FP CONTRA 48
Total FP INCONS 246
Total FP COMP 57
Total FN 330
Total Scores
MCC 0.653
Average MCC ± 95% Confidence Intervals 0.652 ± 0.484
Sensitivity 0.640
Positive Predictive Value 0.666
Nr of predictions 2

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2. Individual counts for CRWrnafold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
CRW_00590 0.61 0.59 0.64 268 1119334 184 21 133 30 184
CRW_00997 0.69 0.69 0.69 318 1135820 167 27 113 27 146

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.