CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	RNAalifold(seed)		CRWrnafold
MCC	0.831	>	0.515
Average MCC ± 95% Confidence Intervals	0.831 ± 0.010	>	0.512 ± 0.050
Sensitivity	0.783	>	0.508
Positive Predictive Value	0.882	>	0.523
Total TP	10266	>	6664
Total TN	32001844	>	32000733
Total FP	1814	<	6747
Total FP CONTRA	356	<	823
Total FP INCONS	1012	<	5258
Total FP COMP	446	<	666
Total FN	2845	<	6447
P-value	5.1503931209e-08

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Performance plots

Comparison of performance of RNAalifold(seed) and CRWrnafold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNAalifold(seed) and CRWrnafold).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNAalifold(seed) and CRWrnafold).
Comparison of average Matthews Correlation Coefficients (MCCs) for RNAalifold(seed) and CRWrnafold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNAalifold(seed) and CRWrnafold).

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Performance of RNAalifold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for RNAalifold(seed)

Total Base Pair Counts
Total TP	10266
Total TN	32001844
Total FP	1814
Total FP CONTRA	356
Total FP INCONS	1012
Total FP COMP	446
Total FN	2845

Total Scores
MCC	0.831
Average MCC ± 95% Confidence Intervals	0.831 ± 0.010
Sensitivity	0.783
Positive Predictive Value	0.882
Nr of predictions	29

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2. Individual counts for RNAalifold(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00054	SSU_rRNA_bacteria links to Rfam database...	0.84	0.81	0.88	369	1107397	60	16	34	10	87
CRW_00068	SSU_rRNA_bacteria links to Rfam database...	0.85	0.81	0.88	370	1108886	58	15	34	9	87
CRW_00140	SSU_rRNA_bacteria links to Rfam database...	0.83	0.79	0.87	367	1135858	62	16	37	9	96
CRW_00173	SSU_rRNA_bacteria links to Rfam database...	0.79	0.76	0.84	336	1082254	76	16	50	10	109
CRW_00245	SSU_rRNA_bacteria links to Rfam database...	0.84	0.81	0.88	366	1105912	60	16	34	10	87
CRW_00270	SSU_rRNA_bacteria links to Rfam database...	0.84	0.81	0.88	368	1111868	59	15	35	9	87
CRW_00271	SSU_rRNA_bacteria links to Rfam database...	0.83	0.78	0.90	359	1122350	51	13	29	9	103
CRW_00273	SSU_rRNA_bacteria links to Rfam database...	0.84	0.80	0.87	358	1085191	60	16	36	8	88
CRW_00275	SSU_rRNA_bacteria links to Rfam database...	0.84	0.80	0.88	366	1114854	59	16	35	8	91
CRW_00277	SSU_rRNA_bacteria links to Rfam database...	0.83	0.79	0.87	359	1110382	64	17	37	10	94
CRW_00278	SSU_rRNA_bacteria links to Rfam database...	0.83	0.78	0.88	349	1129861	58	13	33	12	101
CRW_00280	SSU_rRNA_bacteria links to Rfam database...	0.84	0.80	0.89	363	1117851	59	13	33	13	90
CRW_00281	SSU_rRNA_bacteria links to Rfam database...	0.85	0.80	0.91	372	1144932	48	13	24	11	92
CRW_00283	SSU_rRNA_bacteria links to Rfam database...	0.80	0.75	0.85	323	1015644	67	14	44	9	109
CRW_00284	SSU_rRNA_bacteria links to Rfam database...	0.83	0.78	0.89	356	1131358	59	13	33	13	100
CRW_00285	SSU_rRNA_bacteria links to Rfam database...	0.82	0.78	0.86	356	1117847	66	17	40	9	102
CRW_00292	SSU_rRNA_bacteria links to Rfam database...	0.77	0.71	0.84	329	1123856	76	14	51	11	132
CRW_00466	SSU_rRNA_bacteria links to Rfam database...	0.86	0.82	0.91	377	1116350	49	12	26	11	81
CRW_00589	SSU_rRNA_bacteria links to Rfam database...	0.86	0.81	0.92	361	1094068	53	6	25	22	84
CRW_00590	SSU_rRNA_bacteria links to Rfam database...	0.87	0.81	0.92	366	1119360	52	6	24	22	86
CRW_00591	SSU_rRNA_bacteria links to Rfam database...	0.87	0.82	0.92	365	1098507	56	8	23	25	81
CRW_00772	SSU_rRNA_bacteria links to Rfam database...	0.81	0.75	0.88	302	945656	72	5	37	30	102
CRW_00778	SSU_rRNA_bacteria links to Rfam database...	0.86	0.81	0.91	312	1201683	85	4	26	55	72
CRW_00789	SSU_rRNA_bacteria links to Rfam database...	0.85	0.79	0.91	355	1137395	59	8	28	23	92
CRW_00849	SSU_rRNA_bacteria links to Rfam database...	0.82	0.76	0.88	356	1117856	63	14	34	15	114
CRW_00997	SSU_rRNA_bacteria links to Rfam database...	0.84	0.80	0.88	372	1135856	59	15	35	9	92
CRW_01343	SSU_rRNA_archaea links to Rfam database...	0.83	0.79	0.88	344	977508	71	5	44	22	90
PDB_00703	SSU_rRNA_bacteria links to Rfam database...	0.78	0.69	0.87	344	1073448	73	7	46	20	151
PDB_01273	SSU_rRNA_bacteria links to Rfam database...	0.78	0.70	0.86	346	1117856	80	13	45	22	145

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Performance of CRWrnafold - scored lower in this pairwise comparison

1. Total counts & total scores for CRWrnafold

Total Base Pair Counts
Total TP	6664
Total TN	32000733
Total FP	6747
Total FP CONTRA	823
Total FP INCONS	5258
Total FP COMP	666
Total FN	6447

Total Scores
MCC	0.515
Average MCC ± 95% Confidence Intervals	0.512 ± 0.050
Sensitivity	0.508
Positive Predictive Value	0.523
Nr of predictions	29

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2. Individual counts for CRWrnafold [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00054	SSU_rRNA_bacteria links to Rfam database...	0.57	0.56	0.57	257	1107367	210	22	170	18	199
CRW_00068	SSU_rRNA_bacteria links to Rfam database...	0.57	0.57	0.58	259	1108856	209	20	170	19	198
CRW_00140	SSU_rRNA_bacteria links to Rfam database...	0.49	0.49	0.48	226	1135811	256	30	211	15	237
CRW_00173	SSU_rRNA_bacteria links to Rfam database...	0.38	0.38	0.39	168	1082220	282	31	237	14	277
CRW_00245	SSU_rRNA_bacteria links to Rfam database...	0.53	0.53	0.54	240	1105883	225	26	179	20	213
CRW_00270	SSU_rRNA_bacteria links to Rfam database...	0.49	0.49	0.50	225	1111832	246	27	202	17	230
CRW_00271	SSU_rRNA_bacteria links to Rfam database...	0.69	0.67	0.71	311	1122312	152	21	107	24	151
CRW_00273	SSU_rRNA_bacteria links to Rfam database...	0.41	0.41	0.41	181	1085155	279	39	226	14	265
CRW_00275	SSU_rRNA_bacteria links to Rfam database...	0.65	0.65	0.66	296	1114820	177	28	127	22	161
CRW_00277	SSU_rRNA_bacteria links to Rfam database...	0.44	0.43	0.44	196	1110351	263	35	213	15	257
CRW_00278	SSU_rRNA_bacteria links to Rfam database...	0.41	0.40	0.42	182	1129824	270	20	230	20	268
CRW_00280	SSU_rRNA_bacteria links to Rfam database...	0.67	0.66	0.68	299	1117818	160	18	125	17	154
CRW_00281	SSU_rRNA_bacteria links to Rfam database...	0.60	0.59	0.61	274	1144893	197	27	147	23	190
CRW_00283	SSU_rRNA_bacteria links to Rfam database...	0.38	0.38	0.37	164	1015587	296	41	233	22	268
CRW_00284	SSU_rRNA_bacteria links to Rfam database...	0.51	0.50	0.51	228	1131314	245	27	191	27	228
CRW_00285	SSU_rRNA_bacteria links to Rfam database...	0.68	0.67	0.69	305	1117819	160	25	111	24	153
CRW_00292	SSU_rRNA_bacteria links to Rfam database...	0.33	0.33	0.34	151	1123806	312	48	245	19	310
CRW_00466	SSU_rRNA_bacteria links to Rfam database...	0.71	0.70	0.71	320	1116316	158	22	107	29	138
CRW_00589	SSU_rRNA_bacteria links to Rfam database...	0.35	0.34	0.36	153	1094035	290	40	232	18	292
CRW_00590	SSU_rRNA_bacteria links to Rfam database...	0.61	0.59	0.64	268	1119334	184	21	133	30	184
CRW_00591	SSU_rRNA_bacteria links to Rfam database...	0.56	0.56	0.56	249	1098461	218	30	163	25	197
CRW_00772	SSU_rRNA_bacteria links to Rfam database...	0.19	0.18	0.19	74	945610	325	42	274	9	330
CRW_00778	SSU_rRNA_bacteria links to Rfam database...	0.42	0.41	0.42	159	1201646	291	25	195	71	225
CRW_00789	SSU_rRNA_bacteria links to Rfam database...	0.51	0.50	0.52	224	1137356	236	32	174	30	223
CRW_00849	SSU_rRNA_bacteria links to Rfam database...	0.47	0.47	0.47	222	1117790	269	18	230	21	248
CRW_00997	SSU_rRNA_bacteria links to Rfam database...	0.69	0.69	0.69	318	1135820	167	27	113	27	146
CRW_01343	SSU_rRNA_archaea links to Rfam database...	0.37	0.36	0.38	158	977489	271	43	211	17	276
PDB_00703	SSU_rRNA_bacteria links to Rfam database...	0.65	0.61	0.69	304	1073402	166	18	121	27	191
PDB_01273	SSU_rRNA_bacteria links to Rfam database...	0.54	0.52	0.56	253	1117806	233	20	181	32	238

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of RNAalifold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for RNAalifold(seed)

2. Individual counts for RNAalifold(seed) [ download as .csv ]

Performance of CRWrnafold - scored lower in this pairwise comparison

1. Total counts & total scores for CRWrnafold

2. Individual counts for CRWrnafold [ download as .csv ]