CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	RNAalifold(seed)		ProbKnot
MCC	0.744	>	0.427
Average MCC ± 95% Confidence Intervals	0.742 ± 0.039	>	0.427 ± 0.028
Sensitivity	0.678	>	0.419
Positive Predictive Value	0.818	>	0.435
Total TP	21759	>	13460
Total TN	85766748	>	85762436
Total FP	5870	<	19717
Total FP CONTRA	1107	<	2776
Total FP INCONS	3750	<	14692
Total FP COMP	1013	<	2249
Total FN	10343	<	18642
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of RNAalifold(seed) and ProbKnot. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNAalifold(seed) and ProbKnot).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNAalifold(seed) and ProbKnot).
Comparison of average Matthews Correlation Coefficients (MCCs) for RNAalifold(seed) and ProbKnot. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNAalifold(seed) and ProbKnot).

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Performance of RNAalifold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for RNAalifold(seed)

Total Base Pair Counts
Total TP	21759
Total TN	85766748
Total FP	5870
Total FP CONTRA	1107
Total FP INCONS	3750
Total FP COMP	1013
Total FN	10343

Total Scores
MCC	0.744
Average MCC ± 95% Confidence Intervals	0.742 ± 0.039
Sensitivity	0.678
Positive Predictive Value	0.818
Nr of predictions	68

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2. Individual counts for RNAalifold(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00024	SSU_rRNA_archaea links to Rfam database...	0.87	0.84	0.90	385	1085175	58	7	34	17	73
CRW_00034	SSU_rRNA_bacteria links to Rfam database...	0.82	0.77	0.88	363	1141905	62	14	34	14	111
CRW_00048	SSU_rRNA_bacteria links to Rfam database...	0.84	0.79	0.88	372	1170793	59	16	34	9	98
CRW_00054	SSU_rRNA_bacteria links to Rfam database...	0.84	0.81	0.88	369	1107397	60	16	34	10	87
CRW_00059	SSU_rRNA_bacteria links to Rfam database...	0.82	0.78	0.88	367	1172327	61	16	36	9	106
CRW_00061	SSU_rRNA_bacteria links to Rfam database...	0.82	0.77	0.88	367	1181535	61	16	35	10	109
CRW_00068	SSU_rRNA_bacteria links to Rfam database...	0.85	0.81	0.88	370	1108886	58	15	34	9	87
CRW_00096	SSU_rRNA_bacteria links to Rfam database...	0.84	0.79	0.89	368	1178465	61	12	35	14	97
CRW_00140	SSU_rRNA_bacteria links to Rfam database...	0.83	0.79	0.87	367	1135858	62	16	37	9	96
CRW_00141	SSU_rRNA_bacteria links to Rfam database...	0.83	0.78	0.88	369	1201606	61	16	34	11	107
CRW_00150	SSU_rRNA_bacteria links to Rfam database...	0.85	0.79	0.91	368	1152515	47	13	25	9	98
CRW_00152	SSU_rRNA_bacteria links to Rfam database...	0.85	0.79	0.91	372	1180006	46	13	25	8	99
CRW_00166	SSU_rRNA_bacteria links to Rfam database...	0.83	0.78	0.88	365	1190782	64	12	37	15	103
CRW_00173	SSU_rRNA_bacteria links to Rfam database...	0.79	0.76	0.84	336	1082254	76	16	50	10	109
CRW_00177	SSU_rRNA_bacteria links to Rfam database...	0.82	0.77	0.87	364	1178460	66	16	40	10	109
CRW_00196	SSU_rRNA_bacteria links to Rfam database...	0.82	0.77	0.87	365	1207815	63	16	39	8	110
CRW_00230	SSU_rRNA_bacteria links to Rfam database...	0.83	0.77	0.88	369	1198508	59	15	34	10	109
CRW_00245	SSU_rRNA_bacteria links to Rfam database...	0.84	0.81	0.88	366	1105912	60	16	34	10	87
CRW_00248	SSU_rRNA_bacteria links to Rfam database...	0.82	0.76	0.88	369	1218720	61	16	36	9	115
CRW_00250	SSU_rRNA_bacteria links to Rfam database...	0.82	0.77	0.88	369	1198505	61	16	36	9	109
CRW_00256	SSU_rRNA_bacteria links to Rfam database...	0.85	0.79	0.91	369	1192333	48	13	25	10	99
CRW_00270	SSU_rRNA_bacteria links to Rfam database...	0.84	0.81	0.88	368	1111868	59	15	35	9	87
CRW_00271	SSU_rRNA_bacteria links to Rfam database...	0.83	0.78	0.90	359	1122350	51	13	29	9	103
CRW_00273	SSU_rRNA_bacteria links to Rfam database...	0.84	0.80	0.87	358	1085191	60	16	36	8	88
CRW_00275	SSU_rRNA_bacteria links to Rfam database...	0.84	0.80	0.88	366	1114854	59	16	35	8	91
CRW_00277	SSU_rRNA_bacteria links to Rfam database...	0.83	0.79	0.87	359	1110382	64	17	37	10	94
CRW_00278	SSU_rRNA_bacteria links to Rfam database...	0.83	0.78	0.88	349	1129861	58	13	33	12	101
CRW_00279	SSU_rRNA_bacteria links to Rfam database...	0.85	0.80	0.91	372	1180005	54	13	26	15	92
CRW_00280	SSU_rRNA_bacteria links to Rfam database...	0.84	0.80	0.89	363	1117851	59	13	33	13	90
CRW_00281	SSU_rRNA_bacteria links to Rfam database...	0.85	0.80	0.91	372	1144932	48	13	24	11	92
CRW_00283	SSU_rRNA_bacteria links to Rfam database...	0.80	0.75	0.85	323	1015644	67	14	44	9	109
CRW_00284	SSU_rRNA_bacteria links to Rfam database...	0.83	0.78	0.89	356	1131358	59	13	33	13	100
CRW_00285	SSU_rRNA_bacteria links to Rfam database...	0.82	0.78	0.86	356	1117847	66	17	40	9	102
CRW_00289	SSU_rRNA_bacteria links to Rfam database...	0.80	0.75	0.86	358	1189235	67	16	44	7	118
CRW_00292	SSU_rRNA_bacteria links to Rfam database...	0.77	0.71	0.84	329	1123856	76	14	51	11	132
CRW_00306	SSU_rRNA_eukarya links to Rfam database...	0.45	0.39	0.52	178	1445508	175	32	132	11	284
CRW_00326	SSU_rRNA_eukarya links to Rfam database...	0.44	0.37	0.53	184	1627762	174	32	132	10	318
CRW_00358	SSU_rRNA_eukarya links to Rfam database...	0.44	0.36	0.53	184	1675017	173	32	132	9	323
CRW_00366	SSU_rRNA_eukarya links to Rfam database...	0.42	0.36	0.51	172	1579413	180	32	136	12	310
CRW_00371	SSU_rRNA_eukarya links to Rfam database...	0.44	0.36	0.52	181	1611565	175	31	133	11	315
CRW_00372	SSU_rRNA_eukarya links to Rfam database...	0.44	0.37	0.53	184	1625958	174	32	132	10	314
CRW_00379	SSU_rRNA_eukarya links to Rfam database...	0.40	0.32	0.50	169	2126616	180	32	136	12	365
CRW_00386	SSU_rRNA_eukarya links to Rfam database...	0.44	0.35	0.55	182	1750923	164	28	123	13	333
CRW_00411	SSU_rRNA_eukarya links to Rfam database...	0.45	0.38	0.55	186	1615165	163	28	124	11	310
CRW_00414	SSU_rRNA_eukarya links to Rfam database...	0.45	0.37	0.54	182	1665890	171	28	125	18	313
CRW_00466	SSU_rRNA_bacteria links to Rfam database...	0.86	0.82	0.91	377	1116350	49	12	26	11	81
CRW_00589	SSU_rRNA_bacteria links to Rfam database...	0.86	0.81	0.92	361	1094068	53	6	25	22	84
CRW_00590	SSU_rRNA_bacteria links to Rfam database...	0.87	0.81	0.92	366	1119360	52	6	24	22	86
CRW_00591	SSU_rRNA_bacteria links to Rfam database...	0.87	0.82	0.92	365	1098507	56	8	23	25	81
CRW_00759	SSU_rRNA_eukarya links to Rfam database...	0.41	0.34	0.49	163	1636811	183	35	136	12	318
CRW_00763	SSU_rRNA_bacteria links to Rfam database...	0.85	0.78	0.92	348	1215641	59	6	25	28	98
CRW_00772	SSU_rRNA_bacteria links to Rfam database...	0.81	0.75	0.88	302	945656	72	5	37	30	102
CRW_00778	SSU_rRNA_bacteria links to Rfam database...	0.86	0.81	0.91	312	1201683	85	4	26	55	72
CRW_00789	SSU_rRNA_bacteria links to Rfam database...	0.85	0.79	0.91	355	1137395	59	8	28	23	92
CRW_00795	SSU_rRNA_bacteria links to Rfam database...	0.78	0.73	0.84	288	1152577	109	10	46	53	106
CRW_00800	SSU_rRNA_eukarya links to Rfam database...	0.42	0.33	0.52	156	1401675	160	25	119	16	314
CRW_00849	SSU_rRNA_bacteria links to Rfam database...	0.82	0.76	0.88	356	1117856	63	14	34	15	114
CRW_00997	SSU_rRNA_bacteria links to Rfam database...	0.84	0.80	0.88	372	1135856	59	15	35	9	92
CRW_01153	SSU_rRNA_eukarya links to Rfam database...	0.41	0.34	0.49	172	1606179	193	36	141	16	331
CRW_01171	SSU_rRNA_eukarya links to Rfam database...	0.43	0.36	0.52	181	1593657	177	34	133	10	325
CRW_01343	SSU_rRNA_archaea links to Rfam database...	0.83	0.79	0.88	344	977508	71	5	44	22	90
PDB_00703	SSU_rRNA_bacteria links to Rfam database...	0.78	0.69	0.87	344	1073448	73	7	46	20	151
PDB_00854	SSU_rRNA_bacteria links to Rfam database...	0.74	0.64	0.87	342	1500383	85	10	43	32	193
PDB_01088	SSU_rRNA_bacteria links to Rfam database...	0.73	0.63	0.86	342	1471073	85	8	47	30	205
PDB_01103	SSU_rRNA_bacteria links to Rfam database...	0.74	0.63	0.87	355	1606120	72	10	43	19	207
PDB_01105	SSU_rRNA_bacteria links to Rfam database...	0.76	0.66	0.88	355	1433566	72	7	43	22	185
PDB_01120	SSU_rRNA_bacteria links to Rfam database...	0.77	0.68	0.87	358	1204715	73	7	48	18	169
PDB_01273	SSU_rRNA_bacteria links to Rfam database...	0.78	0.70	0.86	346	1117856	80	13	45	22	145

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Performance of ProbKnot - scored lower in this pairwise comparison

1. Total counts & total scores for ProbKnot

Total Base Pair Counts
Total TP	13460
Total TN	85762436
Total FP	19717
Total FP CONTRA	2776
Total FP INCONS	14692
Total FP COMP	2249
Total FN	18642

Total Scores
MCC	0.427
Average MCC ± 95% Confidence Intervals	0.427 ± 0.028
Sensitivity	0.419
Positive Predictive Value	0.435
Nr of predictions	68

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2. Individual counts for ProbKnot [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00024	SSU_rRNA_archaea links to Rfam database...	0.69	0.68	0.70	312	1085154	184	22	113	49	146
CRW_00034	SSU_rRNA_bacteria links to Rfam database...	0.65	0.64	0.66	305	1141852	193	33	126	34	169
CRW_00048	SSU_rRNA_bacteria links to Rfam database...	0.48	0.46	0.51	215	1170796	225	31	173	21	255
CRW_00054	SSU_rRNA_bacteria links to Rfam database...	0.42	0.41	0.43	186	1107383	267	27	220	20	270
CRW_00059	SSU_rRNA_bacteria links to Rfam database...	0.50	0.48	0.52	225	1172311	230	27	183	20	248
CRW_00061	SSU_rRNA_bacteria links to Rfam database...	0.43	0.42	0.44	201	1181493	284	39	220	25	275
CRW_00068	SSU_rRNA_bacteria links to Rfam database...	0.45	0.43	0.47	198	1108880	243	33	194	16	259
CRW_00096	SSU_rRNA_bacteria links to Rfam database...	0.49	0.48	0.50	222	1178435	246	25	198	23	243
CRW_00140	SSU_rRNA_bacteria links to Rfam database...	0.41	0.40	0.41	185	1135829	286	31	233	22	278
CRW_00141	SSU_rRNA_bacteria links to Rfam database...	0.54	0.52	0.55	248	1201576	229	30	171	28	228
CRW_00150	SSU_rRNA_bacteria links to Rfam database...	0.44	0.42	0.45	198	1152481	263	27	215	21	268
CRW_00152	SSU_rRNA_bacteria links to Rfam database...	0.58	0.56	0.60	265	1179971	202	39	141	22	206
CRW_00166	SSU_rRNA_bacteria links to Rfam database...	0.42	0.41	0.44	190	1190764	263	30	212	21	278
CRW_00173	SSU_rRNA_bacteria links to Rfam database...	0.27	0.26	0.27	115	1082237	320	30	274	16	330
CRW_00177	SSU_rRNA_bacteria links to Rfam database...	0.48	0.46	0.51	219	1178447	241	25	189	27	254
CRW_00196	SSU_rRNA_bacteria links to Rfam database...	0.49	0.48	0.50	229	1207778	250	33	195	22	246
CRW_00230	SSU_rRNA_bacteria links to Rfam database...	0.56	0.53	0.59	255	1198497	206	24	150	32	223
CRW_00245	SSU_rRNA_bacteria links to Rfam database...	0.40	0.40	0.41	179	1105891	278	32	226	20	274
CRW_00248	SSU_rRNA_bacteria links to Rfam database...	0.52	0.52	0.53	250	1218666	257	31	194	32	234
CRW_00250	SSU_rRNA_bacteria links to Rfam database...	0.50	0.50	0.50	238	1198447	265	46	195	24	240
CRW_00256	SSU_rRNA_bacteria links to Rfam database...	0.40	0.40	0.41	185	1192284	296	39	232	25	283
CRW_00270	SSU_rRNA_bacteria links to Rfam database...	0.53	0.53	0.54	241	1111840	228	28	177	23	214
CRW_00271	SSU_rRNA_bacteria links to Rfam database...	0.35	0.33	0.36	154	1122325	292	38	234	20	308
CRW_00273	SSU_rRNA_bacteria links to Rfam database...	0.43	0.41	0.45	183	1085197	235	32	189	14	263
CRW_00275	SSU_rRNA_bacteria links to Rfam database...	0.60	0.58	0.61	266	1114835	193	26	144	23	191
CRW_00277	SSU_rRNA_bacteria links to Rfam database...	0.36	0.35	0.37	157	1110374	282	40	224	18	296
CRW_00278	SSU_rRNA_bacteria links to Rfam database...	0.38	0.36	0.40	162	1129847	266	32	215	19	288
CRW_00279	SSU_rRNA_bacteria links to Rfam database...	0.54	0.52	0.57	243	1179987	211	33	153	25	221
CRW_00280	SSU_rRNA_bacteria links to Rfam database...	0.36	0.35	0.38	158	1117841	277	40	221	16	295
CRW_00281	SSU_rRNA_bacteria links to Rfam database...	0.58	0.56	0.59	260	1144904	208	25	152	31	204
CRW_00283	SSU_rRNA_bacteria links to Rfam database...	0.37	0.38	0.37	162	1015591	302	49	223	30	270
CRW_00284	SSU_rRNA_bacteria links to Rfam database...	0.37	0.35	0.40	159	1131362	267	28	211	28	297
CRW_00285	SSU_rRNA_bacteria links to Rfam database...	0.55	0.53	0.56	244	1117827	214	31	158	25	214
CRW_00289	SSU_rRNA_bacteria links to Rfam database...	0.49	0.48	0.50	228	1189195	264	43	187	34	248
CRW_00292	SSU_rRNA_bacteria links to Rfam database...	0.35	0.34	0.36	157	1123815	302	48	230	24	304
CRW_00306	SSU_rRNA_eukarya links to Rfam database...	0.18	0.19	0.18	86	1445359	473	69	336	68	376
CRW_00326	SSU_rRNA_eukarya links to Rfam database...	0.40	0.41	0.40	207	1627588	371	65	250	56	295
CRW_00358	SSU_rRNA_eukarya links to Rfam database...	0.40	0.40	0.39	202	1674852	365	59	252	54	305
CRW_00366	SSU_rRNA_eukarya links to Rfam database...	0.26	0.27	0.25	130	1579227	438	85	311	42	352
CRW_00371	SSU_rRNA_eukarya links to Rfam database...	0.39	0.39	0.40	191	1611430	345	53	236	56	305
CRW_00372	SSU_rRNA_eukarya links to Rfam database...	0.27	0.27	0.26	136	1625786	435	79	305	51	362
CRW_00379	SSU_rRNA_eukarya links to Rfam database...	0.42	0.43	0.41	229	2126396	414	75	253	86	305
CRW_00386	SSU_rRNA_eukarya links to Rfam database...	0.26	0.27	0.25	138	1750696	459	82	340	37	377
CRW_00411	SSU_rRNA_eukarya links to Rfam database...	0.34	0.35	0.33	172	1614983	394	81	267	46	324
CRW_00414	SSU_rRNA_eukarya links to Rfam database...	0.29	0.30	0.29	149	1665709	429	66	301	62	346
CRW_00466	SSU_rRNA_bacteria links to Rfam database...	0.60	0.59	0.60	272	1116312	211	33	148	30	186
CRW_00589	SSU_rRNA_bacteria links to Rfam database...	0.31	0.30	0.32	135	1094033	316	46	246	24	310
CRW_00590	SSU_rRNA_bacteria links to Rfam database...	0.41	0.39	0.43	176	1119350	259	29	201	29	276
CRW_00591	SSU_rRNA_bacteria links to Rfam database...	0.44	0.44	0.44	198	1098453	275	46	206	23	248
CRW_00759	SSU_rRNA_eukarya links to Rfam database...	0.31	0.31	0.30	151	1636639	423	69	286	68	330
CRW_00763	SSU_rRNA_bacteria links to Rfam database...	0.20	0.20	0.20	90	1215575	395	47	308	40	356
CRW_00772	SSU_rRNA_bacteria links to Rfam database...	0.22	0.22	0.22	90	945593	335	34	283	18	314
CRW_00778	SSU_rRNA_bacteria links to Rfam database...	0.29	0.29	0.28	112	1201627	335	46	240	49	272
CRW_00789	SSU_rRNA_bacteria links to Rfam database...	0.36	0.36	0.37	163	1137340	312	43	240	29	284
CRW_00795	SSU_rRNA_bacteria links to Rfam database...	0.34	0.34	0.33	135	1152513	326	45	228	53	259
CRW_00800	SSU_rRNA_eukarya links to Rfam database...	0.52	0.49	0.54	231	1401550	267	31	163	73	239
CRW_00849	SSU_rRNA_bacteria links to Rfam database...	0.57	0.56	0.58	263	1117810	226	18	169	39	207
CRW_00997	SSU_rRNA_bacteria links to Rfam database...	0.44	0.42	0.46	197	1135851	249	39	191	19	267
CRW_01153	SSU_rRNA_eukarya links to Rfam database...	0.29	0.30	0.28	150	1605991	434	63	324	47	353
CRW_01171	SSU_rRNA_eukarya links to Rfam database...	0.33	0.33	0.33	168	1593497	395	62	278	55	338
CRW_01343	SSU_rRNA_archaea links to Rfam database...	0.37	0.36	0.38	158	977480	279	40	223	16	276
PDB_00703	SSU_rRNA_bacteria links to Rfam database...	0.56	0.51	0.61	253	1073430	187	22	140	25	242
PDB_00854	SSU_rRNA_bacteria links to Rfam database...	0.56	0.54	0.58	288	1500280	260	33	177	50	247
PDB_01088	SSU_rRNA_bacteria links to Rfam database...	0.33	0.32	0.34	175	1470956	367	49	290	28	372
PDB_01103	SSU_rRNA_bacteria links to Rfam database...	0.61	0.58	0.64	324	1606022	220	26	156	38	238
PDB_01105	SSU_rRNA_bacteria links to Rfam database...	0.57	0.53	0.62	286	1433506	213	32	147	34	254
PDB_01120	SSU_rRNA_bacteria links to Rfam database...	0.43	0.40	0.47	211	1204677	265	29	211	25	316
PDB_01273	SSU_rRNA_bacteria links to Rfam database...	0.43	0.41	0.45	200	1117813	276	33	214	29	291

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of RNAalifold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for RNAalifold(seed)

2. Individual counts for RNAalifold(seed) [ download as .csv ]

Performance of ProbKnot - scored lower in this pairwise comparison

1. Total counts & total scores for ProbKnot

2. Individual counts for ProbKnot [ download as .csv ]