CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	RNAalifold(seed)		RNAfold
MCC	0.744	>	0.416
Average MCC ± 95% Confidence Intervals	0.742 ± 0.039	>	0.415 ± 0.031
Sensitivity	0.678	>	0.414
Positive Predictive Value	0.818	>	0.418
Total TP	21759	>	13291
Total TN	85766748	>	85761543
Total FP	5870	<	20397
Total FP CONTRA	1107	<	2787
Total FP INCONS	3750	<	15743
Total FP COMP	1013	<	1867
Total FN	10343	<	18811
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of RNAalifold(seed) and RNAfold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNAalifold(seed) and RNAfold).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNAalifold(seed) and RNAfold).
Comparison of average Matthews Correlation Coefficients (MCCs) for RNAalifold(seed) and RNAfold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNAalifold(seed) and RNAfold).

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Performance of RNAalifold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for RNAalifold(seed)

Total Base Pair Counts
Total TP	21759
Total TN	85766748
Total FP	5870
Total FP CONTRA	1107
Total FP INCONS	3750
Total FP COMP	1013
Total FN	10343

Total Scores
MCC	0.744
Average MCC ± 95% Confidence Intervals	0.742 ± 0.039
Sensitivity	0.678
Positive Predictive Value	0.818
Nr of predictions	68

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2. Individual counts for RNAalifold(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00024	SSU_rRNA_archaea links to Rfam database...	0.87	0.84	0.90	385	1085175	58	7	34	17	73
CRW_00034	SSU_rRNA_bacteria links to Rfam database...	0.82	0.77	0.88	363	1141905	62	14	34	14	111
CRW_00048	SSU_rRNA_bacteria links to Rfam database...	0.84	0.79	0.88	372	1170793	59	16	34	9	98
CRW_00054	SSU_rRNA_bacteria links to Rfam database...	0.84	0.81	0.88	369	1107397	60	16	34	10	87
CRW_00059	SSU_rRNA_bacteria links to Rfam database...	0.82	0.78	0.88	367	1172327	61	16	36	9	106
CRW_00061	SSU_rRNA_bacteria links to Rfam database...	0.82	0.77	0.88	367	1181535	61	16	35	10	109
CRW_00068	SSU_rRNA_bacteria links to Rfam database...	0.85	0.81	0.88	370	1108886	58	15	34	9	87
CRW_00096	SSU_rRNA_bacteria links to Rfam database...	0.84	0.79	0.89	368	1178465	61	12	35	14	97
CRW_00140	SSU_rRNA_bacteria links to Rfam database...	0.83	0.79	0.87	367	1135858	62	16	37	9	96
CRW_00141	SSU_rRNA_bacteria links to Rfam database...	0.83	0.78	0.88	369	1201606	61	16	34	11	107
CRW_00150	SSU_rRNA_bacteria links to Rfam database...	0.85	0.79	0.91	368	1152515	47	13	25	9	98
CRW_00152	SSU_rRNA_bacteria links to Rfam database...	0.85	0.79	0.91	372	1180006	46	13	25	8	99
CRW_00166	SSU_rRNA_bacteria links to Rfam database...	0.83	0.78	0.88	365	1190782	64	12	37	15	103
CRW_00173	SSU_rRNA_bacteria links to Rfam database...	0.79	0.76	0.84	336	1082254	76	16	50	10	109
CRW_00177	SSU_rRNA_bacteria links to Rfam database...	0.82	0.77	0.87	364	1178460	66	16	40	10	109
CRW_00196	SSU_rRNA_bacteria links to Rfam database...	0.82	0.77	0.87	365	1207815	63	16	39	8	110
CRW_00230	SSU_rRNA_bacteria links to Rfam database...	0.83	0.77	0.88	369	1198508	59	15	34	10	109
CRW_00245	SSU_rRNA_bacteria links to Rfam database...	0.84	0.81	0.88	366	1105912	60	16	34	10	87
CRW_00248	SSU_rRNA_bacteria links to Rfam database...	0.82	0.76	0.88	369	1218720	61	16	36	9	115
CRW_00250	SSU_rRNA_bacteria links to Rfam database...	0.82	0.77	0.88	369	1198505	61	16	36	9	109
CRW_00256	SSU_rRNA_bacteria links to Rfam database...	0.85	0.79	0.91	369	1192333	48	13	25	10	99
CRW_00270	SSU_rRNA_bacteria links to Rfam database...	0.84	0.81	0.88	368	1111868	59	15	35	9	87
CRW_00271	SSU_rRNA_bacteria links to Rfam database...	0.83	0.78	0.90	359	1122350	51	13	29	9	103
CRW_00273	SSU_rRNA_bacteria links to Rfam database...	0.84	0.80	0.87	358	1085191	60	16	36	8	88
CRW_00275	SSU_rRNA_bacteria links to Rfam database...	0.84	0.80	0.88	366	1114854	59	16	35	8	91
CRW_00277	SSU_rRNA_bacteria links to Rfam database...	0.83	0.79	0.87	359	1110382	64	17	37	10	94
CRW_00278	SSU_rRNA_bacteria links to Rfam database...	0.83	0.78	0.88	349	1129861	58	13	33	12	101
CRW_00279	SSU_rRNA_bacteria links to Rfam database...	0.85	0.80	0.91	372	1180005	54	13	26	15	92
CRW_00280	SSU_rRNA_bacteria links to Rfam database...	0.84	0.80	0.89	363	1117851	59	13	33	13	90
CRW_00281	SSU_rRNA_bacteria links to Rfam database...	0.85	0.80	0.91	372	1144932	48	13	24	11	92
CRW_00283	SSU_rRNA_bacteria links to Rfam database...	0.80	0.75	0.85	323	1015644	67	14	44	9	109
CRW_00284	SSU_rRNA_bacteria links to Rfam database...	0.83	0.78	0.89	356	1131358	59	13	33	13	100
CRW_00285	SSU_rRNA_bacteria links to Rfam database...	0.82	0.78	0.86	356	1117847	66	17	40	9	102
CRW_00289	SSU_rRNA_bacteria links to Rfam database...	0.80	0.75	0.86	358	1189235	67	16	44	7	118
CRW_00292	SSU_rRNA_bacteria links to Rfam database...	0.77	0.71	0.84	329	1123856	76	14	51	11	132
CRW_00306	SSU_rRNA_eukarya links to Rfam database...	0.45	0.39	0.52	178	1445508	175	32	132	11	284
CRW_00326	SSU_rRNA_eukarya links to Rfam database...	0.44	0.37	0.53	184	1627762	174	32	132	10	318
CRW_00358	SSU_rRNA_eukarya links to Rfam database...	0.44	0.36	0.53	184	1675017	173	32	132	9	323
CRW_00366	SSU_rRNA_eukarya links to Rfam database...	0.42	0.36	0.51	172	1579413	180	32	136	12	310
CRW_00371	SSU_rRNA_eukarya links to Rfam database...	0.44	0.36	0.52	181	1611565	175	31	133	11	315
CRW_00372	SSU_rRNA_eukarya links to Rfam database...	0.44	0.37	0.53	184	1625958	174	32	132	10	314
CRW_00379	SSU_rRNA_eukarya links to Rfam database...	0.40	0.32	0.50	169	2126616	180	32	136	12	365
CRW_00386	SSU_rRNA_eukarya links to Rfam database...	0.44	0.35	0.55	182	1750923	164	28	123	13	333
CRW_00411	SSU_rRNA_eukarya links to Rfam database...	0.45	0.38	0.55	186	1615165	163	28	124	11	310
CRW_00414	SSU_rRNA_eukarya links to Rfam database...	0.45	0.37	0.54	182	1665890	171	28	125	18	313
CRW_00466	SSU_rRNA_bacteria links to Rfam database...	0.86	0.82	0.91	377	1116350	49	12	26	11	81
CRW_00589	SSU_rRNA_bacteria links to Rfam database...	0.86	0.81	0.92	361	1094068	53	6	25	22	84
CRW_00590	SSU_rRNA_bacteria links to Rfam database...	0.87	0.81	0.92	366	1119360	52	6	24	22	86
CRW_00591	SSU_rRNA_bacteria links to Rfam database...	0.87	0.82	0.92	365	1098507	56	8	23	25	81
CRW_00759	SSU_rRNA_eukarya links to Rfam database...	0.41	0.34	0.49	163	1636811	183	35	136	12	318
CRW_00763	SSU_rRNA_bacteria links to Rfam database...	0.85	0.78	0.92	348	1215641	59	6	25	28	98
CRW_00772	SSU_rRNA_bacteria links to Rfam database...	0.81	0.75	0.88	302	945656	72	5	37	30	102
CRW_00778	SSU_rRNA_bacteria links to Rfam database...	0.86	0.81	0.91	312	1201683	85	4	26	55	72
CRW_00789	SSU_rRNA_bacteria links to Rfam database...	0.85	0.79	0.91	355	1137395	59	8	28	23	92
CRW_00795	SSU_rRNA_bacteria links to Rfam database...	0.78	0.73	0.84	288	1152577	109	10	46	53	106
CRW_00800	SSU_rRNA_eukarya links to Rfam database...	0.42	0.33	0.52	156	1401675	160	25	119	16	314
CRW_00849	SSU_rRNA_bacteria links to Rfam database...	0.82	0.76	0.88	356	1117856	63	14	34	15	114
CRW_00997	SSU_rRNA_bacteria links to Rfam database...	0.84	0.80	0.88	372	1135856	59	15	35	9	92
CRW_01153	SSU_rRNA_eukarya links to Rfam database...	0.41	0.34	0.49	172	1606179	193	36	141	16	331
CRW_01171	SSU_rRNA_eukarya links to Rfam database...	0.43	0.36	0.52	181	1593657	177	34	133	10	325
CRW_01343	SSU_rRNA_archaea links to Rfam database...	0.83	0.79	0.88	344	977508	71	5	44	22	90
PDB_00703	SSU_rRNA_bacteria links to Rfam database...	0.78	0.69	0.87	344	1073448	73	7	46	20	151
PDB_00854	SSU_rRNA_bacteria links to Rfam database...	0.74	0.64	0.87	342	1500383	85	10	43	32	193
PDB_01088	SSU_rRNA_bacteria links to Rfam database...	0.73	0.63	0.86	342	1471073	85	8	47	30	205
PDB_01103	SSU_rRNA_bacteria links to Rfam database...	0.74	0.63	0.87	355	1606120	72	10	43	19	207
PDB_01105	SSU_rRNA_bacteria links to Rfam database...	0.76	0.66	0.88	355	1433566	72	7	43	22	185
PDB_01120	SSU_rRNA_bacteria links to Rfam database...	0.77	0.68	0.87	358	1204715	73	7	48	18	169
PDB_01273	SSU_rRNA_bacteria links to Rfam database...	0.78	0.70	0.86	346	1117856	80	13	45	22	145

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Performance of RNAfold - scored lower in this pairwise comparison

1. Total counts & total scores for RNAfold

Total Base Pair Counts
Total TP	13291
Total TN	85761543
Total FP	20397
Total FP CONTRA	2787
Total FP INCONS	15743
Total FP COMP	1867
Total FN	18811

Total Scores
MCC	0.416
Average MCC ± 95% Confidence Intervals	0.415 ± 0.031
Sensitivity	0.414
Positive Predictive Value	0.418
Nr of predictions	68

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2. Individual counts for RNAfold [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00024	SSU_rRNA_archaea links to Rfam database...	0.78	0.76	0.79	350	1085158	132	17	76	39	108
CRW_00034	SSU_rRNA_bacteria links to Rfam database...	0.63	0.63	0.63	300	1141838	201	31	147	23	174
CRW_00048	SSU_rRNA_bacteria links to Rfam database...	0.35	0.35	0.36	164	1170755	315	33	263	19	306
CRW_00054	SSU_rRNA_bacteria links to Rfam database...	0.53	0.52	0.54	238	1107379	215	34	165	16	218
CRW_00059	SSU_rRNA_bacteria links to Rfam database...	0.60	0.60	0.61	283	1172280	205	23	160	22	190
CRW_00061	SSU_rRNA_bacteria links to Rfam database...	0.53	0.53	0.53	252	1181474	240	37	190	13	224
CRW_00068	SSU_rRNA_bacteria links to Rfam database...	0.46	0.46	0.46	210	1108845	266	27	223	16	247
CRW_00096	SSU_rRNA_bacteria links to Rfam database...	0.47	0.47	0.47	220	1178412	266	29	219	18	245
CRW_00140	SSU_rRNA_bacteria links to Rfam database...	0.59	0.58	0.59	270	1135819	209	32	157	20	193
CRW_00141	SSU_rRNA_bacteria links to Rfam database...	0.59	0.58	0.61	277	1201568	204	13	167	24	199
CRW_00150	SSU_rRNA_bacteria links to Rfam database...	0.39	0.38	0.39	179	1152463	296	36	243	17	287
CRW_00152	SSU_rRNA_bacteria links to Rfam database...	0.54	0.53	0.55	249	1179962	229	32	173	24	222
CRW_00166	SSU_rRNA_bacteria links to Rfam database...	0.47	0.46	0.47	217	1190733	262	26	220	16	251
CRW_00173	SSU_rRNA_bacteria links to Rfam database...	0.29	0.29	0.29	131	1082204	330	37	284	9	314
CRW_00177	SSU_rRNA_bacteria links to Rfam database...	0.42	0.42	0.42	197	1178408	288	34	241	13	276
CRW_00196	SSU_rRNA_bacteria links to Rfam database...	0.44	0.44	0.44	208	1207762	286	29	236	21	267
CRW_00230	SSU_rRNA_bacteria links to Rfam database...	0.56	0.54	0.57	259	1198471	217	29	167	21	219
CRW_00245	SSU_rRNA_bacteria links to Rfam database...	0.39	0.39	0.39	176	1105876	287	34	242	11	277
CRW_00248	SSU_rRNA_bacteria links to Rfam database...	0.57	0.57	0.58	276	1218664	233	24	177	32	208
CRW_00250	SSU_rRNA_bacteria links to Rfam database...	0.40	0.40	0.40	190	1198454	296	51	231	14	288
CRW_00256	SSU_rRNA_bacteria links to Rfam database...	0.41	0.41	0.42	190	1192286	279	40	224	15	278
CRW_00270	SSU_rRNA_bacteria links to Rfam database...	0.38	0.37	0.40	170	1111856	279	38	222	19	285
CRW_00271	SSU_rRNA_bacteria links to Rfam database...	0.49	0.48	0.50	224	1122302	241	35	190	16	238
CRW_00273	SSU_rRNA_bacteria links to Rfam database...	0.55	0.54	0.55	240	1085168	217	29	164	24	206
CRW_00275	SSU_rRNA_bacteria links to Rfam database...	0.50	0.49	0.51	226	1114829	235	24	192	19	231
CRW_00277	SSU_rRNA_bacteria links to Rfam database...	0.37	0.37	0.37	169	1110340	304	41	245	18	284
CRW_00278	SSU_rRNA_bacteria links to Rfam database...	0.42	0.41	0.43	186	1129828	264	31	211	22	264
CRW_00279	SSU_rRNA_bacteria links to Rfam database...	0.35	0.34	0.35	157	1179973	303	36	250	17	307
CRW_00280	SSU_rRNA_bacteria links to Rfam database...	0.50	0.49	0.50	222	1117818	233	28	192	13	231
CRW_00281	SSU_rRNA_bacteria links to Rfam database...	0.30	0.30	0.29	138	1144872	346	41	290	15	326
CRW_00283	SSU_rRNA_bacteria links to Rfam database...	0.28	0.28	0.29	120	1015605	317	42	258	17	312
CRW_00284	SSU_rRNA_bacteria links to Rfam database...	0.28	0.27	0.28	124	1131316	333	36	284	13	332
CRW_00285	SSU_rRNA_bacteria links to Rfam database...	0.63	0.62	0.63	284	1117810	186	24	142	20	174
CRW_00289	SSU_rRNA_bacteria links to Rfam database...	0.39	0.38	0.40	181	1189200	291	36	236	19	295
CRW_00292	SSU_rRNA_bacteria links to Rfam database...	0.30	0.30	0.31	136	1123816	309	46	252	11	325
CRW_00306	SSU_rRNA_eukarya links to Rfam database...	0.26	0.26	0.25	121	1445372	410	63	294	53	341
CRW_00326	SSU_rRNA_eukarya links to Rfam database...	0.38	0.38	0.37	190	1627600	364	68	252	44	312
CRW_00358	SSU_rRNA_eukarya links to Rfam database...	0.39	0.39	0.38	199	1674839	381	67	260	54	308
CRW_00366	SSU_rRNA_eukarya links to Rfam database...	0.35	0.36	0.33	174	1579233	393	84	262	47	308
CRW_00371	SSU_rRNA_eukarya links to Rfam database...	0.33	0.33	0.32	166	1611391	395	72	281	42	330
CRW_00372	SSU_rRNA_eukarya links to Rfam database...	0.35	0.36	0.35	181	1625783	379	70	272	37	317
CRW_00379	SSU_rRNA_eukarya links to Rfam database...	0.42	0.43	0.41	227	2126398	426	63	265	98	307
CRW_00386	SSU_rRNA_eukarya links to Rfam database...	0.25	0.27	0.24	137	1750683	473	87	349	37	378
CRW_00411	SSU_rRNA_eukarya links to Rfam database...	0.33	0.34	0.32	169	1614974	406	78	282	46	327
CRW_00414	SSU_rRNA_eukarya links to Rfam database...	0.28	0.29	0.27	143	1665688	437	80	314	43	352
CRW_00466	SSU_rRNA_bacteria links to Rfam database...	0.61	0.59	0.62	272	1116326	195	24	143	28	186
CRW_00589	SSU_rRNA_bacteria links to Rfam database...	0.18	0.18	0.18	78	1094024	373	34	324	15	367
CRW_00590	SSU_rRNA_bacteria links to Rfam database...	0.31	0.31	0.31	138	1119315	322	37	266	19	314
CRW_00591	SSU_rRNA_bacteria links to Rfam database...	0.37	0.38	0.37	168	1098447	302	42	246	14	278
CRW_00759	SSU_rRNA_eukarya links to Rfam database...	0.21	0.22	0.20	105	1636621	473	79	340	54	376
CRW_00763	SSU_rRNA_bacteria links to Rfam database...	0.22	0.21	0.22	95	1215590	376	51	284	41	351
CRW_00772	SSU_rRNA_bacteria links to Rfam database...	0.25	0.24	0.25	98	945608	317	41	253	23	306
CRW_00778	SSU_rRNA_bacteria links to Rfam database...	0.23	0.22	0.23	85	1201662	341	40	238	63	299
CRW_00789	SSU_rRNA_bacteria links to Rfam database...	0.36	0.36	0.36	161	1137337	307	44	244	19	286
CRW_00795	SSU_rRNA_bacteria links to Rfam database...	0.22	0.23	0.21	89	1152504	360	53	275	32	305
CRW_00800	SSU_rRNA_eukarya links to Rfam database...	0.48	0.47	0.48	223	1401508	313	43	201	69	247
CRW_00849	SSU_rRNA_bacteria links to Rfam database...	0.48	0.48	0.48	225	1117795	263	20	220	23	245
CRW_00997	SSU_rRNA_bacteria links to Rfam database...	0.62	0.61	0.62	282	1135826	195	25	145	25	182
CRW_01153	SSU_rRNA_eukarya links to Rfam database...	0.30	0.30	0.30	149	1606023	407	50	306	51	354
CRW_01171	SSU_rRNA_eukarya links to Rfam database...	0.26	0.27	0.25	136	1593470	434	80	319	35	370
CRW_01343	SSU_rRNA_archaea links to Rfam database...	0.37	0.37	0.38	160	977476	278	42	223	13	274
PDB_00703	SSU_rRNA_bacteria links to Rfam database...	0.48	0.46	0.51	228	1073395	247	19	203	25	267
PDB_00854	SSU_rRNA_bacteria links to Rfam database...	0.52	0.51	0.53	274	1500261	287	30	213	44	261
PDB_01088	SSU_rRNA_bacteria links to Rfam database...	0.37	0.36	0.38	196	1470957	345	47	270	28	351
PDB_01103	SSU_rRNA_bacteria links to Rfam database...	0.54	0.52	0.55	295	1605991	270	35	207	28	267
PDB_01105	SSU_rRNA_bacteria links to Rfam database...	0.48	0.47	0.49	254	1433456	289	27	234	28	286
PDB_01120	SSU_rRNA_bacteria links to Rfam database...	0.45	0.43	0.47	228	1204646	269	31	223	15	299
PDB_01273	SSU_rRNA_bacteria links to Rfam database...	0.49	0.47	0.50	232	1117800	256	26	202	28	259

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of RNAalifold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for RNAalifold(seed)

2. Individual counts for RNAalifold(seed) [ download as .csv ]

Performance of RNAfold - scored lower in this pairwise comparison

1. Total counts & total scores for RNAfold

2. Individual counts for RNAfold [ download as .csv ]