CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	RNAalifold(seed)		UNAFold
MCC	0.744	>	0.443
Average MCC ± 95% Confidence Intervals	0.742 ± 0.039	>	0.444 ± 0.034
Sensitivity	0.678	>	0.438
Positive Predictive Value	0.818	>	0.449
Total TP	21759	>	14066
Total TN	85766748	>	85762027
Total FP	5870	<	19124
Total FP CONTRA	1107	<	2570
Total FP INCONS	3750	<	14701
Total FP COMP	1013	<	1853
Total FN	10343	<	18036
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of RNAalifold(seed) and UNAFold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNAalifold(seed) and UNAFold).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNAalifold(seed) and UNAFold).
Comparison of average Matthews Correlation Coefficients (MCCs) for RNAalifold(seed) and UNAFold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNAalifold(seed) and UNAFold).

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Performance of RNAalifold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for RNAalifold(seed)

Total Base Pair Counts
Total TP	21759
Total TN	85766748
Total FP	5870
Total FP CONTRA	1107
Total FP INCONS	3750
Total FP COMP	1013
Total FN	10343

Total Scores
MCC	0.744
Average MCC ± 95% Confidence Intervals	0.742 ± 0.039
Sensitivity	0.678
Positive Predictive Value	0.818
Nr of predictions	68

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2. Individual counts for RNAalifold(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00024	SSU_rRNA_archaea links to Rfam database...	0.87	0.84	0.90	385	1085175	58	7	34	17	73
CRW_00034	SSU_rRNA_bacteria links to Rfam database...	0.82	0.77	0.88	363	1141905	62	14	34	14	111
CRW_00048	SSU_rRNA_bacteria links to Rfam database...	0.84	0.79	0.88	372	1170793	59	16	34	9	98
CRW_00054	SSU_rRNA_bacteria links to Rfam database...	0.84	0.81	0.88	369	1107397	60	16	34	10	87
CRW_00059	SSU_rRNA_bacteria links to Rfam database...	0.82	0.78	0.88	367	1172327	61	16	36	9	106
CRW_00061	SSU_rRNA_bacteria links to Rfam database...	0.82	0.77	0.88	367	1181535	61	16	35	10	109
CRW_00068	SSU_rRNA_bacteria links to Rfam database...	0.85	0.81	0.88	370	1108886	58	15	34	9	87
CRW_00096	SSU_rRNA_bacteria links to Rfam database...	0.84	0.79	0.89	368	1178465	61	12	35	14	97
CRW_00140	SSU_rRNA_bacteria links to Rfam database...	0.83	0.79	0.87	367	1135858	62	16	37	9	96
CRW_00141	SSU_rRNA_bacteria links to Rfam database...	0.83	0.78	0.88	369	1201606	61	16	34	11	107
CRW_00150	SSU_rRNA_bacteria links to Rfam database...	0.85	0.79	0.91	368	1152515	47	13	25	9	98
CRW_00152	SSU_rRNA_bacteria links to Rfam database...	0.85	0.79	0.91	372	1180006	46	13	25	8	99
CRW_00166	SSU_rRNA_bacteria links to Rfam database...	0.83	0.78	0.88	365	1190782	64	12	37	15	103
CRW_00173	SSU_rRNA_bacteria links to Rfam database...	0.79	0.76	0.84	336	1082254	76	16	50	10	109
CRW_00177	SSU_rRNA_bacteria links to Rfam database...	0.82	0.77	0.87	364	1178460	66	16	40	10	109
CRW_00196	SSU_rRNA_bacteria links to Rfam database...	0.82	0.77	0.87	365	1207815	63	16	39	8	110
CRW_00230	SSU_rRNA_bacteria links to Rfam database...	0.83	0.77	0.88	369	1198508	59	15	34	10	109
CRW_00245	SSU_rRNA_bacteria links to Rfam database...	0.84	0.81	0.88	366	1105912	60	16	34	10	87
CRW_00248	SSU_rRNA_bacteria links to Rfam database...	0.82	0.76	0.88	369	1218720	61	16	36	9	115
CRW_00250	SSU_rRNA_bacteria links to Rfam database...	0.82	0.77	0.88	369	1198505	61	16	36	9	109
CRW_00256	SSU_rRNA_bacteria links to Rfam database...	0.85	0.79	0.91	369	1192333	48	13	25	10	99
CRW_00270	SSU_rRNA_bacteria links to Rfam database...	0.84	0.81	0.88	368	1111868	59	15	35	9	87
CRW_00271	SSU_rRNA_bacteria links to Rfam database...	0.83	0.78	0.90	359	1122350	51	13	29	9	103
CRW_00273	SSU_rRNA_bacteria links to Rfam database...	0.84	0.80	0.87	358	1085191	60	16	36	8	88
CRW_00275	SSU_rRNA_bacteria links to Rfam database...	0.84	0.80	0.88	366	1114854	59	16	35	8	91
CRW_00277	SSU_rRNA_bacteria links to Rfam database...	0.83	0.79	0.87	359	1110382	64	17	37	10	94
CRW_00278	SSU_rRNA_bacteria links to Rfam database...	0.83	0.78	0.88	349	1129861	58	13	33	12	101
CRW_00279	SSU_rRNA_bacteria links to Rfam database...	0.85	0.80	0.91	372	1180005	54	13	26	15	92
CRW_00280	SSU_rRNA_bacteria links to Rfam database...	0.84	0.80	0.89	363	1117851	59	13	33	13	90
CRW_00281	SSU_rRNA_bacteria links to Rfam database...	0.85	0.80	0.91	372	1144932	48	13	24	11	92
CRW_00283	SSU_rRNA_bacteria links to Rfam database...	0.80	0.75	0.85	323	1015644	67	14	44	9	109
CRW_00284	SSU_rRNA_bacteria links to Rfam database...	0.83	0.78	0.89	356	1131358	59	13	33	13	100
CRW_00285	SSU_rRNA_bacteria links to Rfam database...	0.82	0.78	0.86	356	1117847	66	17	40	9	102
CRW_00289	SSU_rRNA_bacteria links to Rfam database...	0.80	0.75	0.86	358	1189235	67	16	44	7	118
CRW_00292	SSU_rRNA_bacteria links to Rfam database...	0.77	0.71	0.84	329	1123856	76	14	51	11	132
CRW_00306	SSU_rRNA_eukarya links to Rfam database...	0.45	0.39	0.52	178	1445508	175	32	132	11	284
CRW_00326	SSU_rRNA_eukarya links to Rfam database...	0.44	0.37	0.53	184	1627762	174	32	132	10	318
CRW_00358	SSU_rRNA_eukarya links to Rfam database...	0.44	0.36	0.53	184	1675017	173	32	132	9	323
CRW_00366	SSU_rRNA_eukarya links to Rfam database...	0.42	0.36	0.51	172	1579413	180	32	136	12	310
CRW_00371	SSU_rRNA_eukarya links to Rfam database...	0.44	0.36	0.52	181	1611565	175	31	133	11	315
CRW_00372	SSU_rRNA_eukarya links to Rfam database...	0.44	0.37	0.53	184	1625958	174	32	132	10	314
CRW_00379	SSU_rRNA_eukarya links to Rfam database...	0.40	0.32	0.50	169	2126616	180	32	136	12	365
CRW_00386	SSU_rRNA_eukarya links to Rfam database...	0.44	0.35	0.55	182	1750923	164	28	123	13	333
CRW_00411	SSU_rRNA_eukarya links to Rfam database...	0.45	0.38	0.55	186	1615165	163	28	124	11	310
CRW_00414	SSU_rRNA_eukarya links to Rfam database...	0.45	0.37	0.54	182	1665890	171	28	125	18	313
CRW_00466	SSU_rRNA_bacteria links to Rfam database...	0.86	0.82	0.91	377	1116350	49	12	26	11	81
CRW_00589	SSU_rRNA_bacteria links to Rfam database...	0.86	0.81	0.92	361	1094068	53	6	25	22	84
CRW_00590	SSU_rRNA_bacteria links to Rfam database...	0.87	0.81	0.92	366	1119360	52	6	24	22	86
CRW_00591	SSU_rRNA_bacteria links to Rfam database...	0.87	0.82	0.92	365	1098507	56	8	23	25	81
CRW_00759	SSU_rRNA_eukarya links to Rfam database...	0.41	0.34	0.49	163	1636811	183	35	136	12	318
CRW_00763	SSU_rRNA_bacteria links to Rfam database...	0.85	0.78	0.92	348	1215641	59	6	25	28	98
CRW_00772	SSU_rRNA_bacteria links to Rfam database...	0.81	0.75	0.88	302	945656	72	5	37	30	102
CRW_00778	SSU_rRNA_bacteria links to Rfam database...	0.86	0.81	0.91	312	1201683	85	4	26	55	72
CRW_00789	SSU_rRNA_bacteria links to Rfam database...	0.85	0.79	0.91	355	1137395	59	8	28	23	92
CRW_00795	SSU_rRNA_bacteria links to Rfam database...	0.78	0.73	0.84	288	1152577	109	10	46	53	106
CRW_00800	SSU_rRNA_eukarya links to Rfam database...	0.42	0.33	0.52	156	1401675	160	25	119	16	314
CRW_00849	SSU_rRNA_bacteria links to Rfam database...	0.82	0.76	0.88	356	1117856	63	14	34	15	114
CRW_00997	SSU_rRNA_bacteria links to Rfam database...	0.84	0.80	0.88	372	1135856	59	15	35	9	92
CRW_01153	SSU_rRNA_eukarya links to Rfam database...	0.41	0.34	0.49	172	1606179	193	36	141	16	331
CRW_01171	SSU_rRNA_eukarya links to Rfam database...	0.43	0.36	0.52	181	1593657	177	34	133	10	325
CRW_01343	SSU_rRNA_archaea links to Rfam database...	0.83	0.79	0.88	344	977508	71	5	44	22	90
PDB_00703	SSU_rRNA_bacteria links to Rfam database...	0.78	0.69	0.87	344	1073448	73	7	46	20	151
PDB_00854	SSU_rRNA_bacteria links to Rfam database...	0.74	0.64	0.87	342	1500383	85	10	43	32	193
PDB_01088	SSU_rRNA_bacteria links to Rfam database...	0.73	0.63	0.86	342	1471073	85	8	47	30	205
PDB_01103	SSU_rRNA_bacteria links to Rfam database...	0.74	0.63	0.87	355	1606120	72	10	43	19	207
PDB_01105	SSU_rRNA_bacteria links to Rfam database...	0.76	0.66	0.88	355	1433566	72	7	43	22	185
PDB_01120	SSU_rRNA_bacteria links to Rfam database...	0.77	0.68	0.87	358	1204715	73	7	48	18	169
PDB_01273	SSU_rRNA_bacteria links to Rfam database...	0.78	0.70	0.86	346	1117856	80	13	45	22	145

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Performance of UNAFold - scored lower in this pairwise comparison

1. Total counts & total scores for UNAFold

Total Base Pair Counts
Total TP	14066
Total TN	85762027
Total FP	19124
Total FP CONTRA	2570
Total FP INCONS	14701
Total FP COMP	1853
Total FN	18036

Total Scores
MCC	0.443
Average MCC ± 95% Confidence Intervals	0.444 ± 0.034
Sensitivity	0.438
Positive Predictive Value	0.449
Nr of predictions	68

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2. Individual counts for UNAFold [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00024	SSU_rRNA_archaea links to Rfam database...	0.77	0.76	0.78	347	1085158	132	19	77	36	111
CRW_00034	SSU_rRNA_bacteria links to Rfam database...	0.64	0.64	0.64	303	1141840	196	31	142	23	171
CRW_00048	SSU_rRNA_bacteria links to Rfam database...	0.52	0.51	0.53	241	1170762	229	24	188	17	229
CRW_00054	SSU_rRNA_bacteria links to Rfam database...	0.44	0.43	0.44	195	1107376	258	28	217	13	261
CRW_00059	SSU_rRNA_bacteria links to Rfam database...	0.49	0.48	0.50	227	1172295	238	32	192	14	246
CRW_00061	SSU_rRNA_bacteria links to Rfam database...	0.51	0.51	0.52	241	1181493	233	41	178	14	235
CRW_00068	SSU_rRNA_bacteria links to Rfam database...	0.46	0.46	0.47	209	1108862	250	23	211	16	248
CRW_00096	SSU_rRNA_bacteria links to Rfam database...	0.55	0.54	0.55	250	1178428	227	29	173	25	215
CRW_00140	SSU_rRNA_bacteria links to Rfam database...	0.66	0.65	0.67	303	1135826	172	19	130	23	160
CRW_00141	SSU_rRNA_bacteria links to Rfam database...	0.58	0.58	0.59	275	1201557	219	25	168	26	201
CRW_00150	SSU_rRNA_bacteria links to Rfam database...	0.41	0.41	0.42	190	1152471	280	32	228	20	276
CRW_00152	SSU_rRNA_bacteria links to Rfam database...	0.65	0.63	0.66	299	1179965	174	29	123	22	172
CRW_00166	SSU_rRNA_bacteria links to Rfam database...	0.45	0.44	0.45	207	1190736	269	34	219	16	261
CRW_00173	SSU_rRNA_bacteria links to Rfam database...	0.28	0.28	0.29	126	1082215	327	39	276	12	319
CRW_00177	SSU_rRNA_bacteria links to Rfam database...	0.51	0.49	0.53	234	1178440	221	29	177	15	239
CRW_00196	SSU_rRNA_bacteria links to Rfam database...	0.45	0.44	0.45	211	1207765	281	32	227	22	264
CRW_00230	SSU_rRNA_bacteria links to Rfam database...	0.55	0.54	0.57	256	1198474	218	27	169	22	222
CRW_00245	SSU_rRNA_bacteria links to Rfam database...	0.36	0.36	0.37	163	1105885	293	45	235	13	290
CRW_00248	SSU_rRNA_bacteria links to Rfam database...	0.58	0.57	0.58	276	1218667	230	24	174	32	208
CRW_00250	SSU_rRNA_bacteria links to Rfam database...	0.39	0.39	0.39	186	1198451	301	43	246	12	292
CRW_00256	SSU_rRNA_bacteria links to Rfam database...	0.50	0.49	0.52	228	1192304	228	35	173	20	240
CRW_00270	SSU_rRNA_bacteria links to Rfam database...	0.47	0.45	0.48	207	1111853	250	29	197	24	248
CRW_00271	SSU_rRNA_bacteria links to Rfam database...	0.48	0.47	0.50	217	1122314	236	33	187	16	245
CRW_00273	SSU_rRNA_bacteria links to Rfam database...	0.51	0.50	0.52	222	1085175	222	28	176	18	224
CRW_00275	SSU_rRNA_bacteria links to Rfam database...	0.68	0.68	0.69	310	1114822	160	19	120	21	147
CRW_00277	SSU_rRNA_bacteria links to Rfam database...	0.35	0.34	0.35	154	1110361	293	42	238	13	299
CRW_00278	SSU_rRNA_bacteria links to Rfam database...	0.43	0.41	0.44	186	1129832	259	29	209	21	264
CRW_00279	SSU_rRNA_bacteria links to Rfam database...	0.44	0.42	0.45	197	1179977	258	31	211	16	267
CRW_00280	SSU_rRNA_bacteria links to Rfam database...	0.68	0.67	0.68	302	1117819	159	19	120	20	151
CRW_00281	SSU_rRNA_bacteria links to Rfam database...	0.65	0.63	0.67	291	1144909	165	18	123	24	173
CRW_00283	SSU_rRNA_bacteria links to Rfam database...	0.25	0.24	0.25	103	1015621	323	37	264	22	329
CRW_00284	SSU_rRNA_bacteria links to Rfam database...	0.29	0.28	0.29	129	1131319	325	39	273	13	327
CRW_00285	SSU_rRNA_bacteria links to Rfam database...	0.75	0.74	0.76	338	1117818	130	22	82	26	120
CRW_00289	SSU_rRNA_bacteria links to Rfam database...	0.44	0.43	0.45	203	1189200	274	30	220	24	273
CRW_00292	SSU_rRNA_bacteria links to Rfam database...	0.41	0.40	0.43	184	1123823	255	41	202	12	277
CRW_00306	SSU_rRNA_eukarya links to Rfam database...	0.16	0.16	0.16	76	1445368	444	67	339	38	386
CRW_00326	SSU_rRNA_eukarya links to Rfam database...	0.35	0.35	0.35	176	1627600	377	65	269	43	326
CRW_00358	SSU_rRNA_eukarya links to Rfam database...	0.39	0.39	0.39	200	1674848	370	67	250	53	307
CRW_00366	SSU_rRNA_eukarya links to Rfam database...	0.33	0.35	0.32	167	1579237	391	83	266	42	315
CRW_00371	SSU_rRNA_eukarya links to Rfam database...	0.31	0.32	0.30	159	1611384	399	75	292	32	337
CRW_00372	SSU_rRNA_eukarya links to Rfam database...	0.36	0.36	0.36	180	1625800	366	59	267	40	318
CRW_00379	SSU_rRNA_eukarya links to Rfam database...	0.40	0.40	0.39	215	2126404	429	56	278	95	319
CRW_00386	SSU_rRNA_eukarya links to Rfam database...	0.25	0.27	0.24	137	1750675	476	78	366	32	378
CRW_00411	SSU_rRNA_eukarya links to Rfam database...	0.27	0.28	0.27	138	1614990	413	60	315	38	358
CRW_00414	SSU_rRNA_eukarya links to Rfam database...	0.30	0.31	0.29	154	1665688	426	77	306	43	341
CRW_00466	SSU_rRNA_bacteria links to Rfam database...	0.59	0.58	0.61	265	1116332	195	23	145	27	193
CRW_00589	SSU_rRNA_bacteria links to Rfam database...	0.28	0.27	0.29	121	1094037	315	38	264	13	324
CRW_00590	SSU_rRNA_bacteria links to Rfam database...	0.35	0.34	0.37	153	1119337	287	30	236	21	299
CRW_00591	SSU_rRNA_bacteria links to Rfam database...	0.56	0.54	0.58	243	1098483	208	22	155	31	203
CRW_00759	SSU_rRNA_eukarya links to Rfam database...	0.23	0.24	0.22	117	1636617	466	66	345	55	364
CRW_00763	SSU_rRNA_bacteria links to Rfam database...	0.29	0.27	0.30	122	1215612	330	26	260	44	324
CRW_00772	SSU_rRNA_bacteria links to Rfam database...	0.25	0.25	0.26	101	945612	317	39	248	30	303
CRW_00778	SSU_rRNA_bacteria links to Rfam database...	0.32	0.32	0.33	123	1201647	309	46	209	54	261
CRW_00789	SSU_rRNA_bacteria links to Rfam database...	0.34	0.33	0.34	147	1137356	300	35	248	17	300
CRW_00795	SSU_rRNA_bacteria links to Rfam database...	0.19	0.20	0.19	78	1152508	377	53	282	42	316
CRW_00800	SSU_rRNA_eukarya links to Rfam database...	0.51	0.51	0.52	238	1401519	271	33	185	53	232
CRW_00849	SSU_rRNA_bacteria links to Rfam database...	0.48	0.48	0.49	225	1117800	258	25	210	23	245
CRW_00997	SSU_rRNA_bacteria links to Rfam database...	0.59	0.58	0.61	268	1135838	197	24	148	25	196
CRW_01153	SSU_rRNA_eukarya links to Rfam database...	0.25	0.25	0.25	128	1606016	421	65	319	37	375
CRW_01171	SSU_rRNA_eukarya links to Rfam database...	0.24	0.24	0.24	123	1593484	433	84	314	35	383
CRW_01343	SSU_rRNA_archaea links to Rfam database...	0.35	0.35	0.35	151	977475	287	44	231	12	283
PDB_00703	SSU_rRNA_bacteria links to Rfam database...	0.54	0.52	0.57	258	1073389	221	20	178	23	237
PDB_00854	SSU_rRNA_bacteria links to Rfam database...	0.54	0.53	0.54	285	1500255	284	22	216	46	250
PDB_01088	SSU_rRNA_bacteria links to Rfam database...	0.39	0.37	0.41	202	1470973	322	44	251	27	345
PDB_01103	SSU_rRNA_bacteria links to Rfam database...	0.59	0.58	0.60	324	1605991	243	32	181	30	238
PDB_01105	SSU_rRNA_bacteria links to Rfam database...	0.60	0.58	0.61	315	1433457	227	14	185	28	225
PDB_01120	SSU_rRNA_bacteria links to Rfam database...	0.47	0.44	0.50	232	1204667	242	27	202	13	295
PDB_01273	SSU_rRNA_bacteria links to Rfam database...	0.50	0.48	0.53	235	1117815	238	14	196	28	256

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of RNAalifold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for RNAalifold(seed)

2. Individual counts for RNAalifold(seed) [ download as .csv ]

Performance of UNAFold - scored lower in this pairwise comparison

1. Total counts & total scores for UNAFold

2. Individual counts for UNAFold [ download as .csv ]