CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of RNAfold - scored higher in this pairwise comparison

  4. Performance of Mastr(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for RNAfold & Mastr(seed) [.zip] - may take several seconds...


Overview

Metric RNAfold Mastr(seed)
MCC 0.385 > 0.000
Average MCC ± 95% Confidence Intervals 0.383 ± 0.281 > 0.000 ± 0.000
Sensitivity 0.389 > 0.000
Positive Predictive Value 0.381 > 0.000
Total TP 571 > 0
Total TN 4973278 < 4974778
Total FP 1149 > 0
Total FP CONTRA 169 > 0
Total FP INCONS 760 > 0
Total FP COMP 220 > 0
Total FN 895 < 1466
P-value 0.0

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Performance plots


  1. Comparison of performance of RNAfold and Mastr(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNAfold and Mastr(seed)).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNAfold and Mastr(seed)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for RNAfold and Mastr(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNAfold and Mastr(seed)).

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Performance of RNAfold - scored higher in this pairwise comparison

1. Total counts & total scores for RNAfold

Total Base Pair Counts
Total TP 571
Total TN 4973278
Total FP 1149
Total FP CONTRA 169
Total FP INCONS 760
Total FP COMP 220
Total FN 895
Total Scores
MCC 0.385
Average MCC ± 95% Confidence Intervals 0.383 ± 0.281
Sensitivity 0.389
Positive Predictive Value 0.381
Nr of predictions 3

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2. Individual counts for RNAfold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
CRW_00306 0.26 0.26 0.25 121 1445372 410 63 294 53 341
CRW_00379 0.42 0.43 0.41 227 2126398 426 63 265 98 307
CRW_00800 0.48 0.47 0.48 223 1401508 313 43 201 69 247

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Performance of Mastr(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Mastr(seed)

Total Base Pair Counts
Total TP 0
Total TN 4974778
Total FP 0
Total FP CONTRA 0
Total FP INCONS 0
Total FP COMP 0
Total FN 1466
Total Scores
MCC 0.000
Average MCC ± 95% Confidence Intervals 0.000 ± 0.000
Sensitivity 0.000
Positive Predictive Value 0.000
Nr of predictions 3

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2. Individual counts for Mastr(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
CRW_00306 0.00 0.00 0.00 0 1445850 0 0 0 0 462
CRW_00379 0.00 0.00 0.00 0 2126953 0 0 0 0 534
CRW_00800 0.00 0.00 0.00 0 1401975 0 0 0 0 470

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.