CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	RSpredict(20)		RSpredict(seed)
MCC	0.586	>	0.529
Average MCC ± 95% Confidence Intervals	0.589 ± 0.064	>	0.526 ± 0.068
Sensitivity	0.527	>	0.448
Positive Predictive Value	0.652	>	0.626
Total TP	13031	>	11082
Total TN	65505129	<	65507413
Total FP	8413	>	7941
Total FP CONTRA	1192	>	1087
Total FP INCONS	5771	>	5541
Total FP COMP	1450	>	1313
Total FN	11716	<	13665
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of RSpredict(20) and RSpredict(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RSpredict(20) and RSpredict(seed)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RSpredict(20) and RSpredict(seed)).
Comparison of average Matthews Correlation Coefficients (MCCs) for RSpredict(20) and RSpredict(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RSpredict(20) and RSpredict(seed)).

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Performance of RSpredict(20) - scored higher in this pairwise comparison

1. Total counts & total scores for RSpredict(20)

Total Base Pair Counts
Total TP	13031
Total TN	65505129
Total FP	8413
Total FP CONTRA	1192
Total FP INCONS	5771
Total FP COMP	1450
Total FN	11716

Total Scores
MCC	0.586
Average MCC ± 95% Confidence Intervals	0.589 ± 0.064
Sensitivity	0.527
Positive Predictive Value	0.652
Nr of predictions	52

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2. Individual counts for RSpredict(20) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00024	SSU_rRNA_archaea links to Rfam database...	0.78	0.76	0.80	349	1085166	117	16	70	31	109
CRW_00048	SSU_rRNA_bacteria links to Rfam database...	0.74	0.71	0.78	332	1170788	124	21	74	29	138
CRW_00054	SSU_rRNA_bacteria links to Rfam database...	0.72	0.68	0.76	308	1107412	121	17	79	25	148
CRW_00059	SSU_rRNA_bacteria links to Rfam database...	0.73	0.68	0.78	320	1172336	118	19	71	28	153
CRW_00061	SSU_rRNA_bacteria links to Rfam database...	0.63	0.55	0.72	260	1181590	123	18	85	20	216
CRW_00068	SSU_rRNA_bacteria links to Rfam database...	0.73	0.69	0.77	314	1108895	119	18	78	23	143
CRW_00096	SSU_rRNA_bacteria links to Rfam database...	0.73	0.69	0.78	320	1178470	123	16	74	33	145
CRW_00140	SSU_rRNA_bacteria links to Rfam database...	0.73	0.68	0.79	316	1135876	116	15	71	30	147
CRW_00141	SSU_rRNA_bacteria links to Rfam database...	0.72	0.67	0.77	320	1201607	124	19	79	26	156
CRW_00150	SSU_rRNA_bacteria links to Rfam database...	0.73	0.68	0.79	315	1152520	110	20	66	24	151
CRW_00152	SSU_rRNA_bacteria links to Rfam database...	0.71	0.65	0.77	308	1180015	120	17	76	27	163
CRW_00166	SSU_rRNA_bacteria links to Rfam database...	0.73	0.68	0.79	317	1190796	115	15	68	32	151
CRW_00173	SSU_rRNA_bacteria links to Rfam database...	0.68	0.63	0.74	281	1082274	126	20	81	25	164
CRW_00177	SSU_rRNA_bacteria links to Rfam database...	0.66	0.60	0.74	283	1178495	122	22	80	20	190
CRW_00196	SSU_rRNA_bacteria links to Rfam database...	0.71	0.67	0.76	316	1207819	125	23	77	25	159
CRW_00230	SSU_rRNA_bacteria links to Rfam database...	0.72	0.67	0.77	319	1198513	119	20	74	25	159
CRW_00245	SSU_rRNA_bacteria links to Rfam database...	0.70	0.63	0.78	285	1105963	105	14	66	25	168
CRW_00248	SSU_rRNA_bacteria links to Rfam database...	0.71	0.67	0.76	322	1218719	127	19	81	27	162
CRW_00250	SSU_rRNA_bacteria links to Rfam database...	0.72	0.66	0.78	317	1198517	119	19	73	27	161
CRW_00256	SSU_rRNA_bacteria links to Rfam database...	0.71	0.62	0.81	292	1192380	91	18	50	23	176
CRW_00270	SSU_rRNA_bacteria links to Rfam database...	0.68	0.60	0.77	272	1111934	101	13	67	21	183
CRW_00271	SSU_rRNA_bacteria links to Rfam database...	0.70	0.65	0.75	301	1122349	125	21	80	24	161
CRW_00273	SSU_rRNA_bacteria links to Rfam database...	0.67	0.60	0.76	266	1085250	106	16	69	21	180
CRW_00275	SSU_rRNA_bacteria links to Rfam database...	0.73	0.69	0.77	315	1114864	116	18	74	24	142
CRW_00277	SSU_rRNA_bacteria links to Rfam database...	0.62	0.54	0.71	244	1110451	120	17	83	20	209
CRW_00280	SSU_rRNA_bacteria links to Rfam database...	0.71	0.66	0.75	300	1117861	125	19	80	26	153
CRW_00281	SSU_rRNA_bacteria links to Rfam database...	0.72	0.67	0.77	311	1144937	123	15	78	30	153
CRW_00289	SSU_rRNA_bacteria links to Rfam database...	0.70	0.66	0.76	312	1189241	126	19	81	26	164
CRW_00306	SSU_rRNA_eukarya links to Rfam database...	0.37	0.34	0.39	158	1445446	293	34	212	47	304
CRW_00366	SSU_rRNA_eukarya links to Rfam database...	0.01	0.01	0.01	4	1579393	371	66	290	15	478
CRW_00371	SSU_rRNA_eukarya links to Rfam database...	0.02	0.02	0.02	8	1611495	424	63	344	17	488
CRW_00379	SSU_rRNA_eukarya links to Rfam database...	0.00	0.00	0.00	0	2126541	465	66	346	53	534
CRW_00411	SSU_rRNA_eukarya links to Rfam database...	0.00	0.00	0.00	0	1615135	382	74	294	14	496
CRW_00414	SSU_rRNA_eukarya links to Rfam database...	0.33	0.31	0.36	152	1665808	305	45	220	40	343
CRW_00466	SSU_rRNA_bacteria links to Rfam database...	0.64	0.56	0.73	258	1116413	115	15	79	21	200
CRW_00589	SSU_rRNA_bacteria links to Rfam database...	0.64	0.55	0.75	244	1094136	105	9	71	25	201
CRW_00590	SSU_rRNA_bacteria links to Rfam database...	0.63	0.55	0.73	249	1119415	115	6	86	23	203
CRW_00591	SSU_rRNA_bacteria links to Rfam database...	0.70	0.63	0.76	283	1098533	118	13	74	31	163
CRW_00759	SSU_rRNA_eukarya links to Rfam database...	0.02	0.02	0.02	9	1636732	429	64	340	25	472
CRW_00789	SSU_rRNA_bacteria links to Rfam database...	0.65	0.57	0.75	254	1137446	113	13	73	27	193
CRW_00795	SSU_rRNA_bacteria links to Rfam database...	0.63	0.53	0.75	209	1152644	114	10	58	46	185
CRW_00849	SSU_rRNA_bacteria links to Rfam database...	0.61	0.51	0.72	241	1117925	111	14	80	17	229
CRW_00997	SSU_rRNA_bacteria links to Rfam database...	0.73	0.69	0.77	319	1135862	125	18	79	28	145
CRW_01153	SSU_rRNA_eukarya links to Rfam database...	0.35	0.31	0.40	155	1606145	262	44	184	34	348
CRW_01171	SSU_rRNA_eukarya links to Rfam database...	0.02	0.01	0.02	7	1593610	403	61	327	15	499
PDB_00703	SSU_rRNA_bacteria links to Rfam database...	0.67	0.60	0.75	297	1073447	132	13	88	31	198
PDB_00854	SSU_rRNA_bacteria links to Rfam database...	0.62	0.50	0.76	266	1500430	124	10	72	42	269
PDB_01088	SSU_rRNA_bacteria links to Rfam database...	0.62	0.49	0.77	268	1471123	123	8	71	44	279
PDB_01103	SSU_rRNA_bacteria links to Rfam database...	0.63	0.49	0.80	278	1606180	104	12	58	34	284
PDB_01105	SSU_rRNA_bacteria links to Rfam database...	0.61	0.50	0.75	270	1433609	124	8	84	32	270
PDB_01120	SSU_rRNA_bacteria links to Rfam database...	0.64	0.54	0.76	282	1204758	129	8	80	41	245
PDB_01273	SSU_rRNA_bacteria links to Rfam database...	0.69	0.62	0.77	305	1117865	121	14	76	31	186

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Performance of RSpredict(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for RSpredict(seed)

Total Base Pair Counts
Total TP	11082
Total TN	65507413
Total FP	7941
Total FP CONTRA	1087
Total FP INCONS	5541
Total FP COMP	1313
Total FN	13665

Total Scores
MCC	0.529
Average MCC ± 95% Confidence Intervals	0.526 ± 0.068
Sensitivity	0.448
Positive Predictive Value	0.626
Nr of predictions	52

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2. Individual counts for RSpredict(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00024	SSU_rRNA_archaea links to Rfam database...	0.78	0.76	0.80	346	1085169	116	15	71	30	112
CRW_00048	SSU_rRNA_bacteria links to Rfam database...	0.65	0.57	0.74	268	1170853	120	15	79	26	202
CRW_00054	SSU_rRNA_bacteria links to Rfam database...	0.66	0.59	0.75	269	1107457	114	15	75	24	187
CRW_00059	SSU_rRNA_bacteria links to Rfam database...	0.63	0.54	0.73	257	1172394	120	18	77	25	216
CRW_00061	SSU_rRNA_bacteria links to Rfam database...	0.62	0.54	0.72	258	1181594	124	19	82	23	218
CRW_00068	SSU_rRNA_bacteria links to Rfam database...	0.65	0.57	0.75	261	1108955	113	16	73	24	196
CRW_00096	SSU_rRNA_bacteria links to Rfam database...	0.66	0.57	0.75	267	1178524	119	14	75	30	198
CRW_00140	SSU_rRNA_bacteria links to Rfam database...	0.67	0.59	0.76	273	1135921	112	13	71	28	190
CRW_00141	SSU_rRNA_bacteria links to Rfam database...	0.63	0.55	0.72	260	1201662	126	16	87	23	216
CRW_00150	SSU_rRNA_bacteria links to Rfam database...	0.66	0.58	0.74	270	1152558	117	19	74	24	196
CRW_00152	SSU_rRNA_bacteria links to Rfam database...	0.63	0.54	0.74	252	1180075	110	15	74	21	219
CRW_00166	SSU_rRNA_bacteria links to Rfam database...	0.64	0.55	0.74	258	1190849	118	11	78	29	210
CRW_00173	SSU_rRNA_bacteria links to Rfam database...	0.62	0.55	0.71	243	1082316	119	17	80	22	202
CRW_00177	SSU_rRNA_bacteria links to Rfam database...	0.67	0.58	0.77	274	1178524	103	15	67	21	199
CRW_00196	SSU_rRNA_bacteria links to Rfam database...	0.63	0.54	0.73	257	1207883	117	16	79	22	218
CRW_00230	SSU_rRNA_bacteria links to Rfam database...	0.62	0.54	0.71	257	1198565	127	16	88	23	221
CRW_00245	SSU_rRNA_bacteria links to Rfam database...	0.63	0.55	0.72	248	1105984	121	17	79	25	205
CRW_00248	SSU_rRNA_bacteria links to Rfam database...	0.65	0.57	0.75	278	1218768	123	17	78	28	206
CRW_00250	SSU_rRNA_bacteria links to Rfam database...	0.67	0.60	0.74	285	1198543	124	18	80	26	193
CRW_00256	SSU_rRNA_bacteria links to Rfam database...	0.62	0.54	0.72	251	1192392	119	17	80	22	217
CRW_00270	SSU_rRNA_bacteria links to Rfam database...	0.64	0.56	0.74	255	1111941	113	15	75	23	200
CRW_00271	SSU_rRNA_bacteria links to Rfam database...	0.62	0.53	0.73	243	1122417	115	15	76	24	219
CRW_00273	SSU_rRNA_bacteria links to Rfam database...	0.64	0.56	0.73	250	1085260	113	15	76	22	196
CRW_00275	SSU_rRNA_bacteria links to Rfam database...	0.63	0.54	0.72	249	1114926	120	15	81	24	208
CRW_00277	SSU_rRNA_bacteria links to Rfam database...	0.61	0.52	0.72	235	1110468	113	17	75	21	218
CRW_00280	SSU_rRNA_bacteria links to Rfam database...	0.61	0.53	0.70	240	1117918	122	15	87	20	213
CRW_00281	SSU_rRNA_bacteria links to Rfam database...	0.65	0.56	0.74	260	1144991	117	12	78	27	204
CRW_00289	SSU_rRNA_bacteria links to Rfam database...	0.60	0.50	0.70	240	1189312	122	16	85	21	236
CRW_00306	SSU_rRNA_eukarya links to Rfam database...	0.00	0.00	0.00	0	1445558	306	53	239	14	462
CRW_00366	SSU_rRNA_eukarya links to Rfam database...	0.00	0.00	0.00	0	1579464	301	50	239	12	482
CRW_00371	SSU_rRNA_eukarya links to Rfam database...	0.00	0.00	0.00	0	1611598	319	50	262	7	496
CRW_00379	SSU_rRNA_eukarya links to Rfam database...	0.00	0.00	0.00	0	2126581	414	77	295	42	534
CRW_00411	SSU_rRNA_eukarya links to Rfam database...	0.00	0.00	0.00	0	1615206	309	45	252	12	496
CRW_00414	SSU_rRNA_eukarya links to Rfam database...	0.00	0.00	0.00	0	1665933	312	53	239	20	495
CRW_00466	SSU_rRNA_bacteria links to Rfam database...	0.64	0.55	0.74	252	1116423	114	13	77	24	206
CRW_00589	SSU_rRNA_bacteria links to Rfam database...	0.63	0.53	0.74	236	1094141	110	9	74	27	209
CRW_00590	SSU_rRNA_bacteria links to Rfam database...	0.64	0.54	0.76	245	1119432	103	8	71	24	207
CRW_00591	SSU_rRNA_bacteria links to Rfam database...	0.66	0.58	0.76	258	1098562	118	11	72	35	188
CRW_00759	SSU_rRNA_eukarya links to Rfam database...	0.00	0.00	0.00	1	1636859	310	50	235	25	480
CRW_00789	SSU_rRNA_bacteria links to Rfam database...	0.64	0.56	0.74	249	1137451	114	13	73	28	198
CRW_00795	SSU_rRNA_bacteria links to Rfam database...	0.58	0.47	0.72	184	1152666	117	7	64	46	210
CRW_00849	SSU_rRNA_bacteria links to Rfam database...	0.60	0.49	0.73	232	1117943	100	11	74	15	238
CRW_00997	SSU_rRNA_bacteria links to Rfam database...	0.63	0.55	0.72	256	1135921	123	14	87	22	208
CRW_01153	SSU_rRNA_eukarya links to Rfam database...	0.00	0.00	0.00	0	1606225	319	65	238	16	503
CRW_01171	SSU_rRNA_eukarya links to Rfam database...	0.00	0.00	0.00	0	1593701	318	50	254	14	506
PDB_00703	SSU_rRNA_bacteria links to Rfam database...	0.63	0.53	0.76	261	1073500	115	11	73	31	234
PDB_00854	SSU_rRNA_bacteria links to Rfam database...	0.60	0.48	0.76	259	1500435	126	9	75	42	276
PDB_01088	SSU_rRNA_bacteria links to Rfam database...	0.60	0.47	0.76	259	1471129	122	8	74	40	288
PDB_01103	SSU_rRNA_bacteria links to Rfam database...	0.60	0.47	0.76	266	1606178	119	12	72	35	296
PDB_01105	SSU_rRNA_bacteria links to Rfam database...	0.61	0.50	0.76	268	1433617	119	7	79	33	272
PDB_01120	SSU_rRNA_bacteria links to Rfam database...	0.64	0.53	0.78	280	1204768	120	9	71	40	247
PDB_01273	SSU_rRNA_bacteria links to Rfam database...	0.65	0.55	0.76	272	1117903	116	13	72	31	219

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of RSpredict(20) - scored higher in this pairwise comparison

1. Total counts & total scores for RSpredict(20)

2. Individual counts for RSpredict(20) [ download as .csv ]

Performance of RSpredict(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for RSpredict(seed)

2. Individual counts for RSpredict(seed) [ download as .csv ]