CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of UNAFold - scored higher in this pairwise comparison

  4. Performance of Mastr(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for UNAFold & Mastr(seed) [.zip] - may take several seconds...


Overview

Metric UNAFold Mastr(seed)
MCC 0.358 > 0.000
Average MCC ± 95% Confidence Intervals 0.357 ± 0.447 > 0.000 ± 0.000
Sensitivity 0.361 > 0.000
Positive Predictive Value 0.356 > 0.000
Total TP 529 > 0
Total TN 4973291 < 4974778
Total FP 1144 > 0
Total FP CONTRA 156 > 0
Total FP INCONS 802 > 0
Total FP COMP 186 > 0
Total FN 937 < 1466
P-value 0.0

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Performance plots


  1. Comparison of performance of UNAFold and Mastr(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for UNAFold and Mastr(seed)).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for UNAFold and Mastr(seed)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for UNAFold and Mastr(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for UNAFold and Mastr(seed)).

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Performance of UNAFold - scored higher in this pairwise comparison

1. Total counts & total scores for UNAFold

Total Base Pair Counts
Total TP 529
Total TN 4973291
Total FP 1144
Total FP CONTRA 156
Total FP INCONS 802
Total FP COMP 186
Total FN 937
Total Scores
MCC 0.358
Average MCC ± 95% Confidence Intervals 0.357 ± 0.447
Sensitivity 0.361
Positive Predictive Value 0.356
Nr of predictions 3

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2. Individual counts for UNAFold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
CRW_00306 0.16 0.16 0.16 76 1445368 444 67 339 38 386
CRW_00379 0.40 0.40 0.39 215 2126404 429 56 278 95 319
CRW_00800 0.51 0.51 0.52 238 1401519 271 33 185 53 232

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Performance of Mastr(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Mastr(seed)

Total Base Pair Counts
Total TP 0
Total TN 4974778
Total FP 0
Total FP CONTRA 0
Total FP INCONS 0
Total FP COMP 0
Total FN 1466
Total Scores
MCC 0.000
Average MCC ± 95% Confidence Intervals 0.000 ± 0.000
Sensitivity 0.000
Positive Predictive Value 0.000
Nr of predictions 3

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2. Individual counts for Mastr(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
CRW_00306 0.00 0.00 0.00 0 1445850 0 0 0 0 462
CRW_00379 0.00 0.00 0.00 0 2126953 0 0 0 0 534
CRW_00800 0.00 0.00 0.00 0 1401975 0 0 0 0 470

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.