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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Afold - scored higher in this pairwise comparison

  4. Performance of TurboFold(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for Afold & TurboFold(seed) [.zip] - may take several seconds...


Overview

Metric Afold TurboFold(seed)
MCC 0.665 > 0.539
Average MCC ± 95% Confidence Intervals 0.710 ± 0.398 > 0.558 ± 0.552
Sensitivity 0.684 > 0.537
Positive Predictive Value 0.657 > 0.554
Total TP 65 > 51
Total TN 6640 < 6647
Total FP 53 < 54
Total FP CONTRA 11 < 12
Total FP INCONS 23 < 29
Total FP COMP 19 > 13
Total FN 30 < 44
P-value 0.0

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Performance plots


  1. Comparison of performance of Afold and TurboFold(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Afold and TurboFold(seed)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for Afold and TurboFold(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Afold and TurboFold(seed)).

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Performance of Afold - scored higher in this pairwise comparison

1. Total counts & total scores for Afold

Total Base Pair Counts
Total TP 65
Total TN 6640
Total FP 53
Total FP CONTRA 11
Total FP INCONS 23
Total FP COMP 19
Total FN 30
Total Scores
MCC 0.665
Average MCC ± 95% Confidence Intervals 0.710 ± 0.398
Sensitivity 0.684
Positive Predictive Value 0.657
Nr of predictions 5

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2. Individual counts for Afold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2L94_A 1.00 1.00 1.00 18 339 1 0 0 1 0
2LC8_A 0.64 0.61 0.69 11 512 6 0 5 1 7
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
4A1C_2 0.19 0.25 0.15 5 4483 43 11 17 15 15
4ENB_A 0.81 0.73 0.92 11 460 3 0 1 2 4

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Performance of TurboFold(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for TurboFold(seed)

Total Base Pair Counts
Total TP 51
Total TN 6647
Total FP 54
Total FP CONTRA 12
Total FP INCONS 29
Total FP COMP 13
Total FN 44
Total Scores
MCC 0.539
Average MCC ± 95% Confidence Intervals 0.558 ± 0.552
Sensitivity 0.537
Positive Predictive Value 0.554
Nr of predictions 5

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2. Individual counts for TurboFold(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2L94_A 0.94 0.94 0.94 17 339 2 0 1 1 1
2LC8_A -0.03 0.00 0.00 0 513 15 3 12 0 18
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
4A1C_2 0.20 0.25 0.17 5 4486 37 9 16 12 15
4ENB_A 0.77 0.60 1.00 9 463 0 0 0 0 6

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.