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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Alterna - scored higher in this pairwise comparison

  4. Performance of TurboFold(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for Alterna & TurboFold(seed) [.zip] - may take several seconds...


Overview

Metric Alterna TurboFold(seed)
MCC 0.702 > 0.667
Average MCC ± 95% Confidence Intervals 0.712 ± 0.388 > 0.633 ± 0.723
Sensitivity 0.685 > 0.640
Positive Predictive Value 0.735 > 0.713
Total TP 61 > 57
Total TN 3201 < 3204
Total FP 23 < 24
Total FP CONTRA 5 = 5
Total FP INCONS 17 < 18
Total FP COMP 1 = 1
Total FN 28 < 32
P-value 0.0

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Performance plots


  1. Comparison of performance of Alterna and TurboFold(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Alterna and TurboFold(seed)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for Alterna and TurboFold(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Alterna and TurboFold(seed)).

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Performance of Alterna - scored higher in this pairwise comparison

1. Total counts & total scores for Alterna

Total Base Pair Counts
Total TP 61
Total TN 3201
Total FP 23
Total FP CONTRA 5
Total FP INCONS 17
Total FP COMP 1
Total FN 28
Total Scores
MCC 0.702
Average MCC ± 95% Confidence Intervals 0.712 ± 0.388
Sensitivity 0.685
Positive Predictive Value 0.735
Nr of predictions 4

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2. Individual counts for Alterna [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2L94_A 1.00 1.00 1.00 18 339 1 0 0 1 0
2LC8_A 0.47 0.44 0.53 8 513 7 0 7 0 10
3RKF_A 0.82 0.79 0.86 19 844 3 1 2 0 5
3SD1_A 0.55 0.55 0.57 16 1505 12 4 8 0 13

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Performance of TurboFold(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for TurboFold(seed)

Total Base Pair Counts
Total TP 57
Total TN 3204
Total FP 24
Total FP CONTRA 5
Total FP INCONS 18
Total FP COMP 1
Total FN 32
Total Scores
MCC 0.667
Average MCC ± 95% Confidence Intervals 0.633 ± 0.723
Sensitivity 0.640
Positive Predictive Value 0.713
Nr of predictions 4

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2. Individual counts for TurboFold(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2L94_A 0.94 0.94 0.94 17 339 2 0 1 1 1
2LC8_A -0.03 0.00 0.00 0 513 15 3 12 0 18
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.71 0.69 0.74 20 1506 7 2 5 0 9

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.