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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of CMfinder(20) - scored higher in this pairwise comparison

  4. Performance of NanoFolder - scored lower in this pairwise comparison

  5. Compile and download dataset for CMfinder(20) & NanoFolder [.zip] - may take several seconds...


Overview

Metric CMfinder(20) NanoFolder
MCC 0.629 > 0.218
Average MCC ± 95% Confidence Intervals 0.633 ± 0.829 > 0.218 ± 1.089
Sensitivity 0.522 > 0.275
Positive Predictive Value 0.766 > 0.190
Total TP 36 > 19
Total TN 5769 > 5716
Total FP 14 < 82
Total FP CONTRA 2 < 24
Total FP INCONS 9 < 57
Total FP COMP 3 > 1
Total FN 33 < 50
P-value 0.0

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Performance plots


  1. Comparison of performance of CMfinder(20) and NanoFolder. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for CMfinder(20) and NanoFolder).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for CMfinder(20) and NanoFolder. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for CMfinder(20) and NanoFolder).

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Performance of CMfinder(20) - scored higher in this pairwise comparison

1. Total counts & total scores for CMfinder(20)

Total Base Pair Counts
Total TP 36
Total TN 5769
Total FP 14
Total FP CONTRA 2
Total FP INCONS 9
Total FP COMP 3
Total FN 33
Total Scores
MCC 0.629
Average MCC ± 95% Confidence Intervals 0.633 ± 0.829
Sensitivity 0.522
Positive Predictive Value 0.766
Nr of predictions 2

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2. Individual counts for CMfinder(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J2L_3 0.57 0.50 0.65 17 2994 11 2 7 2 17
3ZEX_D 0.70 0.54 0.90 19 2775 3 0 2 1 16

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Performance of NanoFolder - scored lower in this pairwise comparison

1. Total counts & total scores for NanoFolder

Total Base Pair Counts
Total TP 19
Total TN 5716
Total FP 82
Total FP CONTRA 24
Total FP INCONS 57
Total FP COMP 1
Total FN 50
Total Scores
MCC 0.218
Average MCC ± 95% Confidence Intervals 0.218 ± 1.089
Sensitivity 0.275
Positive Predictive Value 0.190
Nr of predictions 2

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2. Individual counts for NanoFolder [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J2L_3 0.13 0.18 0.12 6 2969 46 14 31 1 28
3ZEX_D 0.30 0.37 0.27 13 2747 36 10 26 0 22

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.