CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Carnac(20) - scored higher in this pairwise comparison

  4. Performance of Carnac(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for Carnac(20) & Carnac(seed) [.zip] - may take several seconds...


Overview

Metric Carnac(20) Carnac(seed)
MCC 0.672 > 0.220
Average MCC ± 95% Confidence Intervals 0.588 ± 0.130 > 0.087 ± 0.125
Sensitivity 0.484 > 0.049
Positive Predictive Value 0.939 < 1.000
Total TP 278 > 28
Total TN 50490 < 50758
Total FP 46 > 1
Total FP CONTRA 4 > 0
Total FP INCONS 14 > 0
Total FP COMP 28 > 1
Total FN 296 < 546
P-value 4.89920829651e-08

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Performance plots


  1. Comparison of performance of Carnac(20) and Carnac(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Carnac(20) and Carnac(seed)).

  2. Comparison of performance of Carnac(20) and Carnac(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Carnac(20) and Carnac(seed)).

  3. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Carnac(20) and Carnac(seed)).

  4. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Carnac(20) and Carnac(seed)).

  5. Comparison of average Matthews Correlation Coefficients (MCCs) for Carnac(20) and Carnac(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Carnac(20) and Carnac(seed)).

  6. Comparison of average Matthews Correlation Coefficients (MCCs) for Carnac(20) and Carnac(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Carnac(20) and Carnac(seed)).

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Performance of Carnac(20) - scored higher in this pairwise comparison

1. Total counts & total scores for Carnac(20)

Total Base Pair Counts
Total TP 278
Total TN 50490
Total FP 46
Total FP CONTRA 4
Total FP INCONS 14
Total FP COMP 28
Total FN 296
Total Scores
MCC 0.672
Average MCC ± 95% Confidence Intervals 0.588 ± 0.130
Sensitivity 0.484
Positive Predictive Value 0.939
Nr of predictions 23

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2. Individual counts for Carnac(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2KDQ_B 0.77 0.60 1.00 6 168 0 0 0 0 4
2L94_A 0.00 0.00 0.00 0 357 0 0 0 0 18
2XKV_B 0.43 0.18 1.00 2 1833 1 0 0 1 9
2XXA_G 0.29 0.09 1.00 3 2042 0 0 0 0 32
3GX2_A 0.68 0.46 1.00 13 1436 0 0 0 0 15
3IVN_B 0.91 0.83 1.00 19 884 0 0 0 0 4
3IZF_C 0.91 0.83 1.00 29 2611 2 0 0 2 6
3JYX_4 0.76 0.58 1.00 7 4749 2 0 0 2 5
3JYX_3 0.83 0.80 0.86 12 2364 13 0 2 11 3
3LA5_A 0.91 0.84 1.00 21 933 0 0 0 0 4
3NPB_A 0.46 0.22 1.00 8 2270 3 0 0 3 29
3O58_3 0.60 0.36 1.00 8 4756 1 0 0 1 14
3O58_2 0.93 0.87 1.00 27 2727 2 0 0 2 4
3PDR_A 0.75 0.58 0.97 29 4810 3 1 0 2 21
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.72 0.55 0.94 16 1516 1 0 1 0 13
3ZEX_C 0.37 0.21 0.67 6 5365 4 1 2 1 23
4A1C_3 0.79 0.73 0.87 27 2732 5 0 4 1 10
4A1C_2 0.42 0.25 0.71 5 4509 3 0 2 1 15
4AOB_A 0.59 0.48 0.74 14 1418 6 2 3 1 15
4ENB_A 0.00 0.00 0.00 0 472 0 0 0 0 15
4ENC_A 0.00 0.00 0.00 0 496 0 0 0 0 15
4FRG_B 0.50 0.25 1.00 6 1196 0 0 0 0 18

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Performance of Carnac(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Carnac(seed)

Total Base Pair Counts
Total TP 28
Total TN 50758
Total FP 1
Total FP CONTRA 0
Total FP INCONS 0
Total FP COMP 1
Total FN 546
Total Scores
MCC 0.220
Average MCC ± 95% Confidence Intervals 0.087 ± 0.125
Sensitivity 0.049
Positive Predictive Value 1.000
Nr of predictions 23

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2. Individual counts for Carnac(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2KDQ_B 1.00 1.00 1.00 10 164 0 0 0 0 0
2L94_A 1.00 1.00 1.00 18 339 1 0 0 1 0
2XKV_B 0.00 0.00 0.00 0 1835 0 0 0 0 11
2XXA_G 0.00 0.00 0.00 0 2045 0 0 0 0 35
3GX2_A 0.00 0.00 0.00 0 1449 0 0 0 0 28
3IVN_B 0.00 0.00 0.00 0 903 0 0 0 0 23
3IZF_C 0.00 0.00 0.00 0 2640 0 0 0 0 35
3JYX_4 0.00 0.00 0.00 0 4756 0 0 0 0 12
3JYX_3 0.00 0.00 0.00 0 2378 0 0 0 0 15
3LA5_A 0.00 0.00 0.00 0 954 0 0 0 0 25
3NPB_A 0.00 0.00 0.00 0 2278 0 0 0 0 37
3O58_3 0.00 0.00 0.00 0 4764 0 0 0 0 22
3O58_2 0.00 0.00 0.00 0 2754 0 0 0 0 31
3PDR_A 0.00 0.00 0.00 0 4840 0 0 0 0 50
3RKF_A 0.00 0.00 0.00 0 866 0 0 0 0 24
3SD1_A 0.00 0.00 0.00 0 1533 0 0 0 0 29
3ZEX_C 0.00 0.00 0.00 0 5374 0 0 0 0 29
4A1C_3 0.00 0.00 0.00 0 2763 0 0 0 0 37
4A1C_2 0.00 0.00 0.00 0 4516 0 0 0 0 20
4AOB_A 0.00 0.00 0.00 0 1437 0 0 0 0 29
4ENB_A 0.00 0.00 0.00 0 472 0 0 0 0 15
4ENC_A 0.00 0.00 0.00 0 496 0 0 0 0 15
4FRG_B 0.00 0.00 0.00 0 1202 0 0 0 0 24

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.