CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Carnac(20) - scored higher in this pairwise comparison

  4. Performance of Murlet(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for Carnac(20) & Murlet(seed) [.zip] - may take several seconds...


Overview

Metric Carnac(20) Murlet(seed)
MCC 0.611 > 0.557
Average MCC ± 95% Confidence Intervals 0.529 ± 0.144 < 0.559 ± 0.058
Sensitivity 0.401 > 0.355
Positive Predictive Value 0.938 > 0.880
Total TP 183 > 162
Total TN 40056 < 40067
Total FP 24 < 34
Total FP CONTRA 4 = 4
Total FP INCONS 8 < 18
Total FP COMP 12 = 12
Total FN 273 < 294
P-value 3.33194562506e-08

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Performance plots


  1. Comparison of performance of Carnac(20) and Murlet(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Carnac(20) and Murlet(seed)).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Carnac(20) and Murlet(seed)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for Carnac(20) and Murlet(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Carnac(20) and Murlet(seed)).

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Performance of Carnac(20) - scored higher in this pairwise comparison

1. Total counts & total scores for Carnac(20)

Total Base Pair Counts
Total TP 183
Total TN 40056
Total FP 24
Total FP CONTRA 4
Total FP INCONS 8
Total FP COMP 12
Total FN 273
Total Scores
MCC 0.611
Average MCC ± 95% Confidence Intervals 0.529 ± 0.144
Sensitivity 0.401
Positive Predictive Value 0.938
Nr of predictions 19

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2. Individual counts for Carnac(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2KDQ_B 0.77 0.60 1.00 6 168 0 0 0 0 4
2L94_A 0.00 0.00 0.00 0 357 0 0 0 0 18
2XKV_B 0.43 0.18 1.00 2 1833 1 0 0 1 9
2XXA_G 0.29 0.09 1.00 3 2042 0 0 0 0 32
3GX2_A 0.68 0.46 1.00 13 1436 0 0 0 0 15
3IVN_B 0.91 0.83 1.00 19 884 0 0 0 0 4
3JYX_4 0.76 0.58 1.00 7 4749 2 0 0 2 5
3LA5_A 0.91 0.84 1.00 21 933 0 0 0 0 4
3NPB_A 0.46 0.22 1.00 8 2270 3 0 0 3 29
3O58_3 0.60 0.36 1.00 8 4756 1 0 0 1 14
3PDR_A 0.75 0.58 0.97 29 4810 3 1 0 2 21
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.72 0.55 0.94 16 1516 1 0 1 0 13
3ZEX_C 0.37 0.21 0.67 6 5365 4 1 2 1 23
4A1C_2 0.42 0.25 0.71 5 4509 3 0 2 1 15
4AOB_A 0.59 0.48 0.74 14 1418 6 2 3 1 15
4ENB_A 0.00 0.00 0.00 0 472 0 0 0 0 15
4ENC_A 0.00 0.00 0.00 0 496 0 0 0 0 15
4FRG_B 0.50 0.25 1.00 6 1196 0 0 0 0 18

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Performance of Murlet(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Murlet(seed)

Total Base Pair Counts
Total TP 162
Total TN 40067
Total FP 34
Total FP CONTRA 4
Total FP INCONS 18
Total FP COMP 12
Total FN 294
Total Scores
MCC 0.557
Average MCC ± 95% Confidence Intervals 0.559 ± 0.058
Sensitivity 0.355
Positive Predictive Value 0.880
Nr of predictions 19

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2. Individual counts for Murlet(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2KDQ_B 0.54 0.30 1.00 3 171 0 0 0 0 7
2L94_A 0.57 0.39 0.88 7 349 2 0 1 1 11
2XKV_B 0.60 0.36 1.00 4 1831 2 0 0 2 7
2XXA_G 0.41 0.17 1.00 6 2039 0 0 0 0 29
3GX2_A 0.70 0.50 1.00 14 1435 1 0 0 1 14
3IVN_B 0.62 0.52 0.75 12 887 4 2 2 0 11
3JYX_4 0.50 0.25 1.00 3 4753 4 0 0 4 9
3LA5_A 0.67 0.56 0.82 14 937 3 1 2 0 11
3NPB_A 0.59 0.35 1.00 13 2265 2 0 0 2 24
3O58_3 0.52 0.27 1.00 6 4758 1 0 0 1 16
3PDR_A 0.53 0.28 1.00 14 4826 0 0 0 0 36
3RKF_A 0.62 0.50 0.80 12 851 3 1 2 0 12
3SD1_A 0.56 0.38 0.85 11 1520 2 0 2 0 18
3ZEX_C 0.49 0.24 1.00 7 5367 0 0 0 0 22
4A1C_2 0.59 0.35 1.00 7 4509 0 0 0 0 13
4AOB_A 0.69 0.48 1.00 14 1423 1 0 0 1 15
4ENB_A 0.63 0.40 1.00 6 466 0 0 0 0 9
4ENC_A 0.63 0.40 1.00 6 490 0 0 0 0 9
4FRG_B 0.17 0.13 0.25 3 1190 9 0 9 0 21

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.