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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of CentroidAlifold(20) - scored higher in this pairwise comparison

  4. Performance of Multilign(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for CentroidAlifold(20) & Multilign(seed) [.zip] - may take several seconds...


Overview

Metric CentroidAlifold(20) Multilign(seed)
MCC 0.691 > 0.669
Average MCC ± 95% Confidence Intervals 0.606 ± 0.364 < 0.660 ± 0.301
Sensitivity 0.569 < 0.632
Positive Predictive Value 0.845 > 0.717
Total TP 82 < 91
Total TN 12212 > 12182
Total FP 20 < 38
Total FP CONTRA 2 < 16
Total FP INCONS 13 < 20
Total FP COMP 5 > 2
Total FN 62 > 53
P-value 0.0

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Performance plots


  1. Comparison of performance of CentroidAlifold(20) and Multilign(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for CentroidAlifold(20) and Multilign(seed)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for CentroidAlifold(20) and Multilign(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for CentroidAlifold(20) and Multilign(seed)).

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Performance of CentroidAlifold(20) - scored higher in this pairwise comparison

1. Total counts & total scores for CentroidAlifold(20)

Total Base Pair Counts
Total TP 82
Total TN 12212
Total FP 20
Total FP CONTRA 2
Total FP INCONS 13
Total FP COMP 5
Total FN 62
Total Scores
MCC 0.691
Average MCC ± 95% Confidence Intervals 0.606 ± 0.364
Sensitivity 0.569
Positive Predictive Value 0.845
Nr of predictions 6

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2. Individual counts for CentroidAlifold(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2L94_A 0.59 0.56 0.67 10 342 6 0 5 1 8
3J3E_8 0.00 0.00 0.00 0 2738 4 1 3 0 15
3RKF_A 0.86 0.75 1.00 18 848 0 0 0 0 6
3SD1_A 0.85 0.76 0.96 22 1510 1 0 1 0 7
3ZEX_C 0.44 0.31 0.64 9 5360 7 1 4 2 20
4AOB_A 0.89 0.79 1.00 23 1414 2 0 0 2 6

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Performance of Multilign(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Multilign(seed)

Total Base Pair Counts
Total TP 91
Total TN 12182
Total FP 38
Total FP CONTRA 16
Total FP INCONS 20
Total FP COMP 2
Total FN 53
Total Scores
MCC 0.669
Average MCC ± 95% Confidence Intervals 0.660 ± 0.301
Sensitivity 0.632
Positive Predictive Value 0.717
Nr of predictions 6

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2. Individual counts for Multilign(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2L94_A 0.97 0.94 1.00 17 340 0 0 0 0 1
3J3E_8 0.19 0.20 0.19 3 2726 13 8 5 0 12
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.66 0.66 0.68 19 1505 9 4 5 0 10
3ZEX_C 0.50 0.45 0.57 13 5351 11 3 7 1 16
4AOB_A 0.73 0.66 0.83 19 1414 5 1 3 1 10

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.