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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of CentroidFold - scored higher in this pairwise comparison

  4. Performance of MaxExpect - scored lower in this pairwise comparison

  5. Compile and download dataset for CentroidFold & MaxExpect [.zip] - may take several seconds...


Overview

Metric CentroidFold MaxExpect
MCC 0.693 > 0.660
Average MCC ± 95% Confidence Intervals 0.760 ± 0.050 > 0.723 ± 0.057
Sensitivity 0.679 > 0.677
Positive Predictive Value 0.708 > 0.644
Total TP 2777 > 2767
Total TN 2572113 > 2571739
Total FP 1581 < 2050
Total FP CONTRA 345 < 434
Total FP INCONS 798 < 1093
Total FP COMP 438 < 523
Total FN 1310 < 1320
P-value 3.56938820447e-08

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Performance plots


  1. Comparison of performance of CentroidFold and MaxExpect. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for CentroidFold and MaxExpect).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for CentroidFold and MaxExpect).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for CentroidFold and MaxExpect. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for CentroidFold and MaxExpect).

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Performance of CentroidFold - scored higher in this pairwise comparison

1. Total counts & total scores for CentroidFold

Total Base Pair Counts
Total TP 2777
Total TN 2572113
Total FP 1581
Total FP CONTRA 345
Total FP INCONS 798
Total FP COMP 438
Total FN 1310
Total Scores
MCC 0.693
Average MCC ± 95% Confidence Intervals 0.760 ± 0.050
Sensitivity 0.679
Positive Predictive Value 0.708
Nr of predictions 130

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2. Individual counts for CentroidFold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2KD8_A - 1.00 1.00 1.00 9 99 0 0 0 0 0
2KE6_A 1.00 1.00 1.00 18 449 1 0 0 1 0
2KPV_A - 0.96 0.92 1.00 12 201 0 0 0 0 1
2KRL_A - 0.91 0.87 0.95 20 2003 9 1 0 8 3
2KU0_A - 0.53 0.42 0.71 5 285 2 2 0 0 7
2KUR_A 1.00 1.00 1.00 19 448 0 0 0 0 0
2KUU_A 1.00 1.00 1.00 18 429 1 0 0 1 0
2KUV_A 1.00 1.00 1.00 19 420 0 0 0 0 0
2KUW_A 1.00 1.00 1.00 18 452 1 0 0 1 0
2KX8_A 1.00 1.00 1.00 16 355 0 0 0 0 0
2KXM_A - 1.00 1.00 1.00 8 141 0 0 0 0 0
2KZL_A - 1.00 1.00 1.00 13 507 1 0 0 1 0
2L1F_B 1.00 1.00 1.00 24 767 0 0 0 0 0
2L1F_A 1.00 1.00 1.00 23 740 0 0 0 0 0
2L2K_A - 1.00 1.00 1.00 17 332 0 0 0 0 0
2L3C_B - 1.00 1.00 1.00 14 225 0 0 0 0 0
2L3E_A - 1.00 1.00 1.00 12 228 1 0 0 1 0
2L3J_B 1.00 1.00 1.00 30 955 0 0 0 0 0
2L5Z_A - 1.00 1.00 1.00 9 102 0 0 0 0 0
2L94_A 0.94 0.94 0.94 17 339 2 0 1 1 1
2LA5_A - 0.77 0.71 0.83 5 269 2 0 1 1 2
2LBS_A - 1.00 1.00 1.00 14 193 0 0 0 0 0
2LC8_A 0.51 0.39 0.70 7 518 3 1 2 0 11
2LDL_A - 1.00 1.00 1.00 9 131 1 0 0 1 0
2LDT_A - 1.00 1.00 1.00 11 151 0 0 0 0 0
2LHP_A - 1.00 1.00 1.00 15 246 0 0 0 0 0
2LI4_A - 1.00 1.00 1.00 14 175 0 0 0 0 0
2LJJ_A - 1.00 1.00 1.00 7 123 3 0 0 3 0
2LK3_A - 1.00 1.00 1.00 9 91 0 0 0 0 0
2LKR_A - 0.88 0.86 0.89 25 2412 8 0 3 5 4
2LQZ_A - 1.00 1.00 1.00 8 124 2 0 0 2 0
2LU0_A - 0.93 0.88 1.00 14 424 0 0 0 0 2
2LWK_A - 1.00 1.00 1.00 11 196 1 0 0 1 0
2M58_A - -0.02 0.00 0.00 0 538 6 0 6 0 12
2RRC_A - 0.83 0.71 1.00 5 70 0 0 0 0 2
2WRQ_Y 1.00 1.00 1.00 9 1143 13 0 0 13 0
2WW9_D - 0.31 0.10 1.00 1 740 3 0 0 3 9
2WW9_E - 0.00 0.00 0.00 0 172 0 0 0 0 5
2WW9_F - 0.68 0.75 0.67 6 103 4 1 2 1 2
2WWQ_V 1.00 1.00 1.00 19 1185 3 0 0 3 0
2XKV_B 0.64 0.73 0.57 8 1821 27 0 6 21 3
2XQD_Y 0.83 0.81 0.85 17 1109 4 0 3 1 4
2XXA_G 0.13 0.11 0.17 4 2021 21 2 18 1 31
2Y8W_B - 1.00 1.00 1.00 6 82 1 0 0 1 0
2Y9C_V - 0.79 0.83 0.75 15 886 8 0 5 3 3
2YIE_Z - 0.53 0.63 0.45 5 591 6 4 2 0 3
2YIE_X - 1.00 1.00 1.00 7 537 3 0 0 3 0
3A2K_C 0.49 0.55 0.46 12 1082 14 3 11 0 10
3ADB_C - 0.98 0.97 1.00 32 1787 0 0 0 0 1
3AKZ_H 0.48 0.50 0.48 10 1106 13 3 8 2 10
3AM1_B - 0.74 0.76 0.73 22 1436 8 3 5 0 7
3AMU_B 0.81 0.79 0.83 15 1139 6 0 3 3 4
3GX2_A 0.94 0.89 1.00 25 1424 1 0 0 1 3
3IAB_R - 1.00 1.00 1.00 12 373 4 0 0 4 0
3IVN_B 0.91 0.83 1.00 19 884 0 0 0 0 4
3IWN_A 0.86 0.79 0.96 22 1449 1 0 1 0 6
3IYQ_A 0.29 0.39 0.22 20 22347 86 39 34 13 31
3IZ4_A 0.60 0.57 0.64 54 25451 38 16 15 7 41
3IZF_C 0.89 0.91 0.86 32 2603 11 0 5 6 3
3J0L_2 - 0.28 0.31 0.28 8 2221 24 2 19 3 18
3J0L_7 - -0.01 0.00 0.00 0 514 5 1 4 0 10
3J0L_h - 0.89 0.88 0.90 28 2109 5 0 3 2 4
3J0L_g - 0.00 0.00 0.00 0 176 0 0 0 0 2
3J0L_1 - 0.73 0.62 0.89 8 475 3 0 1 2 5
3J0L_a - 0.41 0.36 0.50 4 403 5 3 1 1 7
3J0L_8 - 1.00 1.00 1.00 7 69 0 0 0 0 0
3J16_L 0.59 0.57 0.63 12 1140 7 0 7 0 9
3J20_1 1.00 1.00 1.00 20 1092 2 0 0 2 0
3J20_0 0.54 0.57 0.52 12 1196 12 3 8 1 9
3J20_2 0.70 0.69 0.70 286 421962 177 23 97 57 126
3J2C_M - 0.60 0.60 0.60 58 39829 58 14 24 20 38
3J2C_O - 0.95 0.90 1.00 37 3950 6 0 0 6 4
3J2L_3 0.74 0.76 0.72 26 2984 15 1 9 5 8
3J3D_C 0.73 0.79 0.68 15 946 7 3 4 0 4
3J3E_8 0.12 0.13 0.13 2 2726 22 4 10 8 13
3J3E_7 0.61 0.59 0.65 20 2710 13 2 9 2 14
3J3F_8 0.36 0.47 0.28 9 4729 37 12 11 14 10
3J3F_7 0.84 0.86 0.82 31 2896 9 1 6 2 5
3J3V_B 0.72 0.74 0.71 20 2628 16 1 7 8 7
3JYV_7 0.92 0.85 1.00 17 1094 2 0 0 2 3
3JYX_3 0.35 0.47 0.27 7 2352 21 14 5 2 8
3JYX_4 0.41 0.58 0.29 7 4732 25 11 6 8 5
3KIY_A - 0.71 0.68 0.75 536 1485164 253 58 122 73 250
3KTW_C - 0.58 0.60 0.58 15 1754 18 1 10 7 10
3LA5_A 0.91 0.84 1.00 21 933 0 0 0 0 4
3NDB_M - 0.97 0.95 0.98 42 3671 6 0 1 5 2
3NKB_B - 0.66 0.68 0.65 13 715 7 0 7 0 6
3NMU_E - 1.00 1.00 1.00 3 213 3 0 0 3 0
3NPB_A 0.87 0.84 0.91 31 2244 8 1 2 5 6
3O58_2 0.95 0.94 0.97 29 2724 7 0 1 6 2
3O58_3 0.44 0.41 0.47 9 4745 11 1 9 1 13
3OVB_D - 1.00 1.00 1.00 11 215 1 0 0 1 0
3OVS_D - 1.00 1.00 1.00 12 204 0 0 0 0 0
3P22_G - 1.00 1.00 1.00 11 301 1 0 0 1 0
3PDR_A 0.88 0.86 0.90 43 4792 7 2 3 2 7
3R4F_A - 0.83 0.82 0.86 18 885 4 2 1 1 4
3R9X_C - 1.00 1.00 1.00 8 221 2 0 0 2 0
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.70 0.69 0.71 20 1505 8 4 4 0 9
3SIU_F - 0.93 0.88 1.00 7 138 0 0 0 0 1
3SN2_B 0.95 0.92 1.00 11 143 0 0 0 0 1
3TRZ_Z - 1.00 1.00 1.00 5 87 1 0 0 1 0
3TS0_U - 1.00 1.00 1.00 6 112 1 0 0 1 0
3TS2_V - 1.00 1.00 1.00 5 103 0 0 0 0 0
3U4M_B - 0.81 0.77 0.85 17 1256 5 0 3 2 5
3UZL_B 0.93 0.88 1.00 14 1279 7 0 0 7 2
3VJR_D - 1.00 1.00 1.00 12 239 0 0 0 0 0
3W1K_J 0.97 0.97 0.97 30 1647 1 1 0 0 1
3W3S_B 0.95 0.91 1.00 30 1959 1 0 0 1 3
3ZEX_C 0.48 0.34 0.67 10 5359 6 1 4 1 19
3ZEX_G - 0.45 0.44 0.47 20 6464 32 6 17 9 25
3ZEX_E - 0.00 0.00 0.00 0 8255 51 19 30 2 34
3ZEX_D 0.88 0.86 0.91 30 2763 8 0 3 5 5
3ZEX_B - 0.27 0.25 0.31 85 421074 210 38 155 17 261
3ZEX_H - 0.27 0.37 0.21 7 3591 27 16 11 0 12
3ZEX_F - 0.00 0.00 0.00 0 910 9 0 4 5 4
3ZND_W 0.24 0.38 0.16 3 1172 25 9 7 9 5
4A1C_3 0.80 0.78 0.83 29 2728 8 0 6 2 8
4A1C_2 0.22 0.25 0.19 5 4490 29 9 12 8 15
4A4U_A - 1.00 1.00 1.00 9 96 0 0 0 0 0
4AOB_A 0.50 0.48 0.54 14 1411 13 3 9 1 15
4ATO_G - 0.61 0.57 0.67 4 214 2 0 2 0 3
4ENB_A 0.85 0.73 1.00 11 461 1 0 0 1 4
4ENC_A 0.85 0.73 1.00 11 485 1 0 0 1 4
4FNJ_A - 0.91 0.83 1.00 10 240 0 0 0 0 2
4FRG_B 0.75 0.71 0.81 17 1181 4 3 1 0 7
4FRN_A 0.80 0.71 0.91 20 1826 2 1 1 0 8
4HXH_A - 1.00 1.00 1.00 6 89 0 0 0 0 0
4JF2_A 0.89 0.79 1.00 19 1063 0 0 0 0 5
4JRC_A - 0.38 0.41 0.39 7 604 11 0 11 0 10

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Performance of MaxExpect - scored lower in this pairwise comparison

1. Total counts & total scores for MaxExpect

Total Base Pair Counts
Total TP 2767
Total TN 2571739
Total FP 2050
Total FP CONTRA 434
Total FP INCONS 1093
Total FP COMP 523
Total FN 1320
Total Scores
MCC 0.660
Average MCC ± 95% Confidence Intervals 0.723 ± 0.057
Sensitivity 0.677
Positive Predictive Value 0.644
Nr of predictions 130

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2. Individual counts for MaxExpect [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2KD8_A - 1.00 1.00 1.00 9 99 0 0 0 0 0
2KE6_A 0.94 0.94 0.94 17 449 2 0 1 1 1
2KPV_A - 0.96 0.92 1.00 12 201 0 0 0 0 1
2KRL_A - 0.91 0.87 0.95 20 2003 9 1 0 8 3
2KU0_A - -0.04 0.00 0.00 0 283 9 1 8 0 12
2KUR_A 0.95 0.95 0.95 18 448 1 0 1 0 1
2KUU_A 0.94 0.94 0.94 17 429 2 0 1 1 1
2KUV_A 0.94 0.95 0.95 18 420 1 0 1 0 1
2KUW_A 0.94 0.94 0.94 17 452 2 0 1 1 1
2KX8_A 1.00 1.00 1.00 16 355 0 0 0 0 0
2KXM_A - 0.93 0.88 1.00 7 142 0 0 0 0 1
2KZL_A - 1.00 1.00 1.00 13 507 1 0 0 1 0
2L1F_B 1.00 1.00 1.00 24 767 0 0 0 0 0
2L1F_A 1.00 1.00 1.00 23 740 0 0 0 0 0
2L2K_A - 1.00 1.00 1.00 17 332 0 0 0 0 0
2L3C_B - 1.00 1.00 1.00 14 225 0 0 0 0 0
2L3E_A - 1.00 1.00 1.00 12 228 1 0 0 1 0
2L3J_B 1.00 1.00 1.00 30 955 0 0 0 0 0
2L5Z_A - 1.00 1.00 1.00 9 102 0 0 0 0 0
2L94_A 1.00 1.00 1.00 18 339 1 0 0 1 0
2LA5_A - 0.77 0.71 0.83 5 269 3 0 1 2 2
2LBS_A - 1.00 1.00 1.00 14 193 0 0 0 0 0
2LC8_A -0.03 0.00 0.00 0 513 15 3 12 0 18
2LDL_A - 1.00 1.00 1.00 9 131 1 0 0 1 0
2LDT_A - 1.00 1.00 1.00 11 151 0 0 0 0 0
2LHP_A - 1.00 1.00 1.00 15 246 0 0 0 0 0
2LI4_A - 1.00 1.00 1.00 14 175 0 0 0 0 0
2LJJ_A - 1.00 1.00 1.00 7 123 3 0 0 3 0
2LK3_A - 1.00 1.00 1.00 9 91 0 0 0 0 0
2LKR_A - 0.84 0.83 0.86 24 2412 11 0 4 7 5
2LQZ_A - 1.00 1.00 1.00 8 124 2 0 0 2 0
2LU0_A - 1.00 1.00 1.00 16 422 0 0 0 0 0
2LWK_A - 1.00 1.00 1.00 11 196 1 0 0 1 0
2M58_A - -0.02 0.00 0.00 0 531 13 0 13 0 12
2RRC_A - 0.83 0.71 1.00 5 70 0 0 0 0 2
2WRQ_Y 0.94 0.89 1.00 8 1144 14 0 0 14 1
2WW9_D - 0.08 0.10 0.08 1 729 15 2 9 4 9
2WW9_E - -0.03 0.00 0.00 0 168 5 0 4 1 5
2WW9_F - 0.64 0.75 0.60 6 102 4 1 3 0 2
2WWQ_V 0.97 0.95 1.00 18 1186 3 0 0 3 1
2XKV_B 0.64 0.73 0.57 8 1821 26 0 6 20 3
2XQD_Y 0.98 0.95 1.00 20 1109 1 0 0 1 1
2XXA_G 0.24 0.26 0.25 9 2009 28 1 26 1 26
2Y8W_B - 1.00 1.00 1.00 6 82 1 0 0 1 0
2Y9C_V - 0.79 0.83 0.75 15 886 8 0 5 3 3
2YIE_Z - -0.02 0.00 0.00 0 587 15 6 9 0 8
2YIE_X - 0.53 0.57 0.50 4 536 6 1 3 2 3
3A2K_C 0.47 0.50 0.46 11 1084 13 3 10 0 11
3ADB_C - 0.86 0.85 0.88 28 1787 4 0 4 0 5
3AKZ_H 1.00 1.00 1.00 20 1107 2 0 0 2 0
3AM1_B - 0.86 0.86 0.86 25 1437 4 0 4 0 4
3AMU_B 0.73 0.79 0.68 15 1135 10 0 7 3 4
3GX2_A 0.93 0.89 0.96 25 1423 2 1 0 1 3
3IAB_R - 1.00 1.00 1.00 12 373 0 0 0 0 0
3IVN_B 0.91 0.83 1.00 19 884 0 0 0 0 4
3IWN_A 0.80 0.79 0.81 22 1445 6 1 4 1 6
3IYQ_A 0.24 0.33 0.17 17 22342 96 41 40 15 34
3IZ4_A 0.61 0.61 0.62 58 25442 42 14 22 6 37
3IZF_C 0.89 0.91 0.86 32 2603 8 0 5 3 3
3J0L_2 - 0.30 0.31 0.31 8 2224 25 2 16 7 18
3J0L_7 - -0.02 0.00 0.00 0 507 12 3 9 0 10
3J0L_h - 0.93 0.88 1.00 28 2112 2 0 0 2 4
3J0L_g - -0.01 0.00 0.00 0 174 4 0 2 2 2
3J0L_1 - 0.83 0.77 0.91 10 473 4 0 1 3 3
3J0L_a - 0.39 0.36 0.44 4 402 6 4 1 1 7
3J0L_8 - 1.00 1.00 1.00 7 69 0 0 0 0 0
3J16_L 0.34 0.33 0.37 7 1140 12 0 12 0 14
3J20_1 0.75 0.75 0.75 15 1092 6 0 5 1 5
3J20_0 0.53 0.57 0.50 12 1195 13 2 10 1 9
3J20_2 0.60 0.63 0.58 258 421926 239 28 156 55 154
3J2C_M - 0.48 0.54 0.43 52 39804 88 29 40 19 44
3J2C_O - 0.74 0.71 0.78 29 3950 13 0 8 5 12
3J2L_3 0.80 0.82 0.78 28 2984 12 1 7 4 6
3J3D_C 0.47 0.53 0.43 10 945 13 5 8 0 9
3J3E_8 0.10 0.13 0.09 2 2719 32 5 16 11 13
3J3E_7 0.60 0.59 0.63 20 2709 14 2 10 2 14
3J3F_8 0.34 0.42 0.29 8 4733 39 10 10 19 11
3J3F_7 0.94 0.94 0.94 34 2898 4 1 1 2 2
3J3V_B 0.71 0.74 0.69 20 2627 17 2 7 8 7
3JYV_7 0.48 0.45 0.53 9 1094 9 3 5 1 11
3JYX_3 0.77 0.80 0.75 12 2362 24 0 4 20 3
3JYX_4 0.55 0.83 0.37 10 4729 34 14 3 17 2
3KIY_A - 0.67 0.68 0.66 531 1485073 336 81 195 60 255
3KTW_C - 0.72 0.72 0.72 18 1755 14 2 5 7 7
3LA5_A 0.91 0.84 1.00 21 933 0 0 0 0 4
3NDB_M - 0.94 0.93 0.95 41 3671 7 0 2 5 3
3NKB_B - 0.69 0.74 0.67 14 714 7 0 7 0 5
3NMU_E - -0.02 0.00 0.00 0 208 10 5 3 2 3
3NPB_A 0.77 0.73 0.82 27 2245 10 0 6 4 10
3O58_2 0.91 0.94 0.88 29 2721 11 0 4 7 2
3O58_3 0.40 0.50 0.33 11 4731 36 8 14 14 11
3OVB_D - 1.00 1.00 1.00 11 215 1 0 0 1 0
3OVS_D - 1.00 1.00 1.00 12 204 0 0 0 0 0
3P22_G - 1.00 1.00 1.00 11 301 0 0 0 0 0
3PDR_A 0.92 0.90 0.94 45 4792 5 1 2 2 5
3R4F_A - 1.00 1.00 1.00 22 884 1 0 0 1 0
3R9X_C - 1.00 1.00 1.00 8 221 2 0 0 2 0
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.70 0.69 0.71 20 1505 8 3 5 0 9
3SIU_F - 1.00 1.00 1.00 8 137 0 0 0 0 0
3SN2_B 1.00 1.00 1.00 12 142 0 0 0 0 0
3TRZ_Z - 1.00 1.00 1.00 5 87 1 0 0 1 0
3TS0_U - 1.00 1.00 1.00 6 112 1 0 0 1 0
3TS2_V - 1.00 1.00 1.00 5 103 0 0 0 0 0
3U4M_B - 0.58 0.59 0.59 13 1254 9 2 7 0 9
3UZL_B 1.00 1.00 1.00 16 1277 8 0 0 8 0
3VJR_D - 1.00 1.00 1.00 12 239 0 0 0 0 0
3W1K_J 0.97 0.97 0.97 30 1647 1 1 0 0 1
3W3S_B 0.97 0.94 1.00 31 1958 1 0 0 1 2
3ZEX_C 0.54 0.45 0.65 13 5354 17 2 5 10 16
3ZEX_G - 0.98 0.96 1.00 43 6464 17 0 0 17 2
3ZEX_E - -0.01 0.00 0.00 0 8252 54 21 31 2 34
3ZEX_D 0.82 0.77 0.87 27 2765 11 0 4 7 8
3ZEX_B - 0.37 0.39 0.35 134 420964 302 66 188 48 212
3ZEX_H - 0.26 0.37 0.19 7 3589 29 18 11 0 12
3ZEX_F - -0.01 0.00 0.00 0 908 11 2 4 5 4
3ZND_W 0.24 0.38 0.16 3 1172 25 9 7 9 5
4A1C_3 0.83 0.81 0.86 30 2728 7 0 5 2 7
4A1C_2 0.19 0.25 0.16 5 4484 41 10 17 14 15
4A4U_A - 1.00 1.00 1.00 9 96 0 0 0 0 0
4AOB_A 0.60 0.59 0.63 17 1410 11 4 6 1 12
4ATO_G - 0.45 0.43 0.50 3 214 3 3 0 0 4
4ENB_A 0.85 0.73 1.00 11 461 0 0 0 0 4
4ENC_A 0.36 0.33 0.42 5 484 8 0 7 1 10
4FNJ_A - 0.91 0.83 1.00 10 240 0 0 0 0 2
4FRG_B 0.29 0.25 0.35 6 1185 11 4 7 0 18
4FRN_A 0.51 0.46 0.57 13 1825 10 5 5 0 15
4HXH_A - 1.00 1.00 1.00 6 89 0 0 0 0 0
4JF2_A 0.89 0.79 1.00 19 1063 0 0 0 0 5
4JRC_A - 0.34 0.35 0.35 6 605 11 0 11 0 11

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.