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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of CentroidFold - scored higher in this pairwise comparison

  4. Performance of Vsfold5 - scored lower in this pairwise comparison

  5. Compile and download dataset for CentroidFold & Vsfold5 [.zip] - may take several seconds...


Overview

Metric CentroidFold Vsfold5
MCC 0.752 > 0.572
Average MCC ± 95% Confidence Intervals 0.769 ± 0.052 > 0.632 ± 0.063
Sensitivity 0.751 > 0.576
Positive Predictive Value 0.758 > 0.578
Total TP 1790 > 1373
Total TN 189883 > 189869
Total FP 835 < 1215
Total FP CONTRA 196 < 294
Total FP INCONS 375 < 708
Total FP COMP 264 > 213
Total FN 593 < 1010
P-value 3.56938820447e-08

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Performance plots


  1. Comparison of performance of CentroidFold and Vsfold5. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for CentroidFold and Vsfold5).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for CentroidFold and Vsfold5).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for CentroidFold and Vsfold5. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for CentroidFold and Vsfold5).

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Performance of CentroidFold - scored higher in this pairwise comparison

1. Total counts & total scores for CentroidFold

Total Base Pair Counts
Total TP 1790
Total TN 189883
Total FP 835
Total FP CONTRA 196
Total FP INCONS 375
Total FP COMP 264
Total FN 593
Total Scores
MCC 0.752
Average MCC ± 95% Confidence Intervals 0.769 ± 0.052
Sensitivity 0.751
Positive Predictive Value 0.758
Nr of predictions 124

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2. Individual counts for CentroidFold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2KD8_A - 1.00 1.00 1.00 9 99 0 0 0 0 0
2KE6_A 1.00 1.00 1.00 18 449 1 0 0 1 0
2KMJ_A - 1.00 1.00 1.00 11 157 0 0 0 0 0
2KPV_A - 0.96 0.92 1.00 12 201 0 0 0 0 1
2KRL_A - 0.91 0.87 0.95 20 2003 9 1 0 8 3
2KU0_A - 0.53 0.42 0.71 5 285 2 2 0 0 7
2KUR_A 1.00 1.00 1.00 19 448 0 0 0 0 0
2KUU_A 1.00 1.00 1.00 18 429 1 0 0 1 0
2KUV_A 1.00 1.00 1.00 19 420 0 0 0 0 0
2KUW_A 1.00 1.00 1.00 18 452 1 0 0 1 0
2KX8_A 1.00 1.00 1.00 16 355 0 0 0 0 0
2KXM_A - 1.00 1.00 1.00 8 141 0 0 0 0 0
2KZL_A - 1.00 1.00 1.00 13 507 1 0 0 1 0
2L1F_B 1.00 1.00 1.00 24 767 0 0 0 0 0
2L1F_A 1.00 1.00 1.00 23 740 0 0 0 0 0
2L2K_A - 1.00 1.00 1.00 17 332 0 0 0 0 0
2L3C_B - 1.00 1.00 1.00 14 225 0 0 0 0 0
2L3E_A - 1.00 1.00 1.00 12 228 1 0 0 1 0
2L3J_B 1.00 1.00 1.00 30 955 0 0 0 0 0
2L5Z_A - 1.00 1.00 1.00 9 102 0 0 0 0 0
2L94_A 0.94 0.94 0.94 17 339 2 0 1 1 1
2LA5_A - 0.77 0.71 0.83 5 269 2 0 1 1 2
2LBS_A - 1.00 1.00 1.00 14 193 0 0 0 0 0
2LC8_A 0.51 0.39 0.70 7 518 3 1 2 0 11
2LDL_A - 1.00 1.00 1.00 9 131 1 0 0 1 0
2LDT_A - 1.00 1.00 1.00 11 151 0 0 0 0 0
2LHP_A - 1.00 1.00 1.00 15 246 0 0 0 0 0
2LI4_A - 1.00 1.00 1.00 14 175 0 0 0 0 0
2LJJ_A - 1.00 1.00 1.00 7 123 3 0 0 3 0
2LK3_A - 1.00 1.00 1.00 9 91 0 0 0 0 0
2LKR_A - 0.88 0.86 0.89 25 2412 8 0 3 5 4
2LU0_A - 0.93 0.88 1.00 14 424 0 0 0 0 2
2LWK_A - 1.00 1.00 1.00 11 196 1 0 0 1 0
2M58_A - -0.02 0.00 0.00 0 538 6 0 6 0 12
2RPT_A - 1.00 1.00 1.00 7 65 0 0 0 0 0
2RRC_A - 0.83 0.71 1.00 5 70 0 0 0 0 2
2WRQ_Y 1.00 1.00 1.00 9 1143 13 0 0 13 0
2WW9_F - 0.68 0.75 0.67 6 103 4 1 2 1 2
2WW9_E - 0.00 0.00 0.00 0 172 0 0 0 0 5
2WW9_D - 0.31 0.10 1.00 1 740 3 0 0 3 9
2WWQ_V 1.00 1.00 1.00 19 1185 3 0 0 3 0
2XKV_B 0.64 0.73 0.57 8 1821 27 0 6 21 3
2XQD_Y 0.83 0.81 0.85 17 1109 4 0 3 1 4
2XXA_G 0.13 0.11 0.17 4 2021 21 2 18 1 31
2Y8W_B - 1.00 1.00 1.00 6 82 1 0 0 1 0
2Y9C_V - 0.79 0.83 0.75 15 886 8 0 5 3 3
2YIE_X - 1.00 1.00 1.00 7 537 3 0 0 3 0
2YIE_Z - 0.53 0.63 0.45 5 591 6 4 2 0 3
2ZZM_B 0.13 0.13 0.15 2 1345 20 3 8 9 13
2ZZN_D 0.93 0.95 0.91 21 961 3 2 0 1 1
3A2K_C 0.49 0.55 0.46 12 1082 14 3 11 0 10
3A3A_A 0.97 0.93 1.00 28 1472 0 0 0 0 2
3ADB_C - 0.98 0.97 1.00 32 1787 0 0 0 0 1
3AKZ_H 0.48 0.50 0.48 10 1106 13 3 8 2 10
3AM1_B - 0.74 0.76 0.73 22 1436 8 3 5 0 7
3AMU_B 0.81 0.79 0.83 15 1139 6 0 3 3 4
3GX2_A 0.94 0.89 1.00 25 1424 1 0 0 1 3
3IAB_R - 1.00 1.00 1.00 12 373 4 0 0 4 0
3ID5_D - -0.02 0.00 0.00 0 223 6 3 3 0 5
3IVN_B 0.91 0.83 1.00 19 884 0 0 0 0 4
3IWN_A 0.86 0.79 0.96 22 1449 1 0 1 0 6
3IYQ_A 0.29 0.39 0.22 20 22347 86 39 34 13 31
3IZ4_A 0.60 0.57 0.64 54 25451 38 16 15 7 41
3IZF_C 0.89 0.91 0.86 32 2603 11 0 5 6 3
3J0L_h - 0.89 0.88 0.90 28 2109 5 0 3 2 4
3J0L_1 - 0.73 0.62 0.89 8 475 3 0 1 2 5
3J0L_7 - -0.01 0.00 0.00 0 514 5 1 4 0 10
3J0L_g - 0.00 0.00 0.00 0 176 0 0 0 0 2
3J0L_8 - 1.00 1.00 1.00 7 69 0 0 0 0 0
3J0L_a - 0.41 0.36 0.50 4 403 5 3 1 1 7
3J0L_2 - 0.28 0.31 0.28 8 2221 24 2 19 3 18
3J16_L 0.59 0.57 0.63 12 1140 7 0 7 0 9
3J20_0 0.54 0.57 0.52 12 1196 12 3 8 1 9
3J20_1 1.00 1.00 1.00 20 1092 2 0 0 2 0
3J2C_O - 0.95 0.90 1.00 37 3950 6 0 0 6 4
3J2L_3 0.74 0.76 0.72 26 2984 15 1 9 5 8
3J3D_C 0.73 0.79 0.68 15 946 7 3 4 0 4
3J3E_7 0.61 0.59 0.65 20 2710 13 2 9 2 14
3J3E_8 0.12 0.13 0.13 2 2726 22 4 10 8 13
3J3F_8 0.36 0.47 0.28 9 4729 37 12 11 14 10
3J3F_7 0.84 0.86 0.82 31 2896 9 1 6 2 5
3J3V_B 0.72 0.74 0.71 20 2628 16 1 7 8 7
3JYV_7 0.92 0.85 1.00 17 1094 2 0 0 2 3
3JYX_4 0.41 0.58 0.29 7 4732 25 11 6 8 5
3JYX_3 0.35 0.47 0.27 7 2352 21 14 5 2 8
3KTW_C - 0.58 0.60 0.58 15 1754 18 1 10 7 10
3LA5_A 0.91 0.84 1.00 21 933 0 0 0 0 4
3NDB_M - 0.97 0.95 0.98 42 3671 6 0 1 5 2
3NKB_B - 0.66 0.68 0.65 13 715 7 0 7 0 6
3NMU_E - 1.00 1.00 1.00 3 213 3 0 0 3 0
3NPB_A 0.87 0.84 0.91 31 2244 8 1 2 5 6
3O58_3 0.44 0.41 0.47 9 4745 11 1 9 1 13
3O58_2 0.95 0.94 0.97 29 2724 7 0 1 6 2
3OVB_D - 1.00 1.00 1.00 11 215 1 0 0 1 0
3OVS_D - 1.00 1.00 1.00 12 204 0 0 0 0 0
3P22_G - 1.00 1.00 1.00 11 301 1 0 0 1 0
3PDR_A 0.88 0.86 0.90 43 4792 7 2 3 2 7
3R4F_A - 0.83 0.82 0.86 18 885 4 2 1 1 4
3R9X_C - 1.00 1.00 1.00 8 221 2 0 0 2 0
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.70 0.69 0.71 20 1505 8 4 4 0 9
3SIU_F - 0.93 0.88 1.00 7 138 0 0 0 0 1
3SN2_B 0.95 0.92 1.00 11 143 0 0 0 0 1
3TRZ_Z - 1.00 1.00 1.00 5 87 1 0 0 1 0
3TS0_U - 1.00 1.00 1.00 6 112 1 0 0 1 0
3TS2_V - 1.00 1.00 1.00 5 103 0 0 0 0 0
3U4M_B - 0.81 0.77 0.85 17 1256 5 0 3 2 5
3UZL_B 0.93 0.88 1.00 14 1279 7 0 0 7 2
3VJR_D - 1.00 1.00 1.00 12 239 0 0 0 0 0
3W3S_B 0.95 0.91 1.00 30 1959 1 0 0 1 3
3ZEX_E - 0.00 0.00 0.00 0 8255 51 19 30 2 34
3ZEX_D 0.88 0.86 0.91 30 2763 8 0 3 5 5
3ZND_W 0.24 0.38 0.16 3 1172 25 9 7 9 5
4A1C_3 0.80 0.78 0.83 29 2728 8 0 6 2 8
4A1C_2 0.22 0.25 0.19 5 4490 29 9 12 8 15
4A4U_A - 1.00 1.00 1.00 9 96 0 0 0 0 0
4AOB_A 0.50 0.48 0.54 14 1411 13 3 9 1 15
4ATO_G - 0.61 0.57 0.67 4 214 2 0 2 0 3
4ENB_A 0.85 0.73 1.00 11 461 1 0 0 1 4
4ENC_A 0.85 0.73 1.00 11 485 1 0 0 1 4
4FRG_B 0.75 0.71 0.81 17 1181 4 3 1 0 7
4FRN_A 0.80 0.71 0.91 20 1826 2 1 1 0 8
4JF2_A 0.89 0.79 1.00 19 1063 0 0 0 0 5
4JRC_A - 0.38 0.41 0.39 7 604 11 0 11 0 10

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Performance of Vsfold5 - scored lower in this pairwise comparison

1. Total counts & total scores for Vsfold5

Total Base Pair Counts
Total TP 1373
Total TN 189869
Total FP 1215
Total FP CONTRA 294
Total FP INCONS 708
Total FP COMP 213
Total FN 1010
Total Scores
MCC 0.572
Average MCC ± 95% Confidence Intervals 0.632 ± 0.063
Sensitivity 0.576
Positive Predictive Value 0.578
Nr of predictions 124

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2. Individual counts for Vsfold5 [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2KD8_A - 1.00 1.00 1.00 9 99 0 0 0 0 0
2KE6_A 1.00 1.00 1.00 18 449 1 0 0 1 0
2KMJ_A - 0.95 0.91 1.00 10 158 0 0 0 0 1
2KPV_A - 0.96 0.92 1.00 12 201 0 0 0 0 1
2KRL_A - 0.71 0.78 0.64 18 1996 13 8 2 3 5
2KU0_A - -0.04 0.00 0.00 0 281 11 0 11 0 12
2KUR_A 1.00 1.00 1.00 19 448 0 0 0 0 0
2KUU_A 1.00 1.00 1.00 18 429 1 0 0 1 0
2KUV_A 1.00 1.00 1.00 19 420 0 0 0 0 0
2KUW_A 1.00 1.00 1.00 18 452 1 0 0 1 0
2KX8_A 0.97 0.94 1.00 15 356 0 0 0 0 1
2KXM_A - 0.78 0.63 1.00 5 144 0 0 0 0 3
2KZL_A - 1.00 1.00 1.00 13 507 1 0 0 1 0
2L1F_B 0.71 0.63 0.83 15 773 3 0 3 0 9
2L1F_A 0.70 0.61 0.82 14 746 3 0 3 0 9
2L2K_A - 0.94 0.88 1.00 15 334 0 0 0 0 2
2L3C_B - 1.00 1.00 1.00 14 225 0 0 0 0 0
2L3E_A - 1.00 1.00 1.00 12 228 1 0 0 1 0
2L3J_B 0.93 0.87 1.00 26 959 0 0 0 0 4
2L5Z_A - 0.68 0.67 0.75 6 103 2 0 2 0 3
2L94_A 0.97 0.94 1.00 17 340 1 0 0 1 1
2LA5_A - -0.03 0.00 0.00 0 268 7 0 7 0 7
2LBS_A - 1.00 1.00 1.00 14 193 0 0 0 0 0
2LC8_A -0.03 0.00 0.00 0 515 13 0 13 0 18
2LDL_A - 0.94 0.89 1.00 8 132 1 0 0 1 1
2LDT_A - 1.00 1.00 1.00 11 151 0 0 0 0 0
2LHP_A - 1.00 1.00 1.00 15 246 0 0 0 0 0
2LI4_A - 1.00 1.00 1.00 14 175 0 0 0 0 0
2LJJ_A - 1.00 1.00 1.00 7 123 3 0 0 3 0
2LK3_A - 0.94 0.89 1.00 8 92 0 0 0 0 1
2LKR_A - 0.31 0.31 0.32 9 2412 19 5 14 0 20
2LU0_A - 0.68 0.63 0.77 10 425 3 0 3 0 6
2LWK_A - 0.95 0.91 1.00 10 197 1 0 0 1 1
2M58_A - 0.37 0.33 0.44 4 535 5 4 1 0 8
2RPT_A - 0.68 0.71 0.71 5 65 2 0 2 0 2
2RRC_A - 0.83 0.71 1.00 5 70 0 0 0 0 2
2WRQ_Y 0.94 0.89 1.00 8 1144 13 0 0 13 1
2WW9_F - 0.68 0.75 0.67 6 103 4 1 2 1 2
2WW9_E - -0.03 0.00 0.00 0 168 5 0 4 1 5
2WW9_D - 0.08 0.10 0.09 1 730 13 3 7 3 9
2WWQ_V 0.78 0.74 0.82 14 1187 4 1 2 1 5
2XKV_B -0.01 0.00 0.00 0 1803 32 17 15 0 11
2XQD_Y 0.95 0.90 1.00 19 1110 1 0 0 1 2
2XXA_G -0.02 0.00 0.00 0 2014 31 2 29 0 35
2Y8W_B - 1.00 1.00 1.00 6 82 1 0 0 1 0
2Y9C_V - 0.74 0.72 0.76 13 889 7 0 4 3 5
2YIE_X - 0.43 0.57 0.33 4 532 10 2 6 2 3
2YIE_Z - -0.02 0.00 0.00 0 591 11 5 6 0 8
2ZZM_B 0.17 0.20 0.16 3 1339 25 4 12 9 12
2ZZN_D 0.95 0.95 0.95 21 962 1 1 0 0 1
3A2K_C 0.95 0.91 1.00 20 1088 0 0 0 0 2
3A3A_A 0.95 0.90 1.00 27 1473 0 0 0 0 3
3ADB_C - 0.72 0.61 0.87 20 1796 3 0 3 0 13
3AKZ_H 0.97 0.95 1.00 19 1108 1 0 0 1 1
3AM1_B - 0.86 0.86 0.86 25 1437 4 3 1 0 4
3AMU_B 0.77 0.79 0.75 15 1137 8 0 5 3 4
3GX2_A 0.61 0.57 0.67 16 1425 9 0 8 1 12
3IAB_R - 1.00 1.00 1.00 12 373 0 0 0 0 0
3ID5_D - 0.59 0.60 0.60 3 224 4 0 2 2 2
3IVN_B 0.88 0.78 1.00 18 885 0 0 0 0 5
3IWN_A 0.26 0.25 0.30 7 1449 16 2 14 0 21
3IYQ_A 0.30 0.37 0.24 19 22361 71 36 24 11 32
3IZ4_A 0.31 0.31 0.33 29 25448 65 14 45 6 66
3IZF_C 0.85 0.83 0.88 29 2607 5 0 4 1 6
3J0L_h - 0.20 0.19 0.24 6 2115 19 3 16 0 26
3J0L_1 - 0.25 0.23 0.30 3 474 8 3 4 1 10
3J0L_7 - -0.02 0.00 0.00 0 506 13 3 10 0 10
3J0L_g - -0.01 0.00 0.00 0 174 4 0 2 2 2
3J0L_8 - 0.74 0.57 1.00 4 72 0 0 0 0 3
3J0L_a - 0.39 0.36 0.44 4 402 6 4 1 1 7
3J0L_2 - 0.42 0.42 0.44 11 2225 21 1 13 7 15
3J16_L 0.98 0.95 1.00 20 1139 0 0 0 0 1
3J20_0 0.76 0.76 0.76 16 1198 6 3 2 1 5
3J20_1 0.75 0.75 0.75 15 1092 7 0 5 2 5
3J2C_O - 0.33 0.32 0.36 13 3951 26 3 20 3 28
3J2L_3 0.70 0.71 0.71 24 2986 13 3 7 3 10
3J3D_C 0.63 0.68 0.59 13 946 9 3 6 0 6
3J3E_7 0.60 0.59 0.63 20 2709 13 1 11 1 14
3J3E_8 0.10 0.13 0.08 2 2718 31 10 12 9 13
3J3F_8 0.36 0.47 0.27 9 4728 38 13 11 14 10
3J3F_7 0.25 0.25 0.26 9 2900 25 4 21 0 27
3J3V_B 0.18 0.19 0.19 5 2629 28 7 15 6 22
3JYV_7 -0.02 0.00 0.00 0 1092 19 4 15 0 20
3JYX_4 0.63 0.83 0.48 10 4735 32 9 2 21 2
3JYX_3 0.12 0.13 0.11 2 2360 20 6 10 4 13
3KTW_C - 0.46 0.44 0.50 11 1758 15 2 9 4 14
3LA5_A -0.02 0.00 0.00 0 938 16 0 16 0 25
3NDB_M - 0.07 0.07 0.08 3 3678 33 2 31 0 41
3NKB_B - 0.69 0.74 0.67 14 714 7 0 7 0 5
3NMU_E - 0.28 0.33 0.25 1 212 5 2 1 2 2
3NPB_A 0.62 0.54 0.71 20 2250 10 1 7 2 17
3O58_3 0.51 0.59 0.45 13 4735 28 11 5 12 9
3O58_2 0.50 0.52 0.50 16 2722 19 3 13 3 15
3OVB_D - 1.00 1.00 1.00 11 215 1 0 0 1 0
3OVS_D - 1.00 1.00 1.00 12 204 0 0 0 0 0
3P22_G - 1.00 1.00 1.00 11 301 0 0 0 0 0
3PDR_A 0.69 0.64 0.74 32 4797 13 3 8 2 18
3R4F_A - 0.98 0.95 1.00 21 885 1 0 0 1 1
3R9X_C - 1.00 1.00 1.00 8 221 2 0 0 2 0
3RKF_A 0.90 0.92 0.88 22 841 3 3 0 0 2
3SD1_A 0.13 0.14 0.15 4 1507 22 5 17 0 25
3SIU_F - 0.86 0.75 1.00 6 139 0 0 0 0 2
3SN2_B 0.95 0.92 1.00 11 143 0 0 0 0 1
3TRZ_Z - 1.00 1.00 1.00 5 87 1 0 0 1 0
3TS0_U - 1.00 1.00 1.00 6 112 1 0 0 1 0
3TS2_V - 1.00 1.00 1.00 5 103 0 0 0 0 0
3U4M_B - 0.49 0.55 0.46 12 1250 14 3 11 0 10
3UZL_B 0.24 0.31 0.20 5 1268 20 9 11 0 11
3VJR_D - 1.00 1.00 1.00 12 239 0 0 0 0 0
3W3S_B 0.83 0.85 0.82 28 1955 7 2 4 1 5
3ZEX_E - 0.11 0.15 0.09 5 8247 54 21 31 2 29
3ZEX_D 0.09 0.09 0.12 3 2771 24 5 17 2 32
3ZND_W 0.58 0.75 0.46 6 1178 17 4 3 10 2
4A1C_3 0.29 0.30 0.31 11 2727 26 4 21 1 26
4A1C_2 0.33 0.40 0.28 8 4487 37 8 13 16 12
4A4U_A - 1.00 1.00 1.00 9 96 0 0 0 0 0
4AOB_A 0.21 0.21 0.25 6 1413 19 2 16 1 23
4ATO_G - 0.67 0.86 0.55 6 209 5 5 0 0 1
4ENB_A 1.00 1.00 1.00 15 457 0 0 0 0 0
4ENC_A 0.97 1.00 0.94 15 480 1 1 0 0 0
4FRG_B 0.60 0.58 0.64 14 1180 8 3 5 0 10
4FRN_A 0.15 0.14 0.17 4 1825 19 3 16 0 24
4JF2_A 0.96 1.00 0.92 24 1056 2 2 0 0 0
4JRC_A - 0.28 0.29 0.31 5 606 11 2 9 0 12

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.