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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of CentroidHomfold‑LAST - scored higher in this pairwise comparison

  4. Performance of CMfinder(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for CentroidHomfold‑LAST & CMfinder(20) [.zip] - may take several seconds...


Overview

Metric CentroidHomfold‑LAST CMfinder(20)
MCC 0.691 > 0.652
Average MCC ± 95% Confidence Intervals 0.663 ± 0.443 > 0.662 ± 0.224
Sensitivity 0.737 > 0.518
Positive Predictive Value 0.656 < 0.831
Total TP 84 > 59
Total TN 8109 < 8166
Total FP 56 > 16
Total FP CONTRA 13 > 3
Total FP INCONS 31 > 9
Total FP COMP 12 > 4
Total FN 30 < 55
P-value 0.0

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Performance plots


  1. Comparison of performance of CentroidHomfold-LAST and CMfinder(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for CentroidHomfold‑LAST and CMfinder(20)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for CentroidHomfold-LAST and CMfinder(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for CentroidHomfold‑LAST and CMfinder(20)).

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Performance of CentroidHomfold‑LAST - scored higher in this pairwise comparison

1. Total counts & total scores for CentroidHomfold‑LAST

Total Base Pair Counts
Total TP 84
Total TN 8109
Total FP 56
Total FP CONTRA 13
Total FP INCONS 31
Total FP COMP 12
Total FN 30
Total Scores
MCC 0.691
Average MCC ± 95% Confidence Intervals 0.663 ± 0.443
Sensitivity 0.737
Positive Predictive Value 0.656
Nr of predictions 4

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2. Individual counts for CentroidHomfold‑LAST [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J20_0 0.41 0.52 0.34 11 1187 22 7 14 1 10
3J2L_3 0.94 0.94 0.94 32 2986 8 0 2 6 2
3ZEX_D 0.86 0.83 0.91 29 2764 8 0 3 5 6
4FRG_B 0.43 0.50 0.40 12 1172 18 6 12 0 12

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Performance of CMfinder(20) - scored lower in this pairwise comparison

1. Total counts & total scores for CMfinder(20)

Total Base Pair Counts
Total TP 59
Total TN 8166
Total FP 16
Total FP CONTRA 3
Total FP INCONS 9
Total FP COMP 4
Total FN 55
Total Scores
MCC 0.652
Average MCC ± 95% Confidence Intervals 0.662 ± 0.224
Sensitivity 0.518
Positive Predictive Value 0.831
Nr of predictions 4

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2. Individual counts for CMfinder(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J20_0 0.84 0.76 0.94 16 1202 2 1 0 1 5
3J2L_3 0.57 0.50 0.65 17 2994 11 2 7 2 17
3ZEX_D 0.70 0.54 0.90 19 2775 3 0 2 1 16
4FRG_B 0.54 0.29 1.00 7 1195 0 0 0 0 17

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.