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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of CentroidHomfold‑LAST - scored higher in this pairwise comparison

  4. Performance of RNASampler(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for CentroidHomfold‑LAST & RNASampler(seed) [.zip] - may take several seconds...


Overview

Metric CentroidHomfold‑LAST RNASampler(seed)
MCC 0.676 > 0.579
Average MCC ± 95% Confidence Intervals 0.620 ± 0.432 > 0.550 ± 0.344
Sensitivity 0.620 > 0.465
Positive Predictive Value 0.746 > 0.733
Total TP 88 > 66
Total TN 9671 < 9699
Total FP 45 > 34
Total FP CONTRA 9 > 4
Total FP INCONS 21 > 20
Total FP COMP 15 > 10
Total FN 54 < 76
P-value 0.0

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Performance plots


  1. Comparison of performance of CentroidHomfold-LAST and RNASampler(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for CentroidHomfold‑LAST and RNASampler(seed)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for CentroidHomfold-LAST and RNASampler(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for CentroidHomfold‑LAST and RNASampler(seed)).

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Performance of CentroidHomfold‑LAST - scored higher in this pairwise comparison

1. Total counts & total scores for CentroidHomfold‑LAST

Total Base Pair Counts
Total TP 88
Total TN 9671
Total FP 45
Total FP CONTRA 9
Total FP INCONS 21
Total FP COMP 15
Total FN 54
Total Scores
MCC 0.676
Average MCC ± 95% Confidence Intervals 0.620 ± 0.432
Sensitivity 0.620
Positive Predictive Value 0.746
Nr of predictions 6

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2. Individual counts for CentroidHomfold‑LAST [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2L94_A 0.94 0.94 0.94 17 339 2 0 1 1 1
2LC8_A -0.03 0.00 0.00 0 517 11 0 11 0 18
3RKF_A 0.86 0.75 1.00 18 848 0 0 0 0 6
3SD1_A 0.77 0.66 0.90 19 1512 2 1 1 0 10
3W3S_B 0.94 0.88 1.00 29 1960 1 0 0 1 4
4A1C_2 0.24 0.25 0.24 5 4495 29 8 8 13 15

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Performance of RNASampler(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for RNASampler(seed)

Total Base Pair Counts
Total TP 66
Total TN 9699
Total FP 34
Total FP CONTRA 4
Total FP INCONS 20
Total FP COMP 10
Total FN 76
Total Scores
MCC 0.579
Average MCC ± 95% Confidence Intervals 0.550 ± 0.344
Sensitivity 0.465
Positive Predictive Value 0.733
Nr of predictions 6

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2. Individual counts for RNASampler(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2L94_A 0.70 0.56 0.91 10 346 2 0 1 1 8
2LC8_A -0.03 0.00 0.00 0 518 10 0 10 0 18
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.72 0.55 0.94 16 1516 1 0 1 0 13
3W3S_B 0.60 0.36 1.00 12 1977 1 0 0 1 21
4A1C_2 0.40 0.40 0.40 8 4496 20 4 8 8 12

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.