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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of ContextFold - scored higher in this pairwise comparison

  4. Performance of PETfold_2.0(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for ContextFold & PETfold_2.0(seed) [.zip] - may take several seconds...


Overview

Metric ContextFold PETfold_2.0(seed)
MCC 0.938 > 0.866
Average MCC ± 95% Confidence Intervals 0.940 ± 0.524 > 0.868 ± 0.471
Sensitivity 0.914 > 0.845
Positive Predictive Value 0.964 > 0.891
Total TP 53 > 49
Total TN 4279 = 4279
Total FP 9 < 19
Total FP CONTRA 1 < 2
Total FP INCONS 1 < 4
Total FP COMP 7 < 13
Total FN 5 < 9
P-value 0.0

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Performance plots


  1. Comparison of performance of ContextFold and PETfold_2.0(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for ContextFold and PETfold_2.0(seed)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for ContextFold and PETfold_2.0(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for ContextFold and PETfold_2.0(seed)).

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Performance of ContextFold - scored higher in this pairwise comparison

1. Total counts & total scores for ContextFold

Total Base Pair Counts
Total TP 53
Total TN 4279
Total FP 9
Total FP CONTRA 1
Total FP INCONS 1
Total FP COMP 7
Total FN 5
Total Scores
MCC 0.938
Average MCC ± 95% Confidence Intervals 0.940 ± 0.524
Sensitivity 0.914
Positive Predictive Value 0.964
Nr of predictions 2

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2. Individual counts for ContextFold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J3V_B 0.98 0.96 1.00 26 2630 7 0 0 7 1
3W1K_J 0.90 0.87 0.93 27 1649 2 1 1 0 4

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Performance of PETfold_2.0(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for PETfold_2.0(seed)

Total Base Pair Counts
Total TP 49
Total TN 4279
Total FP 19
Total FP CONTRA 2
Total FP INCONS 4
Total FP COMP 13
Total FN 9
Total Scores
MCC 0.866
Average MCC ± 95% Confidence Intervals 0.868 ± 0.471
Sensitivity 0.845
Positive Predictive Value 0.891
Nr of predictions 2

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2. Individual counts for PETfold_2.0(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J3V_B 0.90 0.89 0.92 24 2630 14 0 2 12 3
3W1K_J 0.83 0.81 0.86 25 1649 5 2 2 1 6

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.