CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Contrafold - scored higher in this pairwise comparison

  4. Performance of MCFold - scored lower in this pairwise comparison

  5. Compile and download dataset for Contrafold & MCFold [.zip] - may take several seconds...


Overview

Metric Contrafold MCFold
MCC 0.748 > 0.622
Average MCC ± 95% Confidence Intervals 0.772 ± 0.052 > 0.657 ± 0.062
Sensitivity 0.766 > 0.663
Positive Predictive Value 0.740 > 0.597
Total TP 1665 > 1441
Total TN 133956 > 133792
Total FP 869 < 1310
Total FP CONTRA 182 < 262
Total FP INCONS 404 < 712
Total FP COMP 283 < 336
Total FN 510 < 734
P-value 3.56938820447e-08

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Performance plots


  1. Comparison of performance of Contrafold and MCFold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Contrafold and MCFold).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Contrafold and MCFold).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for Contrafold and MCFold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Contrafold and MCFold).

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Performance of Contrafold - scored higher in this pairwise comparison

1. Total counts & total scores for Contrafold

Total Base Pair Counts
Total TP 1665
Total TN 133956
Total FP 869
Total FP CONTRA 182
Total FP INCONS 404
Total FP COMP 283
Total FN 510
Total Scores
MCC 0.748
Average MCC ± 95% Confidence Intervals 0.772 ± 0.052
Sensitivity 0.766
Positive Predictive Value 0.740
Nr of predictions 131

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2. Individual counts for Contrafold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2K5Z_A - 1.00 1.00 1.00 11 175 0 0 0 0 0
2K63_A - 1.00 1.00 1.00 9 159 2 0 0 2 0
2K66_A - 1.00 1.00 1.00 9 80 0 0 0 0 0
2KD8_A - 1.00 1.00 1.00 9 99 0 0 0 0 0
2KDQ_B 1.00 1.00 1.00 10 164 0 0 0 0 0
2KE6_A 1.00 1.00 1.00 18 449 1 0 0 1 0
2KEZ_A - 1.00 1.00 1.00 8 94 0 0 0 0 0
2KFC_A - 0.71 0.63 0.83 5 230 1 1 0 0 3
2KGP_A - 1.00 1.00 1.00 9 112 1 0 0 1 0
2KMJ_A - 1.00 1.00 1.00 11 157 0 0 0 0 0
2KPV_A - 1.00 1.00 1.00 13 200 0 0 0 0 0
2KU0_A - 0.63 0.58 0.70 7 282 3 2 1 0 5
2KUR_A 1.00 1.00 1.00 19 448 0 0 0 0 0
2KUU_A 1.00 1.00 1.00 18 429 1 0 0 1 0
2KUV_A 1.00 1.00 1.00 19 420 0 0 0 0 0
2KUW_A 1.00 1.00 1.00 18 452 1 0 0 1 0
2KX8_A 1.00 1.00 1.00 16 355 0 0 0 0 0
2KXM_A - 1.00 1.00 1.00 8 141 0 0 0 0 0
2KZL_A - 1.00 1.00 1.00 13 507 5 0 0 5 0
2L1F_A 1.00 1.00 1.00 23 740 0 0 0 0 0
2L1F_B 1.00 1.00 1.00 24 767 0 0 0 0 0
2L2K_A - 1.00 1.00 1.00 17 332 0 0 0 0 0
2L3C_B - 1.00 1.00 1.00 14 225 0 0 0 0 0
2L3E_A - 1.00 1.00 1.00 12 228 1 0 0 1 0
2L3J_B 1.00 1.00 1.00 30 955 0 0 0 0 0
2L5Z_A - 1.00 1.00 1.00 9 102 0 0 0 0 0
2L94_A 0.94 0.94 0.94 17 339 2 0 1 1 1
2LA5_A - 0.77 0.71 0.83 5 269 3 0 1 2 2
2LBS_A - 1.00 1.00 1.00 14 193 0 0 0 0 0
2LC8_A 0.46 0.39 0.58 7 516 5 3 2 0 11
2LDL_A - 1.00 1.00 1.00 9 131 1 0 0 1 0
2LDT_A - 1.00 1.00 1.00 11 151 0 0 0 0 0
2LHP_A - 1.00 1.00 1.00 15 246 0 0 0 0 0
2LI4_A - 1.00 1.00 1.00 14 175 0 0 0 0 0
2LJJ_A - 1.00 1.00 1.00 7 123 3 0 0 3 0
2LK3_A - 1.00 1.00 1.00 9 91 0 0 0 0 0
2LKR_A - 0.88 0.90 0.87 26 2410 11 0 4 7 3
2LQZ_A - 1.00 1.00 1.00 8 124 2 0 0 2 0
2LU0_A - 1.00 1.00 1.00 16 422 0 0 0 0 0
2LWK_A - 1.00 1.00 1.00 11 196 1 0 0 1 0
2M58_A - -0.02 0.00 0.00 0 531 13 0 13 0 12
2RP0_A - 0.84 0.71 1.00 5 111 0 0 0 0 2
2RPT_A - 1.00 1.00 1.00 7 65 0 0 0 0 0
2RRC_A - 1.00 1.00 1.00 7 68 0 0 0 0 0
2WRQ_Y 1.00 1.00 1.00 9 1143 14 0 0 14 0
2WW9_F - 0.68 0.75 0.67 6 103 4 1 2 1 2
2WW9_D - 0.63 0.40 1.00 4 737 5 0 0 5 6
2WW9_E - 0.00 0.00 0.00 0 172 0 0 0 0 5
2WWQ_V 1.00 1.00 1.00 19 1185 4 0 0 4 0
2XKV_B 0.64 0.73 0.57 8 1821 27 0 6 21 3
2XQD_Y 0.85 0.86 0.86 18 1108 4 0 3 1 3
2XXA_G 0.10 0.11 0.12 4 2012 30 2 27 1 31
2Y8W_B - 1.00 1.00 1.00 6 82 3 0 0 3 0
2Y9C_V - 0.79 0.83 0.75 15 886 8 0 5 3 3
2YIE_Z - 0.53 0.63 0.45 5 591 6 4 2 0 3
2YIE_X - 1.00 1.00 1.00 7 537 4 0 0 4 0
2ZY6_A - 0.69 0.78 0.64 7 265 5 2 2 1 2
2ZZN_D 0.93 0.95 0.91 21 961 3 2 0 1 1
3A2K_C 0.49 0.55 0.46 12 1082 14 3 11 0 10
3A3A_A 0.97 0.93 1.00 28 1472 0 0 0 0 2
3AKZ_H 0.44 0.50 0.40 10 1102 18 6 9 3 10
3AM1_B - 0.74 0.76 0.73 22 1436 8 3 5 0 7
3AMU_B 0.75 0.79 0.71 15 1136 9 0 6 3 4
3DW4_A - -0.03 0.00 0.00 0 136 6 1 3 2 6
3GCA_A - 0.76 0.71 0.83 5 152 1 1 0 0 2
3GX2_A 0.93 0.89 0.96 25 1423 2 1 0 1 3
3HAY_E - 1.00 1.00 1.00 14 910 7 0 0 7 0
3HJW_D - 1.00 1.00 1.00 16 593 2 0 0 2 0
3IAB_R - 1.00 1.00 1.00 12 373 4 0 0 4 0
3ID5_D - 0.66 0.60 0.75 3 225 6 0 1 5 2
3IVN_B 0.91 0.83 1.00 19 884 0 0 0 0 4
3IWN_A 0.86 0.79 0.96 22 1449 1 0 1 0 6
3IZF_C 0.89 0.91 0.86 32 2603 11 0 5 6 3
3J0L_8 - 1.00 1.00 1.00 7 69 0 0 0 0 0
3J0L_2 - 0.28 0.31 0.28 8 2221 26 2 19 5 18
3J0L_g - 0.00 0.00 0.00 0 176 1 0 0 1 2
3J0L_7 - -0.02 0.00 0.00 0 512 7 1 6 0 10
3J0L_h - 0.87 0.88 0.88 28 2108 6 0 4 2 4
3J0L_1 - 0.83 0.77 0.91 10 473 3 0 1 2 3
3J0L_a - 0.53 0.55 0.55 6 400 6 3 2 1 5
3J16_L 0.55 0.57 0.55 12 1137 10 3 7 0 9
3J20_0 0.53 0.57 0.50 12 1195 13 3 9 1 9
3J2L_3 0.74 0.76 0.72 26 2984 16 1 9 6 8
3J3D_C 0.71 0.79 0.65 15 945 8 3 5 0 4
3J3E_8 0.12 0.13 0.11 2 2724 32 5 11 16 13
3J3E_7 0.58 0.59 0.59 20 2707 16 2 12 2 14
3J3F_7 0.84 0.86 0.82 31 2896 11 1 6 4 5
3J3F_8 0.35 0.47 0.26 9 4726 44 13 13 18 10
3JYV_7 -0.02 0.00 0.00 0 1091 20 4 16 0 20
3JYX_3 0.33 0.47 0.24 7 2349 24 16 6 2 8
3JYX_4 0.39 0.58 0.27 7 4730 35 13 6 16 5
3KTW_C - 0.56 0.60 0.54 15 1752 20 2 11 7 10
3LA5_A 0.91 0.84 1.00 21 933 0 0 0 0 4
3NDB_M - 0.98 0.98 0.98 43 3670 6 0 1 5 1
3NKB_B - 0.63 0.68 0.59 13 713 9 0 9 0 6
3NMU_E - 1.00 1.00 1.00 3 213 3 0 0 3 0
3O58_3 0.32 0.36 0.29 8 4736 21 7 13 1 14
3O58_2 0.92 0.94 0.91 29 2722 10 0 3 7 2
3OVB_D - 1.00 1.00 1.00 11 215 1 0 0 1 0
3OVS_D - 1.00 1.00 1.00 12 204 0 0 0 0 0
3P22_G - 1.00 1.00 1.00 11 301 1 0 0 1 0
3PDR_A 0.83 0.86 0.80 43 4786 13 5 6 2 7
3R4F_A - 0.81 0.82 0.82 18 884 5 2 2 1 4
3R9X_C - 1.00 1.00 1.00 8 221 2 0 0 2 0
3RKF_A 0.87 0.83 0.91 20 844 2 2 0 0 4
3SD1_A 0.68 0.69 0.69 20 1504 9 5 4 0 9
3SIU_F - 0.87 0.88 0.88 7 137 1 0 1 0 1
3SN2_B 0.95 0.92 1.00 11 143 0 0 0 0 1
3TRZ_Z - 1.00 1.00 1.00 5 87 1 0 0 1 0
3TS0_U - 1.00 1.00 1.00 6 112 1 0 0 1 0
3TS2_V - 1.00 1.00 1.00 5 103 0 0 0 0 0
3U4M_B - 0.81 0.77 0.85 17 1256 5 0 3 2 5
3VJR_D - 1.00 1.00 1.00 12 239 0 0 0 0 0
3ZEX_G - 0.35 0.38 0.34 17 6457 42 9 24 9 28
3ZEX_F - 0.00 0.00 0.00 0 910 9 0 4 5 4
3ZEX_C 0.35 0.34 0.37 10 5347 23 4 13 6 19
3ZEX_H - 0.24 0.37 0.17 7 3583 35 22 13 0 12
3ZEX_D 0.87 0.86 0.88 30 2762 11 0 4 7 5
3ZND_W 0.22 0.38 0.14 3 1170 27 9 9 9 5
4A1C_2 0.21 0.25 0.19 5 4489 33 9 13 11 15
4A1C_3 0.81 0.81 0.81 30 2726 10 0 7 3 7
4A4U_A - 1.00 1.00 1.00 9 96 0 0 0 0 0
4ATO_G - 0.52 0.57 0.50 4 212 4 0 4 0 3
4ENB_A 0.85 0.73 1.00 11 461 1 0 0 1 4
4ENC_A 0.85 0.73 1.00 11 485 1 0 0 1 4
4FNJ_A - 0.91 0.83 1.00 10 240 0 0 0 0 2
4FRG_B 0.73 0.71 0.77 17 1180 5 3 2 0 7
4FRN_A 0.74 0.71 0.77 20 1822 6 1 5 0 8
4HXH_A - 1.00 1.00 1.00 6 89 0 0 0 0 0
4JF2_A 0.89 0.79 1.00 19 1063 0 0 0 0 5
4JRC_A - 0.38 0.41 0.39 7 604 11 0 11 0 10

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Performance of MCFold - scored lower in this pairwise comparison

1. Total counts & total scores for MCFold

Total Base Pair Counts
Total TP 1441
Total TN 133792
Total FP 1310
Total FP CONTRA 262
Total FP INCONS 712
Total FP COMP 336
Total FN 734
Total Scores
MCC 0.622
Average MCC ± 95% Confidence Intervals 0.657 ± 0.062
Sensitivity 0.663
Positive Predictive Value 0.597
Nr of predictions 131

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2. Individual counts for MCFold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2K5Z_A - 1.00 1.00 1.00 11 175 0 0 0 0 0
2K63_A - 1.00 1.00 1.00 9 159 4 0 0 4 0
2K66_A - 1.00 1.00 1.00 9 80 0 0 0 0 0
2KD8_A - 1.00 1.00 1.00 9 99 1 0 0 1 0
2KDQ_B 1.00 1.00 1.00 10 164 1 0 0 1 0
2KE6_A 1.00 1.00 1.00 18 449 1 0 0 1 0
2KEZ_A - 1.00 1.00 1.00 8 94 0 0 0 0 0
2KFC_A - 0.54 0.63 0.50 5 226 5 2 3 0 3
2KGP_A - 1.00 1.00 1.00 9 112 1 0 0 1 0
2KMJ_A - 1.00 1.00 1.00 11 157 1 0 0 1 0
2KPV_A - 1.00 1.00 1.00 13 200 0 0 0 0 0
2KU0_A - 1.00 1.00 1.00 12 280 1 0 0 1 0
2KUR_A 1.00 1.00 1.00 19 448 0 0 0 0 0
2KUU_A 1.00 1.00 1.00 18 429 1 0 0 1 0
2KUV_A 1.00 1.00 1.00 19 420 0 0 0 0 0
2KUW_A 1.00 1.00 1.00 18 452 1 0 0 1 0
2KX8_A 1.00 1.00 1.00 16 355 0 0 0 0 0
2KXM_A - 1.00 1.00 1.00 8 141 1 0 0 1 0
2KZL_A - 1.00 1.00 1.00 13 507 5 0 0 5 0
2L1F_A 0.79 0.78 0.82 18 741 4 0 4 0 5
2L1F_B 0.80 0.79 0.83 19 768 4 0 4 0 5
2L2K_A - 1.00 1.00 1.00 17 332 1 0 0 1 0
2L3C_B - 1.00 1.00 1.00 14 225 1 0 0 1 0
2L3E_A - 1.00 1.00 1.00 12 228 2 0 0 2 0
2L3J_B 1.00 1.00 1.00 30 955 0 0 0 0 0
2L5Z_A - 1.00 1.00 1.00 9 102 0 0 0 0 0
2L94_A 1.00 1.00 1.00 18 339 1 0 0 1 0
2LA5_A - -0.03 0.00 0.00 0 265 10 0 10 0 7
2LBS_A - 1.00 1.00 1.00 14 193 1 0 0 1 0
2LC8_A 0.44 0.44 0.47 8 511 10 0 9 1 10
2LDL_A - 1.00 1.00 1.00 9 131 1 0 0 1 0
2LDT_A - 0.95 0.91 1.00 10 152 0 0 0 0 1
2LHP_A - 1.00 1.00 1.00 15 246 1 0 0 1 0
2LI4_A - 1.00 1.00 1.00 14 175 0 0 0 0 0
2LJJ_A - 1.00 1.00 1.00 7 123 3 0 0 3 0
2LK3_A - 1.00 1.00 1.00 9 91 0 0 0 0 0
2LKR_A - 1.00 1.00 1.00 29 2411 11 0 0 11 0
2LQZ_A - 1.00 1.00 1.00 8 124 3 0 0 3 0
2LU0_A - 1.00 1.00 1.00 16 422 2 0 0 2 0
2LWK_A - 1.00 1.00 1.00 11 196 2 0 0 2 0
2M58_A - 0.22 0.25 0.23 3 531 13 1 9 3 9
2RP0_A - 0.70 0.71 0.71 5 109 2 1 1 0 2
2RPT_A - 1.00 1.00 1.00 7 65 0 0 0 0 0
2RRC_A - 1.00 1.00 1.00 7 68 1 0 0 1 0
2WRQ_Y 0.38 0.56 0.26 5 1133 21 8 6 7 4
2WW9_F - 0.68 0.75 0.67 6 103 4 1 2 1 2
2WW9_D - -0.02 0.00 0.00 0 723 21 6 12 3 10
2WW9_E - -0.03 0.00 0.00 0 165 8 1 6 1 5
2WWQ_V 0.19 0.21 0.19 4 1183 20 3 14 3 15
2XKV_B 0.20 0.27 0.16 3 1816 30 4 12 14 8
2XQD_Y 0.39 0.43 0.38 9 1105 18 2 13 3 12
2XXA_G 0.23 0.26 0.24 9 2007 30 1 28 1 26
2Y8W_B - 1.00 1.00 1.00 6 82 2 0 0 2 0
2Y9C_V - 0.65 0.72 0.59 13 884 12 1 8 3 5
2YIE_Z - 0.53 0.63 0.45 5 591 8 2 4 2 3
2YIE_X - -0.01 0.00 0.00 0 535 15 1 8 6 7
2ZY6_A - 0.77 0.78 0.78 7 267 6 1 1 4 2
2ZZN_D 0.69 0.73 0.67 16 960 11 1 7 3 6
3A2K_C 0.49 0.55 0.46 12 1082 14 3 11 0 10
3A3A_A 0.98 0.97 1.00 29 1471 0 0 0 0 1
3AKZ_H 0.46 0.50 0.43 10 1104 16 5 8 3 10
3AM1_B - 1.00 1.00 1.00 29 1437 1 0 0 1 0
3AMU_B 0.50 0.58 0.44 11 1132 15 4 10 1 8
3DW4_A - 1.00 1.00 1.00 6 134 3 0 0 3 0
3GCA_A - -0.05 0.00 0.00 0 150 8 4 4 0 7
3GX2_A 0.58 0.61 0.57 17 1419 15 1 12 2 11
3HAY_E - 1.00 1.00 1.00 14 910 10 0 0 10 0
3HJW_D - 1.00 1.00 1.00 16 593 5 0 0 5 0
3IAB_R - 1.00 1.00 1.00 12 373 4 0 0 4 0
3ID5_D - 0.54 0.60 0.50 3 223 7 1 2 4 2
3IVN_B 0.45 0.48 0.46 11 879 14 5 8 1 12
3IWN_A 0.19 0.21 0.20 6 1442 24 5 19 0 22
3IZF_C 0.92 0.94 0.89 33 2603 10 0 4 6 2
3J0L_8 - 1.00 1.00 1.00 7 69 0 0 0 0 0
3J0L_2 - 0.25 0.27 0.25 7 2222 29 4 17 8 19
3J0L_g - -0.02 0.00 0.00 0 170 7 4 2 1 2
3J0L_7 - -0.02 0.00 0.00 0 504 15 6 9 0 10
3J0L_h - 0.98 0.97 1.00 31 2109 2 0 0 2 1
3J0L_1 - 0.88 0.85 0.92 11 472 5 0 1 4 2
3J0L_a - 0.14 0.18 0.15 2 398 13 1 10 2 9
3J16_L 0.54 0.57 0.52 12 1136 12 4 7 1 9
3J20_0 0.66 0.71 0.63 15 1195 11 3 6 2 6
3J2L_3 0.77 0.79 0.75 27 2984 15 1 8 6 7
3J3D_C 0.54 0.63 0.48 12 943 13 4 9 0 7
3J3E_8 0.15 0.20 0.12 3 2716 36 11 12 13 12
3J3E_7 0.55 0.56 0.54 19 2706 23 1 15 7 15
3J3F_7 0.88 0.89 0.86 32 2897 9 1 4 4 4
3J3F_8 0.14 0.21 0.10 4 4720 51 17 20 14 15
3JYV_7 0.25 0.30 0.24 6 1086 20 8 11 1 14
3JYX_3 0.46 0.67 0.32 10 2347 28 15 6 7 5
3JYX_4 0.36 0.58 0.23 7 4725 37 19 5 13 5
3KTW_C - 0.55 0.60 0.52 15 1751 20 4 10 6 10
3LA5_A 0.44 0.44 0.48 11 931 12 2 10 0 14
3NDB_M - 0.29 0.30 0.30 13 3671 35 1 29 5 31
3NKB_B - 0.68 0.74 0.64 14 713 8 2 6 0 5
3NMU_E - 0.51 0.67 0.40 2 211 8 1 2 5 1
3O58_3 0.28 0.36 0.22 8 4727 39 14 15 10 14
3O58_2 0.25 0.29 0.23 9 2715 31 6 24 1 22
3OVB_D - 1.00 1.00 1.00 11 215 1 0 0 1 0
3OVS_D - 1.00 1.00 1.00 12 204 0 0 0 0 0
3P22_G - 1.00 1.00 1.00 11 301 1 0 0 1 0
3PDR_A 0.78 0.80 0.77 40 4788 14 5 7 2 10
3R4F_A - 0.95 0.95 0.95 21 884 4 0 1 3 1
3R9X_C - 0.87 0.88 0.88 7 221 5 0 1 4 1
3RKF_A 0.89 0.88 0.91 21 843 3 0 2 1 3
3SD1_A 0.43 0.45 0.43 13 1503 17 1 16 0 16
3SIU_F - 0.53 0.63 0.50 5 135 5 2 3 0 3
3SN2_B 0.58 0.58 0.64 7 143 4 0 4 0 5
3TRZ_Z - -0.05 0.00 0.00 0 88 4 0 4 0 5
3TS0_U - 1.00 1.00 1.00 6 112 1 0 0 1 0
3TS2_V - -0.05 0.00 0.00 0 102 7 0 6 1 5
3U4M_B - 0.74 0.77 0.71 17 1252 10 1 6 3 5
3VJR_D - 1.00 1.00 1.00 12 239 1 0 0 1 0
3ZEX_G - 0.00 0.00 0.00 0 6493 14 6 8 0 45
3ZEX_F - 0.00 0.00 0.00 0 909 22 0 5 17 4
3ZEX_C 0.30 0.34 0.27 10 5337 28 6 21 1 19
3ZEX_H - 0.22 0.32 0.16 6 3588 36 15 16 5 13
3ZEX_D 0.23 0.26 0.23 9 2756 33 6 25 2 26
3ZND_W 0.23 0.38 0.15 3 1171 26 9 8 9 5
4A1C_2 0.18 0.25 0.14 5 4480 45 12 19 14 15
4A1C_3 0.86 0.86 0.86 32 2726 9 0 5 4 5
4A4U_A - 1.00 1.00 1.00 9 96 0 0 0 0 0
4ATO_G - 0.36 0.43 0.33 3 211 8 0 6 2 4
4ENB_A 0.78 0.73 0.85 11 459 4 0 2 2 4
4ENC_A 0.34 0.33 0.38 5 483 11 0 8 3 10
4FNJ_A - 0.91 0.92 0.92 11 238 1 0 1 0 1
4FRG_B 0.35 0.38 0.35 9 1176 17 3 14 0 15
4FRN_A 0.09 0.11 0.10 3 1818 28 2 25 1 25
4HXH_A - 1.00 1.00 1.00 6 89 0 0 0 0 0
4JF2_A 0.74 0.75 0.75 18 1058 7 1 5 1 6
4JRC_A - 0.24 0.29 0.23 5 600 17 0 17 0 12

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.