CompaRNA - on-line benchmarks of RNA structure prediction methods
Home

Methods
Datasets
Rankings
RNA 2D Atlas

Help
FAQ

Contact us
RSS feeds
Twitter

Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Contrafold - scored higher in this pairwise comparison

  4. Performance of Vsfold5 - scored lower in this pairwise comparison

  5. Compile and download dataset for Contrafold & Vsfold5 [.zip] - may take several seconds...


Overview

Metric Contrafold Vsfold5
MCC 0.759 > 0.593
Average MCC ± 95% Confidence Intervals 0.798 ± 0.049 > 0.666 ± 0.062
Sensitivity 0.776 > 0.595
Positive Predictive Value 0.750 > 0.601
Total TP 1788 > 1371
Total TN 175215 < 175318
Total FP 887 < 1089
Total FP CONTRA 207 < 260
Total FP INCONS 390 < 651
Total FP COMP 290 > 178
Total FN 517 < 934
P-value 3.56938820447e-08

^top




Performance plots


  1. Comparison of performance of Contrafold and Vsfold5. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Contrafold and Vsfold5).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Contrafold and Vsfold5).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for Contrafold and Vsfold5. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Contrafold and Vsfold5).

^top





Performance of Contrafold - scored higher in this pairwise comparison

1. Total counts & total scores for Contrafold

Total Base Pair Counts
Total TP 1788
Total TN 175215
Total FP 887
Total FP CONTRA 207
Total FP INCONS 390
Total FP COMP 290
Total FN 517
Total Scores
MCC 0.759
Average MCC ± 95% Confidence Intervals 0.798 ± 0.049
Sensitivity 0.776
Positive Predictive Value 0.750
Nr of predictions 127

^top



2. Individual counts for Contrafold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2K5Z_A - 1.00 1.00 1.00 11 175 0 0 0 0 0
2K63_A - 1.00 1.00 1.00 9 159 2 0 0 2 0
2K66_A - 1.00 1.00 1.00 9 80 0 0 0 0 0
2KD8_A - 1.00 1.00 1.00 9 99 0 0 0 0 0
2KDQ_B 1.00 1.00 1.00 10 164 0 0 0 0 0
2KE6_A 1.00 1.00 1.00 18 449 1 0 0 1 0
2KEZ_A - 1.00 1.00 1.00 8 94 0 0 0 0 0
2KFC_A - 0.71 0.63 0.83 5 230 1 1 0 0 3
2KGP_A - 1.00 1.00 1.00 9 112 1 0 0 1 0
2KMJ_A - 1.00 1.00 1.00 11 157 0 0 0 0 0
2KPV_A - 1.00 1.00 1.00 13 200 0 0 0 0 0
2KRL_A - 0.91 0.87 0.95 20 2003 9 1 0 8 3
2KU0_A - 0.63 0.58 0.70 7 282 3 2 1 0 5
2KUR_A 1.00 1.00 1.00 19 448 0 0 0 0 0
2KUU_A 1.00 1.00 1.00 18 429 1 0 0 1 0
2KUV_A 1.00 1.00 1.00 19 420 0 0 0 0 0
2KUW_A 1.00 1.00 1.00 18 452 1 0 0 1 0
2KX8_A 1.00 1.00 1.00 16 355 0 0 0 0 0
2KXM_A - 1.00 1.00 1.00 8 141 0 0 0 0 0
2KZL_A - 1.00 1.00 1.00 13 507 5 0 0 5 0
2L1F_A 1.00 1.00 1.00 23 740 0 0 0 0 0
2L1F_B 1.00 1.00 1.00 24 767 0 0 0 0 0
2L2K_A - 1.00 1.00 1.00 17 332 0 0 0 0 0
2L3C_B - 1.00 1.00 1.00 14 225 0 0 0 0 0
2L3E_A - 1.00 1.00 1.00 12 228 1 0 0 1 0
2L3J_B 1.00 1.00 1.00 30 955 0 0 0 0 0
2L5Z_A - 1.00 1.00 1.00 9 102 0 0 0 0 0
2L94_A 0.94 0.94 0.94 17 339 2 0 1 1 1
2LA5_A - 0.77 0.71 0.83 5 269 3 0 1 2 2
2LBS_A - 1.00 1.00 1.00 14 193 0 0 0 0 0
2LC8_A 0.46 0.39 0.58 7 516 5 3 2 0 11
2LDL_A - 1.00 1.00 1.00 9 131 1 0 0 1 0
2LDT_A - 1.00 1.00 1.00 11 151 0 0 0 0 0
2LHP_A - 1.00 1.00 1.00 15 246 0 0 0 0 0
2LI4_A - 1.00 1.00 1.00 14 175 0 0 0 0 0
2LJJ_A - 1.00 1.00 1.00 7 123 3 0 0 3 0
2LK3_A - 1.00 1.00 1.00 9 91 0 0 0 0 0
2LKR_A - 0.88 0.90 0.87 26 2410 11 0 4 7 3
2LWK_A - 1.00 1.00 1.00 11 196 1 0 0 1 0
2RP0_A - 0.84 0.71 1.00 5 111 0 0 0 0 2
2RPT_A - 1.00 1.00 1.00 7 65 0 0 0 0 0
2RRC_A - 1.00 1.00 1.00 7 68 0 0 0 0 0
2WRQ_Y 1.00 1.00 1.00 9 1143 14 0 0 14 0
2WW9_E - 0.00 0.00 0.00 0 172 0 0 0 0 5
2WW9_D - 0.63 0.40 1.00 4 737 5 0 0 5 6
2WW9_F - 0.68 0.75 0.67 6 103 4 1 2 1 2
2WWQ_V 1.00 1.00 1.00 19 1185 4 0 0 4 0
2XKV_B 0.64 0.73 0.57 8 1821 27 0 6 21 3
2XQD_Y 0.85 0.86 0.86 18 1108 4 0 3 1 3
2XXA_G 0.10 0.11 0.12 4 2012 30 2 27 1 31
2Y8W_B - 1.00 1.00 1.00 6 82 3 0 0 3 0
2Y9C_V - 0.79 0.83 0.75 15 886 8 0 5 3 3
2YIE_X - 1.00 1.00 1.00 7 537 4 0 0 4 0
2YIE_Z - 0.53 0.63 0.45 5 591 6 4 2 0 3
2ZY6_A - 0.69 0.78 0.64 7 265 5 2 2 1 2
2ZZM_B 0.80 0.80 0.80 12 1343 13 0 3 10 3
2ZZN_D 0.93 0.95 0.91 21 961 3 2 0 1 1
3A2K_C 0.49 0.55 0.46 12 1082 14 3 11 0 10
3A3A_A 0.97 0.93 1.00 28 1472 0 0 0 0 2
3ADB_C - 0.98 0.97 1.00 32 1787 0 0 0 0 1
3AKZ_H 0.44 0.50 0.40 10 1102 18 6 9 3 10
3AM1_B - 0.74 0.76 0.73 22 1436 8 3 5 0 7
3AMU_B 0.75 0.79 0.71 15 1136 9 0 6 3 4
3DW4_A - -0.03 0.00 0.00 0 136 6 1 3 2 6
3G4S_9 0.45 0.50 0.42 13 2705 24 6 12 6 13
3GCA_A - 0.76 0.71 0.83 5 152 1 1 0 0 2
3GX2_A 0.93 0.89 0.96 25 1423 2 1 0 1 3
3HAY_E - 1.00 1.00 1.00 14 910 7 0 0 7 0
3HJW_D - 1.00 1.00 1.00 16 593 2 0 0 2 0
3IAB_R - 1.00 1.00 1.00 12 373 4 0 0 4 0
3ID5_D - 0.66 0.60 0.75 3 225 6 0 1 5 2
3IVN_B 0.91 0.83 1.00 19 884 0 0 0 0 4
3IWN_A 0.86 0.79 0.96 22 1449 1 0 1 0 6
3IYQ_A 0.28 0.39 0.20 20 22341 95 44 35 16 31
3IZ4_A 0.57 0.58 0.57 55 25440 49 18 23 8 40
3IZF_C 0.89 0.91 0.86 32 2603 11 0 5 6 3
3J0L_8 - 1.00 1.00 1.00 7 69 0 0 0 0 0
3J0L_1 - 0.83 0.77 0.91 10 473 3 0 1 2 3
3J0L_h - 0.87 0.88 0.88 28 2108 6 0 4 2 4
3J0L_2 - 0.28 0.31 0.28 8 2221 26 2 19 5 18
3J0L_7 - -0.02 0.00 0.00 0 512 7 1 6 0 10
3J0L_g - 0.00 0.00 0.00 0 176 1 0 0 1 2
3J0L_a - 0.53 0.55 0.55 6 400 6 3 2 1 5
3J16_L 0.55 0.57 0.55 12 1137 10 3 7 0 9
3J20_0 0.53 0.57 0.50 12 1195 13 3 9 1 9
3J20_1 1.00 1.00 1.00 20 1092 5 0 0 5 0
3J2C_O - 0.96 0.95 0.98 39 3947 7 0 1 6 2
3J2L_3 0.74 0.76 0.72 26 2984 16 1 9 6 8
3JYV_7 -0.02 0.00 0.00 0 1091 20 4 16 0 20
3JYX_4 0.39 0.58 0.27 7 4730 35 13 6 16 5
3JYX_3 0.33 0.47 0.24 7 2349 24 16 6 2 8
3KTW_C - 0.56 0.60 0.54 15 1752 20 2 11 7 10
3LA5_A 0.91 0.84 1.00 21 933 0 0 0 0 4
3NDB_M - 0.98 0.98 0.98 43 3670 6 0 1 5 1
3NKB_B - 0.63 0.68 0.59 13 713 9 0 9 0 6
3NMU_E - 1.00 1.00 1.00 3 213 3 0 0 3 0
3NPB_A 0.86 0.84 0.89 31 2243 9 1 3 5 6
3O58_3 0.32 0.36 0.29 8 4736 21 7 13 1 14
3O58_2 0.92 0.94 0.91 29 2722 10 0 3 7 2
3OVB_D - 1.00 1.00 1.00 11 215 1 0 0 1 0
3OVS_D - 1.00 1.00 1.00 12 204 0 0 0 0 0
3P22_G - 1.00 1.00 1.00 11 301 1 0 0 1 0
3PDR_A 0.83 0.86 0.80 43 4786 13 5 6 2 7
3R4F_A - 0.81 0.82 0.82 18 884 5 2 2 1 4
3R9X_C - 1.00 1.00 1.00 8 221 2 0 0 2 0
3RKF_A 0.87 0.83 0.91 20 844 2 2 0 0 4
3SD1_A 0.68 0.69 0.69 20 1504 9 5 4 0 9
3SIU_F - 0.87 0.88 0.88 7 137 1 0 1 0 1
3SN2_B 0.95 0.92 1.00 11 143 0 0 0 0 1
3TRZ_Z - 1.00 1.00 1.00 5 87 1 0 0 1 0
3TS0_U - 1.00 1.00 1.00 6 112 1 0 0 1 0
3TS2_V - 1.00 1.00 1.00 5 103 0 0 0 0 0
3U4M_B - 0.81 0.77 0.85 17 1256 5 0 3 2 5
3UZL_B 0.90 0.88 0.93 14 1278 8 0 1 7 2
3VJR_D - 1.00 1.00 1.00 12 239 0 0 0 0 0
3W3S_B 0.98 0.97 1.00 32 1957 1 0 0 1 1
3ZEX_D 0.87 0.86 0.88 30 2762 11 0 4 7 5
3ZEX_E - -0.01 0.00 0.00 0 8251 58 20 33 5 34
4A1C_3 0.81 0.81 0.81 30 2726 10 0 7 3 7
4A1C_2 0.21 0.25 0.19 5 4489 33 9 13 11 15
4A4U_A - 1.00 1.00 1.00 9 96 0 0 0 0 0
4AOB_A 0.53 0.52 0.56 15 1410 13 3 9 1 14
4ATO_G - 0.52 0.57 0.50 4 212 4 0 4 0 3
4ENB_A 0.85 0.73 1.00 11 461 1 0 0 1 4
4ENC_A 0.85 0.73 1.00 11 485 1 0 0 1 4
4FRG_B 0.73 0.71 0.77 17 1180 5 3 2 0 7
4FRN_A 0.74 0.71 0.77 20 1822 6 1 5 0 8

^top



Performance of Vsfold5 - scored lower in this pairwise comparison

1. Total counts & total scores for Vsfold5

Total Base Pair Counts
Total TP 1371
Total TN 175318
Total FP 1089
Total FP CONTRA 260
Total FP INCONS 651
Total FP COMP 178
Total FN 934
Total Scores
MCC 0.593
Average MCC ± 95% Confidence Intervals 0.666 ± 0.062
Sensitivity 0.595
Positive Predictive Value 0.601
Nr of predictions 127

^top



2. Individual counts for Vsfold5 [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2K5Z_A - 1.00 1.00 1.00 11 175 0 0 0 0 0
2K63_A - 1.00 1.00 1.00 9 159 0 0 0 0 0
2K66_A - 1.00 1.00 1.00 9 80 0 0 0 0 0
2KD8_A - 1.00 1.00 1.00 9 99 0 0 0 0 0
2KDQ_B 0.95 0.90 1.00 9 165 0 0 0 0 1
2KE6_A 1.00 1.00 1.00 18 449 1 0 0 1 0
2KEZ_A - 0.78 0.63 1.00 5 97 0 0 0 0 3
2KFC_A - 0.77 0.88 0.70 7 226 3 2 1 0 1
2KGP_A - 0.81 0.67 1.00 6 115 1 0 0 1 3
2KMJ_A - 0.95 0.91 1.00 10 158 0 0 0 0 1
2KPV_A - 0.96 0.92 1.00 12 201 0 0 0 0 1
2KRL_A - 0.71 0.78 0.64 18 1996 13 8 2 3 5
2KU0_A - -0.04 0.00 0.00 0 281 11 0 11 0 12
2KUR_A 1.00 1.00 1.00 19 448 0 0 0 0 0
2KUU_A 1.00 1.00 1.00 18 429 1 0 0 1 0
2KUV_A 1.00 1.00 1.00 19 420 0 0 0 0 0
2KUW_A 1.00 1.00 1.00 18 452 1 0 0 1 0
2KX8_A 0.97 0.94 1.00 15 356 0 0 0 0 1
2KXM_A - 0.78 0.63 1.00 5 144 0 0 0 0 3
2KZL_A - 1.00 1.00 1.00 13 507 1 0 0 1 0
2L1F_A 0.70 0.61 0.82 14 746 3 0 3 0 9
2L1F_B 0.71 0.63 0.83 15 773 3 0 3 0 9
2L2K_A - 0.94 0.88 1.00 15 334 0 0 0 0 2
2L3C_B - 1.00 1.00 1.00 14 225 0 0 0 0 0
2L3E_A - 1.00 1.00 1.00 12 228 1 0 0 1 0
2L3J_B 0.93 0.87 1.00 26 959 0 0 0 0 4
2L5Z_A - 0.68 0.67 0.75 6 103 2 0 2 0 3
2L94_A 0.97 0.94 1.00 17 340 1 0 0 1 1
2LA5_A - -0.03 0.00 0.00 0 268 7 0 7 0 7
2LBS_A - 1.00 1.00 1.00 14 193 0 0 0 0 0
2LC8_A -0.03 0.00 0.00 0 515 13 0 13 0 18
2LDL_A - 0.94 0.89 1.00 8 132 1 0 0 1 1
2LDT_A - 1.00 1.00 1.00 11 151 0 0 0 0 0
2LHP_A - 1.00 1.00 1.00 15 246 0 0 0 0 0
2LI4_A - 1.00 1.00 1.00 14 175 0 0 0 0 0
2LJJ_A - 1.00 1.00 1.00 7 123 3 0 0 3 0
2LK3_A - 0.94 0.89 1.00 8 92 0 0 0 0 1
2LKR_A - 0.31 0.31 0.32 9 2412 19 5 14 0 20
2LWK_A - 0.95 0.91 1.00 10 197 1 0 0 1 1
2RP0_A - 0.84 0.71 1.00 5 111 0 0 0 0 2
2RPT_A - 0.68 0.71 0.71 5 65 2 0 2 0 2
2RRC_A - 0.83 0.71 1.00 5 70 0 0 0 0 2
2WRQ_Y 0.94 0.89 1.00 8 1144 13 0 0 13 1
2WW9_E - -0.03 0.00 0.00 0 168 5 0 4 1 5
2WW9_D - 0.08 0.10 0.09 1 730 13 3 7 3 9
2WW9_F - 0.68 0.75 0.67 6 103 4 1 2 1 2
2WWQ_V 0.78 0.74 0.82 14 1187 4 1 2 1 5
2XKV_B -0.01 0.00 0.00 0 1803 32 17 15 0 11
2XQD_Y 0.95 0.90 1.00 19 1110 1 0 0 1 2
2XXA_G -0.02 0.00 0.00 0 2014 31 2 29 0 35
2Y8W_B - 1.00 1.00 1.00 6 82 1 0 0 1 0
2Y9C_V - 0.74 0.72 0.76 13 889 7 0 4 3 5
2YIE_X - 0.43 0.57 0.33 4 532 10 2 6 2 3
2YIE_Z - -0.02 0.00 0.00 0 591 11 5 6 0 8
2ZY6_A - 0.66 0.78 0.58 7 264 5 3 2 0 2
2ZZM_B 0.17 0.20 0.16 3 1339 25 4 12 9 12
2ZZN_D 0.95 0.95 0.95 21 962 1 1 0 0 1
3A2K_C 0.95 0.91 1.00 20 1088 0 0 0 0 2
3A3A_A 0.95 0.90 1.00 27 1473 0 0 0 0 3
3ADB_C - 0.72 0.61 0.87 20 1796 3 0 3 0 13
3AKZ_H 0.97 0.95 1.00 19 1108 1 0 0 1 1
3AM1_B - 0.86 0.86 0.86 25 1437 4 3 1 0 4
3AMU_B 0.77 0.79 0.75 15 1137 8 0 5 3 4
3DW4_A - 0.91 0.83 1.00 5 135 0 0 0 0 1
3G4S_9 0.12 0.15 0.11 4 2699 33 9 24 0 22
3GCA_A - 0.84 0.71 1.00 5 153 0 0 0 0 2
3GX2_A 0.61 0.57 0.67 16 1425 9 0 8 1 12
3HAY_E - 1.00 1.00 1.00 14 910 4 0 0 4 0
3HJW_D - 0.50 0.56 0.47 9 590 10 2 8 0 7
3IAB_R - 1.00 1.00 1.00 12 373 0 0 0 0 0
3ID5_D - 0.59 0.60 0.60 3 224 4 0 2 2 2
3IVN_B 0.88 0.78 1.00 18 885 0 0 0 0 5
3IWN_A 0.26 0.25 0.30 7 1449 16 2 14 0 21
3IYQ_A 0.30 0.37 0.24 19 22361 71 36 24 11 32
3IZ4_A 0.31 0.31 0.33 29 25448 65 14 45 6 66
3IZF_C 0.85 0.83 0.88 29 2607 5 0 4 1 6
3J0L_8 - 0.74 0.57 1.00 4 72 0 0 0 0 3
3J0L_1 - 0.25 0.23 0.30 3 474 8 3 4 1 10
3J0L_h - 0.20 0.19 0.24 6 2115 19 3 16 0 26
3J0L_2 - 0.42 0.42 0.44 11 2225 21 1 13 7 15
3J0L_7 - -0.02 0.00 0.00 0 506 13 3 10 0 10
3J0L_g - -0.01 0.00 0.00 0 174 4 0 2 2 2
3J0L_a - 0.39 0.36 0.44 4 402 6 4 1 1 7
3J16_L 0.98 0.95 1.00 20 1139 0 0 0 0 1
3J20_0 0.76 0.76 0.76 16 1198 6 3 2 1 5
3J20_1 0.75 0.75 0.75 15 1092 7 0 5 2 5
3J2C_O - 0.33 0.32 0.36 13 3951 26 3 20 3 28
3J2L_3 0.70 0.71 0.71 24 2986 13 3 7 3 10
3JYV_7 -0.02 0.00 0.00 0 1092 19 4 15 0 20
3JYX_4 0.63 0.83 0.48 10 4735 32 9 2 21 2
3JYX_3 0.12 0.13 0.11 2 2360 20 6 10 4 13
3KTW_C - 0.46 0.44 0.50 11 1758 15 2 9 4 14
3LA5_A -0.02 0.00 0.00 0 938 16 0 16 0 25
3NDB_M - 0.07 0.07 0.08 3 3678 33 2 31 0 41
3NKB_B - 0.69 0.74 0.67 14 714 7 0 7 0 5
3NMU_E - 0.28 0.33 0.25 1 212 5 2 1 2 2
3NPB_A 0.62 0.54 0.71 20 2250 10 1 7 2 17
3O58_3 0.51 0.59 0.45 13 4735 28 11 5 12 9
3O58_2 0.50 0.52 0.50 16 2722 19 3 13 3 15
3OVB_D - 1.00 1.00 1.00 11 215 1 0 0 1 0
3OVS_D - 1.00 1.00 1.00 12 204 0 0 0 0 0
3P22_G - 1.00 1.00 1.00 11 301 0 0 0 0 0
3PDR_A 0.69 0.64 0.74 32 4797 13 3 8 2 18
3R4F_A - 0.98 0.95 1.00 21 885 1 0 0 1 1
3R9X_C - 1.00 1.00 1.00 8 221 2 0 0 2 0
3RKF_A 0.90 0.92 0.88 22 841 3 3 0 0 2
3SD1_A 0.13 0.14 0.15 4 1507 22 5 17 0 25
3SIU_F - 0.86 0.75 1.00 6 139 0 0 0 0 2
3SN2_B 0.95 0.92 1.00 11 143 0 0 0 0 1
3TRZ_Z - 1.00 1.00 1.00 5 87 1 0 0 1 0
3TS0_U - 1.00 1.00 1.00 6 112 1 0 0 1 0
3TS2_V - 1.00 1.00 1.00 5 103 0 0 0 0 0
3U4M_B - 0.49 0.55 0.46 12 1250 14 3 11 0 10
3UZL_B 0.24 0.31 0.20 5 1268 20 9 11 0 11
3VJR_D - 1.00 1.00 1.00 12 239 0 0 0 0 0
3W3S_B 0.83 0.85 0.82 28 1955 7 2 4 1 5
3ZEX_D 0.09 0.09 0.12 3 2771 24 5 17 2 32
3ZEX_E - 0.11 0.15 0.09 5 8247 54 21 31 2 29
4A1C_3 0.29 0.30 0.31 11 2727 26 4 21 1 26
4A1C_2 0.33 0.40 0.28 8 4487 37 8 13 16 12
4A4U_A - 1.00 1.00 1.00 9 96 0 0 0 0 0
4AOB_A 0.21 0.21 0.25 6 1413 19 2 16 1 23
4ATO_G - 0.67 0.86 0.55 6 209 5 5 0 0 1
4ENB_A 1.00 1.00 1.00 15 457 0 0 0 0 0
4ENC_A 0.97 1.00 0.94 15 480 1 1 0 0 0
4FRG_B 0.60 0.58 0.64 14 1180 8 3 5 0 10
4FRN_A 0.15 0.14 0.17 4 1825 19 3 16 0 24

^top


Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.