CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Cylofold - scored higher in this pairwise comparison

  4. Performance of RNAalifold(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for Cylofold & RNAalifold(seed) [.zip] - may take several seconds...


Overview

Metric Cylofold RNAalifold(seed)
MCC 0.666 > 0.664
Average MCC ± 95% Confidence Intervals 0.702 ± 0.155 > 0.616 ± 0.132
Sensitivity 0.647 > 0.510
Positive Predictive Value 0.696 < 0.876
Total TP 268 > 211
Total TN 25752 < 25896
Total FP 144 > 39
Total FP CONTRA 36 > 4
Total FP INCONS 81 > 26
Total FP COMP 27 > 9
Total FN 146 < 203
P-value 0.456379442218

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Performance plots


  1. Comparison of performance of Cylofold and RNAalifold(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Cylofold and RNAalifold(seed)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for Cylofold and RNAalifold(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Cylofold and RNAalifold(seed)).

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Performance of Cylofold - scored higher in this pairwise comparison

1. Total counts & total scores for Cylofold

Total Base Pair Counts
Total TP 268
Total TN 25752
Total FP 144
Total FP CONTRA 36
Total FP INCONS 81
Total FP COMP 27
Total FN 146
Total Scores
MCC 0.666
Average MCC ± 95% Confidence Intervals 0.702 ± 0.155
Sensitivity 0.647
Positive Predictive Value 0.696
Nr of predictions 17

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2. Individual counts for Cylofold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2KX8_A 1.00 1.00 1.00 16 355 0 0 0 0 0
2L1F_A 0.93 0.87 1.00 20 743 0 0 0 0 3
2L1F_B 0.93 0.88 1.00 21 770 0 0 0 0 3
2L94_A 1.00 1.00 1.00 18 339 1 0 0 1 0
2LC8_A 0.64 0.61 0.69 11 512 5 1 4 0 7
2XKV_B 0.41 0.55 0.32 6 1816 25 9 4 12 5
2XXA_G 0.10 0.11 0.11 4 2009 32 2 30 0 31
3O58_3 0.42 0.50 0.35 11 4733 30 9 11 10 11
3PDR_A 0.86 0.78 0.95 39 4799 4 1 1 2 11
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.71 0.69 0.74 20 1506 7 2 5 0 9
3W3S_B 0.48 0.45 0.52 15 1960 15 1 13 1 18
4AOB_A 0.42 0.38 0.48 11 1414 13 3 9 1 18
4ENB_A 1.00 1.00 1.00 15 457 0 0 0 0 0
4ENC_A 0.97 1.00 0.94 15 480 1 1 0 0 0
4FRG_B 0.93 0.88 1.00 21 1181 0 0 0 0 3
4FRN_A 0.23 0.18 0.31 5 1832 11 7 4 0 23

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Performance of RNAalifold(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for RNAalifold(seed)

Total Base Pair Counts
Total TP 211
Total TN 25896
Total FP 39
Total FP CONTRA 4
Total FP INCONS 26
Total FP COMP 9
Total FN 203
Total Scores
MCC 0.664
Average MCC ± 95% Confidence Intervals 0.616 ± 0.132
Sensitivity 0.510
Positive Predictive Value 0.876
Nr of predictions 17

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2. Individual counts for RNAalifold(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2KX8_A 0.00 0.00 0.00 0 371 0 0 0 0 16
2L1F_A 0.68 0.61 0.78 14 745 4 0 4 0 9
2L1F_B 0.65 0.58 0.74 14 772 5 0 5 0 10
2L94_A 0.57 0.39 0.88 7 349 2 0 1 1 11
2LC8_A -0.03 0.00 0.00 0 516 12 0 12 0 18
2XKV_B 0.80 0.64 1.00 7 1828 2 0 0 2 4
2XXA_G 0.50 0.26 1.00 9 2036 0 0 0 0 26
3O58_3 0.60 0.36 1.00 8 4756 1 0 0 1 14
3PDR_A 0.81 0.66 1.00 33 4807 1 0 0 1 17
3RKF_A 0.74 0.67 0.84 16 847 3 1 2 0 8
3SD1_A 0.70 0.59 0.85 17 1513 3 2 1 0 12
3W3S_B 0.71 0.52 1.00 17 1972 2 0 0 2 16
4AOB_A 0.85 0.72 1.00 21 1416 2 0 0 2 8
4ENB_A 0.63 0.40 1.00 6 466 0 0 0 0 9
4ENC_A 0.63 0.40 1.00 6 490 0 0 0 0 9
4FRG_B 0.84 0.71 1.00 17 1185 0 0 0 0 7
4FRN_A 0.78 0.68 0.90 19 1827 2 1 1 0 9

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.