CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of IPknot - scored higher in this pairwise comparison

  4. Performance of RNASampler(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for IPknot & RNASampler(seed) [.zip] - may take several seconds...


Overview

Metric IPknot RNASampler(seed)
MCC 0.660 > 0.530
Average MCC ± 95% Confidence Intervals 0.623 ± 0.299 > 0.498 ± 0.340
Sensitivity 0.595 > 0.425
Positive Predictive Value 0.740 > 0.670
Total TP 91 > 65
Total TN 14683 < 14709
Total FP 45 < 46
Total FP CONTRA 10 > 6
Total FP INCONS 22 < 26
Total FP COMP 13 < 14
Total FN 62 < 88
P-value 0.0

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Performance plots


  1. Comparison of performance of IPknot and RNASampler(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for IPknot and RNASampler(seed)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for IPknot and RNASampler(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for IPknot and RNASampler(seed)).

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Performance of IPknot - scored higher in this pairwise comparison

1. Total counts & total scores for IPknot

Total Base Pair Counts
Total TP 91
Total TN 14683
Total FP 45
Total FP CONTRA 10
Total FP INCONS 22
Total FP COMP 13
Total FN 62
Total Scores
MCC 0.660
Average MCC ± 95% Confidence Intervals 0.623 ± 0.299
Sensitivity 0.595
Positive Predictive Value 0.740
Nr of predictions 6

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2. Individual counts for IPknot [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.41 0.33 0.55 6 517 5 1 4 0 12
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.74 0.69 0.80 20 1508 5 0 5 0 9
3W3S_B 0.94 0.91 0.97 30 1958 2 0 1 1 3
3ZEX_C 0.51 0.34 0.77 10 5361 7 1 2 4 19
4A1C_2 0.23 0.25 0.22 5 4493 26 8 10 8 15

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Performance of RNASampler(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for RNASampler(seed)

Total Base Pair Counts
Total TP 65
Total TN 14709
Total FP 46
Total FP CONTRA 6
Total FP INCONS 26
Total FP COMP 14
Total FN 88
Total Scores
MCC 0.530
Average MCC ± 95% Confidence Intervals 0.498 ± 0.340
Sensitivity 0.425
Positive Predictive Value 0.670
Nr of predictions 6

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2. Individual counts for RNASampler(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.03 0.00 0.00 0 518 10 0 10 0 18
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.72 0.55 0.94 16 1516 1 0 1 0 13
3W3S_B 0.60 0.36 1.00 12 1977 1 0 0 1 21
3ZEX_C 0.39 0.31 0.50 9 5356 14 2 7 5 20
4A1C_2 0.40 0.40 0.40 8 4496 20 4 8 8 12

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.