CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of MXScarna(seed) - scored higher in this pairwise comparison

  4. Performance of Carnac(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for MXScarna(seed) & Carnac(seed) [.zip] - may take several seconds...


Overview

Metric MXScarna(seed) Carnac(seed)
MCC 0.784 > 0.474
Average MCC ± 95% Confidence Intervals 0.738 ± 0.072 > 0.165 ± 0.110
Sensitivity 0.750 > 0.239
Positive Predictive Value 0.820 < 0.942
Total TP 926 > 295
Total TN 481734 < 482550
Total FP 419 > 57
Total FP CONTRA 55 > 6
Total FP INCONS 148 > 12
Total FP COMP 216 > 39
Total FN 308 < 939
P-value 5.19332990918e-08

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Performance plots


  1. Comparison of performance of MXScarna(seed) and Carnac(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for MXScarna(seed) and Carnac(seed)).

  2. Comparison of performance of MXScarna(seed) and Carnac(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for MXScarna(seed) and Carnac(seed)).

  3. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for MXScarna(seed) and Carnac(seed)).

  4. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for MXScarna(seed) and Carnac(seed)).

  5. Comparison of average Matthews Correlation Coefficients (MCCs) for MXScarna(seed) and Carnac(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for MXScarna(seed) and Carnac(seed)).

  6. Comparison of average Matthews Correlation Coefficients (MCCs) for MXScarna(seed) and Carnac(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for MXScarna(seed) and Carnac(seed)).

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Performance of MXScarna(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for MXScarna(seed)

Total Base Pair Counts
Total TP 926
Total TN 481734
Total FP 419
Total FP CONTRA 55
Total FP INCONS 148
Total FP COMP 216
Total FN 308
Total Scores
MCC 0.784
Average MCC ± 95% Confidence Intervals 0.738 ± 0.072
Sensitivity 0.750
Positive Predictive Value 0.820
Nr of predictions 35

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2. Individual counts for MXScarna(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2KDQ_B 1.00 1.00 1.00 10 164 0 0 0 0 0
2KE6_A 0.91 0.89 0.94 16 450 2 0 1 1 2
2KUR_A 0.92 0.89 0.94 17 449 1 0 1 0 2
2KUU_A 0.91 0.89 0.94 16 430 2 0 1 1 2
2KUV_A 0.92 0.89 0.94 17 421 1 0 1 0 2
2KUW_A 0.78 0.72 0.87 13 455 3 0 2 1 5
2L1F_A 0.93 0.91 0.95 21 741 1 0 1 0 2
2L1F_B 0.98 0.96 1.00 23 768 0 0 0 0 1
2L94_A 0.55 0.56 0.59 10 340 8 0 7 1 8
2LC8_A -0.03 0.00 0.00 0 518 12 0 10 2 18
2XKV_B 0.78 0.82 0.75 9 1823 20 0 3 17 2
2XXA_G 0.74 0.69 0.80 24 2015 7 0 6 1 11
3A3A_A 0.84 0.77 0.92 23 1475 4 0 2 2 7
3GX2_A 0.83 0.82 0.85 23 1422 7 2 2 3 5
3IVN_B 0.69 0.57 0.87 13 888 2 2 0 0 10
3IZF_C 0.84 0.83 0.85 29 2606 11 0 5 6 6
3J20_2 0.83 0.82 0.84 337 421969 147 14 48 85 75
3JYX_4 0.70 0.83 0.59 10 4739 21 6 1 14 2
3JYX_3 0.77 0.80 0.75 12 2362 24 0 4 20 3
3LA5_A 0.82 0.72 0.95 18 935 1 1 0 0 7
3NPB_A 0.76 0.70 0.84 26 2247 10 2 3 5 11
3O58_3 0.54 0.50 0.58 11 4745 20 5 3 12 11
3O58_2 0.93 0.94 0.94 29 2723 11 0 2 9 2
3PDR_A 0.87 0.88 0.86 44 4789 10 4 3 3 6
3RKF_A 0.86 0.75 1.00 18 848 0 0 0 0 6
3SD1_A 0.74 0.76 0.73 22 1503 9 4 4 1 7
3W3S_B 0.74 0.70 0.79 23 1960 7 0 6 1 10
3ZEX_C 0.39 0.31 0.50 9 5356 21 3 6 12 20
4A1C_3 0.92 0.92 0.92 34 2726 6 0 3 3 3
4A1C_2 0.45 0.40 0.50 8 4500 20 4 4 12 12
4AOB_A 0.71 0.69 0.74 20 1410 10 2 5 3 9
4ENB_A 0.54 0.40 0.75 6 464 2 0 2 0 9
4ENC_A 0.48 0.40 0.60 6 486 4 1 3 0 9
4FRG_B 0.49 0.42 0.59 10 1185 8 2 5 1 14
4FRN_A 0.70 0.68 0.73 19 1822 7 3 4 0 9

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Performance of Carnac(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Carnac(seed)

Total Base Pair Counts
Total TP 295
Total TN 482550
Total FP 57
Total FP CONTRA 6
Total FP INCONS 12
Total FP COMP 39
Total FN 939
Total Scores
MCC 0.474
Average MCC ± 95% Confidence Intervals 0.165 ± 0.110
Sensitivity 0.239
Positive Predictive Value 0.942
Nr of predictions 35

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2. Individual counts for Carnac(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2KDQ_B 1.00 1.00 1.00 10 164 0 0 0 0 0
2KE6_A 0.00 0.00 0.00 0 467 0 0 0 0 18
2KUR_A 0.60 0.37 1.00 7 460 0 0 0 0 12
2KUU_A 0.62 0.39 1.00 7 440 0 0 0 0 11
2KUV_A 0.68 0.47 1.00 9 430 0 0 0 0 10
2KUW_A 0.70 0.50 1.00 9 461 0 0 0 0 9
2L1F_A 0.00 0.00 0.00 0 763 0 0 0 0 23
2L1F_B 0.00 0.00 0.00 0 791 0 0 0 0 24
2L94_A 1.00 1.00 1.00 18 339 1 0 0 1 0
2LC8_A 0.47 0.22 1.00 4 524 0 0 0 0 14
2XKV_B 0.00 0.00 0.00 0 1835 0 0 0 0 11
2XXA_G 0.00 0.00 0.00 0 2045 0 0 0 0 35
3A3A_A 0.00 0.00 0.00 0 1500 0 0 0 0 30
3GX2_A 0.00 0.00 0.00 0 1449 0 0 0 0 28
3IVN_B 0.00 0.00 0.00 0 903 0 0 0 0 23
3IZF_C 0.00 0.00 0.00 0 2640 0 0 0 0 35
3J20_2 0.72 0.56 0.93 231 422119 56 6 12 38 181
3JYX_4 0.00 0.00 0.00 0 4756 0 0 0 0 12
3JYX_3 0.00 0.00 0.00 0 2378 0 0 0 0 15
3LA5_A 0.00 0.00 0.00 0 954 0 0 0 0 25
3NPB_A 0.00 0.00 0.00 0 2278 0 0 0 0 37
3O58_3 0.00 0.00 0.00 0 4764 0 0 0 0 22
3O58_2 0.00 0.00 0.00 0 2754 0 0 0 0 31
3PDR_A 0.00 0.00 0.00 0 4840 0 0 0 0 50
3RKF_A 0.00 0.00 0.00 0 866 0 0 0 0 24
3SD1_A 0.00 0.00 0.00 0 1533 0 0 0 0 29
3W3S_B 0.00 0.00 0.00 0 1989 0 0 0 0 33
3ZEX_C 0.00 0.00 0.00 0 5374 0 0 0 0 29
4A1C_3 0.00 0.00 0.00 0 2763 0 0 0 0 37
4A1C_2 0.00 0.00 0.00 0 4516 0 0 0 0 20
4AOB_A 0.00 0.00 0.00 0 1437 0 0 0 0 29
4ENB_A 0.00 0.00 0.00 0 472 0 0 0 0 15
4ENC_A 0.00 0.00 0.00 0 496 0 0 0 0 15
4FRG_B 0.00 0.00 0.00 0 1202 0 0 0 0 24
4FRN_A 0.00 0.00 0.00 0 1848 0 0 0 0 28

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.