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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of MaxExpect - scored higher in this pairwise comparison

  4. Performance of MCFold - scored lower in this pairwise comparison

  5. Compile and download dataset for MaxExpect & MCFold [.zip] - may take several seconds...


Overview

Metric MaxExpect MCFold
MCC 0.740 > 0.599
Average MCC ± 95% Confidence Intervals 0.732 ± 0.062 > 0.628 ± 0.068
Sensitivity 0.751 > 0.640
Positive Predictive Value 0.736 > 0.572
Total TP 1484 > 1266
Total TN 127940 > 127743
Total FP 813 < 1246
Total FP CONTRA 146 < 252
Total FP INCONS 385 < 694
Total FP COMP 282 < 300
Total FN 493 < 711
P-value 3.56938820447e-08

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Performance plots


  1. Comparison of performance of MaxExpect and MCFold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for MaxExpect and MCFold).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for MaxExpect and MCFold).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for MaxExpect and MCFold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for MaxExpect and MCFold).

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Performance of MaxExpect - scored higher in this pairwise comparison

1. Total counts & total scores for MaxExpect

Total Base Pair Counts
Total TP 1484
Total TN 127940
Total FP 813
Total FP CONTRA 146
Total FP INCONS 385
Total FP COMP 282
Total FN 493
Total Scores
MCC 0.740
Average MCC ± 95% Confidence Intervals 0.732 ± 0.062
Sensitivity 0.751
Positive Predictive Value 0.736
Nr of predictions 113

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2. Individual counts for MaxExpect [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2KD8_A - 1.00 1.00 1.00 9 99 0 0 0 0 0
2KE6_A 0.94 0.94 0.94 17 449 2 0 1 1 1
2KPV_A - 0.96 0.92 1.00 12 201 0 0 0 0 1
2KU0_A - -0.04 0.00 0.00 0 283 9 1 8 0 12
2KUR_A 0.95 0.95 0.95 18 448 1 0 1 0 1
2KUU_A 0.94 0.94 0.94 17 429 2 0 1 1 1
2KUV_A 0.94 0.95 0.95 18 420 1 0 1 0 1
2KUW_A 0.94 0.94 0.94 17 452 2 0 1 1 1
2KX8_A 1.00 1.00 1.00 16 355 0 0 0 0 0
2KXM_A - 0.93 0.88 1.00 7 142 0 0 0 0 1
2KZL_A - 1.00 1.00 1.00 13 507 1 0 0 1 0
2L1F_A 1.00 1.00 1.00 23 740 0 0 0 0 0
2L1F_B 1.00 1.00 1.00 24 767 0 0 0 0 0
2L2K_A - 1.00 1.00 1.00 17 332 0 0 0 0 0
2L3C_B - 1.00 1.00 1.00 14 225 0 0 0 0 0
2L3E_A - 1.00 1.00 1.00 12 228 1 0 0 1 0
2L3J_B 1.00 1.00 1.00 30 955 0 0 0 0 0
2L5Z_A - 1.00 1.00 1.00 9 102 0 0 0 0 0
2L94_A 1.00 1.00 1.00 18 339 1 0 0 1 0
2LA5_A - 0.77 0.71 0.83 5 269 3 0 1 2 2
2LBS_A - 1.00 1.00 1.00 14 193 0 0 0 0 0
2LC8_A -0.03 0.00 0.00 0 513 15 3 12 0 18
2LDL_A - 1.00 1.00 1.00 9 131 1 0 0 1 0
2LDT_A - 1.00 1.00 1.00 11 151 0 0 0 0 0
2LHP_A - 1.00 1.00 1.00 15 246 0 0 0 0 0
2LI4_A - 1.00 1.00 1.00 14 175 0 0 0 0 0
2LJJ_A - 1.00 1.00 1.00 7 123 3 0 0 3 0
2LK3_A - 1.00 1.00 1.00 9 91 0 0 0 0 0
2LKR_A - 0.84 0.83 0.86 24 2412 11 0 4 7 5
2LQZ_A - 1.00 1.00 1.00 8 124 2 0 0 2 0
2LU0_A - 1.00 1.00 1.00 16 422 0 0 0 0 0
2LWK_A - 1.00 1.00 1.00 11 196 1 0 0 1 0
2M58_A - -0.02 0.00 0.00 0 531 13 0 13 0 12
2RRC_A - 0.83 0.71 1.00 5 70 0 0 0 0 2
2WRQ_Y 0.94 0.89 1.00 8 1144 14 0 0 14 1
2WW9_F - 0.64 0.75 0.60 6 102 4 1 3 0 2
2WW9_E - -0.03 0.00 0.00 0 168 5 0 4 1 5
2WW9_D - 0.08 0.10 0.08 1 729 15 2 9 4 9
2WWQ_V 0.97 0.95 1.00 18 1186 3 0 0 3 1
2XKV_B 0.64 0.73 0.57 8 1821 26 0 6 20 3
2XQD_Y 0.98 0.95 1.00 20 1109 1 0 0 1 1
2XXA_G 0.24 0.26 0.25 9 2009 28 1 26 1 26
2Y8W_B - 1.00 1.00 1.00 6 82 1 0 0 1 0
2Y9C_V - 0.79 0.83 0.75 15 886 8 0 5 3 3
2YIE_X - 0.53 0.57 0.50 4 536 6 1 3 2 3
2YIE_Z - -0.02 0.00 0.00 0 587 15 6 9 0 8
3A2K_C 0.47 0.50 0.46 11 1084 13 3 10 0 11
3AKZ_H 1.00 1.00 1.00 20 1107 2 0 0 2 0
3AM1_B - 0.86 0.86 0.86 25 1437 4 0 4 0 4
3AMU_B 0.73 0.79 0.68 15 1135 10 0 7 3 4
3GX2_A 0.93 0.89 0.96 25 1423 2 1 0 1 3
3IAB_R - 1.00 1.00 1.00 12 373 0 0 0 0 0
3IVN_B 0.91 0.83 1.00 19 884 0 0 0 0 4
3IWN_A 0.80 0.79 0.81 22 1445 6 1 4 1 6
3IZF_C 0.89 0.91 0.86 32 2603 8 0 5 3 3
3J0L_g - -0.01 0.00 0.00 0 174 4 0 2 2 2
3J0L_2 - 0.30 0.31 0.31 8 2224 25 2 16 7 18
3J0L_7 - -0.02 0.00 0.00 0 507 12 3 9 0 10
3J0L_h - 0.93 0.88 1.00 28 2112 2 0 0 2 4
3J0L_1 - 0.83 0.77 0.91 10 473 4 0 1 3 3
3J0L_a - 0.39 0.36 0.44 4 402 6 4 1 1 7
3J0L_8 - 1.00 1.00 1.00 7 69 0 0 0 0 0
3J16_L 0.34 0.33 0.37 7 1140 12 0 12 0 14
3J20_0 0.53 0.57 0.50 12 1195 13 2 10 1 9
3J2L_3 0.80 0.82 0.78 28 2984 12 1 7 4 6
3J3D_C 0.47 0.53 0.43 10 945 13 5 8 0 9
3J3E_8 0.10 0.13 0.09 2 2719 32 5 16 11 13
3J3E_7 0.60 0.59 0.63 20 2709 14 2 10 2 14
3J3F_8 0.34 0.42 0.29 8 4733 39 10 10 19 11
3J3F_7 0.94 0.94 0.94 34 2898 4 1 1 2 2
3JYV_7 0.48 0.45 0.53 9 1094 9 3 5 1 11
3JYX_3 0.77 0.80 0.75 12 2362 24 0 4 20 3
3JYX_4 0.55 0.83 0.37 10 4729 34 14 3 17 2
3KTW_C - 0.72 0.72 0.72 18 1755 14 2 5 7 7
3LA5_A 0.91 0.84 1.00 21 933 0 0 0 0 4
3NDB_M - 0.94 0.93 0.95 41 3671 7 0 2 5 3
3NKB_B - 0.69 0.74 0.67 14 714 7 0 7 0 5
3NMU_E - -0.02 0.00 0.00 0 208 10 5 3 2 3
3O58_3 0.40 0.50 0.33 11 4731 36 8 14 14 11
3O58_2 0.91 0.94 0.88 29 2721 11 0 4 7 2
3OVB_D - 1.00 1.00 1.00 11 215 1 0 0 1 0
3OVS_D - 1.00 1.00 1.00 12 204 0 0 0 0 0
3P22_G - 1.00 1.00 1.00 11 301 0 0 0 0 0
3PDR_A 0.92 0.90 0.94 45 4792 5 1 2 2 5
3R4F_A - 1.00 1.00 1.00 22 884 1 0 0 1 0
3R9X_C - 1.00 1.00 1.00 8 221 2 0 0 2 0
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.70 0.69 0.71 20 1505 8 3 5 0 9
3SIU_F - 1.00 1.00 1.00 8 137 0 0 0 0 0
3SN2_B 1.00 1.00 1.00 12 142 0 0 0 0 0
3TRZ_Z - 1.00 1.00 1.00 5 87 1 0 0 1 0
3TS0_U - 1.00 1.00 1.00 6 112 1 0 0 1 0
3TS2_V - 1.00 1.00 1.00 5 103 0 0 0 0 0
3U4M_B - 0.58 0.59 0.59 13 1254 9 2 7 0 9
3VJR_D - 1.00 1.00 1.00 12 239 0 0 0 0 0
3ZEX_G - 0.98 0.96 1.00 43 6464 17 0 0 17 2
3ZEX_D 0.82 0.77 0.87 27 2765 11 0 4 7 8
3ZEX_H - 0.26 0.37 0.19 7 3589 29 18 11 0 12
3ZEX_C 0.54 0.45 0.65 13 5354 17 2 5 10 16
3ZEX_F - -0.01 0.00 0.00 0 908 11 2 4 5 4
3ZND_W 0.24 0.38 0.16 3 1172 25 9 7 9 5
4A1C_2 0.19 0.25 0.16 5 4484 41 10 17 14 15
4A1C_3 0.83 0.81 0.86 30 2728 7 0 5 2 7
4A4U_A - 1.00 1.00 1.00 9 96 0 0 0 0 0
4ATO_G - 0.45 0.43 0.50 3 214 3 3 0 0 4
4ENB_A 0.85 0.73 1.00 11 461 0 0 0 0 4
4ENC_A 0.36 0.33 0.42 5 484 8 0 7 1 10
4FNJ_A - 0.91 0.83 1.00 10 240 0 0 0 0 2
4FRG_B 0.29 0.25 0.35 6 1185 11 4 7 0 18
4FRN_A 0.51 0.46 0.57 13 1825 10 5 5 0 15
4HXH_A - 1.00 1.00 1.00 6 89 0 0 0 0 0
4JF2_A 0.89 0.79 1.00 19 1063 0 0 0 0 5
4JRC_A - 0.34 0.35 0.35 6 605 11 0 11 0 11

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Performance of MCFold - scored lower in this pairwise comparison

1. Total counts & total scores for MCFold

Total Base Pair Counts
Total TP 1266
Total TN 127743
Total FP 1246
Total FP CONTRA 252
Total FP INCONS 694
Total FP COMP 300
Total FN 711
Total Scores
MCC 0.599
Average MCC ± 95% Confidence Intervals 0.628 ± 0.068
Sensitivity 0.640
Positive Predictive Value 0.572
Nr of predictions 113

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2. Individual counts for MCFold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2KD8_A - 1.00 1.00 1.00 9 99 1 0 0 1 0
2KE6_A 1.00 1.00 1.00 18 449 1 0 0 1 0
2KPV_A - 1.00 1.00 1.00 13 200 0 0 0 0 0
2KU0_A - 1.00 1.00 1.00 12 280 1 0 0 1 0
2KUR_A 1.00 1.00 1.00 19 448 0 0 0 0 0
2KUU_A 1.00 1.00 1.00 18 429 1 0 0 1 0
2KUV_A 1.00 1.00 1.00 19 420 0 0 0 0 0
2KUW_A 1.00 1.00 1.00 18 452 1 0 0 1 0
2KX8_A 1.00 1.00 1.00 16 355 0 0 0 0 0
2KXM_A - 1.00 1.00 1.00 8 141 1 0 0 1 0
2KZL_A - 1.00 1.00 1.00 13 507 5 0 0 5 0
2L1F_A 0.79 0.78 0.82 18 741 4 0 4 0 5
2L1F_B 0.80 0.79 0.83 19 768 4 0 4 0 5
2L2K_A - 1.00 1.00 1.00 17 332 1 0 0 1 0
2L3C_B - 1.00 1.00 1.00 14 225 1 0 0 1 0
2L3E_A - 1.00 1.00 1.00 12 228 2 0 0 2 0
2L3J_B 1.00 1.00 1.00 30 955 0 0 0 0 0
2L5Z_A - 1.00 1.00 1.00 9 102 0 0 0 0 0
2L94_A 1.00 1.00 1.00 18 339 1 0 0 1 0
2LA5_A - -0.03 0.00 0.00 0 265 10 0 10 0 7
2LBS_A - 1.00 1.00 1.00 14 193 1 0 0 1 0
2LC8_A 0.44 0.44 0.47 8 511 10 0 9 1 10
2LDL_A - 1.00 1.00 1.00 9 131 1 0 0 1 0
2LDT_A - 0.95 0.91 1.00 10 152 0 0 0 0 1
2LHP_A - 1.00 1.00 1.00 15 246 1 0 0 1 0
2LI4_A - 1.00 1.00 1.00 14 175 0 0 0 0 0
2LJJ_A - 1.00 1.00 1.00 7 123 3 0 0 3 0
2LK3_A - 1.00 1.00 1.00 9 91 0 0 0 0 0
2LKR_A - 1.00 1.00 1.00 29 2411 11 0 0 11 0
2LQZ_A - 1.00 1.00 1.00 8 124 3 0 0 3 0
2LU0_A - 1.00 1.00 1.00 16 422 2 0 0 2 0
2LWK_A - 1.00 1.00 1.00 11 196 2 0 0 2 0
2M58_A - 0.22 0.25 0.23 3 531 13 1 9 3 9
2RRC_A - 1.00 1.00 1.00 7 68 1 0 0 1 0
2WRQ_Y 0.38 0.56 0.26 5 1133 21 8 6 7 4
2WW9_F - 0.68 0.75 0.67 6 103 4 1 2 1 2
2WW9_E - -0.03 0.00 0.00 0 165 8 1 6 1 5
2WW9_D - -0.02 0.00 0.00 0 723 21 6 12 3 10
2WWQ_V 0.19 0.21 0.19 4 1183 20 3 14 3 15
2XKV_B 0.20 0.27 0.16 3 1816 30 4 12 14 8
2XQD_Y 0.39 0.43 0.38 9 1105 18 2 13 3 12
2XXA_G 0.23 0.26 0.24 9 2007 30 1 28 1 26
2Y8W_B - 1.00 1.00 1.00 6 82 2 0 0 2 0
2Y9C_V - 0.65 0.72 0.59 13 884 12 1 8 3 5
2YIE_X - -0.01 0.00 0.00 0 535 15 1 8 6 7
2YIE_Z - 0.53 0.63 0.45 5 591 8 2 4 2 3
3A2K_C 0.49 0.55 0.46 12 1082 14 3 11 0 10
3AKZ_H 0.46 0.50 0.43 10 1104 16 5 8 3 10
3AM1_B - 1.00 1.00 1.00 29 1437 1 0 0 1 0
3AMU_B 0.50 0.58 0.44 11 1132 15 4 10 1 8
3GX2_A 0.58 0.61 0.57 17 1419 15 1 12 2 11
3IAB_R - 1.00 1.00 1.00 12 373 4 0 0 4 0
3IVN_B 0.45 0.48 0.46 11 879 14 5 8 1 12
3IWN_A 0.19 0.21 0.20 6 1442 24 5 19 0 22
3IZF_C 0.92 0.94 0.89 33 2603 10 0 4 6 2
3J0L_g - -0.02 0.00 0.00 0 170 7 4 2 1 2
3J0L_2 - 0.25 0.27 0.25 7 2222 29 4 17 8 19
3J0L_7 - -0.02 0.00 0.00 0 504 15 6 9 0 10
3J0L_h - 0.98 0.97 1.00 31 2109 2 0 0 2 1
3J0L_1 - 0.88 0.85 0.92 11 472 5 0 1 4 2
3J0L_a - 0.14 0.18 0.15 2 398 13 1 10 2 9
3J0L_8 - 1.00 1.00 1.00 7 69 0 0 0 0 0
3J16_L 0.54 0.57 0.52 12 1136 12 4 7 1 9
3J20_0 0.66 0.71 0.63 15 1195 11 3 6 2 6
3J2L_3 0.77 0.79 0.75 27 2984 15 1 8 6 7
3J3D_C 0.54 0.63 0.48 12 943 13 4 9 0 7
3J3E_8 0.15 0.20 0.12 3 2716 36 11 12 13 12
3J3E_7 0.55 0.56 0.54 19 2706 23 1 15 7 15
3J3F_8 0.14 0.21 0.10 4 4720 51 17 20 14 15
3J3F_7 0.88 0.89 0.86 32 2897 9 1 4 4 4
3JYV_7 0.25 0.30 0.24 6 1086 20 8 11 1 14
3JYX_3 0.46 0.67 0.32 10 2347 28 15 6 7 5
3JYX_4 0.36 0.58 0.23 7 4725 37 19 5 13 5
3KTW_C - 0.55 0.60 0.52 15 1751 20 4 10 6 10
3LA5_A 0.44 0.44 0.48 11 931 12 2 10 0 14
3NDB_M - 0.29 0.30 0.30 13 3671 35 1 29 5 31
3NKB_B - 0.68 0.74 0.64 14 713 8 2 6 0 5
3NMU_E - 0.51 0.67 0.40 2 211 8 1 2 5 1
3O58_3 0.28 0.36 0.22 8 4727 39 14 15 10 14
3O58_2 0.25 0.29 0.23 9 2715 31 6 24 1 22
3OVB_D - 1.00 1.00 1.00 11 215 1 0 0 1 0
3OVS_D - 1.00 1.00 1.00 12 204 0 0 0 0 0
3P22_G - 1.00 1.00 1.00 11 301 1 0 0 1 0
3PDR_A 0.78 0.80 0.77 40 4788 14 5 7 2 10
3R4F_A - 0.95 0.95 0.95 21 884 4 0 1 3 1
3R9X_C - 0.87 0.88 0.88 7 221 5 0 1 4 1
3RKF_A 0.89 0.88 0.91 21 843 3 0 2 1 3
3SD1_A 0.43 0.45 0.43 13 1503 17 1 16 0 16
3SIU_F - 0.53 0.63 0.50 5 135 5 2 3 0 3
3SN2_B 0.58 0.58 0.64 7 143 4 0 4 0 5
3TRZ_Z - -0.05 0.00 0.00 0 88 4 0 4 0 5
3TS0_U - 1.00 1.00 1.00 6 112 1 0 0 1 0
3TS2_V - -0.05 0.00 0.00 0 102 7 0 6 1 5
3U4M_B - 0.74 0.77 0.71 17 1252 10 1 6 3 5
3VJR_D - 1.00 1.00 1.00 12 239 1 0 0 1 0
3ZEX_G - 0.00 0.00 0.00 0 6493 14 6 8 0 45
3ZEX_D 0.23 0.26 0.23 9 2756 33 6 25 2 26
3ZEX_H - 0.22 0.32 0.16 6 3588 36 15 16 5 13
3ZEX_C 0.30 0.34 0.27 10 5337 28 6 21 1 19
3ZEX_F - 0.00 0.00 0.00 0 909 22 0 5 17 4
3ZND_W 0.23 0.38 0.15 3 1171 26 9 8 9 5
4A1C_2 0.18 0.25 0.14 5 4480 45 12 19 14 15
4A1C_3 0.86 0.86 0.86 32 2726 9 0 5 4 5
4A4U_A - 1.00 1.00 1.00 9 96 0 0 0 0 0
4ATO_G - 0.36 0.43 0.33 3 211 8 0 6 2 4
4ENB_A 0.78 0.73 0.85 11 459 4 0 2 2 4
4ENC_A 0.34 0.33 0.38 5 483 11 0 8 3 10
4FNJ_A - 0.91 0.92 0.92 11 238 1 0 1 0 1
4FRG_B 0.35 0.38 0.35 9 1176 17 3 14 0 15
4FRN_A 0.09 0.11 0.10 3 1818 28 2 25 1 25
4HXH_A - 1.00 1.00 1.00 6 89 0 0 0 0 0
4JF2_A 0.74 0.75 0.75 18 1058 7 1 5 1 6
4JRC_A - 0.24 0.29 0.23 5 600 17 0 17 0 12

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.