CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of MaxExpect - scored higher in this pairwise comparison

  4. Performance of RNAfold - scored lower in this pairwise comparison

  5. Compile and download dataset for MaxExpect & RNAfold [.zip] - may take several seconds...


Overview

Metric MaxExpect RNAfold
MCC 0.663 > 0.621
Average MCC ± 95% Confidence Intervals 0.741 ± 0.058 < 0.757 ± 0.055
Sensitivity 0.679 > 0.647
Positive Predictive Value 0.648 > 0.597
Total TP 2599 > 2477
Total TN 2549668 > 2549524
Total FP 1881 < 2160
Total FP CONTRA 399 < 434
Total FP INCONS 1010 < 1241
Total FP COMP 472 < 485
Total FN 1230 < 1352
P-value 3.56938820447e-08

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Performance plots


  1. Comparison of performance of MaxExpect and RNAfold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for MaxExpect and RNAfold).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for MaxExpect and RNAfold).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for MaxExpect and RNAfold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for MaxExpect and RNAfold).

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Performance of MaxExpect - scored higher in this pairwise comparison

1. Total counts & total scores for MaxExpect

Total Base Pair Counts
Total TP 2599
Total TN 2549668
Total FP 1881
Total FP CONTRA 399
Total FP INCONS 1010
Total FP COMP 472
Total FN 1230
Total Scores
MCC 0.663
Average MCC ± 95% Confidence Intervals 0.741 ± 0.058
Sensitivity 0.679
Positive Predictive Value 0.648
Nr of predictions 118

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2. Individual counts for MaxExpect [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2KD8_A - 1.00 1.00 1.00 9 99 0 0 0 0 0
2KE6_A 0.94 0.94 0.94 17 449 2 0 1 1 1
2KPV_A - 0.96 0.92 1.00 12 201 0 0 0 0 1
2KRL_A - 0.91 0.87 0.95 20 2003 9 1 0 8 3
2KU0_A - -0.04 0.00 0.00 0 283 9 1 8 0 12
2KUR_A 0.95 0.95 0.95 18 448 1 0 1 0 1
2KUU_A 0.94 0.94 0.94 17 429 2 0 1 1 1
2KUV_A 0.94 0.95 0.95 18 420 1 0 1 0 1
2KUW_A 0.94 0.94 0.94 17 452 2 0 1 1 1
2KX8_A 1.00 1.00 1.00 16 355 0 0 0 0 0
2KXM_A - 0.93 0.88 1.00 7 142 0 0 0 0 1
2KZL_A - 1.00 1.00 1.00 13 507 1 0 0 1 0
2L1F_B 1.00 1.00 1.00 24 767 0 0 0 0 0
2L1F_A 1.00 1.00 1.00 23 740 0 0 0 0 0
2L2K_A - 1.00 1.00 1.00 17 332 0 0 0 0 0
2L3C_B - 1.00 1.00 1.00 14 225 0 0 0 0 0
2L3E_A - 1.00 1.00 1.00 12 228 1 0 0 1 0
2L3J_B 1.00 1.00 1.00 30 955 0 0 0 0 0
2L5Z_A - 1.00 1.00 1.00 9 102 0 0 0 0 0
2L94_A 1.00 1.00 1.00 18 339 1 0 0 1 0
2LA5_A - 0.77 0.71 0.83 5 269 3 0 1 2 2
2LBS_A - 1.00 1.00 1.00 14 193 0 0 0 0 0
2LC8_A -0.03 0.00 0.00 0 513 15 3 12 0 18
2LDL_A - 1.00 1.00 1.00 9 131 1 0 0 1 0
2LDT_A - 1.00 1.00 1.00 11 151 0 0 0 0 0
2LHP_A - 1.00 1.00 1.00 15 246 0 0 0 0 0
2LI4_A - 1.00 1.00 1.00 14 175 0 0 0 0 0
2LJJ_A - 1.00 1.00 1.00 7 123 3 0 0 3 0
2LK3_A - 1.00 1.00 1.00 9 91 0 0 0 0 0
2LKR_A - 0.84 0.83 0.86 24 2412 11 0 4 7 5
2LQZ_A - 1.00 1.00 1.00 8 124 2 0 0 2 0
2LWK_A - 1.00 1.00 1.00 11 196 1 0 0 1 0
2RRC_A - 0.83 0.71 1.00 5 70 0 0 0 0 2
2WRQ_Y 0.94 0.89 1.00 8 1144 14 0 0 14 1
2WW9_F - 0.64 0.75 0.60 6 102 4 1 3 0 2
2WW9_E - -0.03 0.00 0.00 0 168 5 0 4 1 5
2WW9_D - 0.08 0.10 0.08 1 729 15 2 9 4 9
2WWQ_V 0.97 0.95 1.00 18 1186 3 0 0 3 1
2XKV_B 0.64 0.73 0.57 8 1821 26 0 6 20 3
2XQD_Y 0.98 0.95 1.00 20 1109 1 0 0 1 1
2XXA_G 0.24 0.26 0.25 9 2009 28 1 26 1 26
2Y8W_B - 1.00 1.00 1.00 6 82 1 0 0 1 0
2Y9C_V - 0.79 0.83 0.75 15 886 8 0 5 3 3
2YIE_X - 0.53 0.57 0.50 4 536 6 1 3 2 3
2YIE_Z - -0.02 0.00 0.00 0 587 15 6 9 0 8
3A2K_C 0.47 0.50 0.46 11 1084 13 3 10 0 11
3ADB_C - 0.86 0.85 0.88 28 1787 4 0 4 0 5
3AKZ_H 1.00 1.00 1.00 20 1107 2 0 0 2 0
3AM1_B - 0.86 0.86 0.86 25 1437 4 0 4 0 4
3AMU_B 0.73 0.79 0.68 15 1135 10 0 7 3 4
3GX2_A 0.93 0.89 0.96 25 1423 2 1 0 1 3
3IAB_R - 1.00 1.00 1.00 12 373 0 0 0 0 0
3IVN_B 0.91 0.83 1.00 19 884 0 0 0 0 4
3IWN_A 0.80 0.79 0.81 22 1445 6 1 4 1 6
3IYQ_A 0.24 0.33 0.17 17 22342 96 41 40 15 34
3IZ4_A 0.61 0.61 0.62 58 25442 42 14 22 6 37
3IZF_C 0.89 0.91 0.86 32 2603 8 0 5 3 3
3J0L_1 - 0.83 0.77 0.91 10 473 4 0 1 3 3
3J0L_8 - 1.00 1.00 1.00 7 69 0 0 0 0 0
3J0L_a - 0.39 0.36 0.44 4 402 6 4 1 1 7
3J0L_h - 0.93 0.88 1.00 28 2112 2 0 0 2 4
3J0L_7 - -0.02 0.00 0.00 0 507 12 3 9 0 10
3J0L_g - -0.01 0.00 0.00 0 174 4 0 2 2 2
3J0L_2 - 0.30 0.31 0.31 8 2224 25 2 16 7 18
3J16_L 0.34 0.33 0.37 7 1140 12 0 12 0 14
3J20_2 0.60 0.63 0.58 258 421926 239 28 156 55 154
3J20_1 0.75 0.75 0.75 15 1092 6 0 5 1 5
3J20_0 0.53 0.57 0.50 12 1195 13 2 10 1 9
3J2C_M - 0.48 0.54 0.43 52 39804 88 29 40 19 44
3J2C_O - 0.74 0.71 0.78 29 3950 13 0 8 5 12
3J2L_3 0.80 0.82 0.78 28 2984 12 1 7 4 6
3JYV_7 0.48 0.45 0.53 9 1094 9 3 5 1 11
3JYX_3 0.77 0.80 0.75 12 2362 24 0 4 20 3
3JYX_4 0.55 0.83 0.37 10 4729 34 14 3 17 2
3KIY_A - 0.67 0.68 0.66 531 1485073 336 81 195 60 255
3KTW_C - 0.72 0.72 0.72 18 1755 14 2 5 7 7
3LA5_A 0.91 0.84 1.00 21 933 0 0 0 0 4
3NDB_M - 0.94 0.93 0.95 41 3671 7 0 2 5 3
3NKB_B - 0.69 0.74 0.67 14 714 7 0 7 0 5
3NMU_E - -0.02 0.00 0.00 0 208 10 5 3 2 3
3NPB_A 0.77 0.73 0.82 27 2245 10 0 6 4 10
3O58_2 0.91 0.94 0.88 29 2721 11 0 4 7 2
3O58_3 0.40 0.50 0.33 11 4731 36 8 14 14 11
3OVB_D - 1.00 1.00 1.00 11 215 1 0 0 1 0
3OVS_D - 1.00 1.00 1.00 12 204 0 0 0 0 0
3P22_G - 1.00 1.00 1.00 11 301 0 0 0 0 0
3PDR_A 0.92 0.90 0.94 45 4792 5 1 2 2 5
3R4F_A - 1.00 1.00 1.00 22 884 1 0 0 1 0
3R9X_C - 1.00 1.00 1.00 8 221 2 0 0 2 0
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.70 0.69 0.71 20 1505 8 3 5 0 9
3SIU_F - 1.00 1.00 1.00 8 137 0 0 0 0 0
3SN2_B 1.00 1.00 1.00 12 142 0 0 0 0 0
3TRZ_Z - 1.00 1.00 1.00 5 87 1 0 0 1 0
3TS0_U - 1.00 1.00 1.00 6 112 1 0 0 1 0
3TS2_V - 1.00 1.00 1.00 5 103 0 0 0 0 0
3U4M_B - 0.58 0.59 0.59 13 1254 9 2 7 0 9
3UZL_B 1.00 1.00 1.00 16 1277 8 0 0 8 0
3VJR_D - 1.00 1.00 1.00 12 239 0 0 0 0 0
3W3S_B 0.97 0.94 1.00 31 1958 1 0 0 1 2
3ZEX_G - 0.98 0.96 1.00 43 6464 17 0 0 17 2
3ZEX_D 0.82 0.77 0.87 27 2765 11 0 4 7 8
3ZEX_B - 0.37 0.39 0.35 134 420964 302 66 188 48 212
3ZEX_E - -0.01 0.00 0.00 0 8252 54 21 31 2 34
3ZEX_C 0.54 0.45 0.65 13 5354 17 2 5 10 16
3ZEX_F - -0.01 0.00 0.00 0 908 11 2 4 5 4
3ZEX_H - 0.26 0.37 0.19 7 3589 29 18 11 0 12
4A1C_2 0.19 0.25 0.16 5 4484 41 10 17 14 15
4A1C_3 0.83 0.81 0.86 30 2728 7 0 5 2 7
4A4U_A - 1.00 1.00 1.00 9 96 0 0 0 0 0
4AOB_A 0.60 0.59 0.63 17 1410 11 4 6 1 12
4ATO_G - 0.45 0.43 0.50 3 214 3 3 0 0 4
4ENB_A 0.85 0.73 1.00 11 461 0 0 0 0 4
4ENC_A 0.36 0.33 0.42 5 484 8 0 7 1 10
4FNJ_A - 0.91 0.83 1.00 10 240 0 0 0 0 2
4FRG_B 0.29 0.25 0.35 6 1185 11 4 7 0 18
4FRN_A 0.51 0.46 0.57 13 1825 10 5 5 0 15
4HXH_A - 1.00 1.00 1.00 6 89 0 0 0 0 0

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Performance of RNAfold - scored lower in this pairwise comparison

1. Total counts & total scores for RNAfold

Total Base Pair Counts
Total TP 2477
Total TN 2549524
Total FP 2160
Total FP CONTRA 434
Total FP INCONS 1241
Total FP COMP 485
Total FN 1352
Total Scores
MCC 0.621
Average MCC ± 95% Confidence Intervals 0.757 ± 0.055
Sensitivity 0.647
Positive Predictive Value 0.597
Nr of predictions 118

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2. Individual counts for RNAfold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2KD8_A - 1.00 1.00 1.00 9 99 0 0 0 0 0
2KE6_A 1.00 1.00 1.00 18 449 1 0 0 1 0
2KPV_A - 0.96 0.92 1.00 12 201 0 0 0 0 1
2KRL_A - 0.91 0.87 0.95 20 2003 9 1 0 8 3
2KU0_A - 1.00 1.00 1.00 12 280 0 0 0 0 0
2KUR_A 1.00 1.00 1.00 19 448 0 0 0 0 0
2KUU_A 1.00 1.00 1.00 18 429 1 0 0 1 0
2KUV_A 1.00 1.00 1.00 19 420 0 0 0 0 0
2KUW_A 1.00 1.00 1.00 18 452 1 0 0 1 0
2KX8_A 1.00 1.00 1.00 16 355 0 0 0 0 0
2KXM_A - 1.00 1.00 1.00 8 141 0 0 0 0 0
2KZL_A - 1.00 1.00 1.00 13 507 1 0 0 1 0
2L1F_B 1.00 1.00 1.00 24 767 0 0 0 0 0
2L1F_A 1.00 1.00 1.00 23 740 0 0 0 0 0
2L2K_A - 1.00 1.00 1.00 17 332 0 0 0 0 0
2L3C_B - 1.00 1.00 1.00 14 225 0 0 0 0 0
2L3E_A - 1.00 1.00 1.00 12 228 1 0 0 1 0
2L3J_B 1.00 1.00 1.00 30 955 0 0 0 0 0
2L5Z_A - 1.00 1.00 1.00 9 102 0 0 0 0 0
2L94_A 1.00 1.00 1.00 18 339 1 0 0 1 0
2LA5_A - 0.77 0.71 0.83 5 269 3 0 1 2 2
2LBS_A - 1.00 1.00 1.00 14 193 0 0 0 0 0
2LC8_A 0.64 0.61 0.69 11 512 5 0 5 0 7
2LDL_A - 1.00 1.00 1.00 9 131 1 0 0 1 0
2LDT_A - 1.00 1.00 1.00 11 151 0 0 0 0 0
2LHP_A - 1.00 1.00 1.00 15 246 0 0 0 0 0
2LI4_A - 1.00 1.00 1.00 14 175 0 0 0 0 0
2LJJ_A - 1.00 1.00 1.00 7 123 3 0 0 3 0
2LK3_A - 1.00 1.00 1.00 9 91 0 0 0 0 0
2LKR_A - 1.00 1.00 1.00 29 2411 8 0 0 8 0
2LQZ_A - 1.00 1.00 1.00 8 124 2 0 0 2 0
2LWK_A - 0.95 0.91 1.00 10 197 1 0 0 1 1
2RRC_A - 1.00 1.00 1.00 7 68 0 0 0 0 0
2WRQ_Y 1.00 1.00 1.00 9 1143 14 0 0 14 0
2WW9_F - 0.68 0.75 0.67 6 103 4 1 2 1 2
2WW9_E - 0.89 0.80 1.00 4 168 0 0 0 0 1
2WW9_D - 0.08 0.10 0.08 1 729 15 2 9 4 9
2WWQ_V 1.00 1.00 1.00 19 1185 5 0 0 5 0
2XKV_B 0.64 0.73 0.57 8 1821 25 0 6 19 3
2XQD_Y 0.98 0.95 1.00 20 1109 1 0 0 1 1
2XXA_G 0.35 0.34 0.38 12 2013 21 1 19 1 23
2Y8W_B - 1.00 1.00 1.00 6 82 1 0 0 1 0
2Y9C_V - 0.79 0.83 0.75 15 886 8 0 5 3 3
2YIE_X - 0.33 0.43 0.27 3 533 11 3 5 3 4
2YIE_Z - -0.02 0.00 0.00 0 587 15 6 9 0 8
3A2K_C 0.47 0.50 0.46 11 1084 13 3 10 0 11
3ADB_C - 0.35 0.36 0.36 12 1786 22 1 20 1 21
3AKZ_H 0.48 0.50 0.48 10 1106 13 4 7 2 10
3AM1_B - 0.74 0.76 0.73 22 1436 8 3 5 0 7
3AMU_B 0.81 0.79 0.83 15 1139 6 0 3 3 4
3GX2_A 0.81 0.79 0.85 22 1423 5 2 2 1 6
3IAB_R - 1.00 1.00 1.00 12 373 0 0 0 0 0
3IVN_B 0.91 0.83 1.00 19 884 0 0 0 0 4
3IWN_A 0.69 0.68 0.70 19 1445 9 1 7 1 9
3IYQ_A 0.24 0.33 0.17 17 22340 95 45 38 12 34
3IZ4_A 0.56 0.60 0.52 57 25426 57 26 27 4 38
3IZF_C 0.75 0.77 0.73 27 2603 15 0 10 5 8
3J0L_1 - 0.83 0.77 0.91 10 473 4 0 1 3 3
3J0L_8 - 1.00 1.00 1.00 7 69 0 0 0 0 0
3J0L_a - 0.18 0.18 0.22 2 402 8 3 4 1 9
3J0L_h - 0.87 0.81 0.93 26 2112 4 1 1 2 6
3J0L_7 - -0.02 0.00 0.00 0 507 12 2 10 0 10
3J0L_g - -0.01 0.00 0.00 0 173 5 1 2 2 2
3J0L_2 - 0.30 0.31 0.31 8 2224 25 2 16 7 18
3J16_L 0.90 0.81 1.00 17 1142 0 0 0 0 4
3J20_2 0.56 0.58 0.54 238 421930 251 36 164 51 174
3J20_1 1.00 1.00 1.00 20 1092 3 0 0 3 0
3J20_0 0.51 0.57 0.48 12 1194 14 3 10 1 9
3J2C_M - 0.66 0.71 0.62 68 39816 71 15 26 30 28
3J2C_O - 0.76 0.76 0.78 31 3947 15 2 7 6 10
3J2L_3 0.80 0.82 0.78 28 2984 12 1 7 4 6
3JYV_7 -0.02 0.00 0.00 0 1089 22 4 18 0 20
3JYX_3 0.77 0.80 0.75 12 2362 27 0 4 23 3
3JYX_4 0.61 0.83 0.45 10 4734 33 10 2 21 2
3KIY_A - 0.50 0.53 0.48 414 1485013 501 90 363 48 372
3KTW_C - 0.96 0.96 0.96 24 1755 9 0 1 8 1
3LA5_A 0.91 0.84 1.00 21 933 0 0 0 0 4
3NDB_M - 0.93 0.93 0.93 41 3670 9 0 3 6 3
3NKB_B - 0.69 0.74 0.67 14 714 7 0 7 0 5
3NMU_E - 1.00 1.00 1.00 3 213 5 0 0 5 0
3NPB_A 0.91 0.86 0.97 32 2245 5 1 0 4 5
3O58_2 0.72 0.74 0.70 23 2721 19 0 10 9 8
3O58_3 0.41 0.50 0.34 11 4732 35 6 15 14 11
3OVB_D - 1.00 1.00 1.00 11 215 1 0 0 1 0
3OVS_D - 1.00 1.00 1.00 12 204 0 0 0 0 0
3P22_G - 1.00 1.00 1.00 11 301 0 0 0 0 0
3PDR_A 0.90 0.90 0.90 45 4790 7 2 3 2 5
3R4F_A - 1.00 1.00 1.00 22 884 1 0 0 1 0
3R9X_C - 1.00 1.00 1.00 8 221 2 0 0 2 0
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.77 0.76 0.79 22 1505 6 4 2 0 7
3SIU_F - 1.00 1.00 1.00 8 137 0 0 0 0 0
3SN2_B 0.95 0.92 1.00 11 143 0 0 0 0 1
3TRZ_Z - 1.00 1.00 1.00 5 87 1 0 0 1 0
3TS0_U - 1.00 1.00 1.00 6 112 1 0 0 1 0
3TS2_V - 1.00 1.00 1.00 5 103 0 0 0 0 0
3U4M_B - 0.49 0.55 0.46 12 1250 14 3 11 0 10
3UZL_B 0.49 0.50 0.50 8 1277 15 0 8 7 8
3VJR_D - 1.00 1.00 1.00 12 239 0 0 0 0 0
3W3S_B 0.60 0.61 0.61 20 1956 14 4 9 1 13
3ZEX_G - 0.86 0.84 0.88 38 6464 22 0 5 17 7
3ZEX_D 0.88 0.83 0.94 29 2765 6 0 2 4 6
3ZEX_B - 0.35 0.39 0.32 136 420925 333 77 214 42 210
3ZEX_E - 0.00 0.00 0.00 0 8255 54 17 32 5 34
3ZEX_C 0.30 0.34 0.26 10 5336 43 5 23 15 19
3ZEX_F - -0.01 0.00 0.00 0 908 11 2 4 5 4
3ZEX_H - 0.25 0.37 0.18 7 3586 32 20 12 0 12
4A1C_2 0.19 0.25 0.15 5 4482 43 11 18 14 15
4A1C_3 0.88 0.86 0.89 32 2727 7 0 4 3 5
4A4U_A - 1.00 1.00 1.00 9 96 0 0 0 0 0
4AOB_A 0.60 0.59 0.63 17 1410 11 4 6 1 12
4ATO_G - 0.38 0.43 0.38 3 212 5 5 0 0 4
4ENB_A 0.85 0.73 1.00 11 461 2 0 0 2 4
4ENC_A 0.37 0.33 0.45 5 485 7 0 6 1 10
4FNJ_A - 0.91 0.83 1.00 10 240 0 0 0 0 2
4FRG_B 0.36 0.38 0.38 9 1178 15 2 13 0 15
4FRN_A 0.59 0.57 0.62 16 1822 10 2 8 0 12
4HXH_A - 1.00 1.00 1.00 6 89 0 0 0 0 0

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.