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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Multilign(20) - scored higher in this pairwise comparison

  4. Performance of Alterna - scored lower in this pairwise comparison

  5. Compile and download dataset for Multilign(20) & Alterna [.zip] - may take several seconds...


Overview

Metric Multilign(20) Alterna
MCC 0.811 > 0.750
Average MCC ± 95% Confidence Intervals 0.827 ± 0.244 > 0.776 ± 0.296
Sensitivity 0.811 > 0.756
Positive Predictive Value 0.820 > 0.756
Total TP 73 > 68
Total TN 3824 > 3823
Total FP 20 < 26
Total FP CONTRA 4 < 5
Total FP INCONS 12 < 17
Total FP COMP 4 = 4
Total FN 17 < 22
P-value 0.0

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Performance plots


  1. Comparison of performance of Multilign(20) and Alterna. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Multilign(20) and Alterna).

  2. Comparison of performance of Multilign(20) and Alterna. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Multilign(20) and Alterna).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for Multilign(20) and Alterna. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Multilign(20) and Alterna).

  4. Comparison of average Matthews Correlation Coefficients (MCCs) for Multilign(20) and Alterna. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Multilign(20) and Alterna).

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Performance of Multilign(20) - scored higher in this pairwise comparison

1. Total counts & total scores for Multilign(20)

Total Base Pair Counts
Total TP 73
Total TN 3824
Total FP 20
Total FP CONTRA 4
Total FP INCONS 12
Total FP COMP 4
Total FN 17
Total Scores
MCC 0.811
Average MCC ± 95% Confidence Intervals 0.827 ± 0.244
Sensitivity 0.811
Positive Predictive Value 0.820
Nr of predictions 4

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2. Individual counts for Multilign(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2L94_A 1.00 1.00 1.00 18 339 1 0 0 1 0
3AMU_B 0.71 0.74 0.70 14 1137 9 0 6 3 5
3RKF_A 0.91 0.88 0.95 21 844 1 0 1 0 3
3SD1_A 0.68 0.69 0.69 20 1504 9 4 5 0 9

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Performance of Alterna - scored lower in this pairwise comparison

1. Total counts & total scores for Alterna

Total Base Pair Counts
Total TP 68
Total TN 3823
Total FP 26
Total FP CONTRA 5
Total FP INCONS 17
Total FP COMP 4
Total FN 22
Total Scores
MCC 0.750
Average MCC ± 95% Confidence Intervals 0.776 ± 0.296
Sensitivity 0.756
Positive Predictive Value 0.756
Nr of predictions 4

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2. Individual counts for Alterna [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2L94_A 1.00 1.00 1.00 18 339 1 0 0 1 0
3AMU_B 0.73 0.79 0.68 15 1135 10 0 7 3 4
3RKF_A 0.82 0.79 0.86 19 844 3 1 2 0 5
3SD1_A 0.55 0.55 0.57 16 1505 12 4 8 0 13

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.