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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Multilign(20) - scored higher in this pairwise comparison

  4. Performance of CMfinder(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for Multilign(20) & CMfinder(20) [.zip] - may take several seconds...


Overview

Metric Multilign(20) CMfinder(20)
MCC 0.672 > 0.652
Average MCC ± 95% Confidence Intervals 0.622 ± 0.539 < 0.662 ± 0.224
Sensitivity 0.649 > 0.518
Positive Predictive Value 0.705 < 0.831
Total TP 74 > 59
Total TN 8132 < 8166
Total FP 42 > 16
Total FP CONTRA 4 > 3
Total FP INCONS 27 > 9
Total FP COMP 11 > 4
Total FN 40 < 55
P-value 0.0

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Performance plots


  1. Comparison of performance of Multilign(20) and CMfinder(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Multilign(20) and CMfinder(20)).

  2. Comparison of performance of Multilign(20) and CMfinder(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Multilign(20) and CMfinder(20)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for Multilign(20) and CMfinder(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Multilign(20) and CMfinder(20)).

  4. Comparison of average Matthews Correlation Coefficients (MCCs) for Multilign(20) and CMfinder(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Multilign(20) and CMfinder(20)).

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Performance of Multilign(20) - scored higher in this pairwise comparison

1. Total counts & total scores for Multilign(20)

Total Base Pair Counts
Total TP 74
Total TN 8132
Total FP 42
Total FP CONTRA 4
Total FP INCONS 27
Total FP COMP 11
Total FN 40
Total Scores
MCC 0.672
Average MCC ± 95% Confidence Intervals 0.622 ± 0.539
Sensitivity 0.649
Positive Predictive Value 0.705
Nr of predictions 4

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2. Individual counts for Multilign(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J20_0 0.68 0.71 0.65 15 1196 9 2 6 1 6
3J2L_3 0.80 0.79 0.82 27 2987 10 0 6 4 7
3ZEX_D 0.88 0.83 0.94 29 2765 8 0 2 6 6
4FRG_B 0.13 0.13 0.17 3 1184 15 2 13 0 21

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Performance of CMfinder(20) - scored lower in this pairwise comparison

1. Total counts & total scores for CMfinder(20)

Total Base Pair Counts
Total TP 59
Total TN 8166
Total FP 16
Total FP CONTRA 3
Total FP INCONS 9
Total FP COMP 4
Total FN 55
Total Scores
MCC 0.652
Average MCC ± 95% Confidence Intervals 0.662 ± 0.224
Sensitivity 0.518
Positive Predictive Value 0.831
Nr of predictions 4

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2. Individual counts for CMfinder(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J20_0 0.84 0.76 0.94 16 1202 2 1 0 1 5
3J2L_3 0.57 0.50 0.65 17 2994 11 2 7 2 17
3ZEX_D 0.70 0.54 0.90 19 2775 3 0 2 1 16
4FRG_B 0.54 0.29 1.00 7 1195 0 0 0 0 17

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.