CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Multilign(20) - scored higher in this pairwise comparison

  4. Performance of Mastr(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for Multilign(20) & Mastr(seed) [.zip] - may take several seconds...


Overview

Metric Multilign(20) Mastr(seed)
MCC 0.652 > 0.000
Average MCC ± 95% Confidence Intervals 0.638 ± 0.177 > 0.000 ± 0.000
Sensitivity 0.624 > 0.000
Positive Predictive Value 0.692 > 0.000
Total TP 234 > 0
Total TN 24653 < 24991
Total FP 131 > 0
Total FP CONTRA 23 > 0
Total FP INCONS 81 > 0
Total FP COMP 27 > 0
Total FN 141 < 375
P-value 1.59816551561e-08

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Performance plots


  1. Comparison of performance of Multilign(20) and Mastr(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Multilign(20) and Mastr(seed)).

  2. Comparison of performance of Multilign(20) and Mastr(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Multilign(20) and Mastr(seed)).

  3. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Multilign(20) and Mastr(seed)).

  4. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Multilign(20) and Mastr(seed)).

  5. Comparison of average Matthews Correlation Coefficients (MCCs) for Multilign(20) and Mastr(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Multilign(20) and Mastr(seed)).

  6. Comparison of average Matthews Correlation Coefficients (MCCs) for Multilign(20) and Mastr(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Multilign(20) and Mastr(seed)).

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Performance of Multilign(20) - scored higher in this pairwise comparison

1. Total counts & total scores for Multilign(20)

Total Base Pair Counts
Total TP 234
Total TN 24653
Total FP 131
Total FP CONTRA 23
Total FP INCONS 81
Total FP COMP 27
Total FN 141
Total Scores
MCC 0.652
Average MCC ± 95% Confidence Intervals 0.638 ± 0.177
Sensitivity 0.624
Positive Predictive Value 0.692
Nr of predictions 15

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2. Individual counts for Multilign(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2L94_A 1.00 1.00 1.00 18 339 1 0 0 1 0
2XXA_G -0.01 0.00 0.00 0 2033 12 2 10 0 35
3AMU_B 0.71 0.74 0.70 14 1137 9 0 6 3 5
3J20_0 0.68 0.71 0.65 15 1196 9 2 6 1 6
3J20_1 1.00 1.00 1.00 20 1092 1 0 0 1 0
3J2L_3 0.80 0.79 0.82 27 2987 10 0 6 4 7
3RKF_A 0.91 0.88 0.95 21 844 1 0 1 0 3
3SD1_A 0.68 0.69 0.69 20 1504 9 4 5 0 9
3ZEX_D 0.88 0.83 0.94 29 2765 8 0 2 6 6
4A1C_3 0.88 0.86 0.89 32 2727 6 0 4 2 5
4A1C_2 0.20 0.25 0.16 5 4485 33 9 17 7 15
4AOB_A 0.59 0.55 0.64 16 1412 10 3 6 1 13
4ENB_A 0.39 0.33 0.50 5 462 6 0 5 1 10
4ENC_A 0.73 0.60 0.90 9 486 1 1 0 0 6
4FRG_B 0.13 0.13 0.17 3 1184 15 2 13 0 21

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Performance of Mastr(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Mastr(seed)

Total Base Pair Counts
Total TP 0
Total TN 24991
Total FP 0
Total FP CONTRA 0
Total FP INCONS 0
Total FP COMP 0
Total FN 375
Total Scores
MCC 0.000
Average MCC ± 95% Confidence Intervals 0.000 ± 0.000
Sensitivity 0.000
Positive Predictive Value 0.000
Nr of predictions 15

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2. Individual counts for Mastr(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2L94_A 0.00 0.00 0.00 0 357 0 0 0 0 18
2XXA_G 0.00 0.00 0.00 0 2045 0 0 0 0 35
3AMU_B 0.00 0.00 0.00 0 1157 0 0 0 0 19
3J20_0 0.00 0.00 0.00 0 1219 0 0 0 0 21
3J20_1 0.00 0.00 0.00 0 1112 0 0 0 0 20
3J2L_3 0.00 0.00 0.00 0 3020 0 0 0 0 34
3RKF_A 0.00 0.00 0.00 0 866 0 0 0 0 24
3SD1_A 0.00 0.00 0.00 0 1533 0 0 0 0 29
3ZEX_D 0.00 0.00 0.00 0 2796 0 0 0 0 35
4A1C_3 0.00 0.00 0.00 0 2763 0 0 0 0 37
4A1C_2 0.00 0.00 0.00 0 4516 0 0 0 0 20
4AOB_A 0.00 0.00 0.00 0 1437 0 0 0 0 29
4ENB_A 0.00 0.00 0.00 0 472 0 0 0 0 15
4ENC_A 0.00 0.00 0.00 0 496 0 0 0 0 15
4FRG_B 0.00 0.00 0.00 0 1202 0 0 0 0 24

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.